Colorful brain mapping tool lights up neural connections
A powerful new tool lights up the brains of worms, and may soon help draw maps of other animals brains.
10 January, 2021
Credit: Eviatar Yemini
- A new tool called NeuroPal allows scientists to map the brain in more detail than ever before.
- By using the same color highlight for similar neurons, it allows researchers to more fully understand what areas of the brain do what.
- It has already been made available to other researchers who are publishing new brain studies.
<p> The human brain is one of the most complicated things in the known universe. A fatty mass containing 86 billion neurons connected by 100 trillion synapses, it automatically regulates the foundational bodily functions, reviews sensory data to permit the business of living, and is capable of abstract thought of dazzling complexity and brilliance. </p><p>Exactly how these cells and connections do this remains a mystery, however. These endless connections are difficult to trace, and how different parts of the brain work together—and even what the various components do—is still the subject of cutting edge research. </p><p>That research will soon be a little bit easier and a lot more colorful due to a new technique by scientists at Columbia that can light up neurons and synapses in vibrant <a href="https://news.columbia.edu/news/scientists-paint-multi-color-atlas-neurons-brain" rel="noopener noreferrer" target="_blank">tones</a>. </p>
I’ve heard of a vibrant imagination, but this is ridiculous.
<p> <a href="https://www.biorxiv.org/content/10.1101/676312v2.full" target="_blank" rel="noopener noreferrer">NeuroPAL </a>(Neuronal Polychromatic Atlas of Landmarks)<strong> </strong>is a genetic engineering technique that lights up neurons in fluorescent, easily discerned colors. Neurons expressing the same genetic information will be the same color under a microscope, allowing scientists to produce an easily readable map showing which neurons have similar genetic details and functions. This provides much more information than previous <a href="https://en.wikipedia.org/wiki/Brainbow" target="_blank" rel="noopener noreferrer">methods</a>. When combined with other techniques that record the communications between cells, it can provide previously impossible insights into neural network dynamics.</p><p>In this study, published in <a href="https://www.cell.com/cell/fulltext/S0092-8674(20)31682-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867420316822%3Fshowall%3Dtrue" target="_blank" rel="noopener noreferrer">Cell</a>, the scientists used NeuroPal on <em>Caenorhabditis elegans</em> (<em>C. elegans</em>) worms and on computer screens. </p><p><em>C. elegans</em> is commonly used in biological science for experimentation. A tiny creature, they have a comparatively simple and well-mapped nervous <a href="https://en.wikipedia.org/wiki/Caenorhabditis_elegans#Research_use" target="_blank" rel="noopener noreferrer">system</a>. Previous studies using electron microscopes have mapped the connections in the worm's brain but have faced difficulties identifying every neuron in the system. As mentioned, NeuroPal can identify every neuron that expresses certain genetic features. </p><p>Using this tool, the study found that the connections in this animal's brain are much more complicated than previously <a href="https://www.biorxiv.org/content/10.1101/676312v2.full" target="_blank" rel="noopener noreferrer">known</a>. </p><p>The researchers also created a computer program that provides optimal color schemes for using NeuroPal in other, more complicated <a href="https://eurekalert.org/pub_releases/2021-01/cu-sp010721.php" target="_blank" rel="noopener noreferrer">animals</a>. </p>What use is a mapped brain, exactly?
<iframe width="730" height="430" src="https://www.youtube.com/embed/hg6XUYWj-pk" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen></iframe><p> By providing a way to reliably identify different types of neuron cells and visibly present them for observation, NeuroPal will make creating comprehensive brain maps much simpler. In the discussion section of the recent study, the authors explain the potential uses of this tool in expanding our understanding of neural networks, including those not belonging to small <a href="https://www.biorxiv.org/content/10.1101/676312v2.full" target="_blank" rel="noopener noreferrer">worms</a>: </p><p> "To date, functional networks have been investigated by recording the activity of small subsets of labeled neurons. More recent work has inaugurated whole-brain activity imaging with cellular resolution. However, the inability to reliably identify all neurons within whole-brain recordings has precluded a full picture with circuit-level details […] Coupling NeuroPAL with whole-brain activity imaging methods permits a unified view of network dynamics, across animals, without sacrificing circuit-level details."</p><p>The<strong></strong> lead author of the new study, Dr. Eviatar Yemini, shared another potential use with <a href="https://news.columbia.edu/news/scientists-paint-multi-color-atlas-neurons-brain" target="_blank" rel="noopener noreferrer">Columbia </a><a href="https://news.columbia.edu/news/scientists-paint-multi-color-atlas-neurons-brain" target="_blank" rel="noopener noreferrer">News</a>:</p><p> "Being able to identify neurons, or other types of cells, using color can help scientists visually understand the role of each part of a biological system. That means when something goes wrong with the system, it may help pinpoint where the breakdown occurred."</p><p>NeuroPal has already been given to other researchers, and published studies utilizing it are beginning to trickle out. It is only a matter of time before this tool provides us with a much-improved understanding of the brain and its functions.</p>
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Aphantasia: the rare brain condition that darkens the mind’s eye
A new study provides validation for the recently identified phenomenon.
08 January, 2021
Credit: agsandrew/ Adobe Stock
- Aphantasia, a recently identified psychological phenomenon, describes when people can't conjure visualizations in their mind's eye.
- A new study published in Cortex compared the visual memories of aphantasic participants with a group of controls.
- Its results found experimental validation for the condition.
<p>Escapism is one of the imagination's great joys. Through fantastic literature, we can explore the vast stretches Arrakis's deserts or the forests of Middle Earth alongside Gandalf the Grey. We can embark on vacations weeks in advance and enjoy a sunny beach while at our desks. We can relive a cherished memory with a favorite relative in an instant, and, of course, always rely on our flock of trusty sheep to lull us to sleep.</p><p>We manage this through what is colloquially called "the mind's eye," our ability to generate psychological images without sensory input. However, such escapism is not possible for people with the rare, and only recently identified, condition aphantasia. People with aphantasia cannot conjure mental images—original or from memory. Instead, their minds' eyes produce dark, blank canvases that cannot be painted in. As Wilma Bainbridge, an assistant professor of psychology at the University of Chicago, <a href="https://news.uchicago.edu/story/cant-draw-mental-picture-aphantasia-causes-blind-spots-minds-eye" target="_blank">told UChicago News</a>:</p><p style="margin-left: 20px;">"Some individuals with aphantasia have reported that they don't understand what it means to '<a href="https://www.bbc.com/news/health-34039054" target="_blank" rel="noopener noreferrer">count sheep'</a> before going to bed. They thought it was merely an expression, and had never realized until adulthood that other people could actually visualize sheep without seeing them."</p><p>For such individuals, literature may produce facts but not visual representations. Arrakis isn't a planet of vast deserts but vast emptiness, Gandalf the Grey a colorless, featureless blob. Sunny beaches can't be visited in their imaginations but must remain on the office calendar until summer vacation. And while memories exist, they cannot be visually recalled except between scrapbook cellophane.</p><p>Scientists don't yet know what causes aphantasia, whether it's a distinct psychological condition, or, indeed, if we are simply jarring against language's limited ability to accurately describe our internal realities. But a burgeoning body of research—among it a new study led by Bainbridge and <a href="https://www.sciencedirect.com/science/article/abs/pii/S0010945220304317?via%3Dihub" target="_blank" rel="noopener noreferrer">published in Cortex</a> last month—suggests the condition is more than misfiring expressions.</p>
Changing our understanding of the mind's eye
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNTI2NjM0Mi9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY0ODM2ODE5NX0.SWkNBfgO1uLsAMsetcmmwOHvJqzK1UsPMxc6tL6Je9k/img.jpg?width=1245&coordinates=0%2C228%2C0%2C228&height=700" id="609a9" class="rm-shortcode" data-rm-shortcode-id="121c211fd751fb11eba0e9aa4ec53ef0" data-rm-shortcode-name="rebelmouse-image" data-width="1245" data-height="700" />Francis Galton was the first to describe a condition that would today be recognized as aphantasia.
<p>Though no long-term studies have focused on aphantasia, <a href="https://www.scientificamerican.com/article/when-the-minds-eye-is-blind1/" target="_blank">its history</a> stretches back more than a century. Francis Galton first described people with "no power of visualising" in 1880, an observation made during his breakfast-table survey. At that time, however, the science of psychology was still in its infancy, and Galton's observation was shelved like so many other early-day curios—brought down and dusted off by the occasional psychologist but given little attention before being shelved again.</p><p>That changed in 2003 when neurologist Adam Zeman was contacted by a 65-year-old man who claimed his mind's eye went blind. During a coronary angioplasty, the man suffered a small stroke that damaged his brain. Afterward, he lost his ability to render psychological imagery.</p><p>"He had vivid imagery previously," Zeman told <a href="https://www.sciencefocus.com/the-human-body/aphantasia-life-with-no-minds-eye/" target="_blank">Science Focus</a>. "He used to get himself to sleep by imagining friends and family. Following the cardiac procedure, he couldn't visualise anything, his dreams became avisual, [and] he said that reading was different because previously he used to enter a visual world and that no longer happened. We were intrigued."</p><p>Zeman and his colleagues began a case study into the man's condition. Tests found he could describe objects and their color but could not visualize them. (He claimed he simply knew the answer.) He could rotate three-dimensional images in his mind, but it took him longer to manage than controls. And brain imaging showed brain regions associated with visualization to be dark when he tried to imagine images.</p><p>Zeman published his case study, and it was subsequently <a href="https://www.discovermagazine.com/mind/the-brain-look-deep-into-the-minds-eye" target="_blank" rel="noopener noreferrer">featured in Discover magazine</a>. After the story's publication, more people reached out to Zeman. They too claimed their minds' eyes were blind, but unlike Zeman's original subject, many of these people had lived with the condition their entire lives. They only became aware of their condition later in life when, as Bainbridge mentions above, they realized that the mental worlds described by friends and family were based on more than fanciful expressions. </p><p>While some managed to live normal, even thriving, lives without visual memory, others found the condition distressing. <a href="https://www.sciencedaily.com/releases/2015/08/150826101648.htm" target="_blank" rel="noopener noreferrer">As one subject told Zeman</a> and his coauthors: "After the passing of my mother, I was extremely distraught in that I could not reminisce on the memories we had together. I can remember factually the things we did together, but never an image. After seven years, I hardly remember her."</p><p>Zeman published another case study focusing on <a href="https://ore.exeter.ac.uk/repository/bitstream/handle/10871/17613/Lives%20without%20imagery%20Letter%20version%20FINAL%2017.5.15%20.pdf?sequence=7&isAllowed=y" target="_blank" rel="noopener noreferrer">21 of these individuals in 2015</a>. It was here that he coined the phrase* "aphantasia," from the Greek <em>phantasia</em> meaning "imagination." Since then, <a href="http://sites.exeter.ac.uk/eyesmind/" target="_blank" rel="noopener noreferrer">Zemen has connected with thousands of people</a> claiming to have the condition, and his studies have raised intriguing questions for researchers interested in memory and the mind. </p>Visualizing the difference
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNTI2NjMzNS9vcmlnaW4ucG5nIiwiZXhwaXJlc19hdCI6MTYzMjAyMDk3M30.EYfZH3v5DRhu4ImOjpuuXdHiXbPkgTUCOxJsTQmDYA8/img.png?width=980" id="fed74" class="rm-shortcode" data-rm-shortcode-id="eb2d7c7f78e780fe09bc6d1635cdaad5" data-rm-shortcode-name="rebelmouse-image" data-width="598" data-height="245" />On the left, an aphantastic participant's recreation of a photo from memory. On the right, the participant's recreation when the photo was available for reference.
<p>Bainbridge is one such researcher. <a href="https://www.nature.com/articles/s41467-018-07830-6#Sec10" target="_blank">Her previous work</a> has focused on perception and memory, both their underlying mechanics and how this content is stored. In her latest study, she and her co-authors aimed to not only tease out the distinctions between object and spatial memory but also deepen our understanding of aphantasia.</p><p>To do this, they invited 61 people with aphantasia and a group of controls to participate in their experiment. They showed each participant a photo of a room and then asked them to draw it in as much detail as possible. For one test, the participants were allowed to keep the photo for reference. For the next test, however, they had to draw the room from memory. Bainbridge and her coauthors then put the drawings online to be quantified by nearly 3,000 online assessors, who were asked to score both sets of test images for object and spatial details.</p><p>The results showed the aphantastic participants had difficulty with the memory experiment. They produced reproductions with fewer objects, less color, and fewer details than their control peers. Many leaned on verbal scaffolding in lieu of visual details—for example, one participant drew a rudimentary box with the word "window" rather than a window with a frame and panes of glass.</p><p>Although the aphantastic patients drew rooms with fewer objects, they were very accurate in their placement of those objects. They also made fewer errors than the controls and avoided incorporating features and furniture absent in the original images. The researchers write that this suggests high spatial accuracy despite a lack of visualization.</p><p>"One possible explanation could be that because aphantasics have trouble with this task, they rely on other strategies like verbal-coding of the space," Bainbridge told UChicago News. "Their verbal representations and other compensatory strategies might actually make them better at avoiding false memories."</p><p>The online assessors found no significant differences between the aphantastic participants and the controls when the original photo was available for reference. In fact, some of the aphantastic participants produced stunningly accurate and artistic recreations during this test.</p><p>Bainbridge and her coauthors suggest that these results not only support the idea that object and spatial information is store in separate neural networks. They also provide "experimental validation" for aphantasia as a valid psychological phenomenon.</p>Discovering a new reality in aphantasia?
<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="cc502388d1b548118d6e587ad785fe34"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/zNHDTvqbUm4?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><p>And Bainbridge's study has joined an ever-growing panoply. A <a href="https://www.sciencedirect.com/science/article/abs/pii/S0010945217303581" target="_blank">2018 study, also published in Cortex</a>, measured the binocular rivalry—the visual phenomenon in which awareness fluctuates when different images are presented to each eye—of participants with and without aphantasia. When primed beforehand, control participants choose the primed stimuli more often than not. Meanwhile, aphantastic participants showed no such favoritism, whether primed or not. Like Bainbridge's study, these results suggest a physiological underpinning for aphantasia.</p><p>Another critical factor is growing awareness. As more studies and stories are published, more and more people are realizing they aren't alone. Such a realization can empower others to come forward and share their experiences, which in turn spurs researchers with new questions and experiences to study and hypothesize over.</p><p>Yet, there's still much work to be done. Because this psychological phenomenon has only recently been identified—Galton's observation notwithstanding—there has been sparingly little research on the condition and what research has been done has relied on participants who self-report as having aphantasia. While researchers have used the <a href="https://en.wikipedia.org/wiki/Vividness_of_Visual_Imagery_Questionnaire" target="_blank">Vividness of Visual Imagery Quiz</a> to test for aphantasia, there is currently no universal method for diagnosing the condition. And, of course, there is the ever-vexing question of how one can assess one mind's experiences from another.</p><p>"Skeptics could claim that aphantasia is itself a mere fantasy: describing our inner lives is difficult and undoubtedly liable to error," Zeman and his co-authors wrote in <a href="https://ore.exeter.ac.uk/repository/bitstream/handle/10871/17613/Lives%20without%20imagery%20Letter%20version%20FINAL%2017.5.15%20.pdf?sequence=7&isAllowed=y" target="_blank" rel="noopener noreferrer">their 2015 case study</a>. "We suspect, however, that aphantasia will prove to be a variant of neuropsychological functioning akin to synesthesia [a neurological condition in which one sense is experienced as another] and to congenital prosopagnosia [the inability to recognize faces or learn new ones]."</p><p>Time and further research will tell. But scientists need phenomenon to test and questions to experiment on. Thanks to researchers like Zeman and Bainbridge, alongside the many people who came forward to discuss their experiences, they now have both when it comes to aphantasia.</p><p>* Zeman also coined the term "<a href="https://www.sciencedirect.com/science/article/abs/pii/S0010945220301404" target="_blank">hyperphantasia</a>" to describe the condition in which people's psychological imagery is incredibly vivid and well-defined.</p>
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Designer uses AI to bring 54 Roman emperors to life
It's hard to stop looking back and forth between these faces and the busts they came from.
05 October, 2020
Credit: Daniel Voshart
- A quarantine project gone wild produces the possibly realistic faces of ancient Roman rulers.
- A designer worked with a machine learning app to produce the images.
- It's impossible to know if they're accurate, but they sure look plausible.
<p>Imaginative as humans are, it's often hard not to see historical figures depicted in black-and-white photos as being somehow of another species. Confronted with colorized images can be startling — hey, they look like us — bringing home at last what they were really like. Maybe that person evens look like someone we know.</p><p>The same is true of figures whose appearance we know only from their statues, maybe even moreso. We may know their names and something about them, but, again, it's all sort of not quite real. Now cinematographer and virtual reality designer <a href="https://voshart.com" target="_blank" rel="noopener noreferrer">Daniel Voshart</a> has published amazing, life-like images of 54 Roman emperors based on their statues. He used machine learning and filled in the (many) remaining blanks with his imagination. While he's careful to point out that his renderings are merely what these individuals <em>may</em> have looked like, they're remarkably plausible, and also remarkably familiar.</p><p>Voshart describes the whole thing as a quarantine project that got out of hand, but lots of people are excited about what he's done, and are <a href="https://www.etsy.com/ca/shop/Voshart" target="_blank">purchasing posters</a> of his Roman emperors.</p>
How the Roman emperors got faced
<a href="https://payload.cargocollective.com/1/6/201108/14127595/2K-ENGLISH-24x36-Educational_v8_WATERMARKED_2000.jpg" ><img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDQ2NDk2MS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYyOTUzMzIxMX0.OwHMrgKu4pzu0eCsmOUjybdkTcSlJpL_uWDCF2djRfc/img.jpg?width=980" id="775ca" class="rm-shortcode" data-rm-shortcode-id="436000b6976931b8320313478c624c82" data-rm-shortcode-name="rebelmouse-image" alt="lineup of emperor faces" data-width="1440" data-height="963" /></a>Credit: Daniel Voshart
<p>Voshart's imaginings began with an AI/neural-net program called <a href="https://www.artbreeder.com" target="_blank">Artbreeder</a>. The freemium online app intelligently generates new images from existing ones and can combine multiple images into…well, who knows. It's addictive — people have so far used it to generate nearly 72.7 million images, says the site — and it's easy to see how Voshart fell down the rabbit hole.</p><p>The Roman emperor project began with Voshart feeding Artbreeder images of 800 busts. Obviously, not all busts have weathered the centuries equally. Voshart told <a href="https://www.livescience.com/ai-roman-emperor-portraits.html" target="_blank" rel="noopener noreferrer">Live Science</a>, "There is a rule of thumb in computer programming called 'garbage in garbage out,' and it applies to Artbreeder. A well-lit, well-sculpted bust with little damage and standard face features is going to be quite easy to get a result." Fortunately, there were multiple busts for some of the emperors, and different angles of busts captured in different photographs.</p><p>For the renderings Artbreeder produced, each face required some 15-16 hours of additional input from Voshart, who was left to deduce/guess such details as hair and skin coloring, though in many cases, an individual's features suggested likely pigmentations. Voshart was also aided by written descriptions of some of the rulers.</p><p>There's no way to know for sure how frequently Voshart's guesses hit their marks. It is obviously the case, though, that his interpretations look incredibly plausible when you compare one of his emperors to the sculpture(s) from which it was derived.</p><p>For an in-depth description of Voshart's process, check out his posts on <a href="https://medium.com/@voshart/photoreal-roman-emperor-project-236be7f06c8f" target="_blank">Medium</a> or on his <a href="https://voshart.com/ROMAN-EMPEROR-PROJECT" target="_blank" rel="noopener noreferrer">website</a>.</p><p>It's fascinating to feel like you're face-to-face with these ancient and sometimes notorious figures. Here are two examples, along with some of what we think we know about the men behind the faces.</p>Caligula
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDQ2NDk4Mi9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY3MzQ1NTE5NX0.LiTmhPQlygl9Fa9lxay8PFPCSqShv4ELxbBRFkOW_qM/img.jpg?width=980" id="7bae0" class="rm-shortcode" data-rm-shortcode-id="ce795c554490fe0a36a8714b86f55b16" data-rm-shortcode-name="rebelmouse-image" data-width="992" data-height="558" />One of numerous sculptures of Caligula, left
Credit: Rogers Fund, 1914/Wikimedia Commons/Daniel Voshart
<p><span style="background-color: initial;"><a href="https://en.wikipedia.org/wiki/Caligula" target="_blank">Caligula</a></span> was the third Roman Emperor, ruling the city-state from AD 37 to 41. His name was actually Gaius Caesar Augustus Germanicus — Caligula is a nickname meaning "Little Boot."</p><p>One of the reputed great madmen of history, he was said to have made a horse his consul, had conversations with the moon, and to have ravaged his way through his kingdom, including his three sisters. Caligula is known for extreme cruelty, terrorizing his subjects, and accounts suggest he would deliberately distort his face to surprise and frighten people he wished to intimidate.</p><p>It's <a href="https://www.history.com/news/7-things-you-may-not-know-about-caligula" target="_blank">not totally clear</a> if Caligula was as over-the-top as history paints him, but that hasn't stopped Hollywood from churning out some <a href="https://www.imdb.com/title/tt0080491/" target="_blank" rel="noopener noreferrer">howlers</a> in his name.</p><p>A 1928 journal, <a href="https://www.jstor.org/stable/4172009" target="_blank">Studies in Philology</a>, noted that contemporary descriptions of Caligula depicted him as having a "head misshapen, eyes and temples sunken," and "eyes staring and with a glare savage enough to torture." In some sculptures not shown above, his head <em>is</em> a bit acorn-shaped. </p>Nero
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDQ2NTAwMC9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY1NTQ2ODU0NX0.AgYuQZzRQCanqehSI5UeakpxU8fwLagMc_POH7xB3-M/img.jpg?width=980" id="a8825" class="rm-shortcode" data-rm-shortcode-id="9e0593d79c591c97af4bd70f3423885e" data-rm-shortcode-name="rebelmouse-image" data-width="992" data-height="558" />One of numerous sculptures of Nero, left
Credit: Bibi_Saint-Pol/Wikimedia Commons/Daniel Voshart
<p>There's a good German word for the face of <a href="https://en.wikipedia.org/wiki/Nero" target="_blank" rel="noopener noreferrer">Nero</a>, that guy famous for fiddling as Rome burned. It's "<a href="https://www.urbandictionary.com/define.php?term=Backpfeifengesicht" target="_blank">backpfeifengesicht</a>." Properly named Nero Claudius Caesar Augustus Germanicus, he was Rome's fifth emperor. He ruled from AD 54 until his suicide in AD 68.</p><p>Another Germanicus-family gem, Nero's said to have murdered his own mother, Agrippa, as well as (maybe) his second wife. As for the fiddling, he <em>was</em> a lover of music and the arts, and there are stories of his charitability. And, oh yeah, he may have set the fire as an excuse to rebuild the city center, making it his own.</p><p>While it may not be the most historically sound means of assessing an historical personage, Voshart's imagining of Nero does suggest an over-indulged, entitled young man. Backpfeifengesicht.</p>
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Being in a frisky mood may improve your chances in the dating world
Positive, romantic thoughts could produce positive, romantic outcomes while dating.
25 September, 2020
Credit: 4 PM production on Shutterstock
- Fear of rejection, self-doubt, and anxiety are just some of the obstacles humans need to overcome to make a meaningful, romantic connection with another person.
- According to a 2020 project by a group of psychologists at the University of Rochester (and the Israeli-based Interdisciplinary Center Herzliya), humans see possible romantic partners as a lot more attractive if they go into the interaction with a "sexy mindset."
- Across three separate studies, this team discovered that this sexual activation helps people initiate relationships by inducing them to project their desires onto prospective partners.
<p>What encourages us to seek out potential partners? What interactions encourage us to keep dating, despite the possibility of being rejected? The sexual behavioral system of humans has evolved over millennia and has been the topic of many scientific studies over the years. The concept of dating and pursuing romantic partners has been a curiosity to everyone, it seems, with <a href="https://www.mentalfloss.com/article/79140/10-fascinating-facts-about-evolution-dating-and-courtship" rel="noopener noreferrer" target="_blank">lists like this one from Mental Floss</a> detailing what dating was like throughout the centuries.</p><p>Ultimately, romantic "success" depends on our ability to target the right potential partner whom we not only find attractive but who is also attracted to us. <a href="https://www.sciencedirect.com/science/article/pii/S0747563218301870" target="_blank">Fear of rejection</a>, self-doubt, and <a href="https://www.verywellmind.com/how-anxiety-can-cause-relationship-problems-1393090" target="_blank">anxiety</a> are just some of the obstacles humans need to overcome to make a meaningful, romantic connection with another person.</p><ul class="ee-ul"></ul>
Being in a frisky mood improves your chances with potential romantic partners
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDQzNzk0OC9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY0Mjc3MDA5NH0.lwJquRq9_gTYX5c_2sRzCBfkyWldjMqCJig_kGCL1uA/img.jpg?width=1245&coordinates=0%2C6%2C0%2C6&height=700" id="d0453" class="rm-shortcode" data-rm-shortcode-id="9a29ad6b50ff3868c867fd2d0a64b8aa" data-rm-shortcode-name="rebelmouse-image" alt="man and woman on date woman" data-width="1245" data-height="700" />The right mood could land you the right date, according to a new study.
Credit: BlueSkyImage on Shutterstock
<p><a href="https://www.eurekalert.org/pub_releases/2020-09/uor-ffm092320.php" target="_blank" rel="noopener noreferrer">According to a 2020 study</a> by a group of psychologists at the University of Rochester (and the Israeli-based Interdisciplinary Center Herzliya), humans see possible romantic partners as a lot more attractive if they go into the interaction with a "sexy mindset."</p><p><a href="https://www.sas.rochester.edu/psy/people/faculty/reis_harry/" target="_blank" rel="noopener noreferrer">Harry Reis</a>, professor of psychology and the Dean's Professor in Arts, Sciences & Engineering at Rochester, and <a href="https://www.idc.ac.il/en/pages/faculty.aspx?username=birnbag" target="_blank" rel="noopener noreferrer">Gurit Birnbaum</a>, a social psychologist and associate professor of psychology at the IDC (Interdisciplinary Center Herzliya) have dedicated decades of their lives to studying the intricate dynamics of sexual attraction and human sexual behavior. </p><p>In <a href="https://www.rochester.edu/newscenter/relationships-uncertainty-are-you-really-in-to-me-323512/" target="_blank" rel="noopener noreferrer">a previous study,</a> the pair discovered that when people feel greater certainty about a romantic partner's interest, they put more effort into seeing that person again. Additionally, this study found people will rate the possible partner as more "sexually attractive" if they knew the person was interested in seeing them again.</p><p><a href="https://www.eurekalert.org/pub_releases/2020-09/uor-ffm092320.php" target="_blank" rel="noopener noreferrer">For this project</a>, Reis and Birnbaum, along with their team, examined what would happen if a person's sexual system is activated by exposing them to brief sexual cues that induced a thought process that included the potential for sex or heightened attraction. </p><p>Across three separate studies, the team discovered that this sexual activation helps people initiate relationships by inducing them to project their desires onto prospective partners. </p><p><strong>Study one: Immediacy</strong></p><p>In the first study, 112 heterosexual participants (between the ages of 20-32) who were not in a romantic relationship were randomly paired with an unacquainted participant of the opposite sex. Participants introduced themselves to each other (speaking about their hobbies, positive traits, career plans, etc.), all while being recorded. </p><p>The team then coded the recorded interactions and searched for nonverbal expressions of immediacy (such as close proximity, frequent eye contact, smiles, etc.) that could indicate interest in starting a romantic relationship. </p><p>In the study, the team determined that the participants exposed to a sexual stimulus before the meeting (versus those exposed to a neutral stimulus) exhibited more immediacy behaviors towards their potential partners and also perceived the partners as more attractive and/or more interested in them. </p><p><strong>Study two: Interest</strong></p><p>In the second study, 150 heterosexual participants (between the ages of 19-30) who were not in a romantic relationship served as a control for the potential partner's attractiveness and reactions. All participants in study two watched the same pre-recorded video introduction of a potential partner of the opposite sex. They then introduced themselves to the partner while being filmed themselves. </p><p>The researchers found that the activation of the sexual system led to participants viewing the potential partner as more attractive as well as more interested in them. </p><p><strong>Study three: How it all ties together</strong></p><p>In the third and final study, the team investigated whether a partner's romantic interest could explain why sexual activation impacts how we view other people's romantic interest in ourselves. </p><p>In this study, 120 single heterosexual participants (between the ages of 21-31) interacted online with another participant who was actually an attractive opposite-sex member of the research team. This was a casual "get-to-know-you" kind of interaction. The participants rated their romantic interest in the other person as well as that person's attractiveness and interest in them.</p><p>Again, the team found that sexual activation increased a person's romantic interest in the other person, which, in turn, predicted that the other person would then be more interested in a romantic partnership as well. </p><p><strong>The takeaway: Positive, romantic thoughts could produce positive, romantic outcomes. </strong></p><p>The basis of this multi-study theory is simple: Having active sexual thoughts arouses romantic interest in a prospective partner and often leads to an optimistic outlook on dating. </p><p>"Sexual feelings do more than just motivate us to seek out partners. It also leads us to project our feelings onto the other person," <a href="https://www.eurekalert.org/pub_releases/2020-09/uor-ffm092320.php" target="_blank">said Reis to Eurekalert</a>. </p><p>Reis goes on to explain, "...the sexual feelings need not come from the other person; they can be aroused in any number of ways that have nothing to do with the other person."</p>
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New research suggests a possible treatment for dyslexia
The neurodevelopmental disorder has long baffled researchers.
10 September, 2020
Credit: Muhammad Rifki Adiyanto from Pexels
- Dyslexia affects up to 10 percent of the world's population.
- Though first identified in 1881, no cause has ever been discovered.
- A new study at the University of Geneva found positive results using transcranial alternating current stimulation (tACS).
<p>Dyslexia is a frustrating condition that affects up to 10 percent of the world's population. Although there are three million reported cases each year—up to 7 percent of school children have persistent difficulty learning how to read—there's no known cure. Some <a href="https://books.google.com/books?id=6Rp0BgAAQBAJ" target="_blank">research</a> even suggests that up to 17 percent of the population could suffer from mild symptoms.</p><p>While dyslexia runs in some families, the disorder is generally considered to be caused by the interaction of genes and environmental factors, including parental education and teaching quality. It appears that learning in supportive environments reduces the risks of turning on genetic factors associated with the disorder. </p><p>No specific cause of dyslexia has been discovered, although the condition was first identified in 1881. Traumatic brain injuries sometimes cause it. The condition is also linked to ADHD, issues with hand-eye coordination, and developmental language disorders. </p><p>Researchers have <a href="https://www.nichd.nih.gov/health/topics/reading/conditioninfo/disorders" target="_blank">figured out</a> that dyslexia is related to problems with language processing. The condition is diagnosed through a series of memory, spelling, and reading tests. Since other disorders make reading difficult, identifying dyslexia takes time. </p><p>A <a href="https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000833" target="_blank" rel="noopener noreferrer">new study</a>, published in PLOS Biology, reveals fascinating data about a possible treatment for this longstanding disorder. As mentioned, the strongest evidence for an origin is in the brain's processing of language sounds—in the left auditory cortex. </p><p>A research team at the University of Geneva applied 30 Hz ("low-gamma") oscillations via transcranial alternating current stimulation (tACS) to 30 volunteers. Fifteen were dyslexic; the other 15 were fluent readers. Previous theoretical models suggested 25-35 Hz could be beneficial, though only correlations have been offered. </p>
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMzkxMTE1My9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYyODkzNDM4OH0._inmB2wdWSWpbO--ecxV8Ae_IrAXhDAKnGgeFBWoxUA/img.jpg?width=1245&coordinates=0%2C274%2C0%2C274&height=700" id="3283e" class="rm-shortcode" data-rm-shortcode-id="af19e66be3c14aaecc0b1684b094fd60" data-rm-shortcode-name="rebelmouse-image" alt="child with head down on stack of books" data-width="1245" data-height="700" />
<p class=""><br></p>Credit: Billion Photos / Shutterstock
<p>When 30 Hz was applied, dyslexic volunteers saw the greatest improvement in phonological processing. Interestingly, the reading abilities of those in the control group were slightly disrupted by these oscillations. The researchers speculate fast readers may have developed strategies that skip phonological processing.</p><p>The beneficial effect wasn't noticed when 60 Hz was applied. </p><p>The authors believe this research demonstrates a causal role of low-gamma oscillatory activity in the brains of dyslexics. More importantly, their work could lead to non-invasive therapeutic interventions for treating (and perhaps curing) the disorder. </p><p>Co-lead author Silvia Marchesotti, in the Department of Neuroscience at the University of Geneva, <a href="https://www.sciencedaily.com/releases/2020/09/200908142934.htm" target="_blank">says</a>, </p><p style="margin-left: 20px;">"The next steps for us are to investigate whether normalizing oscillatory function in very young children could have a long-lasting effect on the organization of the reading system, but also to explore even less invasive means of correcting oscillatory activity, for instance using neurofeedback training."</p><p>One session of tCAS lasts for hours or even days—not long enough to ensure long-term change. The authors suggest multiple sessions might inspire long-term potentiation in dyslexics, however. </p><p>They also point out that tACS improved reading accuracy but not reading speed. Future studies could include multiple sessions to discover if reading speeds can be increased.</p><p>--</p><p><em>Stay in touch with Derek on <a href="http://www.twitter.com/derekberes" target="_blank" rel="noopener noreferrer">Twitter</a>, <a href="https://www.facebook.com/DerekBeresdotcom" target="_blank" rel="noopener noreferrer">Facebook</a> and <a href="https://derekberes.substack.com/" target="_blank" rel="noopener noreferrer">Substack</a>. His next book is</em> "<em>Hero's Dose: The Case For Psychedelics in Ritual and Therapy."</em></p>
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