from the world's big
A new approach to Alzheimer’s based on physics and worms
How a study on worms pointed the way towards a treatment for dementia.
- An increasing amount of research suggests that failures in phase transition within cells can cause a variety of aliments.
- The mechanism is believed to involve the inability of moleclues to move from solid to liquid and back, inhibiting cellular function.
- The discoveries open the door to treatments for neurodegenerative disease, some cancers, and other illnesses.
The human brain is both the tool we use to understand the world and one of our existence's great enigmas. For large parts of human history, it wasn't even credited with thinking. Countless great minds have tried to figure out how it works from biological, physical, and philosophical perspectives. Despite their efforts, we're still trying to understand how it works, why it breaks, and how to fix it when it does.
A new study sheds light on how the internal dynamics of the cells that comprise our brains can make it go haywire, and offer a potential route to a solution.
All matter is just going through a phase.
Think of liquid water for a moment. If you put it in the freezer, it'll turn to solid ice. Leave it out, and it will melt again. Boil it or leave it outside on a hot day, and it will all turn into water vapor eventually. This change in state is called a "phase transition" and is familiar to most people who took some physics or chemistry.
Phase transition sometimes takes place in cells. Molecules inside cells responsible for cellular metabolism can change from solid to liquid to carry out specific tasks. However, it occasionally happens that the process that allows this to happen breaks down, and the molecules remain a little more solid than is ideal. This means that the molecules are no longer able to move around the cell and do their jobs.
When this happens in certain cells in the brain, toxins associated with Alzheimer's disease and various other conditions start to build up in and around the cells. This discovery, based on previous studies from 2009, is the foundation of a theory on how neurodegenerative diseases start in our brains.
How did scientists develop this theory?
In 2009, a group of scientists discovered phase transitions and their importance in worms' reproductive cells. For reasons which are probably clear to you, this study didn't garner much attention right away. After a few years, the idea that glitchy phase transitions could cause a variety of issues gained some traction, and studies on phase transition in human brain cells took place. Dr. J Paul Taylor even won the Potamkin Prize, awarded for excellence in dementia research, for work concerning how faulty phase transition relates to neurodegenerative diseases.
What directions does this point in?
In his NPR interview, Dr. Taylor suggests that treatments for Alzheimer's and related diseases based on this new understanding could be available in a few years. In the same article, Dr. Clifford Brangwyane of Princeton explained that some experimental treatments have already shown promise in correcting the issues. He also suggests that phase transition treatments could be used against other illnesses and perhaps even some cancers.
Sometimes tremendous scientific advances are born out of the strangest studies. In this case, a potential treatment for a variety of terrible neurodegenerative diseases traces its roots to a study of worms. More bizarre things have happened in science.
- Dementia may occur less often for people who read - Big Think ›
- Can exercise prevent dementia? - Big Think ›
- Your Diet Might Be Causing Anxiety and Depression - Big Think ›
Innovation in manufacturing has crawled since the 1950s. That's about to speed up.
Here's why you might eat greenhouse gases in the future.
- The company's protein powder, "Solein," is similar in form and taste to wheat flour.
- Based on a concept developed by NASA, the product has wide potential as a carbon-neutral source of protein.
- The man-made "meat" industry just got even more interesting.
Seriously sustainable<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8xOTk0MDIzNS9vcmlnaW4ucG5nIiwiZXhwaXJlc19hdCI6MTYyMjM4NTMzMX0.BCEfYnn6C3z1zUHIS38xOWjXktgamNBi5iyqklSMYK8/img.png?width=980" id="ea524" class="rm-shortcode" data-rm-shortcode-id="50533380eeb18eb5833b6b6aa3abec38" data-rm-shortcode-name="rebelmouse-image" />
Image source: Solar Foods<p>Solar Foods makes Solein by extracting CO₂ from air using <a href="https://www.fastcompany.com/90356326/we-have-the-tech-to-suck-co2-from-the-air-but-can-it-suck-enough-to-make-a-difference" target="_blank">carbon-capture technology</a>, and then combines it with water, nutrients and vitamins, using 100 percent renewable solar energy from partner <a href="https://www.fortum.com" target="_blank">Fortum</a> to promote a natural fermentation process similar to the one that produces yeast and lactic acid bacteria.</p><p>When the company claims its single-celled protein is "free from agricultural limitations," they're not kidding. Being produced indoors means Solar Foods is not dependent on arable land, water (i.e., rain), or favorable weather.</p><p>The company is already working with the European Space Agency to develop foods for off-planet production and consumption. (The idea for Solein actually began at NASA.) They also see potential in bringing protein production to areas whose climate or ground conditions make conventional agriculture impossible.</p><p>And let's not forget all those <a href="https://www.bk.com/menu-item/impossible-whopper" target="_blank">beef-free burgers</a> based on pea and soy proteins currently gaining popularity. The environmental challenge of scaling up the supply of those plants to meet their high demand may provide an opening for the completely renewable Solein — the company could provide companies that produce animal-free "meats," such as <a href="https://www.beyondmeat.com/products/" target="_blank">Beyond Meat</a> and <a href="https://impossiblefoods.com" target="_blank">Impossible Foods</a>, a way to further reduce their environmental impact.</p>
The larger promise<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8xOTk0MDI0MS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY1NjU4MTg2OX0.7dZZYT5WEV_EupBuLVFwHynarTiz8RYR9aJtC6Ts2C4/img.jpg?width=980" id="3415d" class="rm-shortcode" data-rm-shortcode-id="2e6eebe06d795f844752f9e9d30040d7" data-rm-shortcode-name="rebelmouse-image" />
Image source: Solar Foods<p>The impact of the beef — and for that matter, poultry, pork, and fish — industries on our planet is widely recognized as one of the main drivers behind climate change, pollution, habitat loss, and antibiotic-resistant illness. From the cutting down of rainforests for cattle-grazing land, to runoff from factory farming of livestock and plants, to the disruption of the marine food chain, to the overuse of antibiotics in food animals, it's been disastrous.</p><p>The advent of a promising source of protein derived from two of the most renewable things we have, CO₂ and sunlight, <a href="https://solarfoods.fi/environmental-impact/" target="_blank">gets us out of the planet-destruction business</a> at the same time as it offers the promise of a stable, long-term solution to one of the world's most fundamental nutritional needs.</p>
Solar Foods' timetable<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8xOTk0MTEzMS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTU5OTU1OTMwMn0.wnXh56iO_77x2XKV2uIPf78BKw4AJLUpmiyq_JBVGvo/img.jpg?width=1245&coordinates=172%2C146%2C62%2C135&height=700" id="0297c" class="rm-shortcode" data-rm-shortcode-id="125c9a98ec818f5c241fa28ef1423e67" data-rm-shortcode-name="rebelmouse-image" />
Image source: Lubsan / Shutterstock / Big Think<p>While company plans are always moderated by unforeseen events — including the availability of sufficient funding — Solar Foods plans a global commercial rollout for Solein in 2021 and to be producing two million meals annually, with a revenue of $800 million to $1.2 billion by 2023. By 2050, they hope to be providing sustenance to 9 billion people as part of a $500 billion protein market.</p><p>The project began in 2018, and this year, they anticipate achieving three things: Launching Solein (check), beginning the approval process certifying its safety as a Novel Food in the EU, and publishing plans for a 1,000-metric ton-per-year factory capable of producing 500 million meals annually.</p>
The protein powder Solein. Image source: SOLAR FOODS
SEAL training is the ultimate test of both mental and physical strength.
- The fact that U.S. Navy SEALs endure very rigorous training before entering the field is common knowledge, but just what happens at those facilities is less often discussed. In this video, former SEALs Brent Gleeson, David Goggins, and Eric Greitens (as well as authors Jesse Itzler and Jamie Wheal) talk about how the 18-month program is designed to build elite, disciplined operatives with immense mental toughness and resilience.
- Wheal dives into the cutting-edge technology and science that the navy uses to prepare these individuals. Itzler shares his experience meeting and briefly living with Goggins (who was also an Army Ranger) and the things he learned about pushing past perceived limits.
- Goggins dives into why you should leave your comfort zone, introduces the 40 percent rule, and explains why the biggest battle we all face is the one in our own minds. "Usually whatever's in front of you isn't as big as you make it out to be," says the SEAL turned motivational speaker. "We start to make these very small things enormous because we allow our minds to take control and go away from us. We have to regain control of our mind."
Pandemic-inspired housing innovation will collide with techno-acceleration.