Researchers make the case for "deep evidential regression."
- MIT researchers claim that deep learning neural networks need better uncertainty analysis to reduce errors.
- "Deep evidential regression" reduces uncertainty after only one pass on a network, greatly reducing time and memory.
- This could help mitigate problems in medical diagnoses, autonomous driving, and much more.
Credit: scharsfinn86 / Adobe Stock<p>On the road, 1 percent could be the difference between stopping at an intersection or rushing through just as another car runs a stop sign. Amini and colleagues wanted to produce a model that could better detect patterns in giant data sets. They named their solution "deep evidential regression."</p><p>Sorting through billions of parameters is no easy task. Amini's model utilizes uncertainly analysis—learning how much error exists within a model and supplying missing data. This approach in deep learning isn't novel, though it often takes a lot of time and memory. Deep evidential regression estimates uncertainty after only one run of the neural network. According to the team, they can assess uncertainty in both input data <em>and</em> the final decision, after which they can either address the neural network or recognize noise in the input data.</p><p>In real-world terms, this is the difference between trusting an initial medical diagnosis or seeking a second opinion. By arming AI with a built-in detection system for uncertainty, a new level of honesty with data is reached—in this model, with pixels. During a test run, the neural network was given novel images; it was able to detect changes imperceptible to the human eye. Ramini believes this technology can also be used to pinpoint <a href="https://www.theguardian.com/technology/2020/jan/13/what-are-deepfakes-and-how-can-you-spot-them" target="_blank">deepfakes</a>, a serious problem we must begin to grapple with.</p><p>Any field that uses machine learning will have to factor in uncertainty awareness, be it medicine, cars, or otherwise. As Amini says, </p><p style="margin-left: 20px;">"Any user of the method, whether it's a doctor or a person in the passenger seat of a vehicle, needs to be aware of any risk or uncertainty associated with that decision."</p><p>We might not have to worry about alien robots turning on us (yet), but we should be concerned with that new feature we just downloaded into our electric car. There will be many other issues to face with the emergence of AI in our world—and workforce. The safer we can make the transition, the better. </p><p>--</p><p><em>Stay in touch with Derek on <a href="http://www.twitter.com/derekberes" target="_blank">Twitter</a> and <a href="https://www.facebook.com/DerekBeresdotcom" target="_blank" rel="noopener noreferrer">Facebook</a>. His new book is</em> "<em><a href="https://www.amazon.com/gp/product/B08KRVMP2M?pf_rd_r=MDJW43337675SZ0X00FH&pf_rd_p=edaba0ee-c2fe-4124-9f5d-b31d6b1bfbee" target="_blank" rel="noopener noreferrer">Hero's Dose: The Case For Psychedelics in Ritual and Therapy</a>."</em></p>
Vegans and vegetarians often have nutrient deficiencies and lower BMI, which can increase the risk of fractures.
- The study found that vegans were 43% more likely to suffer fractures than meat eaters.
- Similar results were observed for vegetarians and fish eaters, though to a lesser extent.
- It's possible to be healthy on a vegan diet, though it takes some strategic planning to compensate for the nutrients that a plant-based diet can't easily provide.
Comparison of fracture cases by diet group
Credit: Tong et al.<p>The results showed that vegans were especially vulnerable to hip fractures, suffering 2.3 times more cases than meat-eaters. Vegetarians and pescatarians were also more likely to suffer hip fractures, though to a lesser extent.</p><p>One explanation may be that non-meat eaters consume less calcium and protein. Calcium helps the body build strong bones, particularly before age 30, after which the body begins to lose bone mineral density (though consuming enough calcium through diet or supplement can <a href="https://ods.od.nih.gov/factsheets/Calcium-Consumer/" target="_blank">help offset losses</a>). Lower bone mineral density means higher risk of fracture.</p><p>Protein seems to help the body absorb calcium, <a href="https://www.bonejoint.net/blog/did-you-know-that-certain-foods-block-calcium-absorption/#:~:text=Historically%2C%20nutritionists%20have%20warned%20that,may%20increase%20intestinal%20calcium%20absorption." target="_blank" rel="noopener noreferrer">when consumed in normal levels</a>. The recent study, along with past research, shows that people who don't eat meat tend to have lower levels of both protein and calcium. When the researchers accounted for non-meat eaters who supplemented their diets with calcium and protein, fracture risk decreased, but still remained significant.</p>
Credit: Pixabay<p>Another explanation is body mass index (BMI). Non-meat eaters tend to have a lower BMI, which is associated with higher fracture risk, particularly hip fractures. In the new study, vegans with a low BMI were especially likely to suffer hip fractures. That might be because having more body mass provides a cushioning effect when people fall.</p><p>Still, the study has some limitations. For one, White European women were overrepresented in the sample. The researchers also didn't collect precise data on the type of calcium or protein supplementation, diet quality or causes of fractures.</p><p>Another complicating factor: Producers of vegan products, such as plant-based milk, are increasingly fortifying foods with nutrients like calcium and protein, so modern vegans are potentially at lower risk of deficiency.</p><p>The researchers wrote that their findings "suggest that bone health in vegans requires further research."</p>
Staying healthy on a vegan diet<p>So, does a vegan diet necessarily lead to worse bone health? Not necessarily. But it's safe to say that people who don't consume meat, dairy and eggs should be extra vigilant about consuming enough essential nutrients. That can be harder than it seems.<br></p><p>One major reason is that the body generally has an easier time absorbing nutrients from animal foods than plant-based products. So, while a salad could contain the same amount of calcium as a glass of milk, the body absorbs more calcium when you drink milk. What's more, there are some molecules and <a href="https://www.healthline.com/nutrition/7-nutrients-you-cant-get-from-plants#5.-Docosahexaenoic-acid-(DHA)" target="_blank">nutrients you simply can't get from plants</a>.</p><p>As such, many vegans round out their diets with supplements, including zinc, iron, iodine, long-chain omega-3s, and vitamins D, K-2, and B-12, to name a few. If you're on a vegan diet or considering making the switch, it's probably best to consult a dietician, and to make sure you maintain a <a href="https://www.cdc.gov/healthyweight/assessing/bmi/adult_bmi/english_bmi_calculator/bmi_calculator.html" target="_blank" rel="noopener noreferrer">healthy BMI</a>.</p>
These tiny fish are helping scientists understand how the human brain processes sound.
- Fragile X syndrome is a genetic disorder caused by changes in a gene that scientists call the "fragile X mental retardation 1 (FMR1)" gene. People who have FXS or autism often struggle with sensitivity to sound.
- According to the research team, FXS is caused by the disruption of a gene. By disrupting that same gene in zebrafish larvae, they can examine the effects and begin to understand more about this disrupted gene in the human brain.
- Using the zebrafish, Dr. Constantin and the team were able to gather insights into which parts of the brain are used to process sensory information.
By disrupting a specific gene in Zebrafish, we're able to better understand the same disruption of that gene in humans with FXS or autism.
Credit: slowmotiongli on Adobe Stock<p>"Loud noises often cause sensory overload and anxiety in people with autism and Fragile X syndrome -- sensitivity to sound is common to both conditions," <a href="https://www.sciencedaily.com/releases/2020/11/201110102527.htm" target="_blank">Dr. Constantin explained to Science Daily</a>.</p><p><strong>How do zebrafish relate to humans with autism? </strong></p><p>According to the research team, FXS is caused by the disruption of a gene. By disrupting that same gene in zebrafish larvae, they can examine the effects and begin to understand more about this disrupted gene in the human brain. </p><p>The thalamus, according to Dr. Constantin, works as a control center, relaying sensory information from around the body to different parts of the brain. The hindbrain then coordinates different behavioral responses. Using the different sound tests, the team was able to study the whole brain of the zebrafish larvae under microscopes and see the activity of each brain cell individually. </p><p>According to Dr. Constantin, the research team recorded the brain activity of zebrafish larvae while showing them movies or exposing them to bursts of sound. The movies stimulated movement, a reaction to the visual stimuli that was the same for fish with the Fragile X mutation and those without. However, when the fish were given a burst of white noise, there was a dramatic difference in the brain activity of the fish with the Fragile X mutation.<br></p><p>After seeing how the noise radically affected the fish brain, the team designed a range of 12 different volumes of sound and found the Fragile X model fish could hear much quieter volumes than the control fish. </p><p>"The fish with Fragile X mutations had more connections between different regions of their brain and their responses to the sounds were more plentiful in the hindbrain and thalamus," <a href="https://www.sciencedaily.com/releases/2020/11/201110102527.htm" target="_blank">said Dr. Constantin</a>.</p><p>Essentially, the fish with Fragile X mutation had more connections between the regions of their brain and so their responses to the sounds were more notable. </p><p><strong>Understanding how this gene disruption works in zebrafish will give us a better understanding of sound hypersensitivity in humans with FXS or autism.</strong> </p><p>"How our neural pathways develop and respond to the stimulation of our senses gives us insights into which parts of the brain are used and how sensory information is processed," Dr. Constantin said.</p><p>Using the zebrafish, Dr. Constantin and the team were able to gather insights into which parts of the brain are used to process sensory information. </p><p>"We hope that by discovering fundamental information about how the brain processes sound, we will gain further insights into the sensory challenges faced by people with Fragile X syndrome and autism."</p>
A new method is able to create realistic models of the human heart, which could vastly improve how surgeons train for complex procedures.
- 3D bioprinting involves using printers loaded with biocompatible materials to manufacture living or lifelike structures.
- In a recent paper, a team of engineers from Carnegie Mellon University's College of Engineering developed a new way to 3D bioprint a realistic model of the human heart.
- The model is flexible and strong enough to be sutured, meaning it could improve the ways surgeons train for cardiac surgeries.
Modeling incorporates imaging data into the final 3D printed object.
Credit: Carnegie Mellon University College of Engineering<p>The FRESH technique isn't currently able to 3D bioprint models onto which real cells can grow and form a functional heart, but similar methods may someday make that possible. If scientists can print functional human hearts, it could help the healthcare industry finally meet the demand for heart transplants, which <a href="https://nyulangone.org/news/nyu-langone-addresses-demand-heart-transplants-has-never-been-higher#:~:text=the%20Transplant%20Institute.-,The%20demand%20for%20heart%20transplants%20has%20never%20been%20higher.,rise%20by%20some%2050%20percent." target="_blank">far exceeds supply</a>.</p><p style="margin-left: 20px;">"While major hurdles still exist in bioprinting a full-sized functional human heart, we are proud to help establish its foundational groundwork using the FRESH platform while showing immediate applications for realistic surgical simulation," said Eman Mirdamadi, lead author on the paper, in a statement.</p><p>In the meantime, the team behind the FRESH technique hopes to use it to generate models for other organs, like kidneys and liver. </p>
The bubonic plague ravaged the world for centuries, killing up to 200 million people.
People praying for relief from the bubonic plague, circa 1350. Original Artwork: Designed by E Corbould, lithograph by F Howard.
Credit: Hulton Archive/Getty Images
Ambulance men of Florence, Italy, carrying a patient on a stretcher whilst wearing masks to ward off the plague.
Credit: Hulton Archive/Getty Images