Oxytocin may play a role in protecting against Alzheimer's

Preliminary studies on mice show positive results.

illustration of pencil erasing human brain
Photo: Lightspring / Shutterstock
  • While the exact cause of Alzheimer's remains unknown, researchers are targeting toxic beta-amyloid buildup.
  • A recent study on mice found oxytocin could be a protective agent against plaque buildup.
  • Though more research needs to be conducted, this is a hopeful sign in our fight against a crippling disease.

While Americas watch the battle for the most cognitively-fit president unfold on social media and television, the problem pundits are really discussing is dementia. Currently, 5.7 million Americans are suffering from diseases of dementia. Alzheimer's disease accounts for between 60-70 percent of these cases.

There has long been speculation about the cause of Alzheimer's. We know that exercise, diet, and continued education play a role in staving it off. Considering an estimated 13.9 million seniors worldwide will fall victim to dementia by 2060, it's a problem we need to address.

While somewhere between 1 and 5 percent of cases have been identified as genetic, one potential cause of Alzheimer's is the amyloid hypothesis. This idea, first proposed in 1991, states that the brain becomes riddled with extracellular amyloid beta deposits. These amyloid plaques compromise cognitive functioning by negatively affecting memory, decision-making, and planning, while causing depression, distrust in others, delusions, apathy, and changes in sleeping patterns.

Under normal circumstances, beta-amyloid plays a protective and reparative role in the central nervous system. When grouped together in plaques, however, the same peptide leads to disruption in cell function and neuronal death—the trigger for dementia.

This hypothesis was updated in 2009 to reflect the aging-related process of an amyloid-related protein. Regardless, the strongest indicator of Alzheimer's appears to plaque buildup. New research is pointing toward oxytocin as a potential therapeutic intervention.

Oxytocin gained popular currency as the "love hormone" due to its role in mammalian bonding. After an orgasm, oxytocin spreads throughout your bloodstream, resulting in feelings of satisfaction and contentment. Crying babies are calmed by the oxytocin provided by their mother's milk.

Dementia symptoms illustration

Photo: Varlamova Lydmila / Shutterstock

As Eleftheria Kodosaki, an academic associate in Biomedical Sciences at Cardiff Metropolitan University, writes, male mice were recently treated with the toxic beta-amyloid, resulting in the desired effect: their brain's synaptic plasticity suffered. The researchers then treated mice with the toxic beta-amyloid and oxytocin, which did not affect their neural plasticity. The team speculates that oxytocin may play a role in staving off memory loss.

That may is key. Kodosaki notes that this disease remains baffling.

"In theory, being able to stop groups of toxic beta-amyloid from forming could potentially prevent memory loss and cognitive decline. Unfortunately, Alzheimer's disease is way more complicated than just an accumulation of beta-amyloid in the brain."

Plaque buildups have been discovered in people that don't have the disease or suffer from any symptoms. The beta-amyloid angle is only a theory, and there are others: as mentioned, genetics, as well as the Tau hypothesis. In 2002, researchers at the Institute of Psychiatry in De Crespigny Park, London speculated that tau proteins form neurofibrillary tangle inside of nerve cell bodies, resulting in the collapse of neuronal transport systems.

Kodaski points out that all medication targeting beta-amyloid has failed. She also notes that research needs to be conducted on female mice, as women are more likely to develop Alzheimer's than men. Of course, humans are not mice, though taking note of sex differences in mice might help researchers gauge potential therapies in humans.

As most studies conclude, more research is needed. But it is a hopeful sign for treating the frustrating realm of dementia. In an aging world with a declining population, we need to protect our seniors the best we can.


Stay in touch with Derek on Twitter, Facebook and Substack. His next book is "Hero's Dose: The Case For Psychedelics in Ritual and Therapy."

Live on Monday: Does the US need one billion people?

What would happen if you tripled the US population? Join Matthew Yglesias and Charles Duhigg at 1pm ET on Monday, September 28.

‘Time is elastic’: Why time passes faster atop a mountain than at sea level

The idea of 'absolute time' is an illusion. Physics and subjective experience reveal why.

Surprising Science
  • Since Einstein posited his theory of general relativity, we've understood that gravity has the power to warp space and time.
  • This "time dilation" effect occurs even at small levels.
  • Outside of physics, we experience distortions in how we perceive time — sometimes to a startling extent.
Keep reading Show less

Learn innovation with 3-star Michelin chef Dominique Crenn

Dominique Crenn, the only female chef in America with three Michelin stars, joins Big Think Live.

Big Think LIVE

Having been exposed to mavericks in the French culinary world at a young age, three-star Michelin chef Dominique Crenn made it her mission to cook in a way that is not only delicious and elegant, but also expressive, memorable, and true to her experience.

Keep reading Show less

Universe works like a cosmological neural network, argues new paper

Controversial physics theory says reality around us behaves like a computer neural network.

Synapses in space.

Credit: sakkmesterke
Surprising Science
  • Physicist proposes that the universe behaves like an artificial neural network.
  • The scientist's new paper seeks to reconcile classical physics and quantum mechanics.
  • The theory claims that natural selection produces both atoms and "observers".
Keep reading Show less

We studied what happens when guys add their cats to their dating app profiles

43% of people think they can get a sense of someone's personality by their picture.

Photo by Luigi Pozzoli on Unsplash
Sex & Relationships

If you've used a dating app, you'll know the importance of choosing good profile pics.

Keep reading Show less

Quarantine rule breakers in 17th-century Italy partied all night – and some clergy condemned the feasting

17th-century outbreaks of plague in Italy reveal both tensions between religious and public health authorities.

Scroll down to load more…