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What an Anti-Memory Is and How It Frees Your Mind
Wonder how your brain makes space for new memories? Scientists at Oxford just discovered how.
Neuroscientists at Oxford just discovered how your brain moves memories into long-term storage. It’s called an anti-memory, and it’s more helpful than it sounds.
Memories, at their most basic, are electrical impulses. But what happens if those impulses are always firing? Would they overload your brain the same way that running too many programs on your computer would fry its RAM? The answer is yes. Scientists think that these overly excited neurons could be the culprits behind conditions like epilepsy, schizophrenia, and autism. The balancing agent that keeps that from happening are anti-memories.
Think of them as defragging a memory’s RAM. Anti-memories are neurons that lower the electrical activity generated by memory creation. Anti-memories work together with memories to keep the brain from getting overloaded. They don’t affect memories; they just silence the process running them so your brain can do other things.
When you form a memory, your brain assembles it from different parts of your brain, rebuilding it each time from scratch. There are three steps to building a memory -- encoding it (intentionally committing it to memory), consolidating it (different parts of the brain acting gluing the memory together) and retrieving it (recalling the memory). Every time you retrieve a memory, you increase your brain’s ability to recall it by strengthening the neural pathway to that memory. That makes the memory stronger and easier to recall in the long run. Here’s a quick primer:
Credit: Head Squeeze, Brit Lab/YouTube
Anti-memories work in the same way, just in reverse. Scientists had long theorized their existence from models and studies on mice. Neurologists at the University of Oxford were finally able to observe them in humans with this experiment, whose findings were published in the journal Neuron. Lead author Helen Barron explains the process in a press release:
To measure these links, or associative memories, we use a technique called repetition suppression where repeated exposure to a stimulus – the shapes in this case – causes decreasing activity in the area of the brain that represents shapes. By looking at these suppression effects across different stimuli we can use this approach to identify where memories are stored.
The memory paths identified in the study. Credit: Neuron
The researchers were able to do this by observing participants’ brain activity as they memorized the shapes using functional magnetic resonance imaging (fMRI). Over time, the anti-memory neurons kicked in and blocked the memories of the shapes. “Over 24 hours, the shape associations in the brain became silent,” said Barron. Most interestingly, they didn’t look like additional memories; they looked like an absence of brain activity. They're not - they're just active on the same neural path. Think of it as someone retracing their steps, like this:
"The Shining" via GIPHY
That could have been because the brain was rebalanced or it could simply be that the associations were forgotten. The following day, some of the volunteers undertook additional tests to confirm that the silencing was a consequence of rebalancing. If the memories were present but silenced by inhibitory replicas, we thought that it should be possible to re-express the memories by suppressing inhibitory activity.
In order to re-express the memories, researchers used transcranial direct current stimulation (tDCS) to apply a low current of electricity to the volunteers’ brains. By doing this, the researchers reduced the activity of the anti-memory neurons -- and the memories of the shape associations came back.
"This result is consistent with a balancing mechanism,” Barron says. “The increase in excitation seen in learning and memory formation, when excitatory connections are strengthened, appears to be balanced out by a strengthening of inhibitory connections."
While the sample size for this study was small, the research team has big hopes for their findings. "The paradigm has the potential to be translated directly into patient populations, including those suffering from schizophrenia and autism," said Barron. "We hope that this research can now be taken forward in collaboration with psychiatrists and patient populations so that we can develop and apply this new understanding to the diagnosis and treatment of mental disorders."
So do we.
The young man died nearly 2,000 years ago in the volcanic eruption that buried Pompeii.
- A team of researchers in Italy discovered the intact brain cells of a young man who died in the Mount Vesuvius eruption in A.D. 79.
- The brain's cell structure was visible to researchers (who used an electron microscope) in a glassy, black material found inside the man's skull.
- The material was likely the victim's brain preserved through the process of vitrification in which the intense heat followed by rapid cooling turned the organ to glass.
Almost 2,000 years ago, Mount Vesuvius — located on the gulf of what is today Naples in Campania, Italy — erupted, burying the ancient cities of Herculaneum and Pompeii beneath hot ash.
Recently, a team of researchers in Italy discovered the intact brain cells of a young man who died in the disaster in A.D. 79. The team studied remains that were first unearthed in the 1960s from Herculaneum, a city once nestled into the shadow of Mount Vesuvius. The man was around 25 years old when he perished and was discovered lying face-down on a wooden bed in Herculaneum's Collegium Augustalium (the College of the Augustales), located near the city's main street. The building was the headquarters of the cult of Emperor Augustus who was worshipped as a deity, a common Roman tradition at the time.
Discovery of cells
Electron microscope image of brain axons.
Credit: PLOS ONE
Now, subsequent research has described how the researchers, using an electron microscope, discovered cells in the vitrified brain. According to Petrone they were "incredibly well preserved with a resolution that is impossible to find anywhere else." Additionally, the team used another method called energy-dispersive X-ray spectroscopy to determine the chemical compounds of the glassy material. The sample was rich in carbon and oxygen, which indicates that it was organic. The researchers compared those ancient proteins to a database of proteins found in the human brain, and found that all of the discovered proteins are indeed present in human brain tissue.
Additionally, Petrone and his team suspect they also discovered vitrified nerve cells in the ancient victim's spinal cord and cerebellum based on the position of the sample in the mind of the skull and the concentration of the proteins.
These impeccable preservations of brain tissue are unprecedented and will undoubtedly open the door to new and exciting research opportunities on these ancient people and civilizations that weren't possible until now.
The Italian research team will continue to study the remains to learn more about the vitrification process, including the precise temperatures the victims were exposed to and the cooling rate of the ash. They also, according to Petrone, want to analyze proteins from the remains and their related genes.
New data have set the particle physics community abuzz.
- The first question ever asked in Western philosophy, "What's the world made of?" continues to inspire high energy physicists.
- New experimental results probing the magnetic properties of the muon, a heavier cousin of the electron, seem to indicate that new particles of nature may exist, potentially shedding light on the mystery of dark matter.
- The results are a celebration of the human spirit and our insatiable curiosity to understand the world and our place in it.
If brute force doesn't work, then look into the peculiarities of nothingness. This may sound like a Zen koan, but it's actually the strategy that particle physicists are using to find physics beyond the Standard Model, the current registry of all known particles and their interactions. Instead of the usual colliding experiments that smash particles against one another, exciting new results indicate that new vistas into exotic kinds of matter may be glimpsed by carefully measuring the properties of the quantum vacuum. There's a lot to unpack here, so let's go piecemeal.
It is fitting that the first question asked in Western philosophy concerned the material composition of the world. Writing around 350 BCE, Aristotle credited Thales of Miletus (circa 600 BCE) with the honor of being the first Western philosopher when he asked the question, "What is the world made of?" What modern high energy physicists do, albeit with very different methodology and equipment, is to follow along the same philosophical tradition of trying to answer this question, assuming that there are indivisible bricks of matter called elementary particles.
Deficits in the Standard Model
Jumping thousands of years of spectacular discoveries, we now have a very neat understanding of the material composition of the world at the subatomic level: a total of 12 particles and the Higgs boson. The 12 particles of matter are divided into two groups, six leptons and six quarks. The six quarks comprise all particles that interact via the strong nuclear force, like protons and neutrons. The leptons include the familiar electron and its two heavier cousins, the muon and the tau. The muon is the star of the new experiments.
For all its glory, the Standard Model described above is incomplete. The goal of fundamental physics is to answer the most questions with the least number of assumptions. As it stands, the values of the masses of all particles are parameters that we measure in the laboratory, related to how strongly they interact with the Higgs. We don't know why some interact much stronger than others (and, as a consequence, have larger masses), why there is a prevalence of matter over antimatter, or why the universe seems to be dominated by dark matter — a kind of matter we know nothing about, apart from the fact that it's not part of the recipe included in the Standard Model. We know dark matter has mass since its gravitational effects are felt in familiar matter, the matter that makes up galaxies and stars. But we don't know what it is.
Whatever happens, new science will be learned.
Physicists had hoped that the powerful Large Hadron Collider in Switzerland would shed light on the nature of dark matter, but nothing has come up there or in many direct searches, where detectors were mounted to collect dark matter that presumably would rain down from the skies and hit particles of ordinary matter.
Could muons fill in the gaps?
Enter the muons. The hope that these particles can help solve the shortcomings of the Standard Model has two parts to it. The first is that every particle, like a muon, that has an electric charge can be pictured simplistically as a spinning sphere. Spinning spheres and disks of charge create a magnetic field perpendicular to the direction of the spin. Picture the muon as a tiny spinning top. If it's rotating counterclockwise, its magnetic field would point vertically up. (Grab a glass of water with your right hand and turn it counterclockwise. Your thumb will be pointing up, the direction of the magnetic field.) The spinning muons will be placed into a doughnut-shaped tunnel and forced to go around and around. The tunnel will have its own magnetic field that will interact with the tiny magnetic field of the muons. As the muons circle the doughnut, they will wobble about, just like spinning-tops wobble on the ground due to their interaction with Earth's gravity. The amount of wobbling depends on the magnetic properties of the muon which, in turn, depend on what's going on with the muon in space.
Credit: Fabrice Coffrini / Getty Images
This is where the second idea comes in, the quantum vacuum. In physics, there is no empty space. The so-called vacuum is actually a bubbling soup of particles that appear and disappear in fractions of a second. Everything fluctuates, as encapsulated in Heisenberg's Uncertainty Principle. Energy fluctuates too, what we call zero-point energy. Since energy and mass are interconvertible (E=mc2, remember?), these tiny fluctuations of energy can be momentarily converted into particles that pop out and back into the busy nothingness of the quantum vacuum. Every particle of matter is cloaked with these particles emerging from vacuum fluctuations. Thus, a muon is not only a muon, but a muon dressed with these extra fleeting bits of stuff. That being the case, these extra particles affect a muon's magnetic field, and thus, its wobbling properties.
About 20 years ago, physicists at the Brookhaven National Laboratory detected anomalies in the muon's magnetic properties, larger than what theory predicted. This would mean that the quantum vacuum produces particles not accounted for by the Standard Model: new physics! Fast forward to 2017, and the experiment, at four times higher sensitivity, was repeated at the Fermi National Laboratory, where yours truly was a postdoctoral fellow a while back. The first results of the Muon g-2 experiment were unveiled on 7-April-2021 and not only confirmed the existence of a magnetic moment anomaly but greatly amplified it.
To most people, the official results, published recently, don't seem so exciting: a "tension between theory and experiment of 4.2 standard deviations." The gold standard for a new discovery in particle physics is a 5-sigma variation, or one part in 3.5 million. (That is, running the experiment 3.5 million times and only observing the anomaly once.) However, that's enough for plenty of excitement in the particle physics community, given the remarkable precision of the experimental measurements.
A time for excitement?
Now, results must be reanalyzed very carefully to make sure that (1) there are no hidden experimental errors; and (2) the theoretical calculations are not off. There will be a frenzy of calculations and papers in the coming months, all trying to make sense of the results, both on the experimental and theoretical fronts. And this is exactly how it should be. Science is a community-based effort, and the work of many compete with and complete each other.
Whatever happens, new science will be learned, even if less exciting than new particles. Or maybe, new particles have been there all along, blipping in and out of existence from the quantum vacuum, waiting to be pulled out of this busy nothingness by our tenacious efforts to find out what the world is made of.
- Benjamin Franklin wrote essays on a whole range of subjects, but one of his finest was on how to be a nice, likable person.
- Franklin lists a whole series of common errors people make while in the company of others, like over-talking or storytelling.
- His simple recipe for being good company is to be genuinely interested in others and to accept them for who they are.
Think of the nicest person you know. The person who would fit into any group configuration, who no one can dislike, or who makes a room warmer and happier just by being there.
What makes them this way? Why are they so amiable, likeable, or good-natured? What is it, you think, that makes a person good company?
There are really only two things that make someone likable.
This is the kind of advice that comes from one of history's most famously good-natured thinkers: Benjamin Franklin. His essay "On Conversation" is full of practical, surprisingly modern tips about how to be a nice person.
Franklin begins by arguing that there are really only two things that make someone likable. First, they have to be genuinely interested in what others say. Second, they have to be willing "to overlook or excuse Foibles." In other words, being good company means listening to people and ignoring their faults. Being witty, well-read, intelligent, or incredibly handsome can all make a good impression, but they're nothing without these two simple rules.
The sort of person nobody likes
From here, Franklin goes on to give a list of the common errors people tend to make while in company. These are the things people do that makes us dislike them. We might even find, with a sinking feeling in our stomach, that we do some of these ourselves.
1) Talking too much and becoming a "chaos of noise and nonsense." These people invariably talk about themselves, but even if "they speak beautifully," it's still ultimately more a soliloquy than a real conversation. Franklin mentions how funny it can be to see these kinds of people come together. They "neither hear nor care what the other says; but both talk on at any rate, and never fail to part highly disgusted with each other."
2) Asking too many questions. Interrogators are those people who have an "impertinent Inquisitiveness… of ten thousand questions," and it can feel like you're caught between a psychoanalyst and a lawyer. In itself, this might not be a bad thing, but Franklin notes it's usually just from a sense of nosiness and gossip. The questions are only designed to "discover secrets…and expose the mistakes of others."
3) Storytelling. You know those people who always have a scripted story they tell at every single gathering? Utterly painful. They'll either be entirely oblivious to how little others care for their story, or they'll be aware and carry on regardless. Franklin notes, "Old Folks are most subject to this Error," which we might think is perhaps harsh, or comically honest, depending on our age.
4) Debating. Some people are always itching for a fight or debate. The "Wrangling and Disputing" types inevitably make everyone else feel like they need to watch what they say. If you give even the lightest or most modest opinion on something, "you throw them into Rage and Passion." For them, the conversation is a boxing fight, and words are punches to be thrown.
5) Misjudging. Ribbing or mocking someone should be a careful business. We must never mock "Misfortunes, Defects, or Deformities of any kind", and should always be 100% sure we won't upset anyone. If there's any doubt about how a "joke" will be taken, don't say it. Offense is easily taken and hard to forget.
On practical philosophy
Franklin's essay is a trove of great advice, and this article only touches on the major themes. It really is worth your time to read it in its entirety. As you do, it's hard not to smile along or to think, "Yes! I've been in that situation." Though the world has changed dramatically in the 300 years since Franklin's essay, much is exactly the same. Basic etiquette doesn't change.
If there's only one thing to take away from Franklin's essay, it comes at the end, where he revises his simple recipe for being nice:
"Be ever ready to hear what others say… and do not censure others, nor expose their Failings, but kindly excuse or hide them"
So, all it takes to be good company is to listen and accept someone for who they are.
Philosophy doesn't always have to be about huge questions of truth, beauty, morality, art, or meaning. Sometimes it can teach us simply how to not be a jerk.
A recent study analyzed the skulls of early Homo species to learn more about the evolution of primate brains.