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How does hypnosis really impact the brain?
A groundbreaking Stanford University study explains the areas of the brain that are impacted by hypnosis.
- Hypnosis refers to a trance state that is characterized by extreme suggestibility, relaxation, and heightened imagination.
- According to a Stanford University School of Medicine study, there are three areas of our brains that change during a state of hypnosis.
- This groundbreaking study provides information on how hypnosis impacts the brain, which could lead to new and improved pain management and anxiety treatments in the future.
Although hypnosis has been around for hundreds of years, it is still something that even the brightest among us cannot fully understand. The earliest references to hypnosis date back to ancient Egypt and Greece. In fact, the word "hypnos" means "sleep" and refers to the Greek god who is the personification of sleep.
Our definition of hypnosis refers to a trance state that is characterized by extreme suggestibility, relaxation, and heightened imagination. Most often, hypnosis is compared to a sort of daydream state - you're fully conscious, but you have tuned out most of the stimuli around yourself and are focused intently on a particular subject, most of the time through the power of suggestion
Hypnosis: a brief history
Along the way, there have been many pioneers in the feild of hypnosis research.
Photo by Brian A Jackson on Shutterstock
The "modern father" of hypnosis was Austrian physician Franz Mesmer, who gave us the word "mesmerism", which can be another word referencing a hypnotic state. Mesmer had an idea for which he called "animal magnetism" - and the idea was that there are these kinds of natural energy sources that could be transferred between organisms and objects.
Along the way, hypnotism has had many other pioneers who have furthered the fascinating phenomenon. One of the most notable is James Braid, an eye doctor based in Scotland who became intrigued with the idea of hypnosis when he discovered a patient in his waiting room had fallen under something of a trance after staring at a lamp. He gave the patient come commands, and the patient obliged, remaining in a trace-like state the entire time.
Braid's fascination grew and through more tests, he determined that getting a patient to fixate on something was one of the most important components to hypnosis. He later would publish a book on what we now know as the discovery of modern hypnosis.
Later, James Esdaile, a British surgeon based in India during the mid-1800s established that this kind of trance hypnotic state was extremely useful in pain relief practices. He performed hundreds of major operations using hypnotism as his only anesthetic. When he returned to England in an attempt to convince the medical establishments of his findings, they paid no mind to his theory in favor of new chemical anesthetics such as morphine, which was relatively new at the time. This is where the use of hypnotics for medicinal purposes halted and much of the reason why hypnosis is considered an alternative approach to medicine in today's society.
Jumping forward to the 1900s, Frenchman Emile Coué moved away from the conventional approaches that had been pioneered with hypnotism and began his work with the use of auto-suggestion.
He is most famous for the phrase: "Day by day, in every way, I am getting better and better." This technique was one of the first instances where affirmation hypnosis was used and it has been growing through various counseling programs and therapy techniques ever since.
In modern times, one of the most recognized authorities on clinical hypnosis remains to be Milton Erikson, a well-known psychotherapist who did most of his work around 1950-1980. He was fascinated with human psychology and devised countless innovative ways to use hypnosis in his clinical practices.
Scientists scanned the brains of 57 people during a guided hypnosis session.
Image by vrx on Shutterstock
Changes found in three areas of the brain during hypnosis may suggest future alternative treatments for anxiety and pain management.
Over the years, hypnosis has gained a lot of traction and respectability within both the medical and psychotherapy professions. According to a 2016 Stanford University School of Medicine study, there are three areas of our brains that change during a state of hypnosis - and this could actually be used to benefit us.
Scientists scanned the brains of 57 people during a guided hypnosis session, similar to one that may be used to help treat anxiety, pain, or trauma.
First, there is a decrease in dorsal anterior cingulate activity.
This is part of the brain's salience network that is responsible for psychological functions like decision making, evaluation processes, and emotional regulation as well as physiological functions such as blood pressure and heart rate.
Next, there is an increase in the connection between the dorsolateral prefrontal cortex and the insula.
The dorsolateral prefrontal cortex is associated with executive functions such as working memory and self-control. The insula is a small region of the cerebral cortex that plays a significant role in pain perception, social engagements, emotions, and autonomic control.
This is described by the lead researcher of the study as a kind of "brain-body connection" that helps the brain process and control what's going on in the body.
Finally, there are reduced connections between the dorsolateral prefrontal cortex and the medial prefrontal cortex.
The dorsolateral prefrontal cortex becomes less connected to the medial prefrontal cortex and the posterior cingulate cortex, both of which are strongly associated with neural activity and cognitive tasks.
This decrease very likely correlates to the disconnect between someone's actions and their awareness of their actions, according to the lead researcher on the project.
How does this change the way we view hypnosis?
Understanding exactly which areas of the brain are impacted during hypnosis can pave the way for groundbreaking research into the use of hypnosis for medicinal purposes.
"Now that we know which brain regions are involved," says David Spiegel, MD, professor and researcher on the project, "we may be able to use this knowledge to alter someone's capacity to be hypnotized or the effectiveness of the hypnosis for problems such as pain control."
While more research is needed, the study is certainly a groundbreaking head-start in what could eventually be known as hypnotic treatments for things like anxiety, trauma and pain management.
"A treatment that combines brain stimulation with hypnosis could improve known analgesic effects of hypnosis and potentially even replace addictive and side-effect-laden painkillers and anti-anxiety medications," explains Spiegel.
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- Hypnotherapy services through Amazon Alexa by Reveri Health - Big Think ›
Inventions with revolutionary potential made by a mysterious aerospace engineer for the U.S. Navy come to light.
- U.S. Navy holds patents for enigmatic inventions by aerospace engineer Dr. Salvatore Pais.
- Pais came up with technology that can "engineer" reality, devising an ultrafast craft, a fusion reactor, and more.
- While mostly theoretical at this point, the inventions could transform energy, space, and military sectors.
The U.S. Navy controls patents for some futuristic and outlandish technologies, some of which, dubbed "the UFO patents," came to light recently. Of particular note are inventions by the somewhat mysterious Dr. Salvatore Cezar Pais, whose tech claims to be able to "engineer reality." His slate of highly-ambitious, borderline sci-fi designs meant for use by the U.S. government range from gravitational wave generators and compact fusion reactors to next-gen hybrid aerospace-underwater crafts with revolutionary propulsion systems, and beyond.
Of course, the existence of patents does not mean these technologies have actually been created, but there is evidence that some demonstrations of operability have been successfully carried out. As investigated and reported by The War Zone, a possible reason why some of the patents may have been taken on by the Navy is that the Chinese military may also be developing similar advanced gadgets.
Among Dr. Pais's patents are designs, approved in 2018, for an aerospace-underwater craft of incredible speed and maneuverability. This cone-shaped vehicle can potentially fly just as well anywhere it may be, whether air, water or space, without leaving any heat signatures. It can achieve this by creating a quantum vacuum around itself with a very dense polarized energy field. This vacuum would allow it to repel any molecule the craft comes in contact with, no matter the medium. Manipulating "quantum field fluctuations in the local vacuum energy state," would help reduce the craft's inertia. The polarized vacuum would dramatically decrease any elemental resistance and lead to "extreme speeds," claims the paper.
Not only that, if the vacuum-creating technology can be engineered, we'd also be able to "engineer the fabric of our reality at the most fundamental level," states the patent. This would lead to major advancements in aerospace propulsion and generating power. Not to mention other reality-changing outcomes that come to mind.
Among Pais's other patents are inventions that stem from similar thinking, outlining pieces of technology necessary to make his creations come to fruition. His paper presented in 2019, titled "Room Temperature Superconducting System for Use on a Hybrid Aerospace Undersea Craft," proposes a system that can achieve superconductivity at room temperatures. This would become "a highly disruptive technology, capable of a total paradigm change in Science and Technology," conveys Pais.
High frequency gravitational wave generator.
Credit: Dr. Salvatore Pais
Another invention devised by Pais is an electromagnetic field generator that could generate "an impenetrable defensive shield to sea and land as well as space-based military and civilian assets." This shield could protect from threats like anti-ship ballistic missiles, cruise missiles that evade radar, coronal mass ejections, military satellites, and even asteroids.
Dr. Pais's ideas center around the phenomenon he dubbed "The Pais Effect". He referred to it in his writings as the "controlled motion of electrically charged matter (from solid to plasma) via accelerated spin and/or accelerated vibration under rapid (yet smooth) acceleration-deceleration-acceleration transients." In less jargon-heavy terms, Pais claims to have figured out how to spin electromagnetic fields in order to contain a fusion reaction – an accomplishment that would lead to a tremendous change in power consumption and an abundance of energy.
According to his bio in a recently published paper on a new Plasma Compression Fusion Device, which could transform energy production, Dr. Pais is a mechanical and aerospace engineer working at the Naval Air Warfare Center Aircraft Division (NAWCAD), which is headquartered in Patuxent River, Maryland. Holding a Ph.D. from Case Western Reserve University in Cleveland, Ohio, Pais was a NASA Research Fellow and worked with Northrop Grumman Aerospace Systems. His current Department of Defense work involves his "advanced knowledge of theory, analysis, and modern experimental and computational methods in aerodynamics, along with an understanding of air-vehicle and missile design, especially in the domain of hypersonic power plant and vehicle design." He also has expert knowledge of electrooptics, emerging quantum technologies (laser power generation in particular), high-energy electromagnetic field generation, and the "breakthrough field of room temperature superconductivity, as related to advanced field propulsion."
Suffice it to say, with such a list of research credentials that would make Nikola Tesla proud, Dr. Pais seems well-positioned to carry out groundbreaking work.
A craft using an inertial mass reduction device.
Credit: Salvatore Pais
The patents won't necessarily lead to these technologies ever seeing the light of day. The research has its share of detractors and nonbelievers among other scientists, who think the amount of energy required for the fields described by Pais and his ideas on electromagnetic propulsions are well beyond the scope of current tech and are nearly impossible. Yet investigators at The War Zone found comments from Navy officials that indicate the inventions are being looked at seriously enough, and some tests are taking place.
If you'd like to read through Pais's patents yourself, check them out here.
Laser Augmented Turbojet Propulsion System
Credit: Dr. Salvatore Pais
Scientists do not know what is causing the overabundance of the gas.
- A new study looked to understand the source of methane on Saturn's moon Enceladus.
- The scientists used computer models with data from the Cassini spacecraft.
- The explanation could lie in alien organisms or non-biological processes.
Something is producing an overabundance of methane in the ocean hidden under the ice of Saturn's moon Enceladus. A new study analyzed if the source could be an alien life form or some other explanation.
The study, published in Nature Astronomy, was carried out by scientists at the University of Arizona and Paris Sciences & Lettres University, who looked at composition data from the water plumes erupting on Enceladus.
The particular chemistry, discovered by the Cassini spacecraft which flew through the plumes, suggested a high concentration of molecules that have been linked to hydrothermal vents on the bottom of Earth's oceans. Such vents are potential cradles of life on Earth, according to previous studies. The data from Cassini, which has been studying Saturn after entering its orbit in 2004, revealed the presence of molecular hydrogen (dihydrogen), methane, and carbon dioxide, with the amount of methane presenting a particular interest to the scientists."We wanted to know: Could Earthlike microbes that 'eat' the dihydrogen and produce methane explain the surprisingly large amount of methane detected by Cassini?" shared one of the study's lead authors Régis Ferrière, an associate professor in the department of Ecology and Evolutionary Biology at the University of Arizona.
Earth's hydrothermal vents feature microorganisms that use dihydrogen for energy, creating methane from carbon dioxide via the process of methanogenesis.
Searching for such microorganisms known as methanogens on the seafloor of Enceladus is not yet feasible. Likely, it would require very sophisticated deep diving operations that will be the objective of future missions.
So, Ferrière's team took a more available approach to pinpointing the origins of the methane, creating mathematical models that attempted to explain the Cassini data. They wanted to calculate the likelihood that particular processes were responsible for producing the amount of methane observed. For example, is the methane more likely the result of biological or non-biological processes?
They found that the data from Cassini was consistent with either microbial activity at hydrothermal vents or processes that have nothing to do with life but could be quite different from what happens on Earth. Intriguingly, models that didn't involve biological entities didn't seem to produce enough of the gas.
"Obviously, we are not concluding that life exists in Enceladus' ocean," Ferrière stated. "Rather, we wanted to understand how likely it would be that Enceladus' hydrothermal vents could be habitable to Earthlike microorganisms. Very likely, the Cassini data tell us, according to our models."
Still, the scientists think future missions are necessary to either prove or discard the "life hypothesis." One explanation for the methane that does not involve biological organisms is that the gas is the result of a chemical breakdown of primordial organic matter within Enceladus' core. This matter could have become a part of Saturn's moon from comets rich in organic materials.
It marks a breakthrough in using gene editing to treat diseases.
This article was originally published by our sister site, Freethink.
For the first time, researchers appear to have effectively treated a genetic disorder by directly injecting a CRISPR therapy into patients' bloodstreams — overcoming one of the biggest hurdles to curing diseases with the gene editing technology.
The therapy appears to be astonishingly effective, editing nearly every cell in the liver to stop a disease-causing mutation.
The challenge: CRISPR gives us the ability to correct genetic mutations, and given that such mutations are responsible for more than 6,000 human diseases, the tech has the potential to dramatically improve human health.
One way to use CRISPR to treat diseases is to remove affected cells from a patient, edit out the mutation in the lab, and place the cells back in the body to replicate — that's how one team functionally cured people with the blood disorder sickle cell anemia, editing and then infusing bone marrow cells.
Bone marrow is a special case, though, and many mutations cause disease in organs that are harder to fix.
Another option is to insert the CRISPR system itself into the body so that it can make edits directly in the affected organs (that's only been attempted once, in an ongoing study in which people had a CRISPR therapy injected into their eyes to treat a rare vision disorder).
Injecting a CRISPR therapy right into the bloodstream has been a problem, though, because the therapy has to find the right cells to edit. An inherited mutation will be in the DNA of every cell of your body, but if it only causes disease in the liver, you don't want your therapy being used up in the pancreas or kidneys.
A new CRISPR therapy: Now, researchers from Intellia Therapeutics and Regeneron Pharmaceuticals have demonstrated for the first time that a CRISPR therapy delivered into the bloodstream can travel to desired tissues to make edits.
We can overcome one of the biggest challenges with applying CRISPR clinically.
"While these are early data, they show us that we can overcome one of the biggest challenges with applying CRISPR clinically so far, which is being able to deliver it systemically and get it to the right place," she continued.
What they did: During a phase 1 clinical trial, Intellia researchers injected a CRISPR therapy dubbed NTLA-2001 into the bloodstreams of six people with a rare, potentially fatal genetic disorder called transthyretin amyloidosis.
The livers of people with transthyretin amyloidosis produce a destructive protein, and the CRISPR therapy was designed to target the gene that makes the protein and halt its production. After just one injection of NTLA-2001, the three patients given a higher dose saw their levels of the protein drop by 80% to 96%.
A better option: The CRISPR therapy produced only mild adverse effects and did lower the protein levels, but we don't know yet if the effect will be permanent. It'll also be a few months before we know if the therapy can alleviate the symptoms of transthyretin amyloidosis.
This is a wonderful day for the future of gene-editing as a medicine.
If everything goes as hoped, though, NTLA-2001 could one day offer a better treatment option for transthyretin amyloidosis than a currently approved medication, patisiran, which only reduces toxic protein levels by 81% and must be injected regularly.
Looking ahead: Even more exciting than NTLA-2001's potential impact on transthyretin amyloidosis, though, is the knowledge that we may be able to use CRISPR injections to treat other genetic disorders that are difficult to target directly, such as heart or brain diseases.
"This is a wonderful day for the future of gene-editing as a medicine," Fyodor Urnov, a UC Berkeley professor of genetics, who wasn't involved in the trial, told NPR. "We as a species are watching this remarkable new show called: our gene-edited future."