New Nanotechnology Drug Busts Heart Attack-Causing Clots
Researchers have found a way to unclog obstructed blood vessels, leading to heart attacks and strokes, by the use of a low-dose drug delivery system.
Article written by guest writer Rin Mitchell
What’s the Latest Development?
Researchers have found a way to unclog obstructed blood vessels that lead to heart attacks and strokes. These obstructions can lead to shear stress, "attracting platelets that form blood clots." The body contains natural clot producing mechanisms, and scientists “used an approved clot-targeting therapy called tissue plasminogen activator, or tPA, and found that the system allowed for use of less than one-fiftieth the normal dose to dissolve clots.” Medicines used in hospitals to unclog vessels are given in larger doses, which cause serious side effects like excessive bleeding. The drug delivery method “called shear-activated nanotherapeutics, is a bundle of tiny drug-coated particles that travel together until they reach the obstruction, when the shear stress causes them to break apart and attack clots.” The low dosage required will allow more patients to be treated with the medicine.
What’s the Big Idea?
According to the Centers for Disease Control and Prevention, heart disease and stroke is one of the leading causes of death among Americans. Scientists have found ways to target platelets that form blood clots due to a force of shear stress, by the use of a low-dose drug delivery method that activates when the condition takes place. Researchers believe the system could possibly be used to deliver any drug for various diseases. However, only mice have been tested and it will be years before trial studies will be conducted on humans.
Pfizer's partnerships strengthen their ability to deliver vaccines in developing countries.
- Community healthcare workers face many challenges in their work, including often traveling far distances to see their clients
- Pfizer is helping to drive the UN's sustainable development goals through partnerships.
- Pfizer partnered with AMP and the World Health Organization to develop a training program for healthcare workers.
The best-selling author tells us his methods.
- James Patterson has sold 300 million copies of his 130 books, making him one of the most successful authors alive today.
- He talks about how some writers can overdo it by adding too much research, or worse, straying from their outline for too long.
- James' latest book, The President is Missing, co-written with former President Bill Clinton, is out now.
Progressive America would be half as big, but twice as populated as its conservative twin.
- America's two political tribes have consolidated into 'red' and 'blue' nations, with seemingly irreconcilable differences.
- Perhaps the best way to stop the infighting is to go for a divorce and give the two nations a country each
- Based on the UN's partition plan for Israel/Palestine, this proposal provides territorial contiguity and sea access to both 'red' and 'blue' America
It's the first time the association hasn't hired a comedian in 16 years.
- The 2018 WHCA ended in controversy after comedian Michelle Wolf made jokes some considered to be offensive.
- The WHCA apologized for Wolf's jokes, though some journalists and many comedians backed the comedian and decried arguments in favor of limiting the types of speech permitted at the event.
- Ron Chernow, who penned a bestselling biography of Alexander Hamilton, will speak at next year's dinner.
SMARTER FASTER trademarks owned by The Big Think, Inc. All rights reserved.