Researchers develop the first objective tool for assessing the onset of cognitive decline through the measurement of white spots in the brain.
- MRI brain scans may show white spots that scientists believe are linked to cognitive decline.
- Experts have had no objective means of counting and measuring these lesions.
- A new tool counts white spots and also cleverly measures their volumes.
White spots and educated guesses<p>The white spots, or "hyperintensities," are brain lesions—fluid-filled holes in the brain believed to have been left behind by the breaking down of blood vessels that had previously provided nourishment to brain cells.</p><p>Prior to the new research, the quantity of white spots was assessed using an imprecise three-point scale indicating ascending likelihoods of dementia: A minimal number of spots was considered as level 1, a medium number of spots level 2, and a great number of them level 3.</p>
How the new measurements were derived<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDYwMTc1OS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYzNDQ1ODExNX0.vqhQJSvL99KjOe24TOs4E8R7c6-pprbXYSrGcIqbVps/img.jpg?width=980" id="c64d9" class="rm-shortcode" data-rm-shortcode-id="002d9b8ef47b5a86c3a387ad2cd90629" data-rm-shortcode-name="rebelmouse-image" data-width="1440" data-height="960" />
Credit: sfam_photo/Shutterstock<p>The team of researchers from NYU's Langone's <a href="https://med.nyu.edu/departments-institutes/neurology/divisions-centers/center-cognitive-neurology" target="_blank">Center for Cognitive Neurology</a> and <a href="https://med.nyu.edu/departments-institutes/neurology/divisions-centers/center-cognitive-neurology/alzheimers-disease-research-center" target="_blank">Alzheimer's Disease Research Center</a> were led by <a href="https://med.nyu.edu/faculty/jingyun-chen" target="_blank">Jingyun "Josh" Chen</a>. They analyzed 72 MRI scans from a national database of older people taken as part of the <a href="http://adni.loni.usc.edu" target="_blank">Alzheimer's Disease Neuroimaging Initiative</a> (ADNI). The scans were mostly of white people over age 70, and there were a roughly equivalent number of men and women. Some had normal brain function, some were presenting moderate cognitive decline, and some had severe dementia.</p><p>Without knowing each individual's diagnosis, the researchers analyzed the white spots in their scans. While the team counted each scan's lesions, the innovation they introduced was the production of a 3D measurement for each lesion's fluid volume. The measurement was derived by measuring a lesion's distance from opposite sides of the brain.</p><p>Measurements of 0 milliliters (mL) were assessed for areas without white spots, with other white spots coming up as containing 60 mL of fluid. Chen's team predicted that volumes over 100 mL could signify severe dementia.</p><p>"Amounts of white matter lesions above the normal range should serve as an early warning sign for patients and physicians," Chen told <a href="https://nyulangone.org/news/white-matter-lesion-mapping-tool-identifies-early-signs-dementia" target="_blank">NYU Langone Health NewsHub</a>.</p><p>When the team compared the likely diagnoses derived from their calculations against the individuals' medical records, they found that their predictions were correct about 7 out of 10 times.</p><p>The researchers compiled their formulas into an online tool that's available to physicians for free via <a href="https://github.com/jingyunc/wmhs" target="_blank" rel="noopener noreferrer">GitHub</a>. The researchers plan to further refine and test it using an additional 1,495 brain scans representing a more diverse group of individuals from the ADNI database.</p>
The new tool and its limits<p>Chen notes that white spots alone may not tell the entire story of an individual's cognitive decline or the onset of dementia. Other factors must be considered as well, including memory loss, hypertension, and brain injuries.</p><p>Nonetheless, says senior investigator <a href="https://med.nyu.edu/faculty/yulin-ge" target="_blank">Yulin Ge</a>, "Our new calculator for properly sizing white matter hyperintensities, which we call 'bilateral distancing,' offers radiologists and other clinicians an additional standardized test for assessing these lesions in the brain, well before severe dementia or stroke damage."</p><p>Having an objective means of measuring white hyperintensities will allow physicians not only to get a better handle on the association between white spots and dementia, but also to track the spots alongside changes to a person's tau and beta-amyloid proteins, two chemicals implicated in Alzheimer's disease and dementia.</p>
Move over, forest bathing.
- A new study found that weekly 15-minute "awe walks" have positive effects on mental health.
- Volunteers reported higher levels of gratitude and compassion after eight weeks of these short walks.
- Researchers believe this low-cost intervention could help prevent cognitive decline in older adults.
Finding Happiness Through "Awe Walks"<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="0988a4421b47d7cdc45d740014a53b17"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/-nVx6SriWPM?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><p>Importantly, participants were instructed to observe details while walking around the forest. If the goal was only exercise, volunteers were likely to power through trails without noticing their surroundings. This is where awe comes into the picture.</p><p>UC Berkeley psychologist Dacher Keltner <a href="https://www.ucsf.edu/news/2020/09/418551/awe-walks-boost-emotional-well-being" target="_blank">explains</a> the relevance, noting that feelings of awe help us feel more generous and humble, while increasing our overall well-being. </p><p style="margin-left: 20px;">"Awe is a positive emotion triggered by awareness of something vastly larger than the self and not immediately understandable — such as nature, art, music, or being caught up in a collective act such as a ceremony, concert or political march."</p><p>The post-walk selfie is key. Week after week, their smiles grew larger. Incredibly, their bodies shrunk in the photos—the photographer stepped back to include more of nature. Instead of the normal close-ups we associate with selfies, volunteers naturally became more integrated with their environment, without any prompting from the research team.</p><p><a href="https://bigthink.com/21st-century-spirituality/individualism-is-spreading-and-thats-not-good" target="_self">Research</a> on individualist versus collectivist societies shows that the members of individualist societies tend to prioritize independence and autonomy. These seem like positive qualities, though higher rates of anxiety and depression are reported in such cultures. By contrast, collectivist societies emphasize interdependence, which ultimately makes members feel like they're part of a bigger landscape. </p><p>This is exactly what was reflected in those selfies. </p>
Credit: Rudmer Zwerver / Shutterstock<p>Classical Japanese art offers plenty of examples of interdependence. Humans are rarely the focal point in these landscape paintings. People only appear as part of a much larger scene. This trend cuts across Buddhist art, perhaps unsurprisingly given the philosophy stresses collectivity. Happiness levels tend to be higher in these societies than in individualist nations.</p><p>America, arguably the global leader in individualism, has <a href="https://worldhappiness.report/ed/2019/the-sad-state-of-happiness-in-the-united-states-and-the-role-of-digital-media/" target="_blank">continually ranked lower</a> on world happiness charts over the last 40 years. Meanwhile, our rates of Alzheimer's disease <a href="https://bigthink.com/mind-brain/alzheimers-risks" target="_self">rise</a> every year.</p><p>Can a 15-minute awe walk change all of that? Not completely, but we'll take whatever help we can get. As mythologist Joseph Campbell <a href="https://www.jcf.org/works/quote/awe-is-what-moves-us-forward/" target="_blank">once remarked</a>, "awe is what moves us forward." He cited awe as a primary driver in the creation of mythology: the overwhelming sensation that you're part of something grand. </p><p>As Sturm says, this is a low-cost, worthwhile means for alleviating distress and filling people with gratitude and compassion. Given the state of the world, those qualities are in high demand. </p><p style="margin-left: 20px;">"I find it remarkable that the simplest intervention in the world – just a three-minute conversation at the beginning of the study suggesting that participants practice feeling awe on their weekly walks – was able to drive significant shifts in their daily emotional experience. This suggests promoting the experience of awe could be an extremely low-cost tool for improving the emotional health of older adults through a simple shift in mindset." </p><p>--</p><p><em>Stay in touch with Derek on <a href="http://www.twitter.com/derekberes" target="_blank">Twitter</a>, <a href="https://www.facebook.com/DerekBeresdotcom" target="_blank" rel="noopener noreferrer">Facebook</a> and <a href="https://derekberes.substack.com/" target="_blank" rel="noopener noreferrer">Substack</a>. His next book is</em> "<em>Hero's Dose: The Case For Psychedelics in Ritual and Therapy."</em></p>
Yet 80 percent of respondents want to reduce their risk of dementia.
- A new MDVIP/Ipsos survey found that only 35 percent of Americans know the symptoms of Alzheimer's disease.
- Eighty percent of respondents said they want to reduce their risks.
- An estimated 7.1 million Americans over the age of 65 will suffer from Alzheimer's by 2025.
Credit: logika600 / Shutterstock<p>Remaining healthy requires regular screenings. Here again we see a disassociation between risk reduction and proactivity. Seventy-seven percent of respondents don't talk to their doctors about lifestyle habits that support brain health; 51 percent have never been screened for depression; 44 percent have never had a neurological exam; and 32 percent have never been screened for hearing problems. </p><p>Common early warning signs of dementia, <a href="https://news.yahoo.com/americans-worry-alzheimers-disease-survey-140644803.html" target="_blank" rel="noopener noreferrer">according to</a> Dr. Jason Karlawish, co-director of the Penn Memory Center, include repetitive questions and stories, difficulties with complex daily tasks, and trouble with orientation. </p><p>In terms of intervention, <a href="https://bigthink.com/21st-century-spirituality/does-lack-of-exercise-lead-to-dementia" target="_self">exercise</a>, <a href="https://bigthink.com/surprising-science/obesity-dementia" target="_self">diet</a>, building a <a href="https://bigthink.com/mind-brain/brain-reserve" target="_self">brain reserve</a>, and challenging your brain (such as learning a new language or musical instrument) are all proven methods for staving off the ravages of Alzheimer's. Oxytocin has also <a href="https://bigthink.com/mind-brain/alzheimers-oxytocin" target="_self">showed promise</a> in brain-addled mice, while researchers found positive results for a <a href="https://bigthink.com/mind-brain/intermittent-fasting" target="_self">group of intermittent fasters</a> in promoting neurogenesis. </p><p>Epidemiologist Bryan James says that dementia is <a href="https://www.npr.org/sections/health-shots/2013/04/15/176920391/how-exercise-and-other-activities-beat-back-dementia" target="_blank">not an inevitable result</a> of aging. </p><p style="margin-left: 20px;">"It's simply not pre-destined for all human beings. Lots of people live into their 90s and even 100s with no symptoms of dementia." </p><p>Professor of neurology at Boston University School of Medicine, Andrew Budson, <a href="https://news.yahoo.com/americans-worry-alzheimers-disease-survey-140644803.html" target="_blank" rel="noopener noreferrer">recommends</a> aerobic exercise and the Mediterranean diet. As has long been known, whole grains, fruits and vegetables, fish and shellfish, and healthy fasts like nuts and olive oil seem to have brain-boosting properties. </p><p>To learn more, take the <a href="https://www.mdvip.com/brain-health-iq-quiz" target="_blank">Brain Health IQ quiz</a>.</p><p><span></span>--</p><p><em>Stay in touch with Derek on <a href="http://www.twitter.com/derekberes" target="_blank">Twitter</a>, <a href="https://www.facebook.com/DerekBeresdotcom" target="_blank">Facebook</a> and <a href="https://derekberes.substack.com/" target="_blank" rel="noopener noreferrer">Substack</a>. His next book is</em> "<em>Hero's Dose: The Case For Psychedelics in Ritual and Therapy."</em></p>
Preliminary studies on mice show positive results.
- While the exact cause of Alzheimer's remains unknown, researchers are targeting toxic beta-amyloid buildup.
- A recent study on mice found oxytocin could be a protective agent against plaque buildup.
- Though more research needs to be conducted, this is a hopeful sign in our fight against a crippling disease.
Photo: Varlamova Lydmila / Shutterstock<p>As Eleftheria Kodosaki, an academic associate in Biomedical Sciences at Cardiff Metropolitan University, <a href="https://theconversation.com/could-love-hormone-oxytocin-help-treat-alzheimers-disease-heres-what-researchers-currently-know-143301" target="_blank">writes</a>, male mice were recently treated with the toxic beta-amyloid, resulting in the desired effect: their brain's synaptic plasticity suffered. The researchers then treated mice with the toxic beta-amyloid <em>and</em> oxytocin, which did not affect their neural plasticity. The team speculates that oxytocin may play a role in staving off memory loss.</p><p>That <i>may </i>is key. Kodosaki notes that this disease remains baffling. </p><p style="margin-left: 20px;">"In theory, being able to stop groups of toxic beta-amyloid from forming could potentially prevent memory loss and cognitive decline. Unfortunately, Alzheimer's disease is way more complicated than just an accumulation of beta-amyloid in the brain."</p><p>Plaque buildups have been discovered in people that don't have the disease or suffer from any symptoms. The beta-amyloid angle is only a theory, and there are others: as mentioned, genetics, as well as the <a href="https://linkinghub.elsevier.com/retrieve/pii/S0166223600020312" target="_blank">Tau hypothesis</a>. In 2002, researchers at the Institute of Psychiatry in De Crespigny Park, London speculated that tau proteins form neurofibrillary tangle inside of nerve cell bodies, resulting in the collapse of neuronal transport systems. </p><p>Kodaski points out that all medication targeting beta-amyloid has failed. She also notes that research needs to be conducted on female mice, as women are more likely to develop Alzheimer's than men. Of course, humans are not mice, though taking note of sex differences in mice might help researchers gauge potential therapies in humans. </p><p>As most studies conclude, more research is needed. But it is a hopeful sign for treating the frustrating realm of dementia. In an aging world with a <a href="https://bigthink.com/politics-current-affairs/world-population-decline" target="_self">declining population</a>, we need to protect our seniors the best we can. </p><p>--</p><p><em>Stay in touch with Derek on <a href="http://www.twitter.com/derekberes" target="_blank">Twitter</a>, <a href="https://www.facebook.com/DerekBeresdotcom" target="_blank">Facebook</a> and <a href="https://derekberes.substack.com/" target="_blank">Substack</a>. His next book is</em> "<em>Hero's Dose: The Case For Psychedelics in Ritual and Therapy."</em></p>
Researchers at University College London link waist circumference with dementia.
- Researchers at University College London have discovered a link between waist circumference and dementia.
- Seventy-four percent of volunteers that developed dementia were overweight or obese.
- Women with central obesity had a 39 percent greater risk of dementia.