Major study: Drug overdoses over a 38-year period reveal hidden trends
It's just the current cycle that involves opiates, but methamphetamine, cocaine, and others have caused the trajectory of overdoses to head the same direction
- It appears that overdoses are increasing exponentially, no matter the drug itself
- If the study bears out, it means that even reducing opiates will not slow the trajectory.
- The causes of these trends remain obscure, but near the end of the write-up about the study, a hint might be apparent
A new study has just been published in Science.Org magazine detailing the progression of addiction in the United States from 1979 to 2016.
Named "Changing dynamics of the drug overdose epidemic in the United States from 1979 through 2016," it records the deaths from 600,000 overdoses during that 38-year period.
The results are more disturbing because one fact emerges: no matter the drug of choice for those who overdosed, or even the demographic backgrounds of those who overdosed, the mortality rate has increased every year since 1979.
Even more alarming: Even if, for example, the current opioid crises begins to be dealt with, the trajectory is such that deaths from that same drug would not lessen.
Indeed, more than 70,000 died from overdoses in 2017, and nearly 70% of those are were from heroin, opioids, and fentanyl, according to the Centers for Disease Control and Prevention.
From the abstract:
"Better understanding of the dynamics of the current U.S. overdose epidemic may aid in the development of more effective prevention and control strategies. We analyzed records of 599,255 deaths from 1979 through 2016 from the National Vital Statistics System in which accidental drug poisoning was identified as the main cause of death. By examining all available data on accidental poisoning deaths back to 1979 and showing that the overall 38-year curve is exponential, we provide evidence that the current wave of opioid overdose deaths (due to prescription opioids, heroin, and fentanyl) may just be the latest manifestation of a more fundamental longer-term process. The 38+ year smooth exponential curve of total U.S. annual accidental drug poisoning deaths is a composite of multiple distinctive subepidemics of different drugs (primarily prescription opioids, heroin, methadone, synthetic opioids, cocaine, and methamphetamine), each with its own specific demographic and geographic characteristics."
Despair and loss?
Near the end of the study, one of the key items that stands out is that "Sociological and psychological 'pull' forces may be operative to accelerate demand, such as despair, loss of purpose, and dissolution of communities."
In other words, the loss of good jobs with benefits, as well as neighborhoods where people felt like they lived among an actual community, are impacting overdoses and addiction.
The new version's battery has a shorter range and a price $4,000 lower than the previous starting price.
- Tesla's new version of the Model 3 costs $45,000 and can travel 260 miles on one charge.
- The Model 3 is the best-selling luxury car in the U.S.
- Tesla still has yet to introduce a fully self-driving car, even though it once offered the capability as an option to be installed at a future date.
What makes an excellent educator?
- When it comes to educating, says Dr. Elizabeth Alexander, a brave failure is preferable to timid success.
- Fostering an environment where one isn't afraid to fail is tantamount to learning.
- Human beings are complicated and flawed. Working with those complications and flaws leads to true knowledge.
"It's about having employees that are empowered."
Denmark may be the birthplace of the Lego tower, but its workplace hierarchy is the flattest in the world.
According to the World Economic Forum's Global Competitiveness Report 2018, the nation tops an index measuring "willingness to delegate authority" at work, beating 139 other countries.
We all know sleeping with your ex is a bad idea, or is it?
- In the first study of its kind, researchers have found sex with an ex didn't prevent people from getting over their relationship.
- Instead of feeling worse about their breakup after a hookup, the new singles who attempted sexual contact with their ex reported feeling better afterwards.
- The findings suggest that not every piece of relationship advice is to be taken at face value.
It's hard to imagine such a number. But these images will help you try.
The Mega Millions lottery just passed $1 billion for tonight's drawing.
What does that even look like, when represented by various currencies?
It takes just 6 numbers to win. You can only, however, purchase tickets up until 10:45 ET tonight.
Want a happy, satisfying relationship? Psychologists say the best way is to learn to take a joke.
- New research looks at how partners' attitudes toward humor affects the overall quality of a relationship.
- Out of the three basic types of people, people who love to be laughed at made for better partners.
- Fine-tuning your sense of humor might be the secret to a healthy, happy, and committed relationship.
Tiny and efficient, these biodegradable single cells show promise as a way to target hard-to-reach cancers.
- Scientists in Germany have found a potential improvement on the idea of bacteria delivering medicine.
- This kind of microtargeting could be useful in cancer treatments.
- The microswimmers are biodegradable and easy to produce.
Metin Sitti and colleagues at the Max Planck Institute in Germany recently demonstrated that tiny drugs could be attached to individual algae cells and that those algae cells could then be directed through body-like fluid by a magnetic field.
The results were recently published in Advanced Materials, and the paper as a whole offers up a striking portrait of precision and usefulness, perhaps loosely comparable in overall quality to recent work done by The Yale Quantum Institute. It begins by noting that medicine has been attached to bacteria cells before, but bacteria can multiply and end up causing more harm than good.
A potential solution to the problem seems to have been found in an algal cell: the intended object of delivery is given a different electrical charge than the algal cell, which helps attach the object to the cell. The movement of the algae was then tested in 2D and 3D. (The study calls this cell a 'microswimmer.') It would later be found that "3D mean swimming speed of the algal microswimmers increased more than twofold compared to their 2D mean swimming speed." The study continues —
More interestingly, 3D mean swimming speed of the algal microswimmers in the presence of a uniform magnetic field in the x-direction was approximately threefolds higher than their 2D mean swimming speed.
After the 2D and 3D speed of the algal was examined, it was then tested in something made to approximate human fluid, including what they call 'human tubal fluid' (think of the fallopian tubes), plasma, and blood. They then moved to test the compatibility of the microswimmer with cervical cancer cells, ovarian cancer cells, and healthy cells. They found that the microswimmer didn't follow the path of bacteria cells and create something toxic.
The next logical steps from the study include testing this inside a living organism in order to assess the safety of the procedure. Potential future research could include examining how effective this method of drug delivery could be in targeting "diseases in deep body locations," as in, the reproductive and gastrointestinal tracts.
Our modern-day Kafka on his new novel Lake Success and the dark comedy that in 2018 pretty much writes itself
- riding the Greyhounds of hell, from New York to El Paso
- the alternate reality of hedge fund traders
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