The positive steps we are taking to prevent disease might have a negative side effect.
- A new study out of Princeton suggests that measures to prevent COVID-19 are also preventing certain other diseases.
- The nature of seasonal diseases means that people who avoid them this year may just be putting it off, leading to a large wave later.
- These estimates don't mean we should be less preventive now, only that we must be sure to take care in the future.
Why you should still wear a mask<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDc3NDYzNS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYzMzc1ODM1Nn0.UNIHh2X2AtR6fq_fhAwejphFKIOY9J3lGFWgDf-R6oE/img.jpg?width=980" id="d681e" class="rm-shortcode" data-rm-shortcode-id="1dc1e7ee8c2f01ac128b4b48c1675510" data-rm-shortcode-name="rebelmouse-image" />
A chart from another study on the effectiveness of masks and lockdowns. The grey line in the bottom two marks when mask mandates were imposed.
Credit: Zhang, Li, Zhang, and Molina<p><br>Again, before you decide that this means mask mandates are just delaying some kind of reckoning, we can look at the numbers. Several <a href="https://www.nationalgeographic.com/science/2020/07/coronavirus-deadlier-than-many-believed-infection-fatality-rate-cvd/" target="_blank" rel="noopener noreferrer">sources</a> agree <a href="https://www.cdc.gov/flu/symptoms/flu-vs-covid19.htm" target="_blank" rel="noopener noreferrer">that</a> the <a href="https://www.hopkinsmedicine.org/health/conditions-and-diseases/coronavirus/coronavirus-disease-2019-vs-the-flu" target="_blank" rel="noopener noreferrer">coronavirus</a> is <a href="https://www.livescience.com/covid-19-vs-flu-deaths-hospitalized-patients.html" target="_blank" rel="noopener noreferrer">deadlier</a> than <a href="https://www.snopes.com/fact-check/flu-kills-more-people-covid-19/" target="_blank" rel="noopener noreferrer">the </a><a href="https://www.snopes.com/fact-check/flu-kills-more-people-covid-19/" target="_blank" rel="noopener noreferrer">flu</a><a href="https://www.snopes.com/fact-check/flu-kills-more-people-covid-19/" target="_blank" rel="noopener noreferrer">.</a> We also don't have a vaccine for it yet, unlike for the flu, and keeping yourself and others from getting sick now remains extremely important for keeping people alive. </p><p> A friend of mine remarked at the beginning of the pandemic that certain events in society leave marks on the people in it, much like growth rings on a tree showing years of drought decades after it occurred. If the findings of this study are accurate, then COVID-19 will leave rings visible in seasonal outbreaks over the next few years alongside the slew of others it will create. <br></p><p>Given what this study shows us and the hard-learned lessons we have about what happens when you don't listen to scientists, maybe we'll do a better job at controlling those potential epidemics.</p>
Medicago is growing a SARS-CoV-2 vaccine candidate in a relative of the tobacco plant right now.
- Canadian biotech company Medicago is growing a vaccine candidate in Nicotiana benthamiana.
- An Australian relative to tobacco, plant-based vaccines could be cheaper and more reliable than current methods.
- Medicago just completed phase 3 clinical trials of an influenza vaccine, which could be a game-changer for vaccine production.
Credit: alphaspirit / Adobe Stock<p>Clark <a href="https://www.medicago.com/en/newsroom/medicago-begins-phase-i-clinical-trials-for-its-covid-19-vaccine-candidate/" target="_blank">says</a> it's important to attack the novel coronavirus from all sides.</p><p style="margin-left: 20px;">"Creating a sufficient supply of COVID-19 vaccines within the next year is a challenge which will require multiple approaches, with different technologies. Our proven plant-based technology is capable of contributing to the collective solution to this public health emergency."</p><p>Unlike many common vaccines, VLP vaccines contain no genetic material. You won't get infected by it, which is always a risk in live vaccines. </p><p>This SARS-CoV-2 vaccine is not the only project on Medicago's hands. The company <a href="https://clinicaltrials.gov/ct2/show/NCT03301051" target="_blank">just completed</a> phase 3 clinical trials on an influenza. While no plant-based vaccine has been approved for use, the company hopes to replace the more cumbersome and expensive egg-based model, or at least offset some of the costs of that model. The plant model could help researchers adapt more quickly to the ever-changing influenza strains each season. </p><p>Plants offer a wonderful alternative to the current vaccination model. Besides price, VLP vaccines scale much easier and faster. If the SARS-CoV-2 vaccine works, Medicago <a href="https://www.medicago.com/en/newsroom/medicago-begins-phase-i-clinical-trials-for-its-covid-19-vaccine-candidate/" target="_blank" rel="noopener noreferrer">believes</a> they can produce a billion doses a year, by far the most ambitious yield to date. At a time when speed, cost, and reliability are all essential factors in vaccine development, we should put tobacco to better use: healing instead of harming. </p><p>--</p><p><em>Stay in touch with Derek on <a href="http://www.twitter.com/derekberes" target="_blank">Twitter</a> and <a href="https://www.facebook.com/DerekBeresdotcom" target="_blank" rel="noopener noreferrer">Facebook</a>. His new book is</em> "<em><a href="https://www.amazon.com/gp/product/B08KRVMP2M?pf_rd_r=MDJW43337675SZ0X00FH&pf_rd_p=edaba0ee-c2fe-4124-9f5d-b31d6b1bfbee" target="_blank" rel="noopener noreferrer">Hero's Dose: The Case For Psychedelics in Ritual and Therapy</a>."</em></p>
94 percent of men in the study have this mutation, which explains why men are more likely to die.
- Since the pandemic began, we've wondered why some people suffer terribly while others show no symptoms.
- A team at the Howard Hughes Medical Institute discovered a genetic mutation responsible for the production of "auto-antibodies."
- These findings could change treatment protocols and vaccine development moving forward.
The coronavirus is mutating. Now what?<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="bd204431582dd80799581c29db3aa84b"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/Djy3WNLz_mM?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><h3>The Findings</h3><p>The genetic mutations slow down interferon—a group of signaling proteins released in the presence of viruses—production and function. This particular mutation makes these patients vulnerable to certain pathogens, such as the flu. Of the 659 patients initially tested in the Spring, 23 carried gene errors, rendering them unable to produce the necessary antiviral interferons to fight off COVID-19. </p><p>They then tested 987 patients, of which 101 produced auto-antibodies. All of these patients had trouble fending off the ravages of the virus. By testing people for these mutations, the team believes they can predict who will suffer most from the virus, even before they become infected. </p><p>Interestingly, 94 percent of patients that develop harmful antibodies are men, which helps explain why men are <a href="https://www.cidrap.umn.edu/news-perspective/2020/04/studies-find-men-more-prone-covid-19-death#:~:text=Risk%20of%20death%202.4%20times%20higher%20in%20men&text=In%20the%20case%20series,%20men,29.7%25;%20P%20=%200.016)." target="_blank" rel="noopener noreferrer">more likely to die</a> from COVID-19. Cassanova is now investigating whether the production of these auto-antibodies is linked to X chromosomes. Even small genetic errors, the team says, could be responsible for this phenomenon. </p>
Photo: Drazen Zigic / Shutterstock<h3>Why It Matters</h3><p>If researchers can pinpoint genetic markers in healthy patients, this could open up an entirely new testing protocol. People with this genetic mutation will know they are at higher risk for life-threatening problems, and will be able to take precautions until a vaccine is developed. </p><p>This could also affect treatment protocols. The team is looking into procedures that strip these auto-antibodies from patients' blood, for example. They're also investigating protective genetic factors by studying asymptomatic patients. Just as the virus exploits the above genetic mutation, others are naturally protected. They want to know why. </p><p>In regards to the vaccine, this research helps identify high-risk groups. People carrying this genetic mutation could receive the vaccine first, if these studies hold up.</p><p>With all of the above work happening at the center, it's no wonder Cassanova concludes, "Our lab is currently running at full speed."</p><p>--</p><p><em>Stay in touch with Derek on <a href="http://www.twitter.com/derekberes" target="_blank">Twitter</a>, <a href="https://www.facebook.com/DerekBeresdotcom" target="_blank" rel="noopener noreferrer">Facebook</a> and <a href="https://derekberes.substack.com/" target="_blank" rel="noopener noreferrer">Substack</a>. His next book is</em> "<em>Hero's Dose: The Case For Psychedelics in Ritual and Therapy."</em></p>
Andrew Wakefield turned away from science and to the tabloids to spread his fabricated data.
- Investigative journalist Brian Deer has published a new book on anti-vaxx ringleader, Andrew Wakefield.
- Discredited in the science community, Wakefield turned to the media to share his anti-vaxx propaganda.
- The disbarred doctor fabricated results and filed for his own vaccine patents, Deer reports.
Brian Deer on the media's role in vaccine scares<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="8fb353300760fa3da4cff23f5875bc51"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/P8uBzQC3Xz8?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><p>Gershon realized the slides were likely contaminated in the laboratory. He wasn't the only one. Science has long suffered from the "<a href="https://www.newyorker.com/magazine/2010/12/13/the-truth-wears-off" target="_blank">replication crisis</a>"—many studies come to a conclusion that cannot be replicated upon further research. Not only did future research fail to confirm Wakefield's research, the doctor balked when his research institution, Royal Free Hospital School of Medicine, offered a large sum of money to conduct a follow-up study. If Wakefield's work was sturdy, it would have held up.</p><p>Wakefield never even tried. Instead, he turned to an increasingly popular trick when your data fails: let the media do your work for you. Science is hard and expensive. Clickbait, cheap and addictive. </p><p>The actual data is mind-boggling. The 12 children in the original study were handpicked, which is antithetical to clinical research. Wakefield falsified the results from pediatricians. He used microscopic-level stains; a more reliable molecular method found nothing. The parents of study subjects, some with their own agendas (such as litigation), kept changing the timeline of their child's conditions—some children showed symptoms of autism <em>before</em> the MMR vaccine was given while others claimed symptoms started hours after injection when previous reports state that it was months. While Wakefield was raging against the vaccine, he filed for two patents on single measles shots. </p><p>After purchasing a six-bedroom house on five acres of prime Austin real estate—Wakefield moved to America to take advantage of growing anti-vaxx fervor—he realized the equation for success: "<em>Autism + vaccines = money</em>."</p><p>Every chapter drops your jaw. Consider this example to better understand the myth of vaccine-created autism. On July 20, 2005, Wakefield, with support from anti-vaxx congressman Dan Burton, spoke at the National Mall. The event was a rally against the vaccine ingredient, thimerosal, which itself is a red herring: thimerosal was removed from almost all vaccines in 1999, yet autism cases continued to rise. </p>
Dr Andrew Wakefield (C) walks with his wife Carmel after speaking to reporters at the General Medical Council (GMC) on January 28, 2010 in London, England.
Credit: Peter Macdiarmid/Getty Images<p>Wakefield read a statement from a UK newspaper apologizing after the former doctor brought a defamation suit. By this point, Deer had published numerous groundbreaking stories in the Sunday Times (circulation: 1.2 million). A tiny local newspaper, the Cambridge Evening News (circulation: 5,000), had reprinted two sentences from Deer's coverage. Instead of bringing Deer to court (which he would do later, unsuccessfully), Wakefield sued the fragile paper in eastern England, which did not have the resources to defend itself.</p><p>No one on the Mall that day understood the specifics. They weren't told the backstory. All they heard was that Wakefield was vindicated, for which they cheered. </p><p>Every schtick has a shelf life. Deer details the increasingly absurd stakes of Wakefield's career: measles causes Crohn's disease; the MMR vaccine causes autism; all vaccines are suspect. Over the course of two decades, the disbarred doctor chased money wherever it led, taking a willing media along with him. His efforts culminated in the 2016 pseudoscience documentary, "Vaxxed."</p><p>Actions have consequences. Andrew Wakefield saw opportunity in vaccine-resistant parents. At first, he filed for his own single-jab measles vaccine—at the time, the demon was supposedly the triple shot MMR—but he wasn't fully aware of what lurked inside of this Pandora's box. Wakefield was paid hundreds of thousands of dollars to fabricate the study, as Deer's reporting shows. A long game hadn't yet been imagined. </p><p>Twenty-two years later, during the worst pandemic in a century, 35 percent of Americans claim they will not take an FDA-approved, free COVID-19 vaccine, according to a <a href="https://news.gallup.com/poll/317018/one-three-americans-not-covid-vaccine.aspx" target="_blank">Gallup poll</a>. The science community called Wakefield's research out for what it was, yet by manipulating the media—more forcefully, social media—the "doctor with no patients" has made a large percentage of people skeptical of one of the best therapeutic interventions ever devised. The cost, if and when a COVID-19 vaccine is developed, will be high. </p><p>Never say one man cannot change the world. And never think that change is always for the better.</p><p>--</p><p><em>Stay in touch with Derek on <a href="http://www.twitter.com/derekberes" target="_blank">Twitter</a>, <a href="https://www.facebook.com/DerekBeresdotcom" target="_blank" rel="noopener noreferrer">Facebook</a> and <a href="https://derekberes.substack.com/" target="_blank" rel="noopener noreferrer">Substack</a>. His next book is</em> "<em>Hero's Dose: The Case For Psychedelics in Ritual and Therapy."</em></p>
We owe a lot to vaccines and the scientists that develop them. But we've only just touched the surface of what vaccines can do.
- "Vaccines are the best thing science has ever given us," says Larry Brilliant, founding president and acting chairman of Skoll Global Threats. From smallpox, to Ebola, to polio, scientists have successful fought viruses and saved millions of lives. So what's next?
- As Covaxx (formerly United Neuroscience) cofounder Lou Reese explains in this video, the issue with vaccines is that they don't work against "non-external threats." This is a problem, especially now when internal threats (things that cause cancers, Alzheimer's, diabetes, and other chronic illnesses) are killing people more than external threats like viruses.
- The future of vaccine tech, which scientists are already working toward today, is developing safe vaccines to eradicate these destructive internal agents without harming our bodies in the process.