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Despite almost no research, the pet CBD industry will grow to $1 billion
Veterinarians are concerned. Consumers appear not to be.
- The pet CBD industry, valued at $8 million in 2017, is expected to grow to $1.16 billion by 2022.
- Despite the hype, there have been few clinical studies conducted on pets.
- While there is evidence of its potential therapeutic value, all evidence points to much higher dosages than offered on the consumer market.
In 1988, three researchers from the School of Pharmacy at Hebrew University in Jerusalem published a study investigating the effect of CBD on dogs. While the popular cannabinoid had shown efficacy in mice and rats through IV infusion, they wanted to know if oral administration would affect canine health. The dogs were given 180 mg of CBD orally. It turns out that CBD has low bioavailability when taken in this manner.
The researchers note that when ingested, CBD bioavailability is also low in humans—around 6 percent. Over three decades later and that still appears to be the case, though some studies have found bioavailability up to 15 percent. Your body (and your dog's body) wants to store the CBD as fat. Unfortunately that's where most of it stays, never passing the blood-brain barrier. NYU professor Esther Blessing, who researches clinical trials on CBD, puts it this way:
"There's no evidence that doses below 300 mg of CBD have any effect in any psychiatric measure. And in fact, dose-finding studies show that the lowest clinically effective dose of CBD for reducing anxiety is 300 mg."
Mayo Clinic Minute: Is CBD safe to use?
If taken orally, the most CBD you (or your dog) would get if ingesting such a high dose would be 45 mg. (Taking it intravenously or smoking it is another story, though it is not clear how much that story changes; a 2014 study on inhalation found 25 percent bioavailability.) To put that into perspective, consider Charlotte's Web Hemp Extract Drops 17 mg for Dogs. Retailing at $64.99, each prescribed dose contains 17 mg of CBD per mL. The dropper bottle is 30 mL, meaning it contains 510 mg of CBD. If you were to give your dog the entire bottle in one serving (which I don't advise), they would retain roughly 30.6 mg.
None of this is stopping the sales of pet (or human) CBD products, however. In 2017, the pet CBD industry was valued at $8 million. A year later it quadrupled to $32 million. By 2022, it is predicted to reach $1.16 billion.
None of this is to deny the potential therapeutic applications of CBD or any of the other hundred-plus cannabinoids found in cannabis. As a consumer since 1993, it's taken decades (and a move to California) for me to stop worrying about being caught—as ridiculous as this sounds, it's true—with a plant. I also know, anecdotally, what that plant has done for me.
The problem is that most evidence on the efficacy of THC and CBD has been anecdotal. Not all, mind you. Plenty of research has shown how effective CBD is in treating epilepsy, which is why the FDA scheduled Epidiolex for therapeutic use—the first cannabis-based medicine to be given a thumb's up by the agency. On top of this, the cannabis research field is vibrant, growing by the month. We should support that, as cannabis has many potential usages that are desperately needed.
CBD oil for pets on display at the Southern Hemp Expo at the Williamson County Agricultural Exposition Park in Franklin, TN on Friday, Sept. 6, 2019.
Photo: Bill Clark/CQ-Roll Call, Inc via Getty Images
Whether or not the current products on the market are efficacious is another story. First off, CBD is more effective when used in conjunction with THC. That makes sense given that nature doesn't separate out lipids when constructing plants. It's the reason why golden rice was initially such a failure: you can't remove beta-carotene from carrots and expect it to work in a new context. Researchers had to create a second version with 23 more times beta-carotene for it to become effective at fighting childhood blindness.
Suggested doses of CBD are mostly guesswork. Sometimes those guesses prove to be pertinent. In fact—and again, this is only anecdote—when I posted my skepticism of the booming pet CBD industry on social media, a number of people reached out with examples of it working for their dogs. When I asked if it was full spectrum (including THC), all responded that it was. A few replied that they didn't like the psychological effects (sluggishness, "out of it"), but it seemed to do the trick.
At least now the FDA appears to be taking these supplements a little more seriously. The agency sent out warning letters to 15 CBD companies for illegally selling their products. The agency also notes that CBD has not achieved GRAS (generally recognized as safe) status. Apparently a regulatory framework for addressing the quickly-growing field of cannabis products is in the works. This is important given that numerous products turn out to have questionable ingredients (or no CBD at all).
Unfortunately, our pets cannot speak to us. Most observations of the efficacy of CBD will continue to be anecdotal, and we well know that the placebo effect shapes how we view reality. That this could extend to our furry friends should not be surprising; nor should the fact that companies are exploiting this questionable science.
In five years, or two, another magic bullet will be all the rage. Right now it's CBD and we're paying a premium for dropper bottles filled with questions.
How would the ability to genetically customize children change society? Sci-fi author Eugene Clark explores the future on our horizon in Volume I of the "Genetic Pressure" series.
- A new sci-fi book series called "Genetic Pressure" explores the scientific and moral implications of a world with a burgeoning designer baby industry.
- It's currently illegal to implant genetically edited human embryos in most nations, but designer babies may someday become widespread.
- While gene-editing technology could help humans eliminate genetic diseases, some in the scientific community fear it may also usher in a new era of eugenics.
Tribalism and discrimination<p>One question the "Genetic Pressure" series explores: What would tribalism and discrimination look like in a world with designer babies? As designer babies grow up, they could be noticeably different from other people, potentially being smarter, more attractive and healthier. This could breed resentment between the groups—as it does in the series.</p><p>"[Designer babies] slowly find that 'everyone else,' and even their own parents, becomes less and less tolerable," author Eugene Clark told Big Think. "Meanwhile, everyone else slowly feels threatened by the designer babies."</p><p>For example, one character in the series who was born a designer baby faces discrimination and harassment from "normal people"—they call her "soulless" and say she was "made in a factory," a "consumer product." </p><p>Would such divisions emerge in the real world? The answer may depend on who's able to afford designer baby services. If it's only the ultra-wealthy, then it's easy to imagine how being a designer baby could be seen by society as a kind of hyper-privilege, which designer babies would have to reckon with. </p><p>Even if people from all socioeconomic backgrounds can someday afford designer babies, people born designer babies may struggle with tough existential questions: Can they ever take full credit for things they achieve, or were they born with an unfair advantage? To what extent should they spend their lives helping the less fortunate? </p>
Sexuality dilemmas<p>Sexuality presents another set of thorny questions. If a designer baby industry someday allows people to optimize humans for attractiveness, designer babies could grow up to find themselves surrounded by ultra-attractive people. That may not sound like a big problem.</p><p>But consider that, if designer babies someday become the standard way to have children, there'd necessarily be a years-long gap in which only some people are having designer babies. Meanwhile, the rest of society would be having children the old-fashioned way. So, in terms of attractiveness, society could see increasingly apparent disparities in physical appearances between the two groups. "Normal people" could begin to seem increasingly ugly.</p><p>But ultra-attractive people who were born designer babies could face problems, too. One could be the loss of body image. </p><p>When designer babies grow up in the "Genetic Pressure" series, men look like all the other men, and women look like all the other women. This homogeneity of physical appearance occurs because parents of designer babies start following trends, all choosing similar traits for their children: tall, athletic build, olive skin, etc. </p><p>Sure, facial traits remain relatively unique, but everyone's more or less equally attractive. And this causes strange changes to sexual preferences.</p><p>"In a society of sexual equals, they start looking for other differentiators," he said, noting that violet-colored eyes become a rare trait that genetically engineered humans find especially attractive in the series.</p><p>But what about sexual relationships between genetically engineered humans and "normal" people? In the "Genetic Pressure" series, many "normal" people want to have kids with (or at least have sex with) genetically engineered humans. But a minority of engineered humans oppose breeding with "normal" people, and this leads to an ideology that considers engineered humans to be racially supreme. </p>
Regulating designer babies<p>On a policy level, there are many open questions about how governments might legislate a world with designer babies. But it's not totally new territory, considering the West's dark history of eugenics experiments.</p><p>In the 20th century, the U.S. conducted multiple eugenics programs, including immigration restrictions based on genetic inferiority and forced sterilizations. In 1927, for example, the Supreme Court ruled that forcibly sterilizing the mentally handicapped didn't violate the Constitution. Supreme Court Justice Oliver Wendall Holmes wrote, "… three generations of imbeciles are enough." </p><p>After the Holocaust, eugenics programs became increasingly taboo and regulated in the U.S. (though some states continued forced sterilizations <a href="https://www.uvm.edu/~lkaelber/eugenics/" target="_blank">into the 1970s</a>). In recent years, some policymakers and scientists have expressed concerns about how gene-editing technologies could reanimate the eugenics nightmares of the 20th century. </p><p>Currently, the U.S. doesn't explicitly ban human germline genetic editing on the federal level, but a combination of laws effectively render it <a href="https://academic.oup.com/jlb/advance-article/doi/10.1093/jlb/lsaa006/5841599#204481018" target="_blank" rel="noopener noreferrer">illegal to implant a genetically modified embryo</a>. Part of the reason is that scientists still aren't sure of the unintended consequences of new gene-editing technologies. </p><p>But there are also concerns that these technologies could usher in a new era of eugenics. After all, the function of a designer baby industry, like the one in the "Genetic Pressure" series, wouldn't necessarily be limited to eliminating genetic diseases; it could also work to increase the occurrence of "desirable" traits. </p><p>If the industry did that, it'd effectively signal that the <em>opposites of those traits are undesirable. </em>As the International Bioethics Committee <a href="https://academic.oup.com/jlb/advance-article/doi/10.1093/jlb/lsaa006/5841599#204481018" target="_blank" rel="noopener noreferrer">wrote</a>, this would "jeopardize the inherent and therefore equal dignity of all human beings and renew eugenics, disguised as the fulfillment of the wish for a better, improved life."</p><p><em>"Genetic Pressure Volume I: Baby Steps"</em><em> by Eugene Clark is <a href="http://bigth.ink/38VhJn3" target="_blank">available now.</a></em></p>
The father of all giant sea bugs was recently discovered off the coast of Java.
- A new species of isopod with a resemblance to a certain Sith lord was just discovered.
- It is the first known giant isopod from the Indian Ocean.
- The finding extends the list of giant isopods even further.
The ocean depths are home to many creatures that some consider to be unnatural.<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMzU2NzY4My9vcmlnaW4ucG5nIiwiZXhwaXJlc19hdCI6MTYxNTUwMzg0NX0.BTK3zVeXxoduyvXfsvp4QH40_9POsrgca_W5CQpjVtw/img.png?width=980" id="b6fb0" class="rm-shortcode" data-rm-shortcode-id="2739ec50d9f9a3bd0058f937b6d447ac" data-rm-shortcode-name="rebelmouse-image" data-width="1512" data-height="2224" />
What benefit does this find have for science? And is it as evil as it looks?<div class="rm-shortcode" data-media_id="7XqcvwWp" data-player_id="FvQKszTI" data-rm-shortcode-id="8506fcd195866131efb93525ae42dec4"> <div id="botr_7XqcvwWp_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/7XqcvwWp-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/7XqcvwWp-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/7XqcvwWp-FvQKszTI.js"></script> </div> <p>The discovery of a new species is always a cause for celebration in zoology. That this is the discovery of an animal that inhabits the deeps of the sea, one of the least explored areas humans can get to, is the icing on the cake.</p><p>Helen Wong of the National University of Singapore, who co-authored the species' description, explained the importance of the discovery:</p><p>"The identification of this new species is an indication of just how little we know about the oceans. There is certainly more for us to explore in terms of biodiversity in the deep sea of our region." </p><p>The animal's visual similarity to Darth Vader is a result of its compound eyes and the curious shape of its <a href="https://lkcnhm.nus.edu.sg/research/sjades2018/" target="_blank" rel="noopener noreferrer dofollow" style="">head</a>. However, given the location of its discovery, the bottom of the remote seas, it may be associated with all manner of horrifically evil Elder Things and <a href="https://en.wikipedia.org/wiki/Cthulhu" target="_blank" rel="dofollow">Great Old Ones</a>. <em></em></p>
The newly discovered galaxies are 62x bigger than the Milky Way.
- Two recently discovered radio galaxies are among the largest objects in the cosmos.
- The discovery implies that radio galaxies are more common than previously thought.
- The discovery was made while creating a radio map of the sky with a small part of a new radio array.
An extremely active galaxy<p> <br> </p><p>Radio galaxies are galaxies with extremely active central regions, known as nuclei, which shine incredibly brightly in some part of the electromagnetic spectrum. They are known for emitting large jets of ionized matter into intergalactic space at speeds approaching that of light. They are related to quasars and blazars. It is thought that supermassive black holes are the energy source that make these galaxies shine so brightly. </p><p>What makes these two galaxies (known as MGTC J095959.63+024608.6 and MGTC J100016.84+015133.0) so interesting is their size. Only 831 similar, "giant radio galaxies" are known to exist. As study co-author Dr. Matthew Prescott explains, these are particularly large even for <a href="https://www.forbes.com/sites/jamiecartereurope/2021/01/18/we-just-found-two-mysterious-galaxies-62-times-bigger-than-our-milky-way-say-scientists/?sh=76edf29c2892" target="_blank" rel="noopener noreferrer">giants</a>:</p><p>"These two galaxies are special because they are amongst the largest giants known, and in the top 10 percent of all giant radio galaxies. They are more than two mega-parsecs across, which is around 6.5 million light-years or about 62 times the size of the Milky Way. Yet they are fainter than others of the same size."</p><p>The smaller of the two is just over two megaparsecs across, roughly six and a half million light-years. The larger is almost another half megaparsec larger than <a href="http://www.sci-news.com/astronomy/giant-radio-galaxies-09266.html" target="_blank">that</a>. <br></p><p>Exactly how these things get to be so massive remains a mystery. Some have proposed that they are ejecting matter into unusually empty space, allowing for the jet to expand further, though some evidence contradicts this. The most commonly suggested idea is that they are simply much, much older than the previously observed radio galaxies, allowing more time for expansion to occur.</p>
How does this change our understanding of the universe?<p> While exciting and impressive on their own, the findings also suggest that there are very many more of these giant galaxies than previously supposed. If you were going off the previous estimates for how typical these galaxies are, then the odds of finding these two would be 1 in 2.7×10<sup>6. </sup>This suggests that there must be more, given that the alternative is that the scientists were impossibly lucky. </p><p> In the study, the researchers also apply this reasoning to smaller versions of these galaxies, saying:</p><p> "While our analysis has considered only enormous (>2 Mpc) objects, if radio galaxies must grow to reach this size, then we may expect to similarly uncover in our data previously undetected GRGs with smaller sizes."</p><p> Exactly how common radio galaxies and turn out to be remains to be seen. Still, it will undoubtedly be an exciting time for radio astronomy as new telescopes are turned skywards to search for them.</p>
How did they find them?<iframe width="730" height="430" src="https://www.youtube.com/embed/c1ZW3nVfe5A" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen></iframe><p> The new galaxies were discovered by the amusingly named <a href="https://www.sarao.ac.za/gallery/meerkat/" target="_blank" rel="noopener noreferrer">MeerKAT</a> radio telescope in South Africa during the creation of a new radio map of the sky. The MeerKAT is the first of what will soon be the <a href="https://en.wikipedia.org/wiki/Square_Kilometre_Array" target="_blank" rel="noopener noreferrer">Square Kilometre Array</a> of telescopes, which will span several countries in the southern hemisphere and make even more impressive discoveries in radio astronomy possible. </p>
Daydreaming can be a pleasant pastime, but people who suffer from maladaptive daydreamers are trapped by their fantasies.
Maladaptive daydreaming<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNTUwMjgyMy9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY0OTUxNzc3Nn0.yVIUGnZl6VnJhfevESkBpb1TEvwKrHcLtobwNJV55HI/img.jpg?width=1245&coordinates=0%2C63%2C0%2C63&height=700" id="713cf" class="rm-shortcode" data-rm-shortcode-id="e2d24a66284b3aa58ad16b66c135dc9d" data-rm-shortcode-name="rebelmouse-image" data-width="1245" data-height="700" />
One maladaptive dreamer spent hours a day dreaming he was a powerful man who could solve the world's problems.
(Photo: Pixabay)<p>Daydreaming is an indulgence of the mind and imagination, one provided courtesy of the <a href="https://www.sciencedirect.com/topics/neuroscience/default-mode-network#:~:text=The%20default%20mode%20network%20(DMN,and%20Exercise%20Psychology%20Research%2C%202016" target="_blank">default mode network</a>, a network of interacting brain regions that is active even when the conscious mind is not. But like so many of life's indulgences—wine, steak dinners, video games, and even <a href="https://www.healthline.com/health-news/why-too-much-exercise-can-be-bad-042514" target="_blank">exercise</a>—too much daydreaming can be harmful to our well-being. When daydreaming crosses that threshold, it can be considered maladaptive.</p><p>This disorder was first identified by <a href="https://haifa.academia.edu/EliSomer" target="_blank">Eli Somer</a>, a professor of clinical psychology at the University of Haifa, School of Social Work, in <a href="https://link.springer.com/article/10.1023/A:1020597026919" target="_blank" rel="noopener noreferrer">a 2002 paper</a>. That paper looked to six patients in a trauma center whose daydreaming habits replaced human interactions or interfered with their standard life functions, such as going to school or holding down a job. </p><p>Since then, other case studies have looked at <a href="https://www.healthline.com/health/mental-health/maladaptive-daydreaming#:~:text=Maladaptive%20daydreaming%20is%20a%20psychiatric,life%20events%20trigger%20day%20dreams." target="_blank" rel="noopener noreferrer">maladaptive daydreamers</a> and compiled a list of potential symptoms. These include vivid, richly-detailed daydreams; abnormally long daydreaming sessions; daydreams triggered by real-life events; daydreaming sessions that interrupt sleep; and repetitive motions or whisperings while daydreaming. On average, one study reported, maladaptive daydreamers spend <a href="https://bigthink.com/bps-research-digest/people-with-maladaptive-daydreaming-spend-an-average-of-four-hours-a-day-lost-in-their-imagination" target="_self">four hours a day</a> housed in their imaginations.</p><p>"This is not like rehearsing a conversation that you might have with a boss," <a href="https://www.cnn.com/2016/12/30/health/maladaptive-daydreaming-feature/index.html" target="_blank" rel="noopener noreferrer">Somer told CNN</a>. "This is fanciful, weaving of stories. It produces an intense sense of presence."</p><p>While such symptoms are common, though not comprehensive or guaranteed, how maladaptive daydreams manifest are naturally individual to the dreamers. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426361/" target="_blank" rel="noopener noreferrer">In one case study</a>, researchers analyzed the diary of a man codenamed "Peter." Peter described investing as many as 14 hours a day online. The news and images he happened upon would trigger related fantasies. For example, he may envision himself as a multimillionaire genius who could prevent bad news from occurring or self-insert himself into the power fantasies of superhero movies or police procedurals for hours at a time.</p><p>"When I felt this pain as a child, I started imagining how things could be different. I created stories which never happened. To suppress that pain I would hug my pillow or quilt, thinking I was being comforted by someone else," Peter wrote.</p><p>In an interview with CNN, Cordellia Rose described her maladaptive daydreaming like a drug and noted that her daydreams developed into intricate storylines that could last for years. These stories proved so distracted that she was unable to complete everyday tasks such as driving lessons.</p><p>"You get hooked on it, because it can be like an action movie in your head that's so gripping that you cannot turn off," Rose told CNN. "This [condition] needs to be public, because these are people suffering, and badly."</p><p>To be clear, maladaptive dreaming is not a <a href="https://www.webmd.com/schizophrenia/guide/what-is-psychosis#1" target="_blank" rel="noopener noreferrer">psychotic disorder</a> like schizophrenia. Daydreamers such as Peter and Rose are aware that their fantasies are as unreal as they may be unrealistic. Because of this, many maladaptive dreamers understand the difficulties they face and the real-life losses they have endured for the sake of their fantasies. </p>