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Gene-edited babies may live shorter lives, analysis finds
Chinese scientist He Jiankui edited the genes of two babies to be resistant to HIV, provoking outrage. Now, a new genetic analysis shows why this was reckless.
- The gene-editing technique CRISPR offers major benefits to humanity, but scientists don't believe the field is mature enough for widespread editing.
- For this reason, when Chinese scientist He Jiankui edited the genes of two babies to be resistant to HIV, his work provoked outrage.
- A new study of 400,000 genetic profiles reveals that He's genetic editing did indeed have an unintended consequence.
Ever since Frankenstein, scientists have been keen to avoid the public perception that they are playing God. This is part of the reason why the scientific community reacted so strongly to the Chinese biophysicist He Jiankui's announcement in 2018 that he had genetically edited the embryos of two girls in order to make them more resilient to HIV. As a result of his work, He was fired from his position and may face criminal charges.
Now, new research published in Nature Medicine underscores the reason for this backlash. The study examined a database of the genetic profiles of over 400,000 individuals from the UK, narrowing in on those who had the delta-32 mutation to the CCR5 gene. When an individual inherits delta-32 from both parents, they have a markedly strong resistance to HIV — this is the same mutation that He introduced into two subjects known by their pseudonyms Lulu and Nana using the gene-editing technique CRISPR.
HIV resistance is an obvious benefit of this mutation, but the trouble with gene editing is that it can be wildly unpredictable. "This is far too premature," said Dr. Eric Topol, head of the Scripps Research Translational Institute in California. "We're dealing with the operating instructions of a human being. It's a big deal." The new research showed that this tampering did have some unintended consequences: Individuals with this genetic mutation live two years less than those without it.
Playing with fire
He Jiankui during a panel discussion after presenting his results at the Second International Summit on Human Genome Editing in Hong Kong.
ANTHONY WALLACE/AFP/Getty Images
He selected Lulu and Nana for gene editing because their father had HIV. It's far more common for HIV to pass from the mother to the offspring, but it is possible, albeit rare, for HIV to pass from the father to the offspring. Providing Lulu and Nana each with two copies of delta-32 mutation did likely protect them against this possibility as well as from catching HIV later in life.
However, some evidence exists that individuals with two copies of delta-32 catch influenza, West Nile, and certain other diseases more easily. While HIV is a grievous disease, these far more commonly encountered diseases can often be just as deadly, especially in one's older age. This is precisely the result that the researchers uncovered in their analysis. Individuals with two copies of delta-32 were 20% more likely to die before the age of 76, with the highest probability of death occurring at 74.
What's more, because Lulu and Nana had their genes edited while they were embryos, this mutation will be passed down to any offspring that they have later. Given this scope, its increasingly clear why scientists reacted with such horror at He's actions: Gene-editing an embryo could have long-lasting, unintended consequences that could seriously impair what would have been otherwise healthy individuals for generations.
Another potential unknown impact that delta-32 could have is related to the girls' ethnicities. The mutation is far more common in individuals from northern Europe, while its very rare for individuals from Asia and Africa. Some researchers argue that the presence of delta-32 in Europeans is due to the impact of plagues from the Middle Ages, such as the Black Death. The absence of this mutation in other parts of the world is likely because it simply isn't useful there—different environments have different diseases, against which delta-32 could be more deleterious than beneficial.
He's actions and studies such as this one underscore the importance of a smart, evidence-based regulatory framework for gene-editing technologies. One question we need to resolve is whether germline editing, such as that performed on Lulu and Nana, should be permitted since these changes can be passed down to subsequent offspring. We also need a way to gauge the impact of editing specific genes so that we're not surprised by unintended side effects, like the diminished lifespan caused by delta-32. All in all, this study and He's work show us that there are simply too many moving parts to just introduce genetic mutations and see how things go. We need to be more rigorous than that.
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Construction of the $500 billion dollar tech city-state of the future is moving ahead.
- The futuristic megacity Neom is being built in Saudi Arabia.
- The city will be fully automated, leading in health, education and quality of life.
- It will feature an artificial moon, cloud seeding, robotic gladiators and flying taxis.
The Red Sea area where Neom will be built:
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Frequent shopping for single items adds to our carbon footprint.
- A new study shows e-commerce sites like Amazon leave larger greenhouse gas footprints than retail stores.
- Ordering online from retail stores has an even smaller footprint than going to the store yourself.
- Greening efforts by major e-commerce sites won't curb wasteful consumer habits. Consolidating online orders can make a difference.
A pile of recycled cardboard sits on the ground at Recology's Recycle Central on January 4, 2018 in San Francisco, California.
Photo by Justin Sullivan/Getty Images<p>A large part of the reason is speed. In a competitive market, pure players use the equation, <em>speed + convenience</em>, to drive adoption. This is especially relevant to the "last mile" GHG footprint: the distance between the distribution center and the consumer.</p><p>Interestingly, the smallest GHG footprint occurs when you order directly from a physical store—even smaller than going there yourself. Pure players, such as Amazon, are the greatest offenders. Variables like geographic location matter; the team looked at shopping in the UK, the US, China, and the Netherlands. </p><p>Sadegh Shahmohammadi, a PhD student at the Netherlands' Radboud University and corresponding author of the paper, <a href="https://www.cnn.com/2020/02/26/tech/greenhouse-gas-emissions-retail/index.html" target="_blank">says</a> the above "pattern holds true in countries where people mostly drive. It really depends on the country and consumer behavior there."</p><p>The researchers write that this year-and-a-half long study pushes back on previous research that claims online shopping to be better in terms of GHG footprints.</p><p style="margin-left: 20px;">"They have, however, compared the GHG emissions per shopping event and did not consider the link between the retail channels and the basket size, which leads to a different conclusion than that of the current study."</p><p>Online retail is where convenience trumps environment: people tend to order one item at a time when shopping on pure player sites, whereas they stock up on multiple items when visiting a store. Consumers will sometimes order a number of separate items over the course of a week rather than making one trip to purchase everything they need. </p><p>While greening efforts by online retailers are important, until a shift in consumer attitude changes, the current carbon footprint will be a hard obstacle to overcome. Amazon is trying to have it both ways—carbon-free and convenience addicted—and the math isn't adding up. If you need to order things, do it online, but try to consolidate your purchases as much as possible.</p><p>--</p><p><em>Stay in touch with Derek on <a href="http://www.twitter.com/derekberes" target="_blank">Twitter</a>, <a href="https://www.facebook.com/DerekBeresdotcom" target="_blank">Facebook</a> and <a href="https://derekberes.substack.com/" target="_blank">Substack</a>. His next book is</em> "<em>Hero's Dose: The Case For Psychedelics in Ritual and Therapy."</em></p>
Building a personal connection with students can counteract some negative side effects of remote learning.
- Not being able to engage with students in-person due to the pandemic has presented several new challenges for educators, both technical and social. Digital tools have changed the way we all think about learning, but George Couros argues that more needs to be done to make up for what has been lost during "emergency remote teaching."
- One interesting way he has seen to bridge that gap and strengthen teacher-student and student-student relationships is through an event called Identity Day. Giving students the opportunity to share something they are passionate about makes them feel more connected and gets them involved in their education.
- "My hope is that we take these skills and these abilities we're developing through this process and we actually become so much better for our kids when we get back to our face-to-face setting," Couros says. He adds that while no one can predict the future, we can all do our part to adapt to it.
Chronic irregular sleep in children was associated with psychotic experiences in adolescence, according to a recent study out of the University of Birmingham's School of Psychology.