Clifford Hudis, M.D. is Chief of the Breast Cancer Medicine Service and attending physician at Memorial Sloan-Kettering Cancer Center in New York City, where he is also a professor of medicine at the Weill Medical College of Cornell University. He is co-leader of the Breast Disease Management Team at MSKCC, co-chair of the Breast Committee of the Cancer and Leukemia Group B (CALGB), past chair of the Internet Services Committee and present chair of the Information Technology Committee of the American Society of Clinical Oncology (ASCO). He is also past president of the New York Metropolitan Breast Cancer Group and chair of the Scientific Advisory Board of the Breast Cancer Research Foundation.
Question: How has mapping the human genome influenced your field?
Clifford Hudis: So the mapping of the human genome was really the exciting effort of the past decade approximately and we were really excited that by doing this we would open up very specific directions for research, and I think like all good science it has led us to new frontiers but maybe not the ones that we’ve expected. The mapping of the human genome has not yet yielded a narrow “ah-ha” moment: This is the cause of breast cancer specifically or cancers in general. It has, however, taught us amazing things, amazing, about the heterogeneity, that is to say the variations, within the genome for people, that’s me to you, and even within people and even narrowly within tumors. So that has raised the level of complexity for us. It’s better to know that but I guess the short answer is no, the mapping of the genome has not yet yielded for us clinically relevant breakthroughs.
Question: What is the world’s biggest medical challenge?
Clifford Hudis: Well, that’s a really great question for an oncologist in a developed country because again the world’s biggest health challenge is probably pediatric illnesses like infectious diarrhea, malaria, and communicable diseases, and so if you wanted to ask me that same question in another way, “What is the biggest bang for the buck you get with your health care dollar?”, it’s investing in clean water, malaria nets and childhood immunizations around the developing world.
Card: How has science changed humanity?
Clifford Hudis: Yeah. Well, there was a lovely piece in the New York Times either Saturday or Sunday of this past week in the op ed that was written by an author reflecting on initially a request for one of his books from a soldier in Iraq or at least he was writing about this, but it was more broadly a plea for incorporation of science into everyday life and appreciation for it. And it’s a very funny paradoxical moment we have right now. We’ve never been more high tech. We rely on things like video cameras, cell phones, spinning platters of information, hard drives, and we’re willing to essentially not even learn how they work or even care. We want to see them almost as magical and they’re really not. They are all built by very carefully pursued scientific or upon scientifically-- scientific principles that are- have been carefully studied, and the reason I’m emphasizing that area is this. I think that we need to value science far more broadly in our population, in our education systems, than we heretofore have, and I think we have to have an appreciation for science and scientific method across society and across domains whether it’s communications, media, education, economics even or my narrow area of biological sciences. There is no advance that I take advantage treating my patients right now that isn’t born of the scientific method.
Question: What is the most exciting new technology you are working with?
Clifford Hudis: I think the most exciting technology remains actually the same technology that we were talking about when we discussed the mapping of the human genome. Our ability to drill down on and essentially dissect base pair by base pair the code of life, the DNA in our chromosomes, I think ultimately holds the key to everything, and if it doesn’t hold it in a very narrow, specific sense it holds it because it is events that are related to that code that matter. It is the what we call epigenetic events that we only now know about because of our ability to study the genome. I think that fundamentally this is the key to unlocking cancer and many other diseases.
Hudis says mapping the human genome was the most exciting effort of the past decade.
Is everyone's favorite Thanksgiving centerpiece really to blame for the post-dinner doldrums?
- Americans kill around 45 million turkeys every year in preparation for the Thanksgiving meal, only to blame our favorite centerpiece for the following food comas.
- Rumor has it our after-dinner sleepiness results from the tryptophan found in turkey.
- However, it is the meal's overall nutritional imbalance, not just the tryptophan, that make us want to leave the dishes for tomorrow. Or maybe the next day.
Pfizer's partnerships strengthen their ability to deliver vaccines in developing countries.
- Community healthcare workers face many challenges in their work, including often traveling far distances to see their clients
- Pfizer is helping to drive the UN's sustainable development goals through partnerships.
- Pfizer partnered with AMP and the World Health Organization to develop a training program for healthcare workers.
The famed author headed to the pond thanks to Indian philosophy.
- The famed author was heavily influenced by Indian literature, informing his decision to self-exile on Walden Pond.
- He was introduced to these texts by his good friend's father, William Emerson.
- Yoga philosophy was in America a century before any physical practices were introduced.
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