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Why cities are critical to achieving a carbon-neutral world
In May 2018, the city of Paris set an ambition to be carbon-neutral by 2050.
- Countries, governments and companies are aligning on a need for net-zero - and this is an opportunity to rethink decarbonizing our cities.
- There is no "one-size-fits-all" solution – each city's needs must be at the heart of developing integrated energy solutions.
- A city can only decarbonize through collaboration between government, the private sector, and local communities.
Here's what happened when AI and humans met in a strawberry-growing contest
Do they really need the human touch?
- In Pinduoduo's Smart Agriculture Competition, four technology teams competed with traditional farmers over four months to grow strawberries.
- Data analysis, intelligent sensors and greenhouse automation helped the scientists win.
- Fourth Industrial Revolution technologies such as AI are forecast to deliver huge productivity gains – but need the right governance, according to the Global Technology Governance Report 2021.
Pinduoduo
<h3>Growing potential</h3><p>Numerous studies show the potential for Fourth Industrial Revolution technologies like AI to boost economic growth and productivity.</p><p>By 2035, labour productivity in developed countries could rise by 40% due to the influence of AI, according to<a href="https://www.weforum.org/agenda/2020/12/ai-productivity-automation-artificial-intelligence-countries/" target="_blank" rel="noopener noreferrer"> analysis from Accenture and Frontier Economics</a>.</p><p>Sweden, the US and Japan are expected to see the highest productivity increases.</p>How tiny bioelectronic implants may someday replace pharmaceutical drugs
Scientists are using bioelectronic medicine to treat inflammatory diseases, an approach that capitalizes on the ancient "hardwiring" of the nervous system.
Left: The vagus nerve, the body's longest cranial nerve. Right: Vagus nerve stimulation implant by SetPoint Medical.
- Bioelectronic medicine is an emerging field that focuses on manipulating the nervous system to treat diseases.
- Clinical studies show that using electronic devices to stimulate the vagus nerve is effective at treating inflammatory diseases like rheumatoid arthritis.
- Although it's not yet approved by the US Food and Drug Administration, vagus nerve stimulation may also prove effective at treating other diseases like cancer, diabetes and depression.
The nervous system’s ancient reflexes
<p>You accidentally place your hand on a hot stove. Almost instantaneously, your hand withdraws.</p><p>What triggered your hand to move? The answer is <em>not</em> that you consciously decided the stove was hot and you should move your hand. Rather, it was a reflex: Skin receptors on your hand sent nerve impulses to the spinal cord, which ultimately sent back motor neurons that caused your hand to move away. This all occurred before your "conscious brain" realized what happened.</p><p>Similarly, the nervous system has reflexes that protect individual cells in the body.</p><p>"The nervous system evolved because we need to respond to stimuli in the environment," said Dr. Tracey. "Neural signals don't come from the brain down first. Instead, when something happens in the environment, our peripheral nervous system senses it and sends a signal to the central nervous system, which comprises the brain and spinal cord. And then the nervous system responds to correct the problem."</p><p>So, what if scientists could "hack" into the nervous system, manipulating the electrical activity in the nervous system to control molecular processes and produce desirable outcomes? That's the chief goal of bioelectronic medicine.</p><p>"There are billions of neurons in the body that interact with almost every cell in the body, and at each of those nerve endings, molecular signals control molecular mechanisms that can be defined and mapped, and potentially put under control," Dr. Tracey said in a <a href="https://www.youtube.com/watch?v=AJH9KsMKi5M" target="_blank">TED Talk</a>.</p><p>"Many of these mechanisms are also involved in important diseases, like cancer, Alzheimer's, diabetes, hypertension and shock. It's very plausible that finding neural signals to control those mechanisms will hold promises for devices replacing some of today's medication for those diseases."</p><p>How can scientists hack the nervous system? For years, researchers in the field of bioelectronic medicine have zeroed in on the longest cranial nerve in the body: the vagus nerve.</p>The vagus nerve
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNTYyOTM5OC9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY0NTIwNzk0NX0.UCy-3UNpomb3DQZMhyOw_SQG4ThwACXW_rMnc9mLAe8/img.jpg?width=1245&coordinates=0%2C0%2C0%2C0&height=700" id="09add" class="rm-shortcode" data-rm-shortcode-id="f38dbfbbfe470ad85a3b023dd5083557" data-rm-shortcode-name="rebelmouse-image" data-width="1245" data-height="700" />Electrical signals, seen here in a synapse, travel along the vagus nerve to trigger an inflammatory response.
Credit: Adobe Stock via solvod
<p>The vagus nerve ("vagus" meaning "wandering" in Latin) comprises two nerve branches that stretch from the brainstem down to the chest and abdomen, where nerve fibers connect to organs. Electrical signals constantly travel up and down the vagus nerve, facilitating communication between the brain and other parts of the body.</p><p>One aspect of this back-and-forth communication is inflammation. When the immune system detects injury or attack, it automatically triggers an inflammatory response, which helps heal injuries and fend off invaders. But when not deployed properly, inflammation can become excessive, exacerbating the original problem and potentially contributing to diseases.</p><p>In 2002, Dr. Tracey and his colleagues discovered that the nervous system plays a key role in monitoring and modifying inflammation. This occurs through a process called the <a href="https://www.nature.com/articles/nature01321" target="_blank" rel="noopener noreferrer">inflammatory reflex</a>. In simple terms, it works like this: When the nervous system detects inflammatory stimuli, it reflexively (and subconsciously) deploys electrical signals through the vagus nerve that trigger anti-inflammatory molecular processes.</p><p>In rodent experiments, Dr. Tracey and his colleagues observed that electrical signals traveling through the vagus nerve control TNF, a protein that, in excess, causes inflammation. These electrical signals travel through the vagus nerve to the spleen. There, electrical signals are converted to chemical signals, triggering a molecular process that ultimately makes TNF, which exacerbates conditions like rheumatoid arthritis.</p><p>The incredible chain reaction of the inflammatory reflex was observed by Dr. Tracey and his colleagues in greater detail through rodent experiments. When inflammatory stimuli are detected, the nervous system sends electrical signals that travel through the vagus nerve to the spleen. There, the electrical signals are converted to chemical signals, which trigger the spleen to create a white blood cell called a T cell, which then creates a neurotransmitter called acetylcholine. The acetylcholine interacts with macrophages, which are a specific type of white blood cell that creates TNF, a protein that, in excess, causes inflammation. At that point, the acetylcholine triggers the macrophages to stop overproducing TNF – or inflammation.</p><p>Experiments showed that when a specific part of the body is inflamed, specific fibers within the vagus nerve start firing. Dr. Tracey and his colleagues were able to map these relationships. More importantly, they were able to stimulate specific parts of the vagus nerve to "shut off" inflammation.</p><p>What's more, clinical trials show that vagus nerve stimulation not only "shuts off" inflammation, but also triggers the production of cells that promote healing.</p><p>"In animal experiments, we understand how this works," Dr. Tracey said. "And now we have clinical trials showing that the human response is what's predicted by the lab experiments. Many scientific thresholds have been crossed in the clinic and the lab. We're literally at the point of regulatory steps and stages, and then marketing and distribution before this idea takes off."<br></p>The future of bioelectronic medicine
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNTYxMDYxMy9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYzNjQwOTExNH0.uBY1TnEs_kv9Dal7zmA_i9L7T0wnIuf9gGtdRXcNNxo/img.jpg?width=980" id="8b5b2" class="rm-shortcode" data-rm-shortcode-id="c005e615e5f23c2817483862354d2cc4" data-rm-shortcode-name="rebelmouse-image" data-width="2000" data-height="1125" />Vagus nerve stimulation can already treat Crohn's disease and other inflammatory diseases. In the future, it may also be used to treat cancer, diabetes, and depression.
Credit: Adobe Stock via Maridav
<p>Vagus nerve stimulation is currently awaiting approval by the US Food and Drug Administration, but so far, it's proven safe and effective in clinical trials on humans. Dr. Tracey said vagus nerve stimulation could become a common treatment for a wide range of diseases, including cancer, Alzheimer's, diabetes, hypertension, shock, depression and diabetes.</p><p>"To the extent that inflammation is the problem in the disease, then stopping inflammation or suppressing the inflammation with vagus nerve stimulation or bioelectronic approaches will be beneficial and therapeutic," he said.</p><p>Receiving vagus nerve stimulation would require having an electronic device, about the size of lima bean, surgically implanted in your neck during a 30-minute procedure. A couple of weeks later, you'd visit, say, your rheumatologist, who would activate the device and determine the right dosage. The stimulation would take a few minutes each day, and it'd likely be unnoticeable.</p><p>But the most revolutionary aspect of bioelectronic medicine, according to Dr. Tracey, is that approaches like vagus nerve stimulation wouldn't come with harmful and potentially deadly side effects, as many pharmaceutical drugs currently do.</p><p>"A device on a nerve is not going to have systemic side effects on the body like taking a steroid does," Dr. Tracey said. "It's a powerful concept that, frankly, scientists are quite accepting of—it's actually quite amazing. But the idea of adopting this into practice is going to take another 10 or 20 years, because it's hard for physicians, who've spent their lives writing prescriptions for pills or injections, that a computer chip can replace the drug."</p><p>But patients could also play a role in advancing bioelectronic medicine.</p><p>"There's a huge demand in this patient cohort for something better than they're taking now," Dr. Tracey said. "Patients don't want to take a drug with a black-box warning, costs $100,000 a year and works half the time."</p><p>Michael Dowling, president and CEO of Northwell Health, elaborated:</p><p>"Why would patients pursue a drug regimen when they could opt for a few electronic pulses? Is it possible that treatments like this, pulses through electronic devices, could replace some drugs in the coming years as preferred treatments? Tracey believes it is, and that is perhaps why the pharmaceutical industry closely follows his work."</p><p>Over the long term, bioelectronic approaches are unlikely to completely replace pharmaceutical drugs, but they could replace many, or at least be used as supplemental treatments.</p><p>Dr. Tracey is optimistic about the future of the field.</p><p>"It's going to spawn a huge new industry that will rival the pharmaceutical industry in the next 50 years," he said. "This is no longer just a startup industry. [...] It's going to be very interesting to see the explosive growth that's going to occur."</p>Could playing video games be linked to lower depression rates in kids?
Can playing video games really curb the risk of depression? Experts weigh in.
Previous studies have concluded there are some mental health benefits to playing video games.
- A new study published by a UCL researcher has demonstrated how different types of screen time can positively (or negatively) influence young people's mental health.
- Young boys who played video games daily had lower depression scores at age 14 compared to those who played less than once per month or never.
- The study also noted that more frequent video game use was consistently associated with fewer depressive symptoms in boys with lower physical activity, but not in those with high physical activity levels.
How do video games and social media impact young kids?
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNTY3NDY2Mi9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY0NjM5OTQwMn0.FUGlBVN0uGa9jYXpbSjHssFpcdJGcpM-hsA8vJb1mJc/img.jpg?width=1245&coordinates=0%2C488%2C0%2C111&height=700" id="d4200" class="rm-shortcode" data-rm-shortcode-id="6a1be92721c981f409d8c9efb574fe45" data-rm-shortcode-name="rebelmouse-image" alt="two kids sitting on the couch playing video games together" data-width="1245" data-height="700" />The study gained interesting insight into the link between depression rates at age 14 and video game usage a few years earlier.
Credit: Pixel-Shot on Adobe Stock
<p>The study's lead author, Ph.D. student Aaron Kandola, explains to <a href="https://www.eurekalert.org/pub_releases/2021-02/ucl-bwp021721.php" target="_blank">Eurekalert</a>: "Screens allow us to engage in a wide range of activities. Guidelines and recommendations about screen time should be based on our understanding of how these different activities might influence mental health and whether that influence is meaningful."</p><p><strong>How this study was conducted: </strong></p><ul><li>These findings come as part of the Millennium Cohort Study, where over 11,000 (n = 11,341) adolescents were surveyed. </li><li>Depressive symptoms were measured with a Moods and Feelings Questionnaire (age 14). </li><li>"Exposures" were listed as the frequency of video games, social media, and internet usage (age 11). </li><li>Physical activity was also accounted for on a self-reporting basis. </li></ul><p><strong>When comparing young boys (age 11) who played video games to those who don't, the study showed interesting results: </strong></p><ul><li>Boys who played video games <strong>daily</strong> had 24.3 percent lower depression scores at age 14 (compared to those who played less than once per month or never). </li><li>Boys who played video games <strong>at least once per week</strong> had 25.1 percent lower depression scores at age 14 (compared to those who played less than once per month or never). </li><li>BOoys who played video games <strong>at least once per month</strong> had 31.2 percent lower depression scored at age 14 (compared to those who played less than once per month or never). </li></ul><p><strong>When comparing how depression impacted young girls based on their social media usage, the researchers found that:</strong></p><ul><li>Compared with less than once per month/never social media usage, using social media most days at age 11 was associated with a 13% higher depression score at age 14. </li></ul>Can playing video games actually be beneficial?
<p>There has been a lot of speculation in the past two decades about screen-time, social media, and video games. Whether it's <a href="https://www.apa.org/science/about/psa/2003/10/anderson" target="_blank">linking video games to violence</a> and obesity or <a href="https://childmind.org/article/is-social-media-use-causing-depression/#:~:text=In%20several%20recent%20studies%2C%20teenage,who%20spent%20the%20least%20time." target="_blank">linking social media to depression and anxiety</a> — this seems to be a controversial question. According to the research, the answer to this question is yes, video games can be beneficial in moderation when paired with physical activity and real-life application.</p><p><strong>Adding in some physical activity could be the difference between beneficial and harmful.</strong></p><p>The above-mentioned study also noted that more frequent video game use was consistently associated with fewer depressive symptoms in boys with lower physical activity, but not in those with high physical activity levels. </p><p><strong>Previous studies have concluded there are some mental health benefits to playing video games. </strong></p><p><a href="https://edition.cnn.com/2020/11/16/health/video-games-mental-health-study-wellness-scli-intl/index.html#:~:text=It%20found%20that%20time%20spent,reporting%20that%20they%20felt%20happier.&text=%22In%20fact%2C%20play%20can%20be,withhold%20those%20benefits%20from%20players.%22" target="_blank" rel="noopener noreferrer">A 2020 study</a> by the University of Oxford analyzed the impacts of playing two extremely popular games at the time: Nintendo's "Animal Crossing: New Horizons" and Electronic Arts' "Plants vs. Zombies: Battle for Neighborville." The study used data and survey responses from over 3000 players in total — the games' developers shared anonymous data about people's playing habits, and the researchers surveyed those gamers separately about their well-being. </p><p><strong>Results of this study found that time spent playing these games was associated with players reporting that they felt happier. </strong></p><p>Additionally, previous studies (such as <a href="https://it.arizona.edu/blog/can-playing-video-games-make-you-smarter" target="_blank" rel="noopener noreferrer">this University of Arizona study</a>) have linked video game usage with new learning opportunities: <em>"</em></p><p style="margin-left: 20px;">Games like Minecraft are being used in more and more classrooms around the country. MinecraftEdu (recently purchased by Microsoft), allows teachers to structure a sandbox-style play environment around any curriculum. Students can work together to learn the scientific method, build farms, or take advantage of turtle robots to learn basic programming. Not only do these activities improve team-building skills, but they give students the chance to develop and practice technological literacy."</p><p><strong>"Everything in moderation" is an important factor in determining whether video game use is beneficial or harmful. </strong></p><p>While there can be some positive impacts from playing video games, research (such as <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676913/" target="_blank" rel="noopener noreferrer">this study conducted in 2013</a>) has also shown that people who spend a predominant part of their day gaming are at risk of showing lower educational and career attainment in addition to problems with peers and lower social skills. </p>U.S. Navy controls inventions that claim to change "fabric of reality"
Inventions with revolutionary potential made by a mysterious aerospace engineer for the U.S. Navy come to light.
U.S. Navy ships
- U.S. Navy holds patents for enigmatic inventions by aerospace engineer Dr. Salvatore Pais.
- Pais came up with technology that can "engineer" reality, devising an ultrafast craft, a fusion reactor, and more.
- While mostly theoretical at this point, the inventions could transform energy, space, and military sectors.
High frequency gravitational wave generator.
Credit: Dr. Salvatore Pais
A craft using an inertial mass reduction device.
Credit: Salvatore Pais
Laser Augmented Turbojet Propulsion System
Credit: Dr. Salvatore Pais
NASA will pay $500,000 for your innovative ideas about food production in space
Introducing the Deep Space Food Challenge.
European Space Agency astronaut Luca Parmitano handling food packages aboard the International Space Station.
The way to an astronaut's heart
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNTU5Mjg4My9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY0MTkwODAwOH0.5z68HGX5Zup_y_PZfTfTnlibo3B2jKha-gjAT6jF9-w/img.jpg?width=980" id="7a63a" class="rm-shortcode" data-rm-shortcode-id="98e1e8efc2a98052faa9678a62d5f0fe" data-rm-shortcode-name="rebelmouse-image" data-width="520" data-height="402" />An image showing the different challenges a viable space-food system solution must overcome.
<p>In a paper written for <a href="https://academic.oup.com/jn/article/150/9/2242/5870322" target="_blank" rel="noopener noreferrer">The Journal of Nutrition</a>, Grace Douglas, NASA's lead scientist for advanced food technology at Johnson Space Center in Houston, outlined the necessities for food technologies in long-term space exploration. The most critical being, of course, survival.</p><p>"In the history of humankind, explorers set off to see what was over the horizon, and literally millions did not return because of food and nutrition failures," Douglas and her co-authors wrote.</p><p>The difficulty is that the processes we rely on to cook meals on Earth—such as boiling water, hot surfaces, and food preparation—work as they do because they are bound to an environment with gravity, atmosphere, atmospheric pressure, and even certain microbes. Spaceflight replaces that environment with one of microgravity, scarce resources, cabin pressure fluctuation, and unmitigated radiation, each adding their own variable to the cooking calculus.</p><p>To date, <a href="https://www.nasa.gov/audience/foreducators/stem-on-station/ditl_eating" target="_blank" rel="noopener noreferrer">space food</a> preparation has been limited to adding water or heating pre-packaged foods. When supplemented with fresh produce from Earth, the system works fine. But as mentioned, such a system would be infeasible for the more than two-year roundtrip to Mars and back.</p><p>Douglas and her coauthors conclude that any viable solution must provide safe, stable, palatable, and reliable food, while also overcoming environmental constraints, using minimal resources, and producing minimal waste. It would also need to provide all the micro- and macronutrients a spacefaring astronaut needs.</p><p>That alone is a tall order, but there is another wrinkle engineers must consider: the astronauts' mental wellbeing. Douglas and her co-authors note that it's a "common misperception" that astronauts will eat anything to complete the mission. While astronauts are high-performing individuals, they still require moments to revitalize their wellbeing against the stress, workload, and isolation inherent in such a mission. </p><p>Delicious, nutritious meals can provide such moments of mental reprieve, but they also must have variety. Even the tastiest meal in the finest of restaurants would become a mental chore if eaten day-in, day-out for two whole years. Substitute that with a tasteless, yet nutrient-dense food paste in the vacuum of space, and even the highest performers will develop a case of cosmic cabin fever.</p>One tough space nut to crack
<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="52d1849f3d676f8f2781e077fbf33978"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/pVDnGdlIMmA?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><p>To meet these challenges, NASA is crowdsourcing solutions through its <a href="https://www.deepspacefoodchallenge.org/" target="_blank" rel="noopener noreferrer">Deep Space Food Challenge</a>. In collaboration with the Canadian Space Agency, NASA is offering a $500,000 prize purse for solutions that add some flavor to extended spaceflight.</p><p>"NASA has knowledge and capabilities in this area, but we know that technologies and ideas exist outside of the agency," Douglas told <a href="https://www.upi.com/Science_News/2021/02/01/NASA-will-pay-500000-for-good-ideas-on-food-production-in-space/8681611859130/" target="_blank" rel="noopener noreferrer">UPI in an interview</a>. "Raising awareness will help us reach people in a variety of disciplines that may hold the key to developing these new technologies."</p><p>The agency hopes the winning technologies will also bolster food production on Earth. If a system can offer tasty meals with minimal resources in space, the reasoning goes, then it may be modified for deployment to disaster areas and food-insecure regions, as well. The challenge is open to all U.S. citizens and closes on July 30, 2021. Information on the Canadian Space Agency's challenge is <a href="https://www.asc-csa.gc.ca/eng/sciences/food-production/deep-space-food-challenge.asp" target="_blank" rel="noopener noreferrer">available on its website</a>.</p><p>If food isn't your forte but you've got engineering chops, you can still help NASA solve the many other engineering and logistical problems facing the future of space exploration. Through the <a href="https://www.nasa.gov/solve/index.html" target="_blank" rel="noopener noreferrer">NASA Solve</a> initiative, the agency is seeking ideas for breaking lunar ice, shrinking payload sizes, and developing new means of energy distribution. </p><p>And even if engineering isn't for you, you can still <a href="https://www.planetary.org/advocacy/call-congress" target="_blank" rel="noopener noreferrer">call your Congressional representative</a> to request they support NASA and <a href="https://www.planetary.org/advocacy" target="_blank" rel="noopener noreferrer">restore funding from budget cuts</a>. We can all play a small, yet important, role in the future of space exploration and the advancing of scientific knowledge.</p>