- New research from Imperial College London investigated the psychological effects of microdosing LSD in 191 volunteers.
- While microdosers experienced beneficial mental health effects, the placebo group performed statistically similar to those who took LSD.
- Researchers believe the expectation of a trip could produce some of the same sensations as actually ingesting psychedelics.
Swiss physician Paracelsus knew chemicals that heal in small doses can be toxic in large doses. The 16th-century "father of toxicology" spent his career investigating the effects of chemistry on human biology—and consciousness.
Psychedelics offer some of the most profound changes in consciousness known to humankind. As with the work of iatrochemists (chemists that provide chemical treatments for disease, a discipline vocally championed by Paracelsus), modern researchers recognize that understanding the dosage requirements of psychedelics is essential for determining efficacy. While overdosing can be psychologically damaging, psychedelics are generally not deadly, making them ideal for study.
Most people don't worry about overdoing LSD or psilocybin, however. The current trend is almost homeopathic in nature. Microdosing has become the productivity pastime of the Silicon Valley set, with knowledge workers swearing that minute quantities of LSD help them focus. Given the legal status of psychedelics, however, research has been scarce, though growing.
Imperial College London's Centre for Psychedelic Research has led the way in clinical trials. Director Robin Carhart-Harris has published over 100 papers on the effects of psychedelics on a variety of mental health issues. The center recently produced one of the first large-scale studies on microdosing, with a caveat—the psychedelics were self-supplied (to skirt legal issues) and the psychological results self-reported.
Psychedelics: The scientific renaissance of mind-altering drugs
For the study published in eLife, the team recruited 191 citizen cosmonauts to microdose either LSD or a placebo over the course of several weeks and note the psychological effects. Volunteers were already microdosing LSD, so there was no true control. Each volunteer was given instructions on creating their own low-dose gel capsules, some containing LSD, others not. Then they mixed the capsules in envelopes so they didn't know if they were taking the real thing or not.
The trial design was ingenious: each capsule featured a QR code that was scanned after the addition of ingredients but before they were placed in the envelope so that researchers knew what they were ingesting.
The problem: volunteers sourced their own LSD. Lack of quality control could have had a profound effect on the results.
The results: LSD microdosers reported feeling more mindful, satisfied with life, and better overall; they also noticed a reduction in feelings of paranoia.
The catch: the control group felt the same thing, with no statistical difference between the groups.
Lead author Balázs Szigeti comments on the findings: "This suggests that the improvements may not be due to the pharmacological action of the drug but can instead be explained by the placebo effect."
Credit: Alexander / Adobe Stock
Psychedelics are notoriously difficult to control for given the intensity of the experience. Yet there is precedent for the above findings. A 2019 study found that 61 percent of volunteers that took a placebo instead of psilocybin felt some psychedelic effects, with a few volunteers experiencing full-on trips.
"Several stated that they saw the paintings on the walls 'move' or 'reshape' themselves, others felt 'heavy. . . as if gravity [had] a stronger hold', and one had a 'come down' before another 'wave' hit her."
The Imperial team believes the expectation of a trip might have been enough to produce similar results. Senior author David Erritzoe is excited for future studies on the topic, believing they tapped into a new wave of citizen science that could push forward our knowledge of psychedelic substances.
"Accounting for the placebo effect is important when assessing trends such as the use of cannabidiol oils, fad diets or supplements where social pressure or users' expectations can lead to a strong placebo response. Self-blinding citizen science initiatives could be used as an inexpensive, initial screening tool before launching expensive clinical studies."
As investments into the psychedelics market explode, with one company reaching a $2 billion valuation, a recurring irony appears in the long arc of psychedelics and research: the power of our minds might be enough to feel greater life satisfaction and a deeper sense of mindfulness. If that's possible with a placebo, we have to question why the rush to create more pharmacology is necessary.
This is, mind you, a separate conversation over the role of psychedelics and rituals for group bonding. The function of group cohesion around consciousness-altering substances will continue to play an important role in many communities.
Of course, we should continue to explore the efficacy of psychedelics on anxiety, depression, suicidal ideation, PTSD, and addiction. Pharmacological dependence is a stain on the psychiatry industry. Whether or not psychedelics can be prescribed for daily use remains to be seen, but we know a moneyed interest is expecting a return on investment—the above company, ATAI Life Sciences, raised $157 million in its Series D round.
When it comes to wellbeing, some things money just can't buy. How we navigate the tricky terrain of mainstreaming psychedelics remains to be seen.
--
Stay in touch with Derek on Twitter and Facebook. His most recent book is "Hero's Dose: The Case For Psychedelics in Ritual and Therapy."
U.S. Navy ships
The U.S. Navy controls patents for some futuristic and outlandish technologies, some of which, dubbed "the UFO patents," came to light recently. Of particular note are inventions by the somewhat mysterious Dr. Salvatore Cezar Pais, whose tech claims to be able to "engineer reality." His slate of highly-ambitious, borderline sci-fi designs meant for use by the U.S. government range from gravitational wave generators and compact fusion reactors to next-gen hybrid aerospace-underwater crafts with revolutionary propulsion systems, and beyond.
Of course, the existence of patents does not mean these technologies have actually been created, but there is evidence that some demonstrations of operability have been successfully carried out. As investigated and reported by The War Zone, a possible reason why some of the patents may have been taken on by the Navy is that the Chinese military may also be developing similar advanced gadgets.
Among Dr. Pais's patents are designs, approved in 2018, for an aerospace-underwater craft of incredible speed and maneuverability. This cone-shaped vehicle can potentially fly just as well anywhere it may be, whether air, water or space, without leaving any heat signatures. It can achieve this by creating a quantum vacuum around itself with a very dense polarized energy field. This vacuum would allow it to repel any molecule the craft comes in contact with, no matter the medium. Manipulating "quantum field fluctuations in the local vacuum energy state," would help reduce the craft's inertia. The polarized vacuum would dramatically decrease any elemental resistance and lead to "extreme speeds," claims the paper.
Not only that, if the vacuum-creating technology can be engineered, we'd also be able to "engineer the fabric of our reality at the most fundamental level," states the patent. This would lead to major advancements in aerospace propulsion and generating power. Not to mention other reality-changing outcomes that come to mind.
Among Pais's other patents are inventions that stem from similar thinking, outlining pieces of technology necessary to make his creations come to fruition. His paper presented in 2019, titled "Room Temperature Superconducting System for Use on a Hybrid Aerospace Undersea Craft," proposes a system that can achieve superconductivity at room temperatures. This would become "a highly disruptive technology, capable of a total paradigm change in Science and Technology," conveys Pais.
High frequency gravitational wave generator.
Credit: Dr. Salvatore Pais
Another invention devised by Pais is an electromagnetic field generator that could generate "an impenetrable defensive shield to sea and land as well as space-based military and civilian assets." This shield could protect from threats like anti-ship ballistic missiles, cruise missiles that evade radar, coronal mass ejections, military satellites, and even asteroids.
Dr. Pais's ideas center around the phenomenon he dubbed "The Pais Effect". He referred to it in his writings as the "controlled motion of electrically charged matter (from solid to plasma) via accelerated spin and/or accelerated vibration under rapid (yet smooth) acceleration-deceleration-acceleration transients." In less jargon-heavy terms, Pais claims to have figured out how to spin electromagnetic fields in order to contain a fusion reaction – an accomplishment that would lead to a tremendous change in power consumption and an abundance of energy.
According to his bio in a recently published paper on a new Plasma Compression Fusion Device, which could transform energy production, Dr. Pais is a mechanical and aerospace engineer working at the Naval Air Warfare Center Aircraft Division (NAWCAD), which is headquartered in Patuxent River, Maryland. Holding a Ph.D. from Case Western Reserve University in Cleveland, Ohio, Pais was a NASA Research Fellow and worked with Northrop Grumman Aerospace Systems. His current Department of Defense work involves his "advanced knowledge of theory, analysis, and modern experimental and computational methods in aerodynamics, along with an understanding of air-vehicle and missile design, especially in the domain of hypersonic power plant and vehicle design." He also has expert knowledge of electrooptics, emerging quantum technologies (laser power generation in particular), high-energy electromagnetic field generation, and the "breakthrough field of room temperature superconductivity, as related to advanced field propulsion."
Suffice it to say, with such a list of research credentials that would make Nikola Tesla proud, Dr. Pais seems well-positioned to carry out groundbreaking work.
A craft using an inertial mass reduction device.
Credit: Salvatore Pais
The patents won't necessarily lead to these technologies ever seeing the light of day. The research has its share of detractors and nonbelievers among other scientists, who think the amount of energy required for the fields described by Pais and his ideas on electromagnetic propulsions are well beyond the scope of current tech and are nearly impossible. Yet investigators at The War Zone found comments from Navy officials that indicate the inventions are being looked at seriously enough, and some tests are taking place.
If you'd like to read through Pais's patents yourself, check them out here.
Laser Augmented Turbojet Propulsion System
Credit: Dr. Salvatore Pais
Holding a clipboard and wearing a lab coat makes you a very powerful person. Add in a lanyard and a confident voice, and you're pretty much in Ocean's Eleven.
Though we believe ourselves to be contrarians, most of us like to obey authority. We answer questions, help with any number of tasks, and obey commands unthinkingly. The vast majority of the time, this is relatively harmless and even requisite for a functioning society, but it can also lead humanity to very dark places.
It could happen here
As we've seen with Asch's experiments on conformity, the post-World War II community was determined to answer how and why the Holocaust took place. Just after the trial of Adolf Eichmann, the American media and public came to see German society as some special kind of monster in just how willing they were to follow orders unthinkingly, at odds with any sense of duty or morality.
Into this came Stanley Milgram. In 1961, Milgram set out a series of experiments to show, in his view, how the German people were more susceptible to authoritarianism than Americans. Milgram believed, as a lot of people did, that the American people would never be capable of such horrendous evil.
The experiment was to be set up in two stages: the first would be on American subjects, to gauge how far they would obey orders; the second would be on Germans, to prove how much they differed. The results stopped Milgram in his tracks.
Shock, shock, horror
Milgram wanted to ensure that his experiment involved as broad and diverse a group of people as possible. In addition to testing the American vs. German mindset, he wanted to see how much age, education, employment, and so on affected a person's willingness to obey orders.
So, the original 40 participants he gathered came from a wide spectrum of society, and each was told that they were to take part in a "memory test." They were to determine the extent to which punishment affects learning and the ability to memorize.
Milgram believed, as a lot of people did, that the American people would never be capable of such horrendous evil.
The experiment involved three people. First, there was the "experimenter," dressed in a lab coat, who gave instructions and prompts. Second, there was an actor who was the "learner." Third, there was the participant who thought that they were acting as the "teacher" in the memory test. The apparent experimental setup was that the learner had to match two words together after being taught them, and whenever they got the answer wrong, the teacher had to administer an electric shock. (The teachers (participants) were shocked as well to let them know what kind of pain the learner would experience.) At first, the shock was set at 15 volts.
The learner (actor) repeatedly made mistakes for each study, and the teacher was told to increase the voltage each time. A tape recorder was played that had the learner (apparently) make sounds as if in pain. As it went on, the learner would plead and beg for the shocks to stop. The teacher was told to increase the amount of voltage as punishment up to a level that was explicitly described as being fatal — not least because the learner was desperately saying he had a heart condition.
The question Milgram wanted to know: how far would his participants go?
Just obeying orders
Credit: Amos from Stockphotos.com via Unsplash
The results were surprising. Sixty-five percent of the participants were willing to give a 450-volt shock described as lethal, and all administered a 300-volt shock described as traumatically painful. It should be repeated, this occurred despite the learner (actor) begging the teacher (participant) to stop.
In the studies that came after, in a variety of different setups, that 60 percent number came up again and again. They showed that roughly two out of three people would be willing to kill someone if told to by an authority figure. Milgram proved that all genders, ages, and nationalities were depressingly capable of inflicting incredible pain or worse on innocent people.
Major limitations in Milgram's experiment
Milgram took many steps to make sure that his experiment was rigorous and fair. He used the same tape recording of the "learner" screaming, begging, and pleading for all participants. He made sure the experimenters used only the same four prompts each time when the participants were reluctant or wanted to stop. He even made sure that he himself was not present at the experiment, lest he interfere with the procedure (something Phillip Zimbardo did not do).
But, does the Milgram experiment actually prove what we think it does?
First, the experimenters were permitted to remind the participants that they were not responsible for what they did and that the team would take full blame. This, of course, does not make the study any less shocking, but it does perhaps change the scope of the conclusions. Perhaps the experiment reveals more about our ability to surrender responsibility and our willingness simply to become a tool. The conclusion is still pretty depressing, but it shows what we are capable of when offered absolution rather than when simply following orders.
Second, the experiment took place in a single hour, with very little time either to deliberate or talk things over with someone. In most situations, like the Holocaust, the perpetrators had ample time (years) to reflect on their actions, and yet, they still chose to turn up every day. Milgram perhaps highlights only how far we'll go in the heat of the moment.
Finally, the findings do not tell the whole tale. The participants were not engaging in sadistic glee to shock the learner. They all showed signs of serious distress and anxiety, such as nervous laughing fits. Some even had seizures. These were not willing accomplices but participants essentially forced to act a certain way. (Since then, many scientists have argued that Milgram's experiment is hugely unethical.)
The power of authority
That all being said, there's a reason why Milgram's experiment stays with us today. Whether it's evolutionarily or socially drilled into us, it seems that humans are capable of doing terrible things, if only we are told to do so by someone in power — or, at the very least, when we don't feel responsible for the consequences.
One silver lining to Milgram is in how it can inoculate us against such drone-like behavior. It can help us to resist. Simply knowing how far we can be manipulated helps allow us to say, "No."
Jonny Thomson teaches philosophy in Oxford. He runs a popular Instagram account called Mini Philosophy (@philosophyminis). His first book is Mini Philosophy: A Small Book of Big Ideas.
