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Cars Parts Show Us How Some Genetic Stats Mislead
We can “read” genes with ease now, but still can’t say what most of them “mean.” To show why we need clearer “causology” and fitter metaphors, let's scrutinize cars and their parts like we do bodies and genes.

1. We can “read” genes with ease now, but still can’t say what most of them “mean.” Mastering precisely how they “cause” higher-level traits will require clearer “causology” and fitter metaphors.
2. Genes (more precisely, gene products) contribute to fiendishly complex processes that confound the standard stats grinder. To illustrate, imagine scrutinizing cars and their parts like we do bodies and genes in “genome-wide association studies” (GWAS). The details don’t matter here, beyond that a car-GWAS would analyze a car-level trait like fuel efficiency by variations in the properties of all the car’s parts.
3. Consider a car having standard and sporty models. The latter have larger gas-guzzling engines and available pimped-up painted brake calipers. And let’s say sporty buyers more often pick red brakes, then statistically speaking red brakes bring greater gas guzzling “risk.”
4. If I’m not mistaken (please correct me stats geeks), no stats-only data wizardry can distinguish such non-causal entanglements (p-values can’t discern “phantom patterns”).
5. Generally, part-level properties can have non-causal and non-random “links” to higher-level traits. And including non-causal factors distorts the statistics (misallocating the variation that seems “explained by,” “accounted for,” or “linked to”). Lacking causal insights, you always run the “red-brake” risk.
6. Regarding metaphors, gene products work more like words than car parts (genes aren’t static “blueprints”). They act via sentence-like structures with collective effects and multiple “meanings.” But we lack the rules (~cellular syntax, gene grammar) for how parts of biology compose life’s activity-sentences.
7. Genes also sort of work like music: Typically “played” in precise synchrony to orchestrate many molecular melodies (simultaneous biochemical sentences) enabling enormous ensemble effects.
8. And life typically has way more moving parts than cars, and more complex transient casual structures. It’s traits often have multiple hetero-causal etiologies (roadmaps exhibiting sufficient but not necessary logic). Current stats can’t disentangle hetero-causal effects (larger type-mixed samples often won’t help).
9. All this is sort of known (e.g., genetic architecture, causal roles) yet “jump-to-the-genes” GWASing continues (with rickety elaborations like polygenic scoring).
10. Thankfully, fitter thinking is afoot—for instance, geno-pheno mapping (Massimo Pigliucci), better “Laws of Biology” (Kevin Mitchell), Reductionist Bias Corrections (Krakauer), and Causal Structure Modeling (Judea Pearl).
11. Biology and social science need less primarily parts-focused thinking (you can't grasp chess by studying the properties of its pieces alone), and ways to handle different kinds of causes and roles—see Krakauer’s Figure 4, Aristotle’s four causes, Tinbergen's four questions, Marr’s three levels. Much in these fields is more process-or-algorithm shaped (often resisting Occam’s Razor).
12. Related iffy thinking exists far beyond genomics. As mostly practiced, stats presume a flat or “heap” causal structure that’s often ill-suited for process-oriented life, or car making, or even cooking (cooks need step-by-step recipes to turn parts into wholes).
13. Statistical analysis without causal insights often runs the red-brake risk. The habit of adding variables to “control for” factors can misallocate variation (itself often a nonsensical or low quality quantification).
14. Similar structureless-sausage data risks pervade black box approaches to Big Data and AI.
15. You know that correlation doesn’t imply causation, but AI doesn’t “know” that.
Illustration by Julia Suits, The New Yorker cartoonist & author of The Extraordinary Catalog of Peculiar Inventions
‘Designer baby’ book trilogy explores the moral dilemmas humans may soon create
How would the ability to genetically customize children change society? Sci-fi author Eugene Clark explores the future on our horizon in Volume I of the "Genetic Pressure" series.
- A new sci-fi book series called "Genetic Pressure" explores the scientific and moral implications of a world with a burgeoning designer baby industry.
- It's currently illegal to implant genetically edited human embryos in most nations, but designer babies may someday become widespread.
- While gene-editing technology could help humans eliminate genetic diseases, some in the scientific community fear it may also usher in a new era of eugenics.
Tribalism and discrimination
<p>One question the "Genetic Pressure" series explores: What would tribalism and discrimination look like in a world with designer babies? As designer babies grow up, they could be noticeably different from other people, potentially being smarter, more attractive and healthier. This could breed resentment between the groups—as it does in the series.</p><p>"[Designer babies] slowly find that 'everyone else,' and even their own parents, becomes less and less tolerable," author Eugene Clark told Big Think. "Meanwhile, everyone else slowly feels threatened by the designer babies."</p><p>For example, one character in the series who was born a designer baby faces discrimination and harassment from "normal people"—they call her "soulless" and say she was "made in a factory," a "consumer product." </p><p>Would such divisions emerge in the real world? The answer may depend on who's able to afford designer baby services. If it's only the ultra-wealthy, then it's easy to imagine how being a designer baby could be seen by society as a kind of hyper-privilege, which designer babies would have to reckon with. </p><p>Even if people from all socioeconomic backgrounds can someday afford designer babies, people born designer babies may struggle with tough existential questions: Can they ever take full credit for things they achieve, or were they born with an unfair advantage? To what extent should they spend their lives helping the less fortunate? </p>Sexuality dilemmas
<p>Sexuality presents another set of thorny questions. If a designer baby industry someday allows people to optimize humans for attractiveness, designer babies could grow up to find themselves surrounded by ultra-attractive people. That may not sound like a big problem.</p><p>But consider that, if designer babies someday become the standard way to have children, there'd necessarily be a years-long gap in which only some people are having designer babies. Meanwhile, the rest of society would be having children the old-fashioned way. So, in terms of attractiveness, society could see increasingly apparent disparities in physical appearances between the two groups. "Normal people" could begin to seem increasingly ugly.</p><p>But ultra-attractive people who were born designer babies could face problems, too. One could be the loss of body image. </p><p>When designer babies grow up in the "Genetic Pressure" series, men look like all the other men, and women look like all the other women. This homogeneity of physical appearance occurs because parents of designer babies start following trends, all choosing similar traits for their children: tall, athletic build, olive skin, etc. </p><p>Sure, facial traits remain relatively unique, but everyone's more or less equally attractive. And this causes strange changes to sexual preferences.</p><p>"In a society of sexual equals, they start looking for other differentiators," he said, noting that violet-colored eyes become a rare trait that genetically engineered humans find especially attractive in the series.</p><p>But what about sexual relationships between genetically engineered humans and "normal" people? In the "Genetic Pressure" series, many "normal" people want to have kids with (or at least have sex with) genetically engineered humans. But a minority of engineered humans oppose breeding with "normal" people, and this leads to an ideology that considers engineered humans to be racially supreme. </p>Regulating designer babies
<p>On a policy level, there are many open questions about how governments might legislate a world with designer babies. But it's not totally new territory, considering the West's dark history of eugenics experiments.</p><p>In the 20th century, the U.S. conducted multiple eugenics programs, including immigration restrictions based on genetic inferiority and forced sterilizations. In 1927, for example, the Supreme Court ruled that forcibly sterilizing the mentally handicapped didn't violate the Constitution. Supreme Court Justice Oliver Wendall Holmes wrote, "… three generations of imbeciles are enough." </p><p>After the Holocaust, eugenics programs became increasingly taboo and regulated in the U.S. (though some states continued forced sterilizations <a href="https://www.uvm.edu/~lkaelber/eugenics/" target="_blank">into the 1970s</a>). In recent years, some policymakers and scientists have expressed concerns about how gene-editing technologies could reanimate the eugenics nightmares of the 20th century. </p><p>Currently, the U.S. doesn't explicitly ban human germline genetic editing on the federal level, but a combination of laws effectively render it <a href="https://academic.oup.com/jlb/advance-article/doi/10.1093/jlb/lsaa006/5841599#204481018" target="_blank" rel="noopener noreferrer">illegal to implant a genetically modified embryo</a>. Part of the reason is that scientists still aren't sure of the unintended consequences of new gene-editing technologies. </p><p>But there are also concerns that these technologies could usher in a new era of eugenics. After all, the function of a designer baby industry, like the one in the "Genetic Pressure" series, wouldn't necessarily be limited to eliminating genetic diseases; it could also work to increase the occurrence of "desirable" traits. </p><p>If the industry did that, it'd effectively signal that the <em>opposites of those traits are undesirable. </em>As the International Bioethics Committee <a href="https://academic.oup.com/jlb/advance-article/doi/10.1093/jlb/lsaa006/5841599#204481018" target="_blank" rel="noopener noreferrer">wrote</a>, this would "jeopardize the inherent and therefore equal dignity of all human beings and renew eugenics, disguised as the fulfillment of the wish for a better, improved life."</p><p><em>"Genetic Pressure Volume I: Baby Steps"</em><em> by Eugene Clark is <a href="http://bigth.ink/38VhJn3" target="_blank">available now.</a></em></p>Octopus-like creatures inhabit Jupiter’s moon, claims space scientist
A leading British space scientist thinks there is life under the ice sheets of Europa.
Jupiter's moon Europa has a huge ocean beneath its sheets of ice.
- A British scientist named Professor Monica Grady recently came out in support of extraterrestrial life on Europa.
- Europa, the sixth largest moon in the solar system, may have favorable conditions for life under its miles of ice.
- The moon is one of Jupiter's 79.
Neil deGrasse Tyson wants to go ice fishing on Europa
<div class="rm-shortcode" data-media_id="GLGsRX7e" data-player_id="FvQKszTI" data-rm-shortcode-id="f4790eb8f0515e036b24c4195299df28"> <div id="botr_GLGsRX7e_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/GLGsRX7e-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/GLGsRX7e-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/GLGsRX7e-FvQKszTI.js"></script> </div>Water Vapor Above Europa’s Surface Deteced for First Time
<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="9c4abc8473e1b89170cc8941beeb1f2d"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/WQ-E1lnSOzc?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span>Lair of giant predator worms from 20 million years ago found
Scientists discover burrows of giant predator worms that lived on the seafloor 20 million years ago.
Bobbit worm (Eunice aphroditois).
- Scientists in Taiwan find the lair of giant predator worms that inhabited the seafloor 20 million years ago.
- The worm is possibly related to the modern bobbit worm (Eunice aphroditois).
- The creatures can reach several meters in length and famously ambush their pray.
A three-dimensional model of the feeding behavior of Bobbit worms and the proposed formation of Pennichnus formosae.
Credit: Scientific Reports
Beware the Bobbit Worm!
<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="1f9918e77851242c91382369581d3aac"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/_As1pHhyDHY?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span>What is the ‘self’? The 3 layers of your identity.
Answering the question of who you are is not an easy task. Let's unpack what culture, philosophy, and neuroscience have to say.
- Who am I? It's a question that humans have grappled with since the dawn of time, and most of us are no closer to an answer.
- Trying to pin down what makes you you depends on which school of thought you prescribe to. Some argue that the self is an illusion, while others believe that finding one's "true self" is about sincerity and authenticity.
- In this video, author Gish Jen, Harvard professor Michael Puett, psychotherapist Mark Epstein, and neuroscientist Sam Harris discuss three layers of the self, looking through the lens of culture, philosophy, and neuroscience.
Discovery of two giant radio galaxies hints at more to come
The newly discovered galaxies are 62x bigger than the Milky Way.
