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10 Most Dangerous Scientific Experiments in History
The times in history when science was deadly and dangerous.

Science is a force for good in our world, improving lives of people all across Earth in immeasurable ways. But it is also a very powerful tool that can become dangerous in some situations. Especially when it gets entangled in politics. At other times, science’s inherent ambition to push boundaries of what is known can also lead to some heart-stopping moments.
The following list is in no way exhaustive but gives us a place to start when thinking about the serious responsibility that comes with the march of science.
1. Project MKUltra
The infamous project MKUltra was CIA's attempt at mastering mind control. The program started in the 1950s and lasted seemingly until 1966. Under MKUltra, often-unwilling subjects were given drugs, especially hallucinogenics like LSD. The people tested were also put through sleep and sensory deprivation, hypnosis, sexual abuse, and other kinds of psychological torture, while some tests proved lethal.
The supposed goal of the project was some combination of chemical weapons research and effort to create mind-controlling drugs to combat the Soviets.
2. Weaponizing the Plague
The last time plague roamed around, it killed around half of Europe’s population, reducing the amount of people in the world by nearly a 100 million during the 13th and 14th century. In the late 1980s, the Soviet Union’s biological warfare research program figured out how to use the plague as a weapon, to be launched at enemies in missile warheads. What could go wrong? Besides the plague, defectors revealed that the Soviet bio-weapons program also had hundreds of tons of anthrax and tons of smallpox.
3. The Large Hadron Supercollider
The Large Hadron Collider (LHC) in Switzerland, built to study particle physics, is the world’s largest machine and single most sophisticated scientific instrument. Because of this and the cutting-edge research its involved in, the LHC has prompted more than its share of fears from the general public. It has been blamed for causing earthquakes and pulling asteroids towards Earth.
A giant magnet used in the Large Hadron Collider, weighing 1920 tonnes. 28 February, 2007 at the European Organization for Nuclear Research (CERN) in Geneva. (Photo credit: JEAN-PIERRE CLATOT/AFP/Getty Images)
While conspiracy theories around the LHC have generally been disproven, it has also been accused of potentially creating black holes that could swallow Earth, a possibility that was curiously not completely discounted by the CERN, the organization running the collider.
CERN claimed the LHC is not dangerous, but also acknowledged that some type of black hole could be created.
"The LHC will not generate black holes in the cosmological sense. However, some theories suggest that the formation of tiny 'quantum' black holes may be possible. The observation of such an event would be thrilling in terms of our understanding of the Universe; and would be perfectly safe,“ said CERN’s statement.
A quantum black hole would be tiny. Don’t you feel better?
4. The Tuskegee Syphilis Experiment
A government-funded “study” from 1932-1972 denied treatment for syphilis to 399 African American patients in rural Alabama, even as penicillin was found to be effective against the disease in 1947. The patients were actually not told they had syphilis, with doctors blaming their “bad blood” instead and given placebos.
The goal of the experiment, carried out by the U.S. Public Health Service, was to study the natural progress of syphilis if left untreated. 28 of the people in the study died directly from syphilis while 100 died from related complications.
Doctor drawing blood from a patient as part of the Tuskegee Syphilis Study. 1932.
5. Kola Superdeep Borehole
A Soviet experiment, started in 1970, sought to drill as deeply as possible into the crust of the planet. By 1994, they bore a 12-km-deep hole into the Kola Peninsula in Russia’s far northwest. The record dig provided much scientific data, like the finding of ancient microscopic plankton fossils from 24 species.
While nothing negative happened, there were concerns at the time that drilling so deep towards the center of Earth might produce unexpected seismic effects. Like cracking the planet open.
The hole’s site is currently closed.
6. Guatemalan STD study
This horrid experiment is another instance of the U.S. government causing harm in the pursuit of “science”. From 1945 until 1956, around 1500 Guatemalans were deliberately infected with sexually transmitted diseases, including syphilis and gonorrhoea. The subjects included orphans, prisoners, prostitutes and military conscripts. Researchers used disease-infected prostitutes, injections, and other unscrupulous methods to make their subjects sick.
Subjects of the experiment are currently suing John Hopkins University for $1 billion for its role in the study.
7. The Aversion Project
A medical torture program was instituted in South Africa between 1971 and 1989 to “cure” homosexuality in military conscripts. The policy, carried out under apartheid, included forced “aversion therapy” treatments like electric shock therapy and chemical castration. The army also authorized as many as 900 sex change operations.
It was widely believed in the medical community at the time that homosexuality was a mental illness that could be cured. Dr. Aubrey Levin, in charge of the program as chief psychiatrist of the South African military, was eventually accused of human rights abuse by international organizations and received a prison sentence.
8. Nazi Concentration Camp Experiments
Nazis carried out medical experiments on thousands of prisoners in concentration camps, without any regard for human life. Some of their “research” involved purposefully inducing hypothermia, infecting people with malaria, using mustard gas on people, forced sterilization, giving prisoners different poisons, infecting wounds with bacteria and filling them with wood shavings and ground glass.
The Nazi doctor Josef Mengele was the prototypical “evil scientist,” known for his concentration camp experiments, with a particular focus on twins, mostly Jewish or Roma (“Gypsy”). Supposedly in the interest of studying heredity, the SS physician Mengele was responsible for such atrocities as removing organs from people without anesthetics, injections with deadly bacteria, dismemberment and others.
Not surprisingly known as the “Angel of Death”, Mengele collected the eyes of murdered victims for heterochromia research and attempted to prove through experiments the supposed resistance of Jews and Roma to a host of diseases.
circa 1940: Joseph Mengele, before he became known as 'The Doctor of Auschwitz' and 'The Angel of Death' for his pseudo-scientific experiments on inmates in Nazi death camps. (Photo by Keystone/Getty Images)
9. Unit 731
Unit 731 was a secretive R&D unit of the Japanese Army that carried out horrendous experiments on humans during World War 2. Commanded by General Shiro Ishii, the unit experimented on an estimated 250,000 men, women and children. Most of the victims were Chinese, along with some prisoners of war from Russia and the Allies.
The forced medical procedures involved vivisections - cutting open subjects usually without anesthesia, unnecessary limb amputations, and removal of body organs like parts of brain, liver, lung and others. Victims were also subjected to biological warfare, frostbite testing, forced pregnancies, and even weapons testing by grenades or flamethrowers.
Trinity Site - 0.016 second after explosion, July 16, 1945. The highest point of the cloud in this image is about 200 meters high.
10. The Trinity Test
It’s hard not to put the world’s first nuclear test on such a list. In the mad rush to develop the atomic bomb and gain a military advantage in World War 2, America instituted the secretive Manhattan Project. This resulted in the Trinity Test, a detonation of the first-ever nuclear weapon in a New Mexico desert on July 16, 1945.
While the scientists were relatively confident in their work, there were some famous doubters who wondered if the bomb would even explode or if it would perhaps cause the end of the world as we know it.
Waiting for the bomb to go off, Nobel Prize-winning physicist Enrico Fermi, wagered others whether the bomb would just destroy New Mexico or the world, potentially setting the Earth’s atmosphere ablaze.
‘Designer baby’ book trilogy explores the moral dilemmas humans may soon create
How would the ability to genetically customize children change society? Sci-fi author Eugene Clark explores the future on our horizon in Volume I of the "Genetic Pressure" series.
- A new sci-fi book series called "Genetic Pressure" explores the scientific and moral implications of a world with a burgeoning designer baby industry.
- It's currently illegal to implant genetically edited human embryos in most nations, but designer babies may someday become widespread.
- While gene-editing technology could help humans eliminate genetic diseases, some in the scientific community fear it may also usher in a new era of eugenics.
Tribalism and discrimination
<p>One question the "Genetic Pressure" series explores: What would tribalism and discrimination look like in a world with designer babies? As designer babies grow up, they could be noticeably different from other people, potentially being smarter, more attractive and healthier. This could breed resentment between the groups—as it does in the series.</p><p>"[Designer babies] slowly find that 'everyone else,' and even their own parents, becomes less and less tolerable," author Eugene Clark told Big Think. "Meanwhile, everyone else slowly feels threatened by the designer babies."</p><p>For example, one character in the series who was born a designer baby faces discrimination and harassment from "normal people"—they call her "soulless" and say she was "made in a factory," a "consumer product." </p><p>Would such divisions emerge in the real world? The answer may depend on who's able to afford designer baby services. If it's only the ultra-wealthy, then it's easy to imagine how being a designer baby could be seen by society as a kind of hyper-privilege, which designer babies would have to reckon with. </p><p>Even if people from all socioeconomic backgrounds can someday afford designer babies, people born designer babies may struggle with tough existential questions: Can they ever take full credit for things they achieve, or were they born with an unfair advantage? To what extent should they spend their lives helping the less fortunate? </p>Sexuality dilemmas
<p>Sexuality presents another set of thorny questions. If a designer baby industry someday allows people to optimize humans for attractiveness, designer babies could grow up to find themselves surrounded by ultra-attractive people. That may not sound like a big problem.</p><p>But consider that, if designer babies someday become the standard way to have children, there'd necessarily be a years-long gap in which only some people are having designer babies. Meanwhile, the rest of society would be having children the old-fashioned way. So, in terms of attractiveness, society could see increasingly apparent disparities in physical appearances between the two groups. "Normal people" could begin to seem increasingly ugly.</p><p>But ultra-attractive people who were born designer babies could face problems, too. One could be the loss of body image. </p><p>When designer babies grow up in the "Genetic Pressure" series, men look like all the other men, and women look like all the other women. This homogeneity of physical appearance occurs because parents of designer babies start following trends, all choosing similar traits for their children: tall, athletic build, olive skin, etc. </p><p>Sure, facial traits remain relatively unique, but everyone's more or less equally attractive. And this causes strange changes to sexual preferences.</p><p>"In a society of sexual equals, they start looking for other differentiators," he said, noting that violet-colored eyes become a rare trait that genetically engineered humans find especially attractive in the series.</p><p>But what about sexual relationships between genetically engineered humans and "normal" people? In the "Genetic Pressure" series, many "normal" people want to have kids with (or at least have sex with) genetically engineered humans. But a minority of engineered humans oppose breeding with "normal" people, and this leads to an ideology that considers engineered humans to be racially supreme. </p>Regulating designer babies
<p>On a policy level, there are many open questions about how governments might legislate a world with designer babies. But it's not totally new territory, considering the West's dark history of eugenics experiments.</p><p>In the 20th century, the U.S. conducted multiple eugenics programs, including immigration restrictions based on genetic inferiority and forced sterilizations. In 1927, for example, the Supreme Court ruled that forcibly sterilizing the mentally handicapped didn't violate the Constitution. Supreme Court Justice Oliver Wendall Holmes wrote, "… three generations of imbeciles are enough." </p><p>After the Holocaust, eugenics programs became increasingly taboo and regulated in the U.S. (though some states continued forced sterilizations <a href="https://www.uvm.edu/~lkaelber/eugenics/" target="_blank">into the 1970s</a>). In recent years, some policymakers and scientists have expressed concerns about how gene-editing technologies could reanimate the eugenics nightmares of the 20th century. </p><p>Currently, the U.S. doesn't explicitly ban human germline genetic editing on the federal level, but a combination of laws effectively render it <a href="https://academic.oup.com/jlb/advance-article/doi/10.1093/jlb/lsaa006/5841599#204481018" target="_blank" rel="noopener noreferrer">illegal to implant a genetically modified embryo</a>. Part of the reason is that scientists still aren't sure of the unintended consequences of new gene-editing technologies. </p><p>But there are also concerns that these technologies could usher in a new era of eugenics. After all, the function of a designer baby industry, like the one in the "Genetic Pressure" series, wouldn't necessarily be limited to eliminating genetic diseases; it could also work to increase the occurrence of "desirable" traits. </p><p>If the industry did that, it'd effectively signal that the <em>opposites of those traits are undesirable. </em>As the International Bioethics Committee <a href="https://academic.oup.com/jlb/advance-article/doi/10.1093/jlb/lsaa006/5841599#204481018" target="_blank" rel="noopener noreferrer">wrote</a>, this would "jeopardize the inherent and therefore equal dignity of all human beings and renew eugenics, disguised as the fulfillment of the wish for a better, improved life."</p><p><em>"Genetic Pressure Volume I: Baby Steps"</em><em> by Eugene Clark is <a href="http://bigth.ink/38VhJn3" target="_blank">available now.</a></em></p>Massive 'Darth Vader' isopod found lurking in the Indian Ocean
The father of all giant sea bugs was recently discovered off the coast of Java.
A close up of Bathynomus raksasa
- A new species of isopod with a resemblance to a certain Sith lord was just discovered.
- It is the first known giant isopod from the Indian Ocean.
- The finding extends the list of giant isopods even further.
The ocean depths are home to many creatures that some consider to be unnatural.
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMzU2NzY4My9vcmlnaW4ucG5nIiwiZXhwaXJlc19hdCI6MTYxNTUwMzg0NX0.BTK3zVeXxoduyvXfsvp4QH40_9POsrgca_W5CQpjVtw/img.png?width=980" id="b6fb0" class="rm-shortcode" data-rm-shortcode-id="2739ec50d9f9a3bd0058f937b6d447ac" data-rm-shortcode-name="rebelmouse-image" data-width="1512" data-height="2224" />Bathynomus raksasa specimen (left) next to a closely related supergiant isopod, B. giganteus (right)
<p>According to<a href="https://www.livescience.com/supergiant-isopod-newfound-species.html" target="_blank" rel="dofollow"> LiveScience</a>, the Bathynomus genus is sometimes referred to as "Darth Vader of the Seas" because the crustaceans are shaped like the character's menacing helmet. Deemed Bathynomus raksasa ("raksasa" meaning "giant" in Indonesian), this cockroach-like creature can grow to over 30 cm (12 inches). It is one of several known species of giant ocean-going isopod. Like the other members of its order, it has compound eyes, seven body segments, two pairs of antennae, and four sets of <a href="https://www.livescience.com/supergiant-isopod-newfound-species.html" target="_blank" rel="noopener noreferrer dofollow">jaws</a>.</p><p>The incredible size of this species is likely a result of deep-sea gigantism. This is the tendency for creatures that inhabit deeper parts of the ocean to be much larger than closely related species that live in shallower waters. B. raksasa appears to make its home between 950 and 1,260 meters (3,117 and 4,134 ft) below sea <a href="https://news.nus.edu.sg/research/new-species-supergiant-isopod-uncovered" target="_blank" rel="noopener noreferrer dofollow">level</a>. </p><p>Perhaps fittingly for a creature so creepy looking, that is the lower sections of what is commonly called <a href="https://en.wikipedia.org/wiki/Mesopelagic_zone" target="_blank" rel="noopener noreferrer dofollow">The Twilight Zone</a><em>, </em>named for the lack of light available at such depths. </p><p>It isn't the only giant isopod, <a href="https://en.wikipedia.org/wiki/Giant_isopod" target="_blank">far from it</a>. Other species of ocean-going isopod can get up to 50 cm long (20 inches) and also look like they came out of a nightmare. These are the unusual ones, though. Most of the time, isopods stay at much more reasonable <a href="https://indianexpress.com/article/explained/explained-raksasa-cockroach-from-the-deep-the-stuff-nightmares-are-made-of-6513281/" target="_blank" rel="noopener noreferrer dofollow">sizes</a>. </p><p>The discovery of this new species was published in <a href="https://zookeys.pensoft.net/article/53906/" target="_blank" rel="noopener noreferrer dofollow">ZooKeys</a>. The remainder of the specimens from the trip are still being analyzed. The full report will be published <a href="https://www.futurity.org/deep-sea-giant-isopod-bathynomus-raksasa-2422042/" target="_blank" rel="noopener noreferrer dofollow">shortly</a>.<em> </em></p>What benefit does this find have for science? And is it as evil as it looks?
<div class="rm-shortcode" data-media_id="7XqcvwWp" data-player_id="FvQKszTI" data-rm-shortcode-id="8506fcd195866131efb93525ae42dec4"> <div id="botr_7XqcvwWp_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/7XqcvwWp-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/7XqcvwWp-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/7XqcvwWp-FvQKszTI.js"></script> </div> <p>The discovery of a new species is always a cause for celebration in zoology. That this is the discovery of an animal that inhabits the deeps of the sea, one of the least explored areas humans can get to, is the icing on the cake.</p><p>Helen Wong of the National University of Singapore, who co-authored the species' description, explained the importance of the discovery:</p><p>"The identification of this new species is an indication of just how little we know about the oceans. There is certainly more for us to explore in terms of biodiversity in the deep sea of our region." </p><p>The animal's visual similarity to Darth Vader is a result of its compound eyes and the curious shape of its <a href="https://lkcnhm.nus.edu.sg/research/sjades2018/" target="_blank" rel="noopener noreferrer dofollow" style="">head</a>. However, given the location of its discovery, the bottom of the remote seas, it may be associated with all manner of horrifically evil Elder Things and <a href="https://en.wikipedia.org/wiki/Cthulhu" target="_blank" rel="dofollow">Great Old Ones</a>. <em></em></p>These are the world’s greatest threats in 2021
We look back at a year ravaged by a global pandemic, economic downturn, political turmoil and the ever-worsening climate crisis.
Billions are at risk of missing out on the digital leap forward, as growing disparities challenge the social fabric.
Image: Global Risks Report 2021
<h3>Widespread effects</h3><p>"The immediate human and economic costs of COVID-19 are severe," the report says. "They threaten to scale back years of progress on reducing global poverty and inequality and further damage social cohesion and global cooperation."</p><p>For those reasons, the pandemic demonstrates why infectious diseases hits the top of the impact list. Not only has COVID-19 led to widespread loss of life, it is holding back economic development in some of the poorest parts of the world, while amplifying wealth inequalities across the globe.</p><p>At the same time, there are concerns the fight against the pandemic is taking resources away from other critical health challenges - including a <a href="https://www.weforum.org/agenda/2020/09/charts-covid19-malnutrition-educaion-mental-health-children-world/" target="_blank" rel="noopener noreferrer">disruption to measles vaccination programmes</a>.</p>Columbia study finds new way to extract energy from black holes
A new study explains how a chaotic region just outside a black hole's event horizon might provide a virtually endless supply of energy.
- In 1969, the physicist Roger Penrose first proposed a way in which it might be possible to extract energy from a black hole.
- A new study builds upon similar ideas to describe how chaotic magnetic activity in the ergosphere of a black hole may produce vast amounts of energy, which could potentially be harvested.
- The findings suggest that, in the very distant future, it may be possible for a civilization to survive by harnessing the energy of a black hole rather than a star.
The ergosphere
<p>The ergosphere is a region just outside a black hole's event horizon, the boundary of a black hole beyond which nothing, not even light, can escape. But light and matter just outside the event horizon, in the ergosphere, would also be affected by the immense gravity of the black hole. Objects in this zone would spin in the same direction as the black hole at incredibly fast speeds, similar to objects floating around the center of a whirlpool.</p><p>The Penrose process states, in simple terms, that an object could enter the ergosphere and break into two pieces. One piece would head toward the event horizon, swallowed by the black hole. But if the other piece managed to escape the ergosphere, it could emerge with more energy than it entered with.</p><p>The movie "Interstellar" provides an example of the Penrose process. Facing a fuel shortage on a deep-space mission, the crew makes a last-ditch effort to return home by entering the ergosphere of a blackhole, ditching part of their spacecraft, and "slingshotting" away from the black hole with vast amounts of energy.</p><p>In a recent study published in the American Physical Society's <a href="https://journals.aps.org/prd/abstract/10.1103/PhysRevD.103.023014" target="_blank" style="">Physical Review D</a><em>, </em>physicists Luca Comisso and Felipe A. Asenjo used similar ideas to describe another way energy could be extracted from a black hole. The idea centers on the magnetic fields of black holes.</p><p style="margin-left: 20px;">"Black holes are commonly surrounded by a hot 'soup' of plasma particles that carry a magnetic field," Comisso, a research scientist at Columbia University and lead study author, told <a href="https://news.columbia.edu/energy-particles-magnetic-fields-black-holes" target="_blank" rel="noopener noreferrer">Columbia News</a>.</p>Ergosphere representation
<p>In the ergosphere of a rotating black hole, magnetic field lines are constantly breaking and reconnecting at fast speeds. The researchers theorized that when these lines reconnect, plasma particles shoot out in two different directions. One flow of particles shoots off against the direction of the spinning black hole, eventually getting "swallowed" by the black hole. But the other flow shoots in the same direction as the spin, potentially gaining enough velocity to escape the black hole's gravitational pull.</p><p>The researchers proposed that this occurs because the breaking and reconnecting of magnetic field lines can generate negative-energy particles. If the negative-energy particles get "swallowed" by the black hole, the positive particles would theoretically be exponentially accelerated.</p><p style="margin-left: 20px;">"Our theory shows that when magnetic field lines disconnect and reconnect, in just the right way, they can accelerate plasma particles to negative energies and large amounts of black hole energy can be extracted," Comisso said. "It is like a person could lose weight by eating candy with negative calories."</p>Black hole
Event Horizon Telescope Collaboration
<p>While there might not be immediate applications for the theory, it could help scientists better understand and observe black holes. On an abstract level, the findings may expand the limits of what scientists imagine is possible in deep space.</p><p style="margin-left: 20px;">"Thousands or millions of years from now, humanity might be able to survive around a black hole without harnessing energy from stars," Comisso said. "It is essentially a technological problem. If we look at the physics, there is nothing that prevents it."</p>A psychiatric diagnosis can be more than an unkind ‘label’
A popular and longstanding wave of thought in psychology and psychotherapy is that diagnosis is not relevant for practitioners in those fields.
