Oxytocin may play a role in protecting against Alzheimer's

Preliminary studies on mice show positive results.

illustration of pencil erasing human brain
Photo: Lightspring / Shutterstock
  • While the exact cause of Alzheimer's remains unknown, researchers are targeting toxic beta-amyloid buildup.
  • A recent study on mice found oxytocin could be a protective agent against plaque buildup.
  • Though more research needs to be conducted, this is a hopeful sign in our fight against a crippling disease.

While Americas watch the battle for the most cognitively-fit president unfold on social media and television, the problem pundits are really discussing is dementia. Currently, 5.7 million Americans are suffering from diseases of dementia. Alzheimer's disease accounts for between 60-70 percent of these cases.

There has long been speculation about the cause of Alzheimer's. We know that exercise, diet, and continued education play a role in staving it off. Considering an estimated 13.9 million seniors worldwide will fall victim to dementia by 2060, it's a problem we need to address.

While somewhere between 1 and 5 percent of cases have been identified as genetic, one potential cause of Alzheimer's is the amyloid hypothesis. This idea, first proposed in 1991, states that the brain becomes riddled with extracellular amyloid beta deposits. These amyloid plaques compromise cognitive functioning by negatively affecting memory, decision-making, and planning, while causing depression, distrust in others, delusions, apathy, and changes in sleeping patterns.

Under normal circumstances, beta-amyloid plays a protective and reparative role in the central nervous system. When grouped together in plaques, however, the same peptide leads to disruption in cell function and neuronal death—the trigger for dementia.

This hypothesis was updated in 2009 to reflect the aging-related process of an amyloid-related protein. Regardless, the strongest indicator of Alzheimer's appears to plaque buildup. New research is pointing toward oxytocin as a potential therapeutic intervention.

Oxytocin gained popular currency as the "love hormone" due to its role in mammalian bonding. After an orgasm, oxytocin spreads throughout your bloodstream, resulting in feelings of satisfaction and contentment. Crying babies are calmed by the oxytocin provided by their mother's milk.

Dementia symptoms illustration

Photo: Varlamova Lydmila / Shutterstock

As Eleftheria Kodosaki, an academic associate in Biomedical Sciences at Cardiff Metropolitan University, writes, male mice were recently treated with the toxic beta-amyloid, resulting in the desired effect: their brain's synaptic plasticity suffered. The researchers then treated mice with the toxic beta-amyloid and oxytocin, which did not affect their neural plasticity. The team speculates that oxytocin may play a role in staving off memory loss.

That may is key. Kodosaki notes that this disease remains baffling.

"In theory, being able to stop groups of toxic beta-amyloid from forming could potentially prevent memory loss and cognitive decline. Unfortunately, Alzheimer's disease is way more complicated than just an accumulation of beta-amyloid in the brain."

Plaque buildups have been discovered in people that don't have the disease or suffer from any symptoms. The beta-amyloid angle is only a theory, and there are others: as mentioned, genetics, as well as the Tau hypothesis. In 2002, researchers at the Institute of Psychiatry in De Crespigny Park, London speculated that tau proteins form neurofibrillary tangle inside of nerve cell bodies, resulting in the collapse of neuronal transport systems.

Kodaski points out that all medication targeting beta-amyloid has failed. She also notes that research needs to be conducted on female mice, as women are more likely to develop Alzheimer's than men. Of course, humans are not mice, though taking note of sex differences in mice might help researchers gauge potential therapies in humans.

As most studies conclude, more research is needed. But it is a hopeful sign for treating the frustrating realm of dementia. In an aging world with a declining population, we need to protect our seniors the best we can.

--

Stay in touch with Derek on Twitter, Facebook and Substack. His next book is "Hero's Dose: The Case For Psychedelics in Ritual and Therapy."


There are 5 eras in the universe's lifecycle. Right now, we're in the second era.

Astronomers find these five chapters to be a handy way of conceiving the universe's incredibly long lifespan.

Image based on logarithmic maps of the Universe put together by Princeton University researchers, and images produced by NASA based on observations made by their telescopes and roving spacecraft

Image source: Pablo Carlos Budassi
Surprising Science
  • We're in the middle, or thereabouts, of the universe's Stelliferous era.
  • If you think there's a lot going on out there now, the first era's drama makes things these days look pretty calm.
  • Scientists attempt to understand the past and present by bringing together the last couple of centuries' major schools of thought.
Keep reading Show less

Dark energy: The apocalyptic wild card of the universe

Dr. Katie Mack explains what dark energy is and two ways it could one day destroy the universe.

Videos
  • The universe is expanding faster and faster. Whether this acceleration will end in a Big Rip or will reverse and contract into a Big Crunch is not yet understood, and neither is the invisible force causing that expansion: dark energy.
  • Physicist Dr. Katie Mack explains the difference between dark matter, dark energy, and phantom dark energy, and shares what scientists think the mysterious force is, its effect on space, and how, billions of years from now, it could cause peak cosmic destruction.
  • The Big Rip seems more probable than a Big Crunch at this point in time, but scientists still have much to learn before they can determine the ultimate fate of the universe. "If we figure out what [dark energy is] doing, if we figure out what it's made of, how it's going to change in the future, then we will have a much better idea for how the universe will end," says Mack.
Keep reading Show less

Astrophysicists find unique "hot Jupiter" planet without clouds

A unique exoplanet without clouds or haze was found by astrophysicists from Harvard and Smithsonian.

Illustration of WASP-62b, the Jupiter-like planet without clouds or haze in its atmosphere.

Credit: M. Weiss/Center for Astrophysics | Harvard & Smithsonian
Surprising Science
  • Astronomers from Harvard and Smithsonian find a very rare "hot Jupiter" exoplanet without clouds or haze.
  • Such planets were formed differently from others and offer unique research opportunities.
  • Only one other such exoplanet was found previously.
Keep reading Show less
Scroll down to load more…
Quantcast