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DMT: the strongest psychedelic you’ve never heard of
Some scientists believe that DMT could revolutionize the treatment of depression.
- Psychedelic therapy shows promise where other mental health treatments have failed.
- DMT, an incredibly powerful drug, may be particularly useful in conjunction with therapy.
- The use of DMT is still highly experimental and possibly dangerous.
As psychedelic research returns to the mainstream of medical science, several lesser known drugs are being seen as possible therapies for mental illness. One of these is DMT, which is the subject of a slew of new studies about its potential use in treating depression.
What is DMT?
DMT is the common term for N,N-dimethyltryptamine, a powerful psychedelic drug. Its chemical structure is similar to that of serotonin and melatonin, and it is believed to bind to certain serotonin receptors in the brain.
Since the 1960s, scientists have thought that some mammals may produce DMT in their bodies. Its presence in the brains of rodents has been reported, and trace amounts have been found in the human body and cerebrospinal fluid. Exactly what naturally occurring DMT is doing remains a subject of investigation.
Because DMT is also found in a variety of plants, teas containing the drug have been consumed by many native peoples of South America for at least 1000 years, often for religious purposes. It only received serious scientific attention as a therapeutic drug beginning in the 1950s.
Dr. Stephen Szára, a Hungarian psychologist working in the mid-20th century, was denied access to LSD by the Western companies that then produced it. At the time, LSD was considered a powerful tool with applications in spycraft, so neither communist countries nor their biomedical scientists were allowed access to it. Unable to work with that psychedelic, he turned to DMT as an alternative.
Eventually moving to the U.S., he continued to work with DMT and explored its possible applications as well as those of other psychedelics.
What does DMT do?
Unlike the more famous LSD or psilocybin, DMT trips are often quite short, sometimes lasting as little as five minutes. The short duration is more than made up in its intensity, however, with users reporting extremely vivid hallucinations. Typical doses lead to visions of complex, multicolored geometric patterns, ego death, and altered thought patterns.
DMT has another unique feature: high doses of it can lead to an occurrence called a "breakthrough," at which point the user no longer perceives themself as being in the same plane of existence. The new location can be truly phantasmagoric, ranging from hyperspace to non-Euclidean realms. These strange places are often populated by even stranger creatures known as "machine elves."
The machine elves, named by the ethnobotanist Terence McKenna who popularized DMT in certain circles, have been reported by users since Dr. Szára's experiments. Reports of the elves can vary dramatically, especially in appearance, but users tend to agree that the hallucinated creatures are intelligent and benevolent. The frequency with which these beings are reported may explain the use of DMT as a religious tool for contacting the spirit world. Though some users have speculated if these beings are real, author and psychedelic authority James Kent stresses that they are hallucinations.
Is DMT legal?
Generally speaking, DMT is not legal. The Convention on Psychotropic Substances, an international treaty signed in 1971, bans the drug but not the plants that contain it. Many countries have their own bans on the substance or the plants from which it can be extracted. However, many jurisdictions have exemptions for the use of DMT-containing products (like ayahuasca) by certain religious groups as part of their rituals. Some American cities have recently decriminalized the drug.
What is ayahuasca?
Typically, DMT cannot be consumed orally. It must be smoked or, as is common in medical studies, injected. If it is combined with a monoamine oxidase inhibitor, it can be consumed in tea. Variations of this tea, some including different hallucinogenic substances, are often known as ayahuasca from one of the names given it by indigenous South Americans.
While the production and consumption of ayahuasca go back millennia, it has only recently become popular with Western psychonauts. An entire industry of ayahuasca tourism has formed in South America, focused around northeastern Peru, with more than a few psychedelic tourists and celebrities shelling out for a chance to drink the tea in a ritual setting.
By all accounts, a trip on ayahuasca is similar to a DMT trip but with a much longer duration. It also prominently features the purging of the contents of the participants' stomach and bowels. Some practitioners consider this part of the purification process. However, tourists looking for an "authentic" experience may be getting high on hype.
Can DMT be used as medicine?
Current studies focus on how the drug works in the brain and how it might be used to treat mental illness. As Dr. Carol Routledge of Small Pharma explained to Freethink, the extreme effects of this drug might be exactly what some patients need, especially when more common drugs like SSRIs have failed:
"A lot of the mental health disorders like depression, like post-traumatic stress disorder, even OCD, have this real negative cycling thought process which leads to ingrained neuronal processes. And it's almost impossible to get out of those, and I think that's why SSRIs don't really even attempt to do that. What psychedelics do is they break that pathway, they break those neuronal connections, and then they increase neuronal connectivity and synaptic connectivity."
Early reports from Small Pharma suggest that DMT, in conjunction with therapy, can be used to help break away from undesired behavioral patterns. Other studies also suggest that it could prove useful in helping with depression and anxiety. Dr. Routledge suggests that the stimulated connectivity among neurons allows the brain to "reset." As a result, these conditions can be more effectively treated. There is also discussion about how the mystical experiences triggered by the drug might help those with mental health problems to examine the root causes.
Whatever the outcome of this research, definitely don't try this at home. At least a dozen tourist deaths have been associated with the consumption of improperly brewed ayahuasca. These poor souls have permanently relocated to a different plane of existence.
- What are DMT elves? - Big Think ›
- DMT and near-death experiences are similar, study finds - Big Think ›
- 5-MeO-DMT: The new psychedelic with promising mental health ... ›
- The DMT 'elves' people meet while tripping - Big Think ›
"You dream about these kinds of moments when you're a kid," said lead paleontologist David Schmidt.
- The triceratops skull was first discovered in 2019, but was excavated over the summer of 2020.
- It was discovered in the South Dakota Badlands, an area where the Triceratops roamed some 66 million years ago.
- Studying dinosaurs helps scientists better understand the evolution of all life on Earth.
David Schmidt, a geology professor at Westminster College, had just arrived in the South Dakota Badlands in summer 2019 with a group of students for a fossil dig when he received a call from the National Forest Service. A nearby rancher had discovered a strange object poking out of the ground. They wanted Schmidt to take a look.
"One of the very first bones that we saw in the rock was this long cylindrical bone," Schmidt told St. Louis Public Radio. "The first thing that came out of our mouths was, 'That kind of looks like the horn of a triceratops.'"
After authorities gave the go-ahead, Schmidt and a small group of students returned this summer and spent nearly every day of June and July excavating the skull.
Credit: David Schmidt / Westminster College
"We had to be really careful," Schmidt told St. Louis Public Radio. "We couldn't disturb anything at all, because at that point, it was under law enforcement investigation. They were telling us, 'Don't even make footprints,' and I was thinking, 'How are we supposed to do that?'"
Another difficulty was the mammoth size of the skull: about 7 feet long and more than 3,000 pounds. (For context, the largest triceratops skull ever unearthed was about 8.2 feet long.) The skull of Schmidt's dinosaur was likely a Triceratops prorsus, one of two species of triceratops that roamed what's now North America about 66 million years ago.
Credit: David Schmidt / Westminster College
The triceratops was an herbivore, but it was also a favorite meal of the Tyrannosaurus rex. That probably explains why the Dakotas contain many scattered triceratops bone fragments, and, less commonly, complete bones and skulls. In summer 2019, for example, a separate team on a dig in North Dakota made headlines after unearthing a complete triceratops skull that measured five feet in length.
Michael Kjelland, a biology professor who participated in that excavation, said digging up the dinosaur was like completing a "multi-piece, 3-D jigsaw puzzle" that required "engineering that rivaled SpaceX," he jokingly told the New York Times.
Morrison Formation in Colorado
James St. John via Flickr
The Badlands aren't the only spot in North America where paleontologists have found dinosaurs. In the 1870s, Colorado and Wyoming became the first sites of dinosaur discoveries in the U.S., ushering in an era of public fascination with the prehistoric creatures — and a competitive rush to unearth them.
Since, dinosaur bones have been found in 35 states. One of the most fruitful locations for paleontologists has been the Morrison formation, a sequence of Upper Jurassic sedimentary rock that stretches under the Western part of the country. Discovered here were species like Camarasaurus, Diplodocus, Apatosaurus, Stegosaurus, and Allosaurus, to name a few.
|Credit: Nobu Tamura/Wikimedia Commons|
As for "Shady" (the nickname of the South Dakota triceratops), Schmidt and his team have safely transported it to the Westminster campus. They hope to raise funds for restoration, and to return to South Dakota in search of more bones that once belonged to the triceratops.
Studying dinosaurs helps scientists gain a more complete understanding of our evolution, illuminating a through-line that extends from "deep time" to present day. For scientists like Schmidt, there's also the simple joy of coming to face-to-face with a lost world.
"You dream about these kinds of moments when you're a kid," Schmidt told St. Louis Public Radio. "You don't ever think that these things will ever happen."
In ancient Greece, the Olympics were never solely about the athletes themselves.
Because of a dramatic rise in COVID-19 cases, the opening and closing ceremonies of the 2021 Olympics will unfold in a stadium absent the eyes, ears and voices of a once-anticipated 68,000 ticket holders from around the world.
Events during the intervening days will likewise occur in silent arenas missing the hundreds of thousands of spectators who paid US$815 million for their now-useless tickets.
After 48 years teaching classics, I can't help but wonder what the Greeks – who invented the Games nearly 3,000 years ago, in 776 B.C. – would make of such a ghostly version of their Olympic festival.
In many ways, they'd view the prospect as absurd.
In ancient Greece, the Olympics were never solely about the athletes themselves; instead, the heart and soul of the festival was the experience shared by all who attended. Every four years, athletes and spectators traveled from far-flung corners of the Greek-speaking world to Olympia, lured by a longing for contact with their compatriots and their gods.
In the shadow of dreams
For the Greeks, during five days in the late-summer heat, two worlds miraculously merged at Olympia: the domain of everyday life, with its human limits, and a supernatural sphere from the days superior beings, gods and heroes populated Earth.
Greek athletics, like today's, plunged participants into performances that pushed the envelope of human ability to its breaking point. But to the Greeks, the cauldron of competition could trigger revelations in which ordinary mortals might briefly intermingle with the extraordinary immortals.
The poet Pindar, famous for the victory songs he composed for winners at Olympia, captured this sort of transcendent moment when he wrote, “Humans are creatures of a day. But what is humankind? What is it not? A human is just the shadow of a dream – but when a flash of light from Zeus comes down, a shining light falls on humans and their lifetime can be sweet as honey."
However, these epiphanies could occur only if witnesses were physically present to immerse themselves – and share in – the spine-tingling flirtation with the divine.
Simply put, Greek athletics and religious experience were inseparable.
At Olympia, both athletes and spectators were making a pilgrimage to a sacred place. A modern Olympics can legitimately take place in any city selected by the International Olympic Committee. But the ancient games could occur in only one location in western Greece. The most profoundly moving events didn't even occur in the stadium that accommodated 40,000 or in the wrestling and boxing arenas.
Instead, they took place in a grove called the Althis, where Hercules is said to have first erected an altar, sacrificed oxen to Zeus and planted a wild olive tree. Easily half the events during the festival engrossed spectators not in feats like discus, javelin, long jump, foot race and wrestling, but in feasts where animals were sacrificed to gods in heaven and long-dead heroes whose spirits still lingered.
On the evening of the second day, thousands gathered in the Althis to reenact the funeral rites of Pelops, a human hero who once raced a chariot to win a local chief's daughter. But the climactic sacrifice was on the morning of the third day at the Great Altar of Zeus, a mound of plastered ashes from previous sacrifices that stood 22 feet tall and 125 feet around. In a ritual called the hecatomb, 100 bulls were slaughtered and their thigh bones, wrapped in fat, burned atop the altar so that the rising smoke and aroma would reach the sky where Zeus could savor it.
No doubt many a spectator shivered at the thought of Zeus hovering above them, smiling and remembering Hercules' first sacrifice.
Just a few yards from the Great Altar another, more visual encounter with the god awaited. In the Temple of Zeus, which was erected around 468 to 456 B.C., stood a colossal image, 40 feet high, of the god on a throne, his skin carved from ivory and his clothing made of gold. In one hand he held the elusive goddess of victory, Nike, and in the other a staff on which his sacred bird, the eagle, perched. The towering statue was reflected in a shimmering pool of olive oil surrounding it.
During events, the athletes performed in the nude, imitating heroic figures like Hercules, Theseus or Achilles, who all crossed the dividing line between human and superhuman and were usually represented nude in painting and sculpture.
The athletes' nudity declared to spectators that in this holy place, contestants hoped to reenact, in the ritual of sport, the shudder of contact with divinity. In the Althis stood a forest of hundreds of nude statues of men and boys, all previous victors whose images set the bar for aspiring newcomers.
“There are a lot of truly marvelous things one can see and hear about in Greece," the Greek travel writer Pausanias noted in the second century B.C., “but there is something unique about how the divine is encountered at … the games at Olympia."
Communion and community
The Greeks lived in roughly 1,500 to 2,000 small-scale states scattered across the Mediterranean and Black Sea regions.
Since sea travel in summertime was the only viable way to cross this fragile geographical web, the Olympics might entice a Greek living in Southern Europe and another residing in modern-day Ukraine to interact briefly in a festival celebrating not only Zeus and Heracles but also the Hellenic language and culture that produced them.
Besides athletes, poets, philosophers and orators came to perform before crowds that included politicians and businessmen, with everyone communing in an “oceanic feeling" of what it meant to be momentarily united as Greeks.
Now, there's no way we could explain the miracle of TV to the Greeks and how its electronic eye recruits millions of spectators to the modern games by proxy. But visitors to Olympia engaged in a distinct type of spectating.
The ordinary Greek word for someone who observes – “theatês" – connects not only to “theater" but also to “theôria," a special kind of seeing that requires a journey from home to a place where something wondrous unfolds. Theôria opens a door into the sacred, whether it's visiting an oracle or participating in a religious cult.
Attending an athletic-religious festival like the Olympics transformed an ordinary spectator, a theatês, into a theôros – a witness observing the sacred, an ambassador reporting home the wonders observed abroad.
It's hard to imagine TV images from Tokyo achieving similar ends.
No matter how many world records are broken and unprecedented feats accomplished at the 2020 games, the empty arenas will attract no gods or genuine heroes: The Tokyo games are even less enchanted than previous modern games.
But while medal counts will confer fleeting glory on some nations and disappointing shame on others, perhaps a dramatic moment or two might unite athletes and TV viewers in an oceanic feeling of what it means to be “kosmopolitai," citizens of the world, celebrants of the wonder of what it means to be human – and perhaps, briefly, superhuman as well.
The ancient Greeks wouldn't recognize some aspects of the modern Olympics.
Vincent Farenga, Professor of Classics and Comparative Literature, USC Dornsife College of Letters, Arts and Sciences
A new brain imaging study explored how different levels of the brain's excitatory and inhibitory neurotransmitters are linked to math abilities.
- Glutamate and GABA are neurotransmitters that help regulate brain activity.
- Scientists have long known that both are important to learning and neuroplasticity, but their relationship to acquiring complex cognitive skills like math has remained unclear.
- The new study shows that having certain levels of these neurotransmitters predict math performance, but that these levels switch with age.
Why do roughly one in five people find math especially difficult?
You might blame teaching methods, which some argue explains why the U.S. lags behind other countries in standardized math test scores. You could point to math anxiety, which affects about 20 percent of students and 25 percent of teachers, according to surveys. And there are also medical conditions that make math difficult, such as dyscalculia, a learning disability that disrupts the normal development of arithmetic skills.
But another explanation centers on neurotransmitters. In a new study published in PLOS Biology, researchers explored how the brain's levels of GABA and glutamate relate to math abilities over time in students of varying ages. The results showed that levels of these neurotransmitters can predict students' performance on math tests. However, this relationship seems to flip as people get older.
GABA and glutamate are responsible for regulating brain activity. In the mature brain, GABA is the brain's main inhibitory neurotransmitter, helping to block impulses between nerve cells in the brain, which can calm feelings of stress, anxiety, or fear. GABA is made from glutamate, the brain's major excitatory neurotransmitter that helps send signals throughout the central nervous system.
Researchers have long known that these neurotransmitters play crucial roles in learning, development, and neuroplasticity. That is partly because they are thought to help trigger developmental windows (or "sensitive periods") during which neural systems become more plastic and better able to acquire certain cognitive skills.
"Importantly, sensitive periods vary for different functions, with relatively simple abilities (e.g., sensorimotor integration) occurring earlier in development, while the sensitive period for acquiring more complex cognitive functions extends into the third decade of life," the researchers wrote.
GABA, glutamate, and math
Still, the exact relationship between GABA, glutamate, and complex cognitive functions has remained unclear. The new study explored that relationship by focusing on associations between the neurotransmitters and math abilities, which "provides a unique cognitive model to examine these questions due to its protracted skill acquisition period that starts already from early childhood and can continue for nearly two decades," the researchers wrote.
For the study, the researchers measured levels of GABA and glutamate in the left intraparietal sulcus (IPS) of 255 students, ranging from primary school to college. The participants completed a math test as their brains were imaged. About a year and a half later, the participants repeated the same process.
"The longitudinal design allowed us to further examine whether neurotransmitter concentration is linked to MA [mathematical abilities] as well as predict MA in the future," the researchers wrote. "Crucially, adopting this design allowed us to discern the selective effect of glutamate and GABA in response to natural (i.e., learning in school) rather than artificial environmental stimulation, thus allowing us to test the knowledge gained from lab-based experiments in high ecological settings."
The results suggest that GABA and glutamate play an important role in math abilities, but that the dynamic switches with age. For the young participants, higher GABA levels in the IPS were associated with higher scores on math tests. The opposite was observed among older students: higher glutamate levels correlated with higher scores. Both results held true on subsequent math tests.
Although the study sheds light on how neurotransmitter levels at different stages of development contribute to learning some cognitive skills, like math, the researchers noted that acquiring other skills may involve different processes.
"Our findings may also highlight a general principle that the developmental dynamics of regional excitation and inhibition levels in regulating the sensitive period and plasticity of a given high-level cognitive function (i.e., MA) may be different compared to another high-level cognitive function (i.e., general intelligence) that draws on similar, albeit not identical, cognitive and neural mechanisms," they wrote.