Russia threatens ‘retaliation’ after U.S. declares plan to withdraw from arms treaty
On Tuesday, Secretary of State Mike Pompeo said the U.S. will withdraw from the 1987 agreement unless Russia falls back into compliance.
- The 1987 Intermediate-Range Nuclear Forces Treaty (INF) was an agreement between the Soviet Union and the U.S. to ban mid-ranged, nuclear-tipped missiles.
- Both Russia and the U.S. have accused each other of violating the pact in recent years.
- As it stands, Russia has 60 days to return to terms agreed upon in the deal or the U.S. will withdraw from the pact.
Russian officials said Wednesday that the United States' decision to withdraw from a long-standing arms agreement would be met with "retaliation" from Moscow in the form of developing new, previously banned nuclear weapons.
On Tuesday, Secretary of State Mike Pompeo declared that Russia is "in material breach" of the 1987 Intermediate-Range Nuclear Forces Treaty (INF) and the U.S. plans to withdraw from the pact in 60 days unless Russia falls back into compliance. The INF was a landmark agreement between the U.S. and former Soviet Union that banned mid-range, nuclear-tipped missiles, and resulted in the destruction of more than 2,500 missiles. Both nations have accused each other of violating the treaty multiple times since signing the pact.
In October, U.S. officials announced plans to withdraw from the treaty, alleging that Russia had been violating the treaty for years, particularly with its new SSC-8 ground-fired cruise missile. President Donald Trump said as much at a rally in October, and the comments ostensibly prompted Putin to later say that Russians will "go to heaven" in the event of nuclear war, while the "aggressors" — presumably Americans — will be annihilated and "won't even have time to repent."
On Wednesday, Putin said U.S. officials offer "no proof of violations on our side," and noted that the U.S. has, for months, been researching the development of weapons banned under the treaty — though researching such weapons isn't banned by the pact.
We are against destruction of the treaty," Putin added. "But if it happens, we will react accordingly.
Why withdrawal could benefit the U.S.
With credible evidence suggesting Russia has for years been violating the INF and shows no signs of stopping, the U.S. has little to gain by sticking to the treaty as it stands. Withdrawal, it seems, could be the smarter play because it'd allow the U.S. to take up strategic positions in the Pacific, as Elbridge Colby, director of the defense program at the Center for a New American Security, wrote for the Washington Post in October.
The most compelling reason for withdrawal is that the United States could materially improve the military balance against China in East Asia by developing and deploying INF-noncompliant systems. China poses a much larger and more sophisticated long-term military threat than Russia, and U.S. strike options are more constrained by the geography of the Pacific. Washington would benefit from having the ability to deploy survivable land-based ballistic and cruise missile systems to provide a larger, more diverse and resilient greater strike capability in the event of a conflict in the western Pacific.
Nuclear arsenals of the U.S. and Russia
- Total nuclear weapons: ~6,800
- Total nuclear tests: ~ 715
- First tested: August 1949
- Most recent test: October 1990
- Total nuclear weapons: ~ 6,550
- Total nuclear tests: ~ 1,030
- First tested: July 1945
- Most recent test: September 1992
Young people could even end up less anxiety-ridden, thanks to newfound confidence
- The coronavirus pandemic may have a silver lining: It shows how insanely resourceful kids really are.
- Let Grow, a non-profit promoting independence as a critical part of childhood, ran an "Independence Challenge" essay contest for kids. Here are a few of the amazing essays that came in.
- Download Let Grow's free Independence Kit with ideas for kids.
Philosophers like to present their works as if everything before it was wrong. Sometimes, they even say they have ended the need for more philosophy. So, what happens when somebody realizes they were mistaken?
Sometimes philosophers are wrong and admitting that you could be wrong is a big part of being a real philosopher. While most philosophers make minor adjustments to their arguments to correct for mistakes, others make large shifts in their thinking. Here, we have four philosophers who went back on what they said earlier in often radical ways.
New research establishes an unexpected connection.
- A study provides further confirmation that a prolonged lack of sleep can result in early mortality.
- Surprisingly, the direct cause seems to be a buildup of Reactive Oxygen Species in the gut produced by sleeplessness.
- When the buildup is neutralized, a normal lifespan is restored.
We don't have to tell you what it feels like when you don't get enough sleep. A night or two of that can be miserable; long-term sleeplessness is out-and-out debilitating. Though we know from personal experience that we need sleep — our cognitive, metabolic, cardiovascular, and immune functioning depend on it — a lack of it does more than just make you feel like you want to die. It can actually kill you, according to study of rats published in 1989. But why?
A new study answers that question, and in an unexpected way. It appears that the sleeplessness/death connection has nothing to do with the brain or nervous system as many have assumed — it happens in your gut. Equally amazing, the study's authors were able to reverse the ill effects with antioxidants.
The study, from researchers at Harvard Medical School (HMS), is published in the journal Cell.
An unexpected culprit
The new research examines the mechanisms at play in sleep-deprived fruit flies and in mice — long-term sleep-deprivation experiments with humans are considered ethically iffy.
What the scientists found is that death from sleep deprivation is always preceded by a buildup of Reactive Oxygen Species (ROS) in the gut. These are not, as their name implies, living organisms. ROS are reactive molecules that are part of the immune system's response to invading microbes, and recent research suggests they're paradoxically key players in normal cell signal transduction and cell cycling as well. However, having an excess of ROS leads to oxidative stress, which is linked to "macromolecular damage and is implicated in various disease states such as atherosclerosis, diabetes, cancer, neurodegeneration, and aging." To prevent this, cellular defenses typically maintain a balance between ROS production and removal.
"We took an unbiased approach and searched throughout the body for indicators of damage from sleep deprivation," says senior study author Dragana Rogulja, admitting, "We were surprised to find it was the gut that plays a key role in causing death." The accumulation occurred in both sleep-deprived fruit flies and mice.
"Even more surprising," Rogulja recalls, "we found that premature death could be prevented. Each morning, we would all gather around to look at the flies, with disbelief to be honest. What we saw is that every time we could neutralize ROS in the gut, we could rescue the flies." Fruit flies given any of 11 antioxidant compounds — including melatonin, lipoic acid and NAD — that neutralize ROS buildups remained active and lived a normal length of time in spite of sleep deprivation. (The researchers note that these antioxidants did not extend the lifespans of non-sleep deprived control subjects.)
Image source: Tomasz Klejdysz/Shutterstock/Big Think
The study's tests were managed by co-first authors Alexandra Vaccaro and Yosef Kaplan Dor, both research fellows at HMS.
You may wonder how you compel a fruit fly to sleep, or for that matter, how you keep one awake. The researchers ascertained that fruit flies doze off in response to being shaken, and thus were the control subjects induced to snooze in their individual, warmed tubes. Each subject occupied its own 29 °C (84F) tube.
For their sleepless cohort, fruit flies were genetically manipulated to express a heat-sensitive protein in specific neurons. These neurons are known to suppress sleep, and did so — the fruit flies' activity levels, or lack thereof, were tracked using infrared beams.
Starting at Day 10 of sleep deprivation, fruit flies began dying, with all of them dead by Day 20. Control flies lived up to 40 days.
The scientists sought out markers that would indicate cell damage in their sleepless subjects. They saw no difference in brain tissue and elsewhere between the well-rested and sleep-deprived fruit flies, with the exception of one fruit fly.
However, in the guts of sleep-deprived fruit flies was a massive accumulation of ROS, which peaked around Day 10. Says Vaccaro, "We found that sleep-deprived flies were dying at the same pace, every time, and when we looked at markers of cell damage and death, the one tissue that really stood out was the gut." She adds, "I remember when we did the first experiment, you could immediately tell under the microscope that there was a striking difference. That almost never happens in lab research."
The experiments were repeated with mice who were gently kept awake for five days. Again, ROS built up over time in their small and large intestines but nowhere else.
As noted above, the administering of antioxidants alleviated the effect of the ROS buildup. In addition, flies that were modified to overproduce gut antioxidant enzymes were found to be immune to the damaging effects of sleep deprivation.
The research leaves some important questions unanswered. Says Kaplan Dor, "We still don't know why sleep loss causes ROS accumulation in the gut, and why this is lethal." He hypothesizes, "Sleep deprivation could directly affect the gut, but the trigger may also originate in the brain. Similarly, death could be due to damage in the gut or because high levels of ROS have systemic effects, or some combination of these."
The HMS researchers are now investigating the chemical pathways by which sleep-deprivation triggers the ROS buildup, and the means by which the ROS wreak cell havoc.
"We need to understand the biology of how sleep deprivation damages the body so that we can find ways to prevent this harm," says Rogulja.
Referring to the value of this study to humans, she notes,"So many of us are chronically sleep deprived. Even if we know staying up late every night is bad, we still do it. We believe we've identified a central issue that, when eliminated, allows for survival without sleep, at least in fruit flies."
We must rethink the "chemical imbalance" theory of mental health.
- A new review found that withdrawal symptoms from antidepressants and antipsychotics can last for over a year.
- Side effects from SSRIs, SNRIs, and antipsychotics last longer than benzodiazepines like Valium or Prozac.
- The global antidepressant market is expected to reach $28.6 billion this year.