What Is Alzheimer’s Disease?
While much remains unknown about the deadly disease, advances in research have shed new light on its mechanisms, and on how dementia affects the aging brain.
Alzheimer’s disease is an incurable—and ultimately deadly—form of dementia that causes loss of memory and other cognitive abilities. A degenerative disorder, the disease unravels the fundamental functions of the brain over time, taking with it many components of personality and identity. An estimated 5.3 million people in the U.S. currently have Alzheimer's, and each year the disease ranks as the nation's sixth or seventh leading cause of death. In 2007 alone, over 74,000 Americans died from Alzheimer's.
While much remains unknown about the disease, advances in research over the past decade have shed new light on its mechanisms, and on how dementia affects the aging brain. In Big Think's "Breakthroughs: Alzheimer's Disease" panel, Dr. Samuel Gandy, associate director of the Mount Sinai Alzheimer's Disease Research Center, said that the disease is first a biochemical pathology—a deficit among brain transmitters between nerve cells—but that there also does seem to be a correlation with beta amyloid proteins that can function normally among neurons for over 50 years, then "clump and accumulate and build up and kill cells of the brain."
"Synaptic function is the key to everything," responded Dr. Ottavio Arancio, a professor at the Taub Institute for Research in Alzheimer's Disease and the Aging Brain at Columbia University. Dementia and Alzheimer's disease, he says, weaken synapses among the brain’s 100 billion nerve cells and 100 trillion neural points connection points. This weakening, he says, "is the key to understand the mystery of this disease."
Using cutting-edge genetic testing and increasingly more accurate data, researchers have linked specific genes to Alzheimer’s disease, and have determined some of the environmental and health factors which may trigger its onset. Meanwhile, rapidly advancing neuroimaging techniques are allowing us to understand how the disease deposits its dangerous plaques and tangled strands of protein into the brain. These deposits choke brain cells, impairing their ability to form new memories and to store old ones. Eventual death from the disease comes as the brain chokes on the debris and half-dissolved remains of dead neurons.
But even with all this information—a list of potential predispositions and a map of how the disease progresses—we still don’t know why some people get Alzheimer’s disease and others with latent triggers do not. We still do not know what Alzheimer’s disease is, and we do not know where the key connection is that might turn the disease on or off.
Finding this connection is becoming ever more essential, as our population gets older and Alzheimer's reaches near-epidemic proportions. Today, one in eight people over 65 have Alzheimer’s disease, with someone new developing the disease every 33 seconds. This rate will only get worse. Beginning January 1st, 2011, a new member of the Baby Boom generation will turn 65 years old every 8 seconds—at the rate of 10,000 per day and 4 million per year. Unless research and medicine achieves real progress, Alzheimer’s disease is poised to become the malady of our age.
"We have a big problem on our hands, and the problem is diseases of aging, diseases where aging is a major component of the onset of the disease," said Dr. Leonard Guarente, Director of Glenn Lab for Science of Aging at MIT. "I would say Alzheimer's is number one on the list of diseases of aging and we really have to worry about it."
— "Alzheimer's Disease Facts and Figures 2010." Alzheimer's Association
— "Alzheimer's Disease Fast Stats." Centers for Disease Control and Prevention.
The views expressed here are solely those of the participants, and do not represent the views of Big Think or its sponsors.
The way that you think about stress can actually transform the effect that it has on you – and others.
- Stress is contagious, and the higher up in an organization you are the more your stress will be noticed and felt by others.
- Kelly McGonigal teaches "Reset your mindset to reduce stress" for Big Think Edge.
- Subscribe to Big Think Edge before we launch on March 30 to get 20% off monthly and annual memberships.
Three scientists publish paper proving that not Venus but Mercury is the closest planet to Earth
- Earth is the third planet from the Sun, so our closest neighbour must be planet two of four, right?
- Wrong! Neither Venus nor Mars is the right answer.
- Three scientists ran the numbers. In this YouTube video, one of them explains why our nearest neighbour is... Mercury!
The blood of horseshoe crabs is harvested on a massive scale in order to retrieve a cell critical to medical research. However, recent innovations might make this practice obsolete.
- Horseshoe crabs' blue blood is so valuable that a quart of it can be sold for $15,000.
- This is because it contains a molecule that is crucial to the medical research community.
- Today, however, new innovations have resulted in a synthetic substitute that may end the practice of farming horseshoe crabs for their blood.
The distance between the American dream and reality is expressed best through literature.
- Literature expands our ability to feel empathy and inspires compassion.
- These ten novels tackle some facet of the American experience.
- The list includes a fictional retelling of the first Native American to graduate from Harvard and hiding out in inner city Newark.
SMARTER FASTER trademarks owned by The Big Think, Inc. All rights reserved.