"Such studies will lead to a better understanding of brain development in both autistic and typical individuals."
- Autism spectrum disorder (ASD) is a neurodevelopmental condition that can cause significant social, communication, and behavioral challenges.
- Although a diagnosis of autism can typically be made around the age of 2, the average age for diagnosis in the United States is after 4 years old.
- A new study shows that the atypical development of autism in human brain cells starts at the very earliest stages of brain organization, which can happen as early as the third week of pregnancy.
Nerve cells in the autistic brain differ before birth, new research finds<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="97bc70ff8b04dcea1a5e712e3789a970"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/JPO-uOPK5RI?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><p><a href="https://www.sciencedaily.com/releases/2020/08/200824091958.htm" target="_blank" rel="noopener noreferrer">A new study</a> shows that the atypical development of autism in human brain cells starts at the very earliest stages of brain organization, which can happen as early as the <a href="https://www.enfagrow.com.sg/my-pregnancy/development/per-month/baby-brain-development-during-pregnancy#:~:text=Your%20developing%20baby's%20brain%20development%20technically%20begins%20during%20the%20third,%2C%20hindbrain%2C%20and%20spinal%20cord." target="_blank">third week of pregnancy</a>.</p><p>The study was performed by scientists at King's College London and Cambridge University. </p><p><strong>The study used induced pluripotent stem cells to recreate the development of each sample in the womb.<br></strong>The researchers isolated hair samples from nine autistic people and six typical people. By treating the cells with an array of growth factors, the scientists were able to drive the hair cells to become nerve cells (or neurons), much like those found in either the cortex or the midbrain region.</p><p>These induced pluripotent stem cells (referred to as IPSCs) retain the genetic identity of the person from which they came, and the cells restart their development as it would have happened in the womb. This provides a look into that person's brain development.</p><p>At various stages, the researchers examined the developing cells' appearance and sequenced their RNA to see which genes the cells were expressing. On day 9 of the study, developing neurons from typical people formed "neural rosettes" (an intricate, dandelion-like shape indicative of typically developing neurons). Cells from autistic people formed smaller rosettes (or did not form any rosettes at all), and key developmental genes were expressed at lower levels.</p><p>Days 21 and 35 of the study showed cells from typical and autistic people differed significantly in a number of ways, proving that the makeup of neurons in the cortex differs in the autistic and typically developing brains.</p><p>John Krystal, Ph.D., Editor-in-Chief of Biological Psychiatry, <a href="https://www.sciencedaily.com/releases/2020/08/200824091958.htm" target="_blank">explains</a>: "The emergence of differences associated with autism in these nerve cells shows that these differences arise very early in life."</p><p><strong>Along with the variations, there were some things that proved similar.<br></strong>Additionally, cells directed to develop as midbrain neurons (a brain region that's not implicated in autism dysfunction) showed only negligible differences between typical and autistic individuals. The similarities are just as important as the differences, as they mark how the autistic brain and typical brain develop uniquely from the earliest stages of growth.</p><p>"The use of iPSCs allows us to examine more precisely the differences in cell fates and gene pathways that occur in neural cells from autistic and typical individuals. These findings will hopefully contribute to our understanding of why there is such diversity in brain development," said Dr. Dr. Deepak Srivastava, who supervised the study.</p><p><strong>The intention of this study is not to find ways to "cure" autism, but to better understand the key genetic components that contribute to it.<br></strong>Simon Baron-Cohen, Ph.D., Director of the Autism Research Centre at Cambridge and the study's co-lead, added that "some people may be worried that basic research into differences in the autistic and typical brain prenatally may be intended to 'prevent,' 'eradicate,' or 'cure' autism. This is not our motivation, and we are outspoken in our values in standing up against eugenics and in valuing neurodiversity. Such studies will lead to a better understanding of brain development in both autistic and typical individuals."</p>
In "Douglas," the Australian comedian opens up about her autism diagnosis.
- In her new Netflix special, "Douglas," comedian Hannah Gadsby targets anti-vaxxers.
- Diagnosed with autism four years ago, Gadsby discusses the dangers of believing vaccinations cause autism.
- Some high-profile anti-vax activists use their platform in order to sell supplements and books.
How Hannah Gadsby's High-Functioning Autism Works | Netflix Is A Joke<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="b2bb91d719bd25e853753d4ade362893"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/5lXbpgU9OWk?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><p>In a scathing yet hilarious indictment of the anti-vax movement, Gadsby says activists are highly organized and coordinated. They're also prone to "willfully manipulate statistics," as the osteopathic study proves. This doesn't change the fact that anti-vaxxers are woefully outnumbered, however loud social media seems. Tragically, the loudest voice in the room gets taken seriously, sometimes. </p><p>After discussing her autism diagnosis, Gadsby begins the skit. </p><p style="margin-left: 20px;">"Do you know what causes autism? No, you f***ing don't. If you honestly think you do, your confidence is making you stupid." </p><p>She's aware anti-vaxxers are likely in the room. Her core demographic is wealthy, entitled white women, which is "a Venn diagram with a lot of crossover." Gadsby holds no hope in changing minds, because that's not how closed minds work: "They don't work; they're closed for business." </p><p>She then pretends vaccines cause autism, although "pretending is not science." She's not upset about being on the spectrum. That doesn't mean having autism is easy; quite the contrary. It's difficult to always be the odd one out. That said, Gadsby brilliantly advocates for autism. </p><p style="margin-left: 20px;">"As difficult as this life is, it's nice to have a life. And it's particularly nice to have this life in a world without polio. Polio is bad, and that is a fact, not a feeling."</p><p>Text on a screen will never compare to Gadsby's delivery: the crescendo of "polio," the playful yet serious expression on her face when delivering this information. Her critique doesn't stop there. </p><p style="margin-left: 20px;">"I would rather have autism than be a sociopath like you."</p><p>Tough statement, which she qualifies. Believing your child is more important than all other children means you're not playing for the team. You've wrapped yourself up so tightly in a belief system that self-righteousness has become your creed. Far from being a posture on Twitter, this mindset has real-world consequences. </p><p>First, there's the economic angle. Discredited physician Andrew Wakefield, who was <a href="https://www.bmj.com/content/342/bmj.c5347" target="_blank">paid to falsify data</a> in his infamous measles vaccine-autism study, <a href="http://www.medicine.mcgill.ca/epidemiology/hanley/c609/Material/BMJpartII.pdf" target="_blank">filed a patent</a> for a single-jab measles vaccine as the same time he was decrying vaccines. His objective appears to have been financial from day one. </p>
Protesters hold banners against the 5G technology and vaccines as others shout slogans during an anti-government protest in front of the parliament in Sofia on May 14, 2020.
Photo by Nikolay Doychinov/AFP via Getty Images<p>Wakefield isn't the only opportunist. Osteopath Joseph Mercola's net worth has <a href="https://www.washingtonpost.com/investigations/2019/10/15/fdc01078-c29c-11e9-b5e4-54aa56d5b7ce_story.html" target="_blank">grown to over $100 million</a> as he promotes his products to anti-vaxxers. Then there's Judy Mikovits, the subject of the discredited film, "<a href="https://bigthink.com/coronavirus/the-plandemic" target="_self">Plandemic</a>," whose book <a href="https://www.rollingstone.com/culture/culture-news/plandemic-judy-mikovits-plague-of-corruption-998224/" target="_blank">became a bestseller</a> after the film's release. Her book was published by a house whose <a href="https://www.youtube.com/watch?v=j9WuTxRZFNQ&t=74s" target="_blank">sole focus</a> is promoting anti-vaccination rhetoric.</p><p>Second, the health consequences. As Gadsby says, anti-vaxxers are coordinated. Two case studies: Samoa and Orthodox Judaism. </p><p>Recently anti-vax rhetoric has <a href="https://www.washingtonpost.com/opinions/samoa-has-become-a-case-study-for-anti-vax-success/2019/12/09/76848830-1ac8-11ea-b4c1-fd0d91b60d9e_story.html" target="_blank">rooted</a> in Samoa. The result: over 4,000 children were infected with measles last fall. At least 70 died. An anti-vax advocate <a href="https://www.bbc.com/news/world-asia-50682881" target="_blank">promoted</a> the use of papaya leaf for treating measles; he was later arrested. The situation was so bad, the Samoan government declared a state of emergency and banned children under the age of 17 from gathering publicly. </p><p>Anti-vax rhetoric <a href="https://khn.org/news/why-measles-hits-so-hard-within-n-y-orthodox-jewish-community/" target="_blank">also hit</a> Orthodox Jewish communities hard last year. In March, 2019 over 275 cases of measles were confirmed in New York state. The <a href="https://www.washingtonpost.com/national/health-science/meet-the-new-york-couple-donating-millions-to-the-anti-vax-movement/2019/06/18/9d791bcc-8e28-11e9-b08e-cfd89bd36d4e_story.html" target="_blank">funding</a> for this effort was provided by a wealthy Manhattan couple that has donated over $3 million to anti-vax organizations. One group is Informed Consent Action Network, an anti-vax organization run by a former television producer that specifically targets Orthodox Jewish communities in Brooklyn and Rockland County. </p><p>"Douglas" is a masterful piece of common sense propaganda. Gadsby is ready for the vitriol certain to come her way for exposing the public to basic science. She snacks on hate. Following that statement, she stares out into the crowd to ask if they understand why she would eat the bluster of haters. Her response is priceless.<br></p><p style="margin-left: 20px;">"It builds immunity; it's called microdosing. Your hate is my vaccine."</p><p>A slight pause. </p><p style="margin-left: 20px;">"What are you going to do? I already have autism."</p><p>--</p><p><em>Stay in touch with Derek on <a href="http://www.twitter.com/derekberes" target="_blank">Twitter</a>, <a href="https://www.facebook.com/DerekBeresdotcom" target="_blank">Facebook</a> and <a href="https://derekberes.substack.com/" target="_blank">Substack</a>. His next book is</em> "<em>Hero's Dose: The Case For Psychedelics in Ritual and Therapy."</em></p>
More vaccine-autism facts for the fact-averse.
- A massive new study finds absolutely no link between MMR vaccination and autism.
- Some question the expenditure of yet more research money on convincing conspiracy theorists.
- There are already 206 measles cases this year in the U.S., and the disease is up by 30% globally, despite previous near-eradication.
The 2019 Danish vaccine-autism study<p>The study from scientists at Denmark's Statens Serum Institut finds no statistical link whatsoever between the administration of MMR doses and the likelihood of developing autism. It also found no correlation between areas in which vaccines are administered and clusters of autism diagnoses occur. In fact, as the anti-vax movement has grown, so has the incidence of autism, from 1 out of 68 eight-year-olds having it in 2016, to <a href="http://www.autism-society.org/news/2018-cdc-autism-incidence-rate-statement-from-the-autism-society/" target="_blank" data-vivaldi-spatnav-clickable="1">1 out of 59 in 2018</a>.</p><p>The researchers studied the medical histories of Danish children born between 1999 and the end of 2010. Using population registries, they were able assess other risk factors — including sibling histories of autism — and look for correspondences between vaccinations and the occurrence of autism. Speaking of the statistics presented in the study, global health expert <a href="http://vaccines.emory.edu/faculty-evc/primary-faculty/omer_saad.html" target="_blank" data-vivaldi-spatnav-clickable="1">Saad Omer</a> tells the <a href="https://www.washingtonpost.com/nation/2019/03/05/measles-vaccine-doesnt-cause-autism-says-new-decade-long-study-half-million-people/?utm_term=.b8972078fe24" target="_blank" data-vivaldi-spatnav-clickable="1"><em>Washington Post</em></a>, "The appropriate interpretation is that there's no association whatsoever."</p>
Money well spent or wasted?<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8xOTI1ODc0Mi9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY0MjMyMTI3Nn0.vYCGA4qiVQfOniVQ7psQueQDLUvAGp-D_DFagc6TYE8/img.jpg?width=980" id="92bd1" class="rm-shortcode" data-rm-shortcode-id="16890fa6a8ed7970265eae363c83ac0c" data-rm-shortcode-name="rebelmouse-image" />
(Fred Tanneau/AFP/Getty Images)<p>Dispositive as the new study's evidence is, Omer and others consider it questionable to use research money sorely needed elsewhere to convince anti-vaxxers. As bioethicist <a href="https://sites.google.com/site/sydmjohnson/" target="_blank" data-vivaldi-spatnav-clickable="1">Syd M Johnson</a> says, "They are immune to facts." Alongside the study in <em>Annals</em> is an <a href="https://annals.org/aim/fullarticle/2727208/further-evidence-mmr-vaccine-safety-scientific-communications-considerations" target="_blank" data-vivaldi-spatnav-clickable="1">editorial</a> by Omer decrying this waste of time, effort, and money on people living in what he calls a "fact-resistant" world.</p><p>Omer's concerned that anti-vaxxer beliefs undermine general public faith in vaccines, so he sees value in spending <em>some</em> money on continuing to gather contrary evidence, but only "if the cost, including the opportunity cost, of these studies is not too high." By "opportunity cost," Omer refers to the lost chance of developing cures with these funds, warning, "continuing to evaluate the MMR-autism hypothesis might come at the expense of not pursuing some of the more promising leads."</p>
A teen leading the way<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8xOTI1ODc1OC9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY0Mzg5MjM3Nn0.z45s5snGwksRvU2UCoPtHwEwHTJLkOw1OD8w6jYmAtc/img.jpg?width=980" id="7b218" class="rm-shortcode" data-rm-shortcode-id="18e486afe78bcfe29e74f940d86c571f" data-rm-shortcode-name="rebelmouse-image" />
Ethan Lindenberger addresses the U.S. Senate.
(Jim Watson/AFP/Getty Images)<p>The new report coincides with last week's worrying hearing in the U.S. Senate at which 18-year-old <a href="https://www.npr.org/2019/03/06/700617424/18-year-old-testifies-about-getting-vaccinated-despite-mothers-anti-vaccine-beli" target="_blank" data-vivaldi-spatnav-clickable="1">Ethan Lindenberger</a> testified about his decision to get himself vaccinated against the wishes of his parents. He's written on <a href="https://www.reddit.com/r/NoStupidQuestions/comments/9xm989/my_parents_are_kind_of_stupid_and_dont_believe_in/?st=JRTFJJR5&sh=0b2c98a8" target="_blank" data-vivaldi-spatnav-clickable="1">Reddit</a> that his mother became convinced from Facebook posts that vaccinations "are some kind of government scheme." His Reddit thread says, "I have an appointment in a few weeks to get my shots! My mom was especially angry but my dad said because I'm 18 he doesn't care that much. Although my mom's trying to convince me to not do it and saying I don't care about her, I know that this is something I need to do regardless."</p><p>Facebook <a href="https://www.washingtonpost.com/business/2019/02/15/facebook-will-consider-removing-or-demoting-anti-vaccination-recommendations-amid-backlash/?utm_term=.f3f6430fe4d0" target="_blank" data-vivaldi-spatnav-clickable="1">claims</a> to have "taken steps to reduce the distribution of health-related misinformation on Facebook, but we know we have more to do." On March 6, Facebook announced a <a href="https://www.businessinsider.com/facebook-plans-tackle-anti-vaccine-misinformation-rejecting-ads-de-ranking-pages-2019-3" target="_blank" data-vivaldi-spatnav-clickable="1">new plan</a>. </p>
Your child or mine?<p>It's understandable that anti-vaxxer parents expect to be able to control the health decisions regarding their own children, but unfortunately, their kids — and the other with whom they come in contact — are not immune to infectious diseases.</p><p>As a result, everyone else has no choice but to sit by and watch the unwarranted return of serious diseases. Many U.S. states allow "religious" exemptions that allow parents to opt out of vaccinating their children, but it's not just a U.S. problem. With the prevalence of measles up by 30% globally, the World Health Organization ranks "<a href="https://www.who.int/emergencies/ten-threats-to-global-health-in-2019" target="_blank" data-vivaldi-spatnav-clickable="1">vaccine hesitancy</a>" among the top 10 threats to global health in 2019, at a cost of 1.5 million lives annually .</p>
Musical savants have “enhanced pitch discrimination” and “increased auditory perceptual capacity.” But why?
We often see in the media autistic savants who can write and play music like grand masters with incredible talent and flourish. In fact, of autistic savants and savants in general, having extraordinary musical talent is one of the most common advantages. A new study published in the journal Cognition, suggests a reason for it. Those with autism spectrum disorder (ASD) have superior hearing.