Self-Motivation
David Goggins
Former Navy Seal
Career Development
Bryan Cranston
Actor
Critical Thinking
Liv Boeree
International Poker Champion
Emotional Intelligence
Amaryllis Fox
Former CIA Clandestine Operative
Management
Chris Hadfield
Retired Canadian Astronaut & Author
Learn
from the world's big
thinkers
Start Learning

CRISPR-edited babies born in China may have enhanced brain functions

The brains of two genetically edited babies born last year in China might have enhanced memory and cognition, but that doesn't mean the scientific community is pleased.

CRISPR-edited babies born in China may have enhanced brain functions
YouTube
  • In November, Chinese scientist He Jiankui reported that he'd used the CRISPR tool to edit the embryos of two girls.
  • He deleted a gene called CCR5, which allows humans to contract HIV, the virus which causes AIDS.
  • In addition to blocking AIDS, deleting this gene might also have positive effects on memory and cognition. Still, virtually all scientists say we're not ready to use gene-editing technology on babies.

The controversial decision to genetically edit the embryos of two girls born in China last year might have enhanced their memory and cognition, scientists say.

Chinese scientist He Jiankui reported in November that he'd used the CRISPR editing tool to delete a gene called CCR5, which enables humans to contract HIV, the virus that causes AIDS. In addition to potentially blocking the development of AIDS, recent research suggests knocking out CCR5 can also make mice smarter and help the human brain recover from strokes.

"The answer is likely yes, it did affect their brains," Alcino J. Silva, a neurobiologist at the University of California, Los Angeles, whose lab studied the CCR5 gene's role in memory and cognition, told MIT Technology Review. "The simplest interpretation is that those mutations will probably have an impact on cognitive function in the twins."

Despite any potential benefits, the scientific community has almost universally condemned the move, which was generally described as a premature use of technology whose physiological and philosophical consequences on human life remain unclear. When Silva learned He had used CRISPR to delete the CCR5 gene, his reaction was "visceral repulsion and sadness."

"I suddenly realized, 'Oh, holy shit, they are really serious about this bullshit,'" he told MIT Technology Review.

The CRISPR co-founder's response to He

Jennifer Doudna, a professor of chemistry and molecular and cell biology at UC Berkeley and co-inventor of CRISPR, published a statement in November saying the public should consider the following points on the use of gene-editing technology:

  • The clinical report has not been published in the peer-reviewed scientific literature.
  • Because the data has not been peer reviewed, the fidelity of the gene editing process cannot be evaluated.
  • The work, as described to date, reinforces the urgent need to confine the use of gene editing in human embryos to cases where a clear unmet medical need exists, and where no other medical approach is a viable option, as recommended by the National Academy of Sciences.

In 2017, Doudna spoke to Big Think about the tricky regulatory and philosophical questions we might soon wrestle with if genetically designing babies becomes an option for parents.

As Silva told MIT Technology Review, this kind of selective gene-editing wouldn't just have consequences for parents and their kids, but also for society at large:

"Could it be conceivable that at one point in the future we could increase the average IQ of the population? I would not be a scientist if I said no. The work in mice demonstrates the answer may be yes. But mice are not people. We simply don't know what the consequences will be in mucking around. We are not ready for it yet."

Take your career to the next level by raising your EQ

Emotional intelligence is a skill sought by many employers. Here's how to raise yours.

Gear
  • Daniel Goleman's 1995 book Emotional Intelligence catapulted the term into widespread use in the business world.
  • One study found that EQ (emotional intelligence) is the top predictor of performance and accounts for 58% of success across all job types.
  • EQ has been found to increase annual pay by around $29,000 and be present in 90% of top performers.
Keep reading Show less

Just How Much Land Does the Federal Government Own — and Why?

The rough beauty of the American West seems as far as you can get from the polished corridors of power in Washington DC.

Surprising Science

The rough beauty of the American West seems as far as you can get from the polished corridors of power in Washington DC. Until you look at the title to the land. The federal government owns large tracts of the western states: from a low of 29.9% in Montana, already more than the national average, up to a whopping 84.5% in Nevada.

Keep reading Show less

Can VR help us understand layers of oppression?

Researchers are using technology to make visual the complex concepts of racism, as well as its political and social consequences.

Future of Learning
  • Often thought of first as gaming tech, virtual reality has been increasingly used in research as a tool for mimicking real-life scenarios and experiences in a safe and controlled environment.
  • Focusing on issues of oppression and the ripple affect it has throughout America's political, educational, and social systems, Dr. Courtney D. Cogburn of Columbia University School of Social Work and her team developed a VR experience that gives users the opportunity to "walk a mile" in the shoes of a black man as he faces racism at three stages in his life: as a child, during adolescence, and as an adult.
  • Cogburn says that the goal is to show how these "interwoven oppressions" continue to shape the world beyond our individual experiences. "I think the most important and powerful human superpower is critical consciousness," she says. "And that is the ability to think, be aware and think critically about the world and people around you...it's not so much about the interpersonal 'Do I feel bad, do I like you?'—it's more 'Do I see the world as it is? Am I thinking critically about it and engaging it?'"
Keep reading Show less

Russia claims world's first COVID-19 vaccine but skepticism abounds

President Vladimir Putin announces approval of Russia's coronavirus vaccine but scientists warn it may be unsafe.

Russian President Vladimir Putin announced coronavirus vaccine at the Novo-Ogaryovo residence outside Moscow, Russia, Tuesday, Aug. 11, 2020.

Credit: Alexei Nikolsky, Sputnik, Kremlin Pool Photo via AP
Coronavirus
  • Vladimir Putin announced on Tuesday that a COVID-19 vaccine has been approved in Russia.
  • Scientists around the world are worried that the vaccine is unsafe and that Russia fast-tracked the vaccine without performing the necessary phase 3 trials.
  • To date, Russia has had nearly 900,000 registered cases of coronavirus.
  • Keep reading Show less
    Scroll down to load more…
    Quantcast