‘Designer baby’ book trilogy explores the moral dilemmas humans may soon create
How would the ability to genetically customize children change society? Sci-fi author Eugene Clark explores the future on our horizon in Volume I of the "Genetic Pressure" series.
Stephen Johnson is a St. Louis-based writer whose work has been published by outlets including PBS Digital Studios, HuffPost, MSN, U.S. News & World Report, Eleven Magazine and The Missourian.
- A new sci-fi book series called "Genetic Pressure" explores the scientific and moral implications of a world with a burgeoning designer baby industry.
- It's currently illegal to implant genetically edited human embryos in most nations, but designer babies may someday become widespread.
- While gene-editing technology could help humans eliminate genetic diseases, some in the scientific community fear it may also usher in a new era of eugenics.
Imagine it's 2045. You start hearing rumors from your well-heeled friends about a mysterious corporation based on an undisclosed island that's offering an unprecedented service: the ability to genetically design your baby.
The baby will have some of your genetics, and some genetics from a sperm or egg donor, selected by you. But the rest of your child's genetic profile will be engineered by science. These changes will make it impossible for your child to develop genetic diseases. They'll also allow you to customize your child for dozens of traits, including intelligence level, emotional disposition, sexual orientation, height, skin tone, hair color, and eye color, to name a few.
This raises unsettling philosophical questions for some customers. "When does my child stop being my child?" they ask the corporate representatives. These wary customers are reminded of how risky it is to reproduce the old-fashioned way. The Better Genetics Corporation's motto sums it up: "Only God plays dice—humans don't have to."
This is the world described in a new science-fiction series by Eugene Clark titled "Genetic Pressure", which explores the moral and scientific implications of a future in which designer babies are becoming a major industry. The first book begins with the story of Rachel, a renowned horse breeder who befriends a billionaire client, and soon gets the funding to visit the tropical island on which the Better Genetics Corporation is headquartered.
There, corporate executives walk her through the process of designing a baby—an experience that feels like an uncanny mix between visiting a doctor and designing a luxury car. The series is told from multiple perspectives, serving as a deep dive into a complex moral web that today's scientists may already be weaving.
[T]he introduction of designer babies would create a labyrinth of philosophical dilemmas that society is only beginning to explore.
Case in point: In 2018, Chinese scientist He Jiankui announced that he had helped create the world's first genetically engineered babies. Using the gene-editing tool CRISPR on embryos, He Jiankui modified a gene called CCR5, which enables HIV to enter and infect immune system cells. His goal was to engineer children that were immune to the virus.
It's unclear whether he succeeded. But what's certain is that the experiment shocked the international scientific community, which generally agreed that it's unethical to conduct gene-editing procedures on humans, given that scientists don't yet fully understand the consequences.
"This experiment is monstrous," Julian Savulescu, a professor of practical ethics at the University of Oxford, told The Guardian. "The embryos were healthy. No known diseases. Gene editing itself is experimental and is still associated with off-target mutations, capable of causing genetic problems early and later in life, including the development of cancer."
Importantly, He Jiankui wasn't treating a disease, but rather genetically engineering babies to prevent the future contraction of a virus. These kinds of changes are heritable, meaning the experiment could have major downstream effects on future generations. So, too, would a designer-baby industry, even if scientists can do it safely.
With major implications on inequality, discrimination, sexuality, and our conceptions of life, the introduction of designer babies would create a labyrinth of philosophical dilemmas that society is only beginning to explore.
Tribalism and discrimination
One question the "Genetic Pressure" series explores: What would tribalism and discrimination look like in a world with designer babies? As designer babies grow up, they could be noticeably different from other people, potentially being smarter, more attractive and healthier. This could breed resentment between the groups—as it does in the series.
"[Designer babies] slowly find that 'everyone else,' and even their own parents, becomes less and less tolerable," author Eugene Clark told Big Think. "Meanwhile, everyone else slowly feels threatened by the designer babies."
For example, one character in the series who was born a designer baby faces discrimination and harassment from "normal people"—they call her "soulless" and say she was "made in a factory," a "consumer product."
Would such divisions emerge in the real world? The answer may depend on who's able to afford designer baby services. If it's only the ultra-wealthy, then it's easy to imagine how being a designer baby could be seen by society as a kind of hyper-privilege, which designer babies would have to reckon with.
Even if people from all socioeconomic backgrounds can someday afford designer babies, people born designer babies may struggle with tough existential questions: Can they ever take full credit for things they achieve, or were they born with an unfair advantage? To what extent should they spend their lives helping the less fortunate?
Sexuality presents another set of thorny questions. If a designer baby industry someday allows people to optimize humans for attractiveness, designer babies could grow up to find themselves surrounded by ultra-attractive people. That may not sound like a big problem.
But consider that, if designer babies someday become the standard way to have children, there'd necessarily be a years-long gap in which only some people are having designer babies. Meanwhile, the rest of society would be having children the old-fashioned way. So, in terms of attractiveness, society could see increasingly apparent disparities in physical appearances between the two groups. "Normal people" could begin to seem increasingly ugly.
But ultra-attractive people who were born designer babies could face problems, too. One could be the loss of body image.
When designer babies grow up in the "Genetic Pressure" series, men look like all the other men, and women look like all the other women. This homogeneity of physical appearance occurs because parents of designer babies start following trends, all choosing similar traits for their children: tall, athletic build, olive skin, etc.
Sure, facial traits remain relatively unique, but everyone's more or less equally attractive. And this causes strange changes to sexual preferences.
"In a society of sexual equals, they start looking for other differentiators," he said, noting that violet-colored eyes become a rare trait that genetically engineered humans find especially attractive in the series.
But what about sexual relationships between genetically engineered humans and "normal" people? In the "Genetic Pressure" series, many "normal" people want to have kids with (or at least have sex with) genetically engineered humans. But a minority of engineered humans oppose breeding with "normal" people, and this leads to an ideology that considers engineered humans to be racially supreme.
Regulating designer babies
On a policy level, there are many open questions about how governments might legislate a world with designer babies. But it's not totally new territory, considering the West's dark history of eugenics experiments.
In the 20th century, the U.S. conducted multiple eugenics programs, including immigration restrictions based on genetic inferiority and forced sterilizations. In 1927, for example, the Supreme Court ruled that forcibly sterilizing the mentally handicapped didn't violate the Constitution. Supreme Court Justice Oliver Wendall Holmes wrote, "… three generations of imbeciles are enough."
After the Holocaust, eugenics programs became increasingly taboo and regulated in the U.S. (though some states continued forced sterilizations into the 1970s). In recent years, some policymakers and scientists have expressed concerns about how gene-editing technologies could reanimate the eugenics nightmares of the 20th century.
Currently, the U.S. doesn't explicitly ban human germline genetic editing on the federal level, but a combination of laws effectively render it illegal to implant a genetically modified embryo. Part of the reason is that scientists still aren't sure of the unintended consequences of new gene-editing technologies.
But there are also concerns that these technologies could usher in a new era of eugenics. After all, the function of a designer baby industry, like the one in the "Genetic Pressure" series, wouldn't necessarily be limited to eliminating genetic diseases; it could also work to increase the occurrence of "desirable" traits.
If the industry did that, it'd effectively signal that the opposites of those traits are undesirable. As the International Bioethics Committee wrote, this would "jeopardize the inherent and therefore equal dignity of all human beings and renew eugenics, disguised as the fulfillment of the wish for a better, improved life."
"Genetic Pressure Volume I: Baby Steps" by Eugene Clark is available now.
This storm rained electrons, shifted energy from the sun's rays to the magnetosphere, and went unnoticed for a long time.
- An international team of scientists has confirmed the existence of a "space hurricane" seven years ago.
- The storm formed in the magnetosphere above the North magnetic pole.
- The storm posed to risk to life on Earth, though it might have interfered with some electronics.
What do you call that kind of storm when it forms over the Arctic ocean?<iframe width="730" height="430" src="https://www.youtube.com/embed/8GqnzBJkWcw" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen></iframe><p> Many objects in space, like Earth, the Sun, most of the planets, and even some large moons, have magnetic fields. The area around these objects which is affected by these fields is known as the magnetosphere.</p><p>For us Earthlings, the magnetosphere is what protects us from the most intense cosmic radiation and keeps the solar wind from affecting our atmosphere. When charged particles interact with it, we see the aurora. Its fluctuations lead to changes in what is known as "space weather," which can impact electronics. </p><p>This "space hurricane," as the scientists are calling it, was formed by the interactions between Earth's magnetosphere and the <a href="https://en.wikipedia.org/wiki/Interplanetary_magnetic_field" target="_blank" rel="noopener noreferrer">interplanetary magnetic field,</a> the part of the sun's magnetosphere that goes out into the solar system. It took on the familiar shape of a cyclone as it followed magnetic fields. For example, the study's authors note that the numerous arms traced out the "footprints of the reconnected magnetic field lines." It rotated counter-clockwise with a speed of nearly 7,000 feet per second. The eye, of course, was still and <a href="https://www.sciencealert.com/for-the-first-time-a-plasma-hurricane-has-been-detected-in-space" target="_blank" rel="noopener noreferrer">calm</a>.</p><p>The storm, which was invisible to the naked eye, rained electrons and shifted energy from space into the ionosphere. It seems as though such a thing can only form under calm situations when large amounts of energy are moving between the solar wind and the upper <a href="https://www.reading.ac.uk/news-and-events/releases/PR854520.aspx" target="_blank">atmosphere</a>. These conditions were modeled by the scientists using 3-D <a href="https://www.nature.com/articles/s41467-021-21459-y#Sec10" target="_blank">imaging</a>.<br><br>Co-author Larry Lyons of UCLA explained the process of putting the data together to form the models to <a href="https://www.nbcnews.com/science/space/space-hurricane-rained-electrons-observed-first-time-rcna328" target="_blank">NBC</a>:<br><br>"We had various instruments measuring various things at different times, so it wasn't like we took a big picture and could see it. The really fun thing about this type of work is that we had to piece together bits of information and put together the whole picture."<br><br>He further mentioned that these findings were completely unexpected and that nobody that even theorized a thing like this could exist. <br></p><p>While this storm wasn't a threat to any life on Earth, a storm like this could have noticeable effects on space weather. This study suggests that this could have several effects, including "increased satellite drag, disturbances in High Frequency (HF) radio communications, and increased errors in over-the-horizon radar location, satellite navigation, and communication systems."</p><p>The authors <a href="https://www.nature.com/articles/s41467-021-21459-y#Sec8" target="_blank" rel="noopener noreferrer">speculate</a> that these "space hurricanes" could also exist in the magnetospheres of other planets.</p><p>Lead author Professor Qing-He Zhang of Shandong University discussed how these findings will influence our understanding of the magnetosphere and its changes with <a href="https://www.eurekalert.org/pub_releases/2021-03/uor-sho030221.php" target="_blank" rel="noopener noreferrer">EurekaAlert</a>:</p><p>"This study suggests that there are still existing local intense geomagnetic disturbance and energy depositions which is comparable to that during super storms. This will update our understanding of the solar wind-magnetosphere-ionosphere coupling process under extremely quiet geomagnetic conditions."</p>
The chariot survived ancient eruptions and modern-day looters to become a part of the world heritage site.
- Archeologists recently discovered a first-of-its-kind chariot in Pompeii.
- The ceremonial chariot is decorated with bronze and tin medallions, while the sides sport bronzesheets and red-and-black paintings.
- Given looting activity in the area, it's lucky the 2,000-year-old treasure wasn't lost to the world heritage site.
One dope Pompeian whip<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNTcxOTUzNS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY2MjU3Nzk5MH0.M3HW5tPe17JuKMhLtKgbOlqK4sMbspqYskR_jz6t9sg/img.jpg?width=1245&coordinates=0%2C70%2C0%2C230&height=700" id="497f9" class="rm-shortcode" data-rm-shortcode-id="1bda1a9c489b85c8a56c189eb21706d1" data-rm-shortcode-name="rebelmouse-image" data-width="1245" data-height="700" />
Researchers carefully extract the chariot from the sedimentary rock encasing it.
(Photo: Archaeological Park of Pompeii)<p>In a recent discovery, researchers unearthed a first-of-its-kind chariot at Civita Giuliana, an excavation site north of Pompeii's ancient walls. In Roman times, the site served as a getaway for Rome's elite and wealthy citizens, a serene countryside brimming with villas and Mediterranean farms. So, it's understandable why such an exquisite chariot was found here.</p><p>"I was astounded," Eric Poehler, a professor at the University of Massachusetts Amherst, who specializes in Pompeii traffic, <a href="https://www.npr.org/2021/02/27/972118983/a-lamborghini-of-chariots-is-discovered-at-pompeii-archaeologists-are-wowed?ft=nprml&f=1001" target="_blank">told <em>NPR</em></a>. "Many of the vehicles I'd written about before ... are your standard station wagon or vehicle for taking the kids to soccer. This is a Lamborghini. This is an outright fancy, fancy car."</p><p>Located in a double-level portico, the chariot is a far cry from anything Ben-Hur would have been seen cruising around in. It sports four iron wheels and a high seat complete with arm- and backrest. The sides are adorned with engraved bronze and wooden panels painted with red-and-black figures. And the rear bumps with a register of bronze and tin medallion depicting Eros-inspired scenes of satyrs, nymphs, and cupids. In short, this chariot is slab.</p><p>"It is an extraordinary discovery for the advancement of our knowledge of the ancient world," Massimo Osanna, the director of the archaeological park, <a href="http://pompeiisites.org/en/comunicati/the-four-wheeled-processional-chariot-the-last-discovery-of-pompeii/" target="_blank" rel="noopener noreferrer">said in a statement</a>. "At Pompeii vehicles used for transport have been found in the past, […] but nothing like the Civita Giuliana chariot."</p><p>But unlike a Lamborghini—which serves only to show the owner has more money than sense—this chariot served a social and cultural role. Likely a <em>pilentum</em>, it would have been rolled out in times of ceremony, potentially during festivals, processions, or weddings.</p><p>While similar chariots have been uncovered in northern Greece, this is the first such chariot to be discovered in Italy. Its presence in Pompeii will further help historians understand the people who called the city home, as well as their relation to the Mediterranean world.</p><p>As Poehler added, "This is precisely the kind of find that one wants to find at Pompeii, the really well-articulated, very well-preserved moments in time. And it happens to be in this case an object that is relatively rare despite its ubiquity in the past."</p>
It belongs in a museum (not the black market)<p>Beyond its gilded appeal, the chariot is also special because it survived so we could learn from it. The area where the vehicle was found has been favored in recent years by looters, and illicit tunnels had been dug precariously close to the chariot's resting place. For this reason, the archeological park has teamed up with the Public Prosecutor's Office of Torre Annunziata to protect Pompeii's history and excavate its treasures before they become lost or stolen.</p><p>"The collaboration between the Public Prosecutor's Office of Torre Annunziata and the Archaeological Park of Pompeii has proved itself to be a formidable instrument, not only for bringing finds of exceptional historical and artistic value to light, but also for halting the criminal actions of individuals who for years have been the protagonists in a systematic looting of the priceless archaeological heritage preserved in the vast area of the Civita Giuliana villa, which is still largely buried and to which the recent exceptional findings bear witness," Nunzio Fragliasso, chief prosecutor of Torre Annunziata, said in his joint statement with Osanna.</p><p>Nor is everything that glitters historic gold. Even Pompeii's everyday ephemera can have an outsized impact on history. Pompeian citizens, for example, viewed street walls as a type of "<a href="https://www.thegreatcoursesdaily.com/how-pompeii-graffiti-preserved-the-ordinary-voices-of-ancient-rome/" target="_blank">public advertisement space</a>" and so painted them thick with graffiti. As historians must often rely on the written works of the literate elite, this graffiti gives the ordinary Pompeians their voice back. <a href="https://www.sciencemag.org/news/2018/10/ancient-graffiti-shifts-date-pompeii-s-destruction-back-2-months" target="_blank" rel="noopener noreferrer">One such charcoal tag</a> even corrected the record of Vesuvius's eruption by two months, from August to October, contradicting the traditionally accepted date set by Pliny the Younger.</p><p>"Today, archaeologists try to understand ancient societies by studying the entire material record -- not just the beautiful or luxurious objects, but also the broken bits of cooking pottery, the animal bones thrown into the trash, the microscopic grains of pollen in the soil, and much more," Caitlín Barrett, associate professor at Cornell University, <a href="https://www.cnn.com/travel/article/pompeii-new-excavations-looting/index.html" target="_blank" rel="noopener noreferrer">told <em>CNN</em></a>.</p><p>This ephemera is also at risk. Looters looking for eye-catching treasure and artwork will often destroy everyday objects in their pursuit. And after centuries encased in protective sedimentary rock, the city has again been exposed to the rains, winds, and human blunders that erode. The goal now isn't just to excavate fantastic treasures, but to preserve the world heritage site and learn from it for as long as time (<a href="http://volcano.oregonstate.edu/what%E2%80%99s-most-recent-eruption-vesuvius-and-will-it-erupt-again" target="_blank" rel="noopener noreferrer">and maybe Vesuvius</a>) will allow.</p>
New study suggests the placebo effect can be as powerful as microdosing LSD.
- New research from Imperial College London investigated the psychological effects of microdosing LSD in 191 volunteers.
- While microdosers experienced beneficial mental health effects, the placebo group performed statistically similar to those who took LSD.
- Researchers believe the expectation of a trip could produce some of the same sensations as actually ingesting psychedelics.
Psychedelics: The scientific renaissance of mind-altering drugs | Sam Harris, Michael Pollan & more<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="92360c805fe66c11de38a75b0967f417"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/5T0LmbWROKY?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><p>Published in <em>eLife</em>, the team recruited 191 citizen cosmonauts to microdose either LSD or a placebo over the course of several weeks and note the psychological effects. Volunteers were already microdosing LSD, so there was no true control. Each volunteer was given instructions on creating their own low-dose gel capsules, some containing LSD, others not. Then they mixed the capsules in envelopes so they didn't know if they were taking the real thing or not.</p><p>The trial design was ingenious: each capsule featured a QR code that was scanned after the addition of ingredients but before they were placed in the envelope so that researchers knew what they were ingesting.</p><p>The problem: volunteers sourced their own LSD. Lack of quality control could have had a profound effect on the results. </p><p>The results: LSD microdosers reported feeling more mindful, satisfied with life, and better overall; they also noticed a reduction in feelings of paranoia. </p><p>The catch: the control group felt the same thing, with no statistical difference between the groups. </p><p>Lead author Balázs Szigeti comments on the findings: "This suggests that the improvements may not be due to the pharmacological action of the drug but can instead be explained by the placebo effect." </p>
Photo: Alexander / Adobe Stock<p>Psychedelics are notoriously difficult to control for given the intensity of the experience. Yet there is precedent for the above findings. A <a href="https://link.springer.com/article/10.1007/s00213-020-05464-5" target="_blank">2019 study</a> found that 61 percent of volunteers that took a placebo instead of psilocybin felt some psychedelic effects, with a few volunteers experiencing full-on trips.</p><p style="margin-left: 20px;">"Several stated that they saw the paintings on the walls 'move' or 'reshape' themselves, others felt 'heavy. . . as if gravity [had] a stronger hold', and one had a 'come down' before another 'wave' hit her."</p><p>The Imperial team believes the expectation of a trip might have been enough to produce similar results. Senior author David Erritzoe is excited for future studies on the topic, believing they tapped into a new wave of citizen science that could push forward our knowledge of psychedelic substances.</p><p style="margin-left: 20px;">"Accounting for the placebo effect is important when assessing trends such as the use of cannabidiol oils, fad diets or supplements where social pressure or users' expectations can lead to a strong placebo response. Self-blinding citizen science initiatives could be used as an inexpensive, initial screening tool before launching expensive clinical studies."</p><p>As investments into the psychedelics market explode, with one company <a href="https://www.bloomberg.com/news/articles/2021-03-03/thiel-backed-magic-mushroom-firm-atai-hits-2-billion-valuation" target="_blank">reaching a $2 billion valuation</a>, a recurring irony appears in the long arc of psychedelics and research: the power of our minds might be enough to feel greater life satisfaction and a deeper sense of mindfulness. If that's possible with a placebo, we have to question why the rush to create more pharmacology is necessary. </p><p>This is, mind you, a separate conversation over the role of psychedelics and rituals for group bonding. The function of group cohesion around consciousness-altering substances will continue to play an important role in many communities. </p><p>Of course, we should continue to explore the efficacy of psychedelics on anxiety, depression, suicidal ideation, PTSD, and addiction. <a href="https://bigthink.com/surprising-science/antidepressant-effects" target="_self">Pharmacological dependence</a> is a stain on the psychiatry industry. Whether or not psychedelics can be prescribed for daily use remains to be seen, but we know a moneyed interest is expecting a return on investment—the above company, ATAI Life Sciences, raised $157 million in its Series D round. </p><p>When it comes to wellbeing, some things money just can't buy. How we navigate the tricky terrain of mainstreaming psychedelics remains to be seen. </p><p>--</p><p><em>Stay in touch with Derek on <a href="http://www.twitter.com/derekberes" target="_blank">Twitter</a> and <a href="https://www.facebook.com/DerekBeresdotcom" target="_blank" rel="noopener noreferrer">Facebook</a>. His most recent book is</em> "<em><a href="https://www.amazon.com/gp/product/B08KRVMP2M?pf_rd_r=MDJW43337675SZ0X00FH&pf_rd_p=edaba0ee-c2fe-4124-9f5d-b31d6b1bfbee" target="_blank" rel="noopener noreferrer">Hero's Dose: The Case For Psychedelics in Ritual and Therapy</a>."</em></p>
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