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Nerves that sense touch may play role in autism
This small-scale study may have uncovered a new link between the peripheral nerve system and autism.

What does the peripheral nerve system have to do with autism?
- Autism refers to a broad range of conditions characterized by challenges with social skills, repetitive behaviors, speech, and nonverbal communication. According to the CDC, autism impacts an estimated 1 in 54 children in the United States.
- An October 2020 study suggests that the peripheral nervous system may play a role in autism.
- The parameters of the study may not show the entire picture —more research is needed in this area.
Autism (commonly referred to as ASD, autism spectrum disorder) refers to a broad range of conditions characterized by challenges with social skills, repetitive behaviors, speech, and nonverbal communication. According to the CDC, autism impacts an estimated 1 in 54 children in the United States—and because autism is a spectrum disorder, each person with autism has a distinct set of strengths and challenges.
There is not just one type of autism, but many, according to AutismSpeaks.org. Most of these types are influenced by a combination of genetic and environmental factors. Autism is also often accompanied by various sensory sensitivities that can lead the person to experience sensory overload, which you can see a representation of in the video below.
The nerves that sense touch and pain may play a role in autism, new research suggests
An October 2020 study suggests that the peripheral nervous system (the nerves that control our sense of touch, pain, and other sensations), may play a role in autism.
Study author Sung-Tsang Hsieh, M.D., Ph.D., of National Taiwan University Hospital in Taipei and a Fellow of the American Academy of Neurology, explains to Science Daily: "More than 70% of people with autism have differences in their sensory perception. For some people, even a light touch can feel unbearable while others may not even notice a cut on their foot. If larger studies can confirm these results, it is possible that further insight into the peripheral nervous system could help us understand how this disorder develops and potentially light the way for treating these distressing sensory symptoms that most people with autism experience."
The study involved 32 men with autism (with an average age of 27). They were compared to 27 men and women (with an average age of 33) who did not have autism or any diseases that would impact their peripheral nerves.
The people with autism completed questionnaires on their sensory symptoms. All of the participants then had tests of their sensory nerves, including skin biopsies to look for damage to the small fibers of their nerves. Then, another test was administered, where heat pulses were applied to the skin so researchers could look at the electrical signals produced by the nerves to see how they responded to the heat.
53 percent of people with autism had reduced nerve fiber density.
The results of the skin biopsy tests showed 53 percent of people with autism had reduced nerve fiber density, while all of the people in the control group (participants without autism) had levels in the normal range.
"This indicates that the nerves have degenerated, similar to what happens for people with the condition of peripheral neuropathy, where the threshold for feeling heat and other sensations is higher than for other people," said Hsieh.
The response to touch differed among people with autism according to whether or not they had nerve fiber damage.
According to the results, people who had undamaged nerves were more likely to say they disliked being touched and were uncomfortable with some textures, while people with nerve fiber damage were more likely to say that they preferred going barefoot and could be unaware that they had gotten scratched or bruised.
"This indicates that the nerves have degenerated, similar to what happens for people with the condition of peripheral neuropathy, where the threshold for feeling heat and other sensations is higher than for other people," Hsieh explained in his interview.
The parameters of the study may not show the entire picture—more research is needed in this area.
- 7 things everyone should know about autism - Big Think ›
- The Surprising Symmetry of Brains on the Autism Spectrum - Big Think ›
- Zebrafish give new insight to sound sensitivity in autism - Big Think ›
‘Designer baby’ book trilogy explores the moral dilemmas humans may soon create
How would the ability to genetically customize children change society? Sci-fi author Eugene Clark explores the future on our horizon in Volume I of the "Genetic Pressure" series.
- A new sci-fi book series called "Genetic Pressure" explores the scientific and moral implications of a world with a burgeoning designer baby industry.
- It's currently illegal to implant genetically edited human embryos in most nations, but designer babies may someday become widespread.
- While gene-editing technology could help humans eliminate genetic diseases, some in the scientific community fear it may also usher in a new era of eugenics.
Tribalism and discrimination
<p>One question the "Genetic Pressure" series explores: What would tribalism and discrimination look like in a world with designer babies? As designer babies grow up, they could be noticeably different from other people, potentially being smarter, more attractive and healthier. This could breed resentment between the groups—as it does in the series.</p><p>"[Designer babies] slowly find that 'everyone else,' and even their own parents, becomes less and less tolerable," author Eugene Clark told Big Think. "Meanwhile, everyone else slowly feels threatened by the designer babies."</p><p>For example, one character in the series who was born a designer baby faces discrimination and harassment from "normal people"—they call her "soulless" and say she was "made in a factory," a "consumer product." </p><p>Would such divisions emerge in the real world? The answer may depend on who's able to afford designer baby services. If it's only the ultra-wealthy, then it's easy to imagine how being a designer baby could be seen by society as a kind of hyper-privilege, which designer babies would have to reckon with. </p><p>Even if people from all socioeconomic backgrounds can someday afford designer babies, people born designer babies may struggle with tough existential questions: Can they ever take full credit for things they achieve, or were they born with an unfair advantage? To what extent should they spend their lives helping the less fortunate? </p>Sexuality dilemmas
<p>Sexuality presents another set of thorny questions. If a designer baby industry someday allows people to optimize humans for attractiveness, designer babies could grow up to find themselves surrounded by ultra-attractive people. That may not sound like a big problem.</p><p>But consider that, if designer babies someday become the standard way to have children, there'd necessarily be a years-long gap in which only some people are having designer babies. Meanwhile, the rest of society would be having children the old-fashioned way. So, in terms of attractiveness, society could see increasingly apparent disparities in physical appearances between the two groups. "Normal people" could begin to seem increasingly ugly.</p><p>But ultra-attractive people who were born designer babies could face problems, too. One could be the loss of body image. </p><p>When designer babies grow up in the "Genetic Pressure" series, men look like all the other men, and women look like all the other women. This homogeneity of physical appearance occurs because parents of designer babies start following trends, all choosing similar traits for their children: tall, athletic build, olive skin, etc. </p><p>Sure, facial traits remain relatively unique, but everyone's more or less equally attractive. And this causes strange changes to sexual preferences.</p><p>"In a society of sexual equals, they start looking for other differentiators," he said, noting that violet-colored eyes become a rare trait that genetically engineered humans find especially attractive in the series.</p><p>But what about sexual relationships between genetically engineered humans and "normal" people? In the "Genetic Pressure" series, many "normal" people want to have kids with (or at least have sex with) genetically engineered humans. But a minority of engineered humans oppose breeding with "normal" people, and this leads to an ideology that considers engineered humans to be racially supreme. </p>Regulating designer babies
<p>On a policy level, there are many open questions about how governments might legislate a world with designer babies. But it's not totally new territory, considering the West's dark history of eugenics experiments.</p><p>In the 20th century, the U.S. conducted multiple eugenics programs, including immigration restrictions based on genetic inferiority and forced sterilizations. In 1927, for example, the Supreme Court ruled that forcibly sterilizing the mentally handicapped didn't violate the Constitution. Supreme Court Justice Oliver Wendall Holmes wrote, "… three generations of imbeciles are enough." </p><p>After the Holocaust, eugenics programs became increasingly taboo and regulated in the U.S. (though some states continued forced sterilizations <a href="https://www.uvm.edu/~lkaelber/eugenics/" target="_blank">into the 1970s</a>). In recent years, some policymakers and scientists have expressed concerns about how gene-editing technologies could reanimate the eugenics nightmares of the 20th century. </p><p>Currently, the U.S. doesn't explicitly ban human germline genetic editing on the federal level, but a combination of laws effectively render it <a href="https://academic.oup.com/jlb/advance-article/doi/10.1093/jlb/lsaa006/5841599#204481018" target="_blank" rel="noopener noreferrer">illegal to implant a genetically modified embryo</a>. Part of the reason is that scientists still aren't sure of the unintended consequences of new gene-editing technologies. </p><p>But there are also concerns that these technologies could usher in a new era of eugenics. After all, the function of a designer baby industry, like the one in the "Genetic Pressure" series, wouldn't necessarily be limited to eliminating genetic diseases; it could also work to increase the occurrence of "desirable" traits. </p><p>If the industry did that, it'd effectively signal that the <em>opposites of those traits are undesirable. </em>As the International Bioethics Committee <a href="https://academic.oup.com/jlb/advance-article/doi/10.1093/jlb/lsaa006/5841599#204481018" target="_blank" rel="noopener noreferrer">wrote</a>, this would "jeopardize the inherent and therefore equal dignity of all human beings and renew eugenics, disguised as the fulfillment of the wish for a better, improved life."</p><p><em>"Genetic Pressure Volume I: Baby Steps"</em><em> by Eugene Clark is <a href="http://bigth.ink/38VhJn3" target="_blank">available now.</a></em></p>Designer uses AI to bring 54 Roman emperors to life
It's hard to stop looking back and forth between these faces and the busts they came from.
Meet Emperors Augustus, left, and Maximinus Thrax, right
- A quarantine project gone wild produces the possibly realistic faces of ancient Roman rulers.
- A designer worked with a machine learning app to produce the images.
- It's impossible to know if they're accurate, but they sure look plausible.
How the Roman emperors got faced
<a href="https://payload.cargocollective.com/1/6/201108/14127595/2K-ENGLISH-24x36-Educational_v8_WATERMARKED_2000.jpg" ><img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDQ2NDk2MS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYyOTUzMzIxMX0.OwHMrgKu4pzu0eCsmOUjybdkTcSlJpL_uWDCF2djRfc/img.jpg?width=980" id="775ca" class="rm-shortcode" data-rm-shortcode-id="436000b6976931b8320313478c624c82" data-rm-shortcode-name="rebelmouse-image" alt="lineup of emperor faces" data-width="1440" data-height="963" /></a>Credit: Daniel Voshart
<p>Voshart's imaginings began with an AI/neural-net program called <a href="https://www.artbreeder.com" target="_blank">Artbreeder</a>. The freemium online app intelligently generates new images from existing ones and can combine multiple images into…well, who knows. It's addictive — people have so far used it to generate nearly 72.7 million images, says the site — and it's easy to see how Voshart fell down the rabbit hole.</p><p>The Roman emperor project began with Voshart feeding Artbreeder images of 800 busts. Obviously, not all busts have weathered the centuries equally. Voshart told <a href="https://www.livescience.com/ai-roman-emperor-portraits.html" target="_blank" rel="noopener noreferrer">Live Science</a>, "There is a rule of thumb in computer programming called 'garbage in garbage out,' and it applies to Artbreeder. A well-lit, well-sculpted bust with little damage and standard face features is going to be quite easy to get a result." Fortunately, there were multiple busts for some of the emperors, and different angles of busts captured in different photographs.</p><p>For the renderings Artbreeder produced, each face required some 15-16 hours of additional input from Voshart, who was left to deduce/guess such details as hair and skin coloring, though in many cases, an individual's features suggested likely pigmentations. Voshart was also aided by written descriptions of some of the rulers.</p><p>There's no way to know for sure how frequently Voshart's guesses hit their marks. It is obviously the case, though, that his interpretations look incredibly plausible when you compare one of his emperors to the sculpture(s) from which it was derived.</p><p>For an in-depth description of Voshart's process, check out his posts on <a href="https://medium.com/@voshart/photoreal-roman-emperor-project-236be7f06c8f" target="_blank">Medium</a> or on his <a href="https://voshart.com/ROMAN-EMPEROR-PROJECT" target="_blank" rel="noopener noreferrer">website</a>.</p><p>It's fascinating to feel like you're face-to-face with these ancient and sometimes notorious figures. Here are two examples, along with some of what we think we know about the men behind the faces.</p>Caligula
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDQ2NDk4Mi9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY3MzQ1NTE5NX0.LiTmhPQlygl9Fa9lxay8PFPCSqShv4ELxbBRFkOW_qM/img.jpg?width=980" id="7bae0" class="rm-shortcode" data-rm-shortcode-id="ce795c554490fe0a36a8714b86f55b16" data-rm-shortcode-name="rebelmouse-image" data-width="992" data-height="558" />One of numerous sculptures of Caligula, left
Credit: Rogers Fund, 1914/Wikimedia Commons/Daniel Voshart
<p><span style="background-color: initial;"><a href="https://en.wikipedia.org/wiki/Caligula" target="_blank">Caligula</a></span> was the third Roman Emperor, ruling the city-state from AD 37 to 41. His name was actually Gaius Caesar Augustus Germanicus — Caligula is a nickname meaning "Little Boot."</p><p>One of the reputed great madmen of history, he was said to have made a horse his consul, had conversations with the moon, and to have ravaged his way through his kingdom, including his three sisters. Caligula is known for extreme cruelty, terrorizing his subjects, and accounts suggest he would deliberately distort his face to surprise and frighten people he wished to intimidate.</p><p>It's <a href="https://www.history.com/news/7-things-you-may-not-know-about-caligula" target="_blank">not totally clear</a> if Caligula was as over-the-top as history paints him, but that hasn't stopped Hollywood from churning out some <a href="https://www.imdb.com/title/tt0080491/" target="_blank" rel="noopener noreferrer">howlers</a> in his name.</p><p>A 1928 journal, <a href="https://www.jstor.org/stable/4172009" target="_blank">Studies in Philology</a>, noted that contemporary descriptions of Caligula depicted him as having a "head misshapen, eyes and temples sunken," and "eyes staring and with a glare savage enough to torture." In some sculptures not shown above, his head <em>is</em> a bit acorn-shaped. </p>Nero
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNDQ2NTAwMC9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY1NTQ2ODU0NX0.AgYuQZzRQCanqehSI5UeakpxU8fwLagMc_POH7xB3-M/img.jpg?width=980" id="a8825" class="rm-shortcode" data-rm-shortcode-id="9e0593d79c591c97af4bd70f3423885e" data-rm-shortcode-name="rebelmouse-image" data-width="992" data-height="558" />One of numerous sculptures of Nero, left
Credit: Bibi_Saint-Pol/Wikimedia Commons/Daniel Voshart
<p>There's a good German word for the face of <a href="https://en.wikipedia.org/wiki/Nero" target="_blank" rel="noopener noreferrer">Nero</a>, that guy famous for fiddling as Rome burned. It's "<a href="https://www.urbandictionary.com/define.php?term=Backpfeifengesicht" target="_blank">backpfeifengesicht</a>." Properly named Nero Claudius Caesar Augustus Germanicus, he was Rome's fifth emperor. He ruled from AD 54 until his suicide in AD 68.</p><p>Another Germanicus-family gem, Nero's said to have murdered his own mother, Agrippa, as well as (maybe) his second wife. As for the fiddling, he <em>was</em> a lover of music and the arts, and there are stories of his charitability. And, oh yeah, he may have set the fire as an excuse to rebuild the city center, making it his own.</p><p>While it may not be the most historically sound means of assessing an historical personage, Voshart's imagining of Nero does suggest an over-indulged, entitled young man. Backpfeifengesicht.</p>Archaeologists identify contents of ancient Mayan drug containers
Scientists use new methods to discover what's inside drug containers used by ancient Mayan people.
A Muna-type paneled flask with distinctive serrated-edge decoration from AD 750-900.
- Archaeologists used new methods to identify contents of Mayan drug containers.
- They were able to discover a non-tobacco plant that was mixed in by the smoking Mayans.
- The approach promises to open up new frontiers in the knowledge of substances ancient people consumed.
PARME staff archaeologists excavating a burial site at the Tamanache site, Mérida, Yucatan.
Credit: WSU
Ten “keys to reality” from a Nobel-winning physicist
To understand ourselves and our place in the universe, "we should have humility but also self-respect," Frank Wilczek writes in a new book.
This is your brain on political arguments
Debating is cognitively taxing but also important for the health of a democracy—provided it's face-to-face.
