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Stem cells help restore damaged teeth, new study finds
Stem cells have endless uses. This study suggests they can even bring half dead teeth back to life.
- A new study demonstrates that stem cells from baby teeth can be used to repair damaged permanent teeth in young children.
- The findings suggest a new treatment for childhood dental issues may be around the corner.
- The treatment's potential applications go much further than just dental health.
Half of all children suffer some kind of dental injury while young. Sometimes the damage isn't to the baby teeth they will lose anyway, but to the permanent adult teeth lying below the gums that they will need for the rest of their lives. In some cases, trauma can cut off the blood supply to a tooth and rot out the living pulp inside it; a condition called "pulp necrosis." This condition often leads to the loss of the tooth. While treatment exists, it is often unsatisfactory.
But stem cells might do the trick.
Few people really like going to the dentist. This new treatment might reduce the need for the less pleasant treatments.
A new clinical trial by Yan Jin, Kun Xuan, and Bei Li of the Fourth Military Medicine University in Xi'an, China and Songtao Shi of the University of Pennsylvania's School of Dental Medicine demonstrates how to repair teeth suffering from pulp necrosis by taking stem cells from the patient's baby teeth.
The study, carried out in China on 40 children who had both damaged adult teeth and baby teeth that had yet to fall out, was published in the journal Science Translational Medicine. The test subjects were selected to either receive the new treatment or an older treatment called apexification, which attempts to address the issue by encouraging root development. This was considered the control group.
The patients who received the stem cell treatment, called human deciduous pulp stem cell (hDPSC) treatment, had pulp tissue taken out of one of their healthy baby teeth. This pulp is rich in stem cells. The cells were grown in a lab and then placed into the injured adult tooth. The hope was that the stem cells would encourage the growth of new pulp inside the tooth.
Follow-ups were carried out for up to three years. The patients who had received the hDPSC treatment showed better blood flow in their teeth, better root systems, and thicker dentin than the patents who underwent the traditional procedure. They also had recovered sensation in their teeth, while the control group had not. The use of a patient's own cells in the treatment also reduced the risk of their body rejecting the therapy, making the concept even more attractive.
"This treatment gives patients sensation back in their teeth. If you give them a warm or cold stimulation, they can feel it; they have living teeth again," Dr. Shi told Penn Today. "For me, the results are very exciting. To see something we discovered take a step forward to potentially become a routine therapy in the clinic is gratifying."
What applications will this have?
Before you get too excited, the research is still in the early stages. The problem of how to treat adults with dental problems after they have no more baby teeth to take stem cells from still remains unsolved. It will also be some time before the dental treatment gets approval for use in the United States, so don't hold your breath for getting a stem cell boost to your smile just yet.
Many children suffer dental injuries that can have a lasting impact later in life, often leading to the loss of permanent teeth. This can lead to a loss of self-esteem, speech issues, and jaw problems. This new treatment option, while currently limited to very young children, could provide a breakthrough in dental care. The potential applications for treating systemic diseases such as lupus are also promising.
"We're really eager to see what we can do in the dental field, and then building on that to open up channels for systemic disease therapy," Dr. Shi said.
Educators and administrators must build new supports for faculty and student success in a world where the classroom might become virtual in the blink of an eye.
- If you or someone you know is attending school remotely, you are more than likely learning through emergency remote instruction, which is not the same as online learning, write Rich DeMillo and Steve Harmon.
- Education institutions must properly define and understand the difference between a course that is designed from inception to be taught in an online format and a course that has been rapidly converted to be offered to remote students.
- In a future involving more online instruction than any of us ever imagined, it will be crucial to meticulously design factors like learner navigation, interactive recordings, feedback loops, exams and office hours in order to maximize learning potential within the virtual environment.
A leading British space scientist thinks there is life under the ice sheets of Europa.
- A British scientist named Professor Monica Grady recently came out in support of extraterrestrial life on Europa.
- Europa, the sixth largest moon in the solar system, may have favorable conditions for life under its miles of ice.
- The moon is one of Jupiter's 79.
Neil deGrasse Tyson wants to go ice fishing on Europa<div class="rm-shortcode" data-media_id="GLGsRX7e" data-player_id="FvQKszTI" data-rm-shortcode-id="f4790eb8f0515e036b24c4195299df28"> <div id="botr_GLGsRX7e_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/GLGsRX7e-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/GLGsRX7e-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/GLGsRX7e-FvQKszTI.js"></script> </div>
Water Vapor Above Europa’s Surface Deteced for First Time<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="9c4abc8473e1b89170cc8941beeb1f2d"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/WQ-E1lnSOzc?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span>
New study shows white dwarf stars create an essential component of life.
- White dwarf stars create carbon atoms in the Milky Way galaxy, shows new study.
- Carbon is an essential component of life.
- White dwarfs make carbon in their hot insides before the stars die.
What Are White Dwarf Stars?<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="7b046e546ce994682b2553a8c978eb32"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/77a1KSxfaR0?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span>
Master negotiator Chris Voss breaks down how to get what you want during negotiations.
- Former FBI negotiator Chris Voss explains how forced empathy is a powerful negotiating tactic.
- The key is starting a sentence with "What" or "How," causing the other person to look at the situation through your eyes.
- What appears to signal weakness is turned into a strength when using this tactic.
3 Tips on Negotiations, with FBI Negotiator Chris Voss | Best of '16 | Big Think<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="b86d518e9f0c9f9d7a7c686e07798152"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/-FLlBchonwM?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><p>This question forces a response, but—and this is key—the other person has to consider your side of the argument. They have to look at the situation from your perspective if they hope to offer a solution.</p><p>Offering a real-world example, Voss mentions coaching a high-end real estate agent. They were leasing an expensive home in the Hollywood Hills. The first time the negotiators asked the "how" question, the leasing agent relented on a number of terms. A little while later, they asked again. This time, the agent said, "If you want the house you're going to have to do it," signaling that the end of negotiations had been reached. </p><p>Voss says that "how" is not the only word that works. "What" is also a powerful entry into negotiations, such as "What am I supposed to do?" Again, you're forcing the other person to empathize. </p><p>This is a particularly tricky skill during a time when most conversations are online. Nuance is impossible without the immediacy of pantomimes and vocal fluctuations. Whataboutism is too easy an escape. </p>
Aikido Morihei Ueshiba (1883 - 1969, standing, centre left), founder of the Japanese martial art of aikido, demonstrating his art with a follower, at the opening ceremony of the newly-opened aikido headquarters, Hombu Dojo, in Shinjuku, Tokyo, 1967.
(Photo by Keystone/Hulton Archive/Getty Images)<p>Online debates often amount to little more than frustrated individuals pulling out their hair. In his book, "Against Empathy," Yale psychology professor Paul Bloom writes that effective altruists are able to focus on what really matters in everyday life.</p><p>For example, he compares politics to sports. Rooting for your favorite team isn't based in rationality. If you're a Red Sox fan, Yankees stats don't matter. You just want to destroy them. This, he believes, is how most people treat politics. "They don't care about truth because, for them, it's not really about truth."</p><p>Bloom writes that if his son believed our ancestors rode dinosaurs, it would horrify him, but "I can't think of a view that matters less for everyday life." We have to strive for rationality when the stakes are high. When involved in real decision-making processes that will affect their life, people are better able to express ideas and make arguments, and are more receptive to opposing ideas. </p><p>Because we "become inured to problems that seem unrelenting," it's imperative to make the problem seem immediate. As Voss says, giving the other side "the illusion of control" is one way of accomplishing this, as it forces them to take action. When people feel out of control, negotiations are impossible. People dig their heels in and refuse to budge. </p><p>What seems to be weakness is actually a strength. To borrow another martial arts metaphor, negotiations are like aikido: using your opponent's force against them while also protecting them from injury. Forcing empathy is one way to accomplish this task. You may get more than you ask for without the other side ever realizing they surrendered anything.</p><p>--</p><p><em>Stay in touch with Derek on <a href="http://www.twitter.com/derekberes" target="_blank">Twitter</a>, <a href="https://www.facebook.com/DerekBeresdotcom" target="_blank">Facebook</a> and <a href="https://derekberes.substack.com/" target="_blank">Substack</a>. His next book is</em> "<em>Hero's Dose: The Case For Psychedelics in Ritual and Therapy."</em></p>