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Dealing with loneliness during the pandemic
Sheltering at home is anti-instinctual behavior. Yet doing so saves lives.
- Mental health disorders are on the rise during the COVID-19 pandemic.
- Lack of social contact is anti-instinctual behavior for humans, yet it is needed during this particular crisis.
- How we cope with social distancing and sheltering at home will in large part dictate how long this crisis lasts.
There have been many comparisons between the COVID-19 pandemic and previous historical incidents. Obviously, the last great flu pandemic of 1918-19 has been receiving a lot of attention. There's also quantitative comparisons. Pundits compare this pandemic death toll to wars and terrorist attacks. This week, America surpassed the death toll in Vietnam. In previous weeks, rates were compares to the War in Afghanistan and 9/11.
Comparing a virus to a war isn't fair, though the headlines can be forgiven. We're trying to wrap our heads around the enormity of tragedy. One feature of consciousness is qualia, instances of subjective experience. In order to understand something—say, a glass of wine—we relate to it by stating "this is like this." This Bordeaux smells like peppercorn and chocolate. Comparison gives us a point of reference in an effort to understand concepts. We do it with everything.
While death tolls are one thing, conditions on the ground are entirely different. Consider 9/11. During the months following that day, New Yorkers were more likely to say hello to random passerby on the street. There was an uptick in kindness and charity. People were present for one another on an unprecedented scale. There was a real feeling of "we're in this together."
Feeling like you're a part of something requires presence, which is exactly what's lacking as we shelter at home. Even on 9/11, as I walked from downtown Manhattan to my girlfriend's apartment in the Upper East Side—I lived in Jersey City and had no way of returning home—I would stop to talk to people on the street. We were able to look one another in the eyes. Life was briefly upended, sure, but we could still physically be there for one another. We could even touch each other.
Why loneliness is a danger to individuals and societies | Andrew Horn
Lack of contact is driving loneliness during this pandemic. Health care workers are experiencing an increase in mental health conditions. Being on the front lines is emotionally taxing. But those forced to shelter at home, especially when living alone, are also facing increased anxiety and depression.
An avoidance of social contact is an evolutionary mismatch, argue three researchers in a recent essay published in the journal, Current Biology. Evolutionary biology dictates that we come together during times of crisis. We're social animals. The inability to make contact is frustrating and leads to trauma as self-isolation persists.
The authors (Guillaume Dezecache, Chris Frith, and Ophelia Deroy) write that the media is driving narratives counter to natural behavior. During tragedies, we tend to want to help others more than take care of ourselves. Empathy is our biological inheritance. The media, they write, has adopted a Hobbesian view of the world: every man for himself.
The focus on irrational hoarding of supplies is one example. While running from a fire is a natural reaction to danger, they note that our intuitive responses are cooperation, not selfishness. News outlets perpetuate problems by homing in on aberrant behavior. In fact, they drive the problem. We believe supplies are running short, creating this Hobbesian mentality: I must hoard as well.
This mindset seems worse in cities. As they write,
"In all likelihood, the mismatch between our misperception of the severity of the threat and its consequences is likely to become even more destructive in dense urban areas in which social isolation is a costly good."
A man rests on an empty Staten Island Ferry on March 24, 2020 in New York City.
Photo by Spencer Platt/Getty Images
Then there's the flip side: refusing to social distance or shelter at home. Because the threat is invisible we tend to downplay the risks. This is in stark contrast to 9/11, in which more fearful minds associated any Muslim with terrorism. Fortunately, this trend was relatively rare in New York City, though anti-Islam sentiments exploded across the nation, usually in regions with less diverse cultures.
Sine we cannot see this virus, and therefore don't necessarily understand how it's transmitted or concern ourselves much if we're not in a high-risk group, we don't take precautions. The short-term benefit of contact might, however, fuel the long-term detriment of increased hospitalization and death.
Nonchalance isn't the only reason for such behavior. It might be something much more ingrained in us.
"It is because our infection-avoidance mechanisms are overwhelmed by a much stronger drive to affiliate and seek close contact."
As the authors conclude, the more we can stave off loneliness for the greater good of society—at-risk populations, such as the elderly and immunodeficient; health care workers; supply chains providing hospitals with necessary resources; workers contracted to produce those supplies—dictates how we emerge on the other side of this pandemic.
Sadly, there is no easy response. Collectively we're facing a range of terrible outcomes. The best we can do is strive for the least tragic result. We passed 60,000 deaths in America today. How high that number climbs is in large part in our hands, yet keeping it low requires anti-instinctual behavior. That conundrum is shaping what our society will look like in the future.
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- Empathy and social distancing aren't mutually exclusive - Big Think ›
Inventions with revolutionary potential made by a mysterious aerospace engineer for the U.S. Navy come to light.
- U.S. Navy holds patents for enigmatic inventions by aerospace engineer Dr. Salvatore Pais.
- Pais came up with technology that can "engineer" reality, devising an ultrafast craft, a fusion reactor, and more.
- While mostly theoretical at this point, the inventions could transform energy, space, and military sectors.
The U.S. Navy controls patents for some futuristic and outlandish technologies, some of which, dubbed "the UFO patents," came to light recently. Of particular note are inventions by the somewhat mysterious Dr. Salvatore Cezar Pais, whose tech claims to be able to "engineer reality." His slate of highly-ambitious, borderline sci-fi designs meant for use by the U.S. government range from gravitational wave generators and compact fusion reactors to next-gen hybrid aerospace-underwater crafts with revolutionary propulsion systems, and beyond.
Of course, the existence of patents does not mean these technologies have actually been created, but there is evidence that some demonstrations of operability have been successfully carried out. As investigated and reported by The War Zone, a possible reason why some of the patents may have been taken on by the Navy is that the Chinese military may also be developing similar advanced gadgets.
Among Dr. Pais's patents are designs, approved in 2018, for an aerospace-underwater craft of incredible speed and maneuverability. This cone-shaped vehicle can potentially fly just as well anywhere it may be, whether air, water or space, without leaving any heat signatures. It can achieve this by creating a quantum vacuum around itself with a very dense polarized energy field. This vacuum would allow it to repel any molecule the craft comes in contact with, no matter the medium. Manipulating "quantum field fluctuations in the local vacuum energy state," would help reduce the craft's inertia. The polarized vacuum would dramatically decrease any elemental resistance and lead to "extreme speeds," claims the paper.
Not only that, if the vacuum-creating technology can be engineered, we'd also be able to "engineer the fabric of our reality at the most fundamental level," states the patent. This would lead to major advancements in aerospace propulsion and generating power. Not to mention other reality-changing outcomes that come to mind.
Among Pais's other patents are inventions that stem from similar thinking, outlining pieces of technology necessary to make his creations come to fruition. His paper presented in 2019, titled "Room Temperature Superconducting System for Use on a Hybrid Aerospace Undersea Craft," proposes a system that can achieve superconductivity at room temperatures. This would become "a highly disruptive technology, capable of a total paradigm change in Science and Technology," conveys Pais.
High frequency gravitational wave generator.
Credit: Dr. Salvatore Pais
Another invention devised by Pais is an electromagnetic field generator that could generate "an impenetrable defensive shield to sea and land as well as space-based military and civilian assets." This shield could protect from threats like anti-ship ballistic missiles, cruise missiles that evade radar, coronal mass ejections, military satellites, and even asteroids.
Dr. Pais's ideas center around the phenomenon he dubbed "The Pais Effect". He referred to it in his writings as the "controlled motion of electrically charged matter (from solid to plasma) via accelerated spin and/or accelerated vibration under rapid (yet smooth) acceleration-deceleration-acceleration transients." In less jargon-heavy terms, Pais claims to have figured out how to spin electromagnetic fields in order to contain a fusion reaction – an accomplishment that would lead to a tremendous change in power consumption and an abundance of energy.
According to his bio in a recently published paper on a new Plasma Compression Fusion Device, which could transform energy production, Dr. Pais is a mechanical and aerospace engineer working at the Naval Air Warfare Center Aircraft Division (NAWCAD), which is headquartered in Patuxent River, Maryland. Holding a Ph.D. from Case Western Reserve University in Cleveland, Ohio, Pais was a NASA Research Fellow and worked with Northrop Grumman Aerospace Systems. His current Department of Defense work involves his "advanced knowledge of theory, analysis, and modern experimental and computational methods in aerodynamics, along with an understanding of air-vehicle and missile design, especially in the domain of hypersonic power plant and vehicle design." He also has expert knowledge of electrooptics, emerging quantum technologies (laser power generation in particular), high-energy electromagnetic field generation, and the "breakthrough field of room temperature superconductivity, as related to advanced field propulsion."
Suffice it to say, with such a list of research credentials that would make Nikola Tesla proud, Dr. Pais seems well-positioned to carry out groundbreaking work.
A craft using an inertial mass reduction device.
Credit: Salvatore Pais
The patents won't necessarily lead to these technologies ever seeing the light of day. The research has its share of detractors and nonbelievers among other scientists, who think the amount of energy required for the fields described by Pais and his ideas on electromagnetic propulsions are well beyond the scope of current tech and are nearly impossible. Yet investigators at The War Zone found comments from Navy officials that indicate the inventions are being looked at seriously enough, and some tests are taking place.
If you'd like to read through Pais's patents yourself, check them out here.
Laser Augmented Turbojet Propulsion System
Credit: Dr. Salvatore Pais
Scientists do not know what is causing the overabundance of the gas.
- A new study looked to understand the source of methane on Saturn's moon Enceladus.
- The scientists used computer models with data from the Cassini spacecraft.
- The explanation could lie in alien organisms or non-biological processes.
Something is producing an overabundance of methane in the ocean hidden under the ice of Saturn's moon Enceladus. A new study analyzed if the source could be an alien life form or some other explanation.
The study, published in Nature Astronomy, was carried out by scientists at the University of Arizona and Paris Sciences & Lettres University, who looked at composition data from the water plumes erupting on Enceladus.
The particular chemistry, discovered by the Cassini spacecraft which flew through the plumes, suggested a high concentration of molecules that have been linked to hydrothermal vents on the bottom of Earth's oceans. Such vents are potential cradles of life on Earth, according to previous studies. The data from Cassini, which has been studying Saturn after entering its orbit in 2004, revealed the presence of molecular hydrogen (dihydrogen), methane, and carbon dioxide, with the amount of methane presenting a particular interest to the scientists."We wanted to know: Could Earthlike microbes that 'eat' the dihydrogen and produce methane explain the surprisingly large amount of methane detected by Cassini?" shared one of the study's lead authors Régis Ferrière, an associate professor in the department of Ecology and Evolutionary Biology at the University of Arizona.
Earth's hydrothermal vents feature microorganisms that use dihydrogen for energy, creating methane from carbon dioxide via the process of methanogenesis.
Searching for such microorganisms known as methanogens on the seafloor of Enceladus is not yet feasible. Likely, it would require very sophisticated deep diving operations that will be the objective of future missions.
So, Ferrière's team took a more available approach to pinpointing the origins of the methane, creating mathematical models that attempted to explain the Cassini data. They wanted to calculate the likelihood that particular processes were responsible for producing the amount of methane observed. For example, is the methane more likely the result of biological or non-biological processes?
They found that the data from Cassini was consistent with either microbial activity at hydrothermal vents or processes that have nothing to do with life but could be quite different from what happens on Earth. Intriguingly, models that didn't involve biological entities didn't seem to produce enough of the gas.
"Obviously, we are not concluding that life exists in Enceladus' ocean," Ferrière stated. "Rather, we wanted to understand how likely it would be that Enceladus' hydrothermal vents could be habitable to Earthlike microorganisms. Very likely, the Cassini data tell us, according to our models."
Still, the scientists think future missions are necessary to either prove or discard the "life hypothesis." One explanation for the methane that does not involve biological organisms is that the gas is the result of a chemical breakdown of primordial organic matter within Enceladus' core. This matter could have become a part of Saturn's moon from comets rich in organic materials.
It marks a breakthrough in using gene editing to treat diseases.
This article was originally published by our sister site, Freethink.
For the first time, researchers appear to have effectively treated a genetic disorder by directly injecting a CRISPR therapy into patients' bloodstreams — overcoming one of the biggest hurdles to curing diseases with the gene editing technology.
The therapy appears to be astonishingly effective, editing nearly every cell in the liver to stop a disease-causing mutation.
The challenge: CRISPR gives us the ability to correct genetic mutations, and given that such mutations are responsible for more than 6,000 human diseases, the tech has the potential to dramatically improve human health.
One way to use CRISPR to treat diseases is to remove affected cells from a patient, edit out the mutation in the lab, and place the cells back in the body to replicate — that's how one team functionally cured people with the blood disorder sickle cell anemia, editing and then infusing bone marrow cells.
Bone marrow is a special case, though, and many mutations cause disease in organs that are harder to fix.
Another option is to insert the CRISPR system itself into the body so that it can make edits directly in the affected organs (that's only been attempted once, in an ongoing study in which people had a CRISPR therapy injected into their eyes to treat a rare vision disorder).
Injecting a CRISPR therapy right into the bloodstream has been a problem, though, because the therapy has to find the right cells to edit. An inherited mutation will be in the DNA of every cell of your body, but if it only causes disease in the liver, you don't want your therapy being used up in the pancreas or kidneys.
A new CRISPR therapy: Now, researchers from Intellia Therapeutics and Regeneron Pharmaceuticals have demonstrated for the first time that a CRISPR therapy delivered into the bloodstream can travel to desired tissues to make edits.
We can overcome one of the biggest challenges with applying CRISPR clinically.
"While these are early data, they show us that we can overcome one of the biggest challenges with applying CRISPR clinically so far, which is being able to deliver it systemically and get it to the right place," she continued.
What they did: During a phase 1 clinical trial, Intellia researchers injected a CRISPR therapy dubbed NTLA-2001 into the bloodstreams of six people with a rare, potentially fatal genetic disorder called transthyretin amyloidosis.
The livers of people with transthyretin amyloidosis produce a destructive protein, and the CRISPR therapy was designed to target the gene that makes the protein and halt its production. After just one injection of NTLA-2001, the three patients given a higher dose saw their levels of the protein drop by 80% to 96%.
A better option: The CRISPR therapy produced only mild adverse effects and did lower the protein levels, but we don't know yet if the effect will be permanent. It'll also be a few months before we know if the therapy can alleviate the symptoms of transthyretin amyloidosis.
This is a wonderful day for the future of gene-editing as a medicine.
If everything goes as hoped, though, NTLA-2001 could one day offer a better treatment option for transthyretin amyloidosis than a currently approved medication, patisiran, which only reduces toxic protein levels by 81% and must be injected regularly.
Looking ahead: Even more exciting than NTLA-2001's potential impact on transthyretin amyloidosis, though, is the knowledge that we may be able to use CRISPR injections to treat other genetic disorders that are difficult to target directly, such as heart or brain diseases.
"This is a wonderful day for the future of gene-editing as a medicine," Fyodor Urnov, a UC Berkeley professor of genetics, who wasn't involved in the trial, told NPR. "We as a species are watching this remarkable new show called: our gene-edited future."