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OxyContin maker patents new drug that helps addicts wean off opioids
The maker of OxyContin, one of the world's most widely abused opioids, has patented a drug that aims to help addicts wean off opioids.
Purdue Pharma, maker of the prescription painkiller OxyContin, has patented a new drug aimed at weaning addicts off opioids.
The new drug is a faster-acting form of buprenorphine, a mild opiate that helps addicts control cravings.
“While opioids have always been known to be useful in pain treatment, they also display an addictive potential,” reads the patent, which was first reported by the Financial Times. “Thus, if opioids are taken by healthy human subjects with a drug-seeking behaviour, they may lead to psychological as well as physical dependence.”
The patent comes as more than two dozen states and hundreds of cities are suing Purdue and its competitors for their role in the opioid crisis, which is estimated to kill more than 46 people every day in the U.S. This week, Colorado became the latest state to sue Purdue Pharma L.P. and Purdue Pharma Inc.
“Purdue’s habit-forming medications coupled with their reckless marketing have robbed children of their parents, families of their sons and daughters, and destroyed the lives of our friends, neighbours, and co-workers,” Colorado Attorney General Cynthia Coffman said. “While no amount of money can bring back loved ones, it can compensate for the enormous costs brought about by Purdue’s intentional misconduct.”
The lawsuit claims Purdue downplayed OxyContin’s risks, exaggerated its benefits and “advised healthcare professionals that they were violating their Hippocratic Oath and failing their patients unless they treated pain symptoms with opioids,” according to the Colorado attorney general’s office.
Purdue denied the allegations in a statement.
“The state claims Purdue acted improperly by communicating with prescribers about scientific and medical information that [the] FDA has expressly considered and continues to approve,” a spokesman for Purdue Pharma said in the statement. “We believe it is inappropriate for the state to substitute its judgment for the judgment of the regulatory, scientific and medical experts at FDA.
Purdue’s new drug aims to curb the very crisis the company helped start, first by inventing OxyContin in 1995 and then by using aggressive marketing tactics to push the drug on health-care providers despite evidence of addiction potential and increasing overdose deaths in the U.S.
In 2007, Purdue settled a lawsuit with the Justice Department for more than $600 million in fines after the company was found to have misled regulators, doctors and patients about OxyContin’s risks of addiction and abuse. However, the company appears to have done little or nothing to change its tactics in the years that followed.
In June, CBS This Morning published an interview with an ex-employee for Purdue, Carol Panara, who said the company trained its sales representatives to convince doctors to prescribe higher doses of OxyContin to as many patients as possible. In her training as a sales representative, Panara said the company told her that some patients weren’t actually addicted to OxyContin but instead suffered from "pseudoaddiction."
“So the cure for ‘pseudoaddiction,’ you were trained, is more opioids?” CBS correspondent Tony Dokoupil asked.
“A higher dose, yes,” Panara said.
“Did this concept of pseudoaddiction come with studies backing it up?”
“We had no studies. We actually—we did not have any studies. That’s the thing that was kind of disturbing, was that we didn't have studies to present to the doctors,” Panara responded.
“You know how that sounds?” Dokoupil asked.
“I know. I was naïve,” Panara said.
"You dream about these kinds of moments when you're a kid," said lead paleontologist David Schmidt.
- The triceratops skull was first discovered in 2019, but was excavated over the summer of 2020.
- It was discovered in the South Dakota Badlands, an area where the Triceratops roamed some 66 million years ago.
- Studying dinosaurs helps scientists better understand the evolution of all life on Earth.
Credit: David Schmidt / Westminster College<p style="margin-left: 20px;">"We had to be really careful," Schmidt told St. Louis Public Radio. "We couldn't disturb anything at all, because at that point, it was under law enforcement investigation. They were telling us, 'Don't even make footprints,' and I was thinking, 'How are we supposed to do that?'"</p><p>Another difficulty was the mammoth size of the skull: about 7 feet long and more than 3,000 pounds. (For context, the largest triceratops skull ever unearthed was about <a href="https://www.tandfonline.com/doi/abs/10.1080/02724634.2010.483632" target="_blank">8.2 feet long</a>.) The skull of Schmidt's dinosaur was likely a <em>Triceratops prorsus, </em>one of two species of triceratops that roamed what's now North America about 66 million years ago.</p>
Credit: David Schmidt / Westminster College<p>The triceratops was an herbivore, but it was also a favorite meal of the T<em>yrannosaurus rex</em>. That probably explains why the Dakotas contain many scattered triceratops bone fragments, and, less commonly, complete bones and skulls. In summer 2019, for example, a separate team on a dig in North Dakota made <a href="https://www.nytimes.com/2019/07/26/science/triceratops-skull-65-million-years-old.html" target="_blank">headlines</a> after unearthing a complete triceratops skull that measured five feet in length.</p><p>Michael Kjelland, a biology professor who participated in that excavation, said digging up the dinosaur was like completing a "multi-piece, 3-D jigsaw puzzle" that required "engineering that rivaled SpaceX," he jokingly told the <a href="https://www.nytimes.com/2019/07/26/science/triceratops-skull-65-million-years-old.html" target="_blank">New York Times</a>.</p>
Morrison Formation in Colorado
James St. John via Flickr
|Credit: Nobu Tamura/Wikimedia Commons|
The world's 10 most affected countries are spending up to 59% of their GDP on the effects of violence.
- Conflict and violence cost the world more than $14 trillion a year.
- That's the equivalent of $5 a day for every person on the planet.
- Research shows that peace brings prosperity, lower inflation and more jobs.
- Just a 2% reduction in conflict would free up as much money as the global aid budget.
- Report urges governments to improve peacefulness, especially amid COVID-19.
The lush biodiversity of South America's rainforests is rooted in one of the most cataclysmic events that ever struck Earth.
- One especially mysterious thing about the asteroid impact, which killed the dinosaurs, is how it transformed Earth's tropical rainforests.
- A recent study analyzed ancient fossils collected in modern-day Colombia to determine how tropical rainforests changed after the bolide impact.
- The results highlight how nature is able to recover from cataclysmic events, though it may take millions of years.