Why ET Never Calls
Peter Ward
Peter Ward conducts his research within The Environment Institute's Sprigg Geobiolgy Centre at the University of Adelaide.
Peter Ward has been active in Paleontology, Biology, and more recently, Astrobiology for more than 40 years. Since his Ph.D. in 1976, Ward has published more than 140 scientific papers dealing with paleontological, zoological, and astronomical topics.
He is an acknowledged world expert on mass extinctions and the role of extraterrestrial impacts on Earth. Ward was the Principal Investigator of the University of Washington node of the NASA Astrobiology Institute from 2001-2006, and in that capacity led a team of over 40 scientists and students. His career was profiled by the Pulitzer Prize winning reporter William Dietrich in The Seattle Times article "Prophet, Populist, Poet of Science."
Peter has written a memoir of his research on the Nautilus for Nautilus magazine's "Ingenious" feature entitled "Nautilus and me. My wonderful, dangerous life with the amazing Nautilus."
His books include the best-selling "Rare Earth: Why Complex Life Is Uncommon in the Universe" (co-author Donald Brownlee, 2000), "Under a Green Sky: Global Warming, the Mass Extinctions of the Past, and What They Can Tell Us About Our Future" (2007), and "The Medea Hypothesis: Is Life on Earth Ultimately Self-Destructive?" (2009).
Question: What do you estimate are the chances that we are the only intelligent life in the universe?
Peter Ward: I bet that’s near zero. How couldn't there be? The numbers are out there. How could there not be lots of them out there? But what is the possibility that there are so few that the distances involved make it so, not only SETI could find anybody else. I mean, SETI, we already know from the SETI work to date that there’s nobody near us. This blasting out the sort of messages that the movie “Contact” is suggesting. I mean, that’s not happening. SETI itself agrees that, gee if we don’t find anybody in the next 30-40 years, there could be a pretty good chance there’s nobody close enough to us that we would ever be able to either talk to them, let alone get out there and see them.
Question: Do you predict that humans will ever make contact with life elsewhere?
Peter Ward: I suspect the chances are that we will not, at least in the next few centuries. Perhaps our technology will get to the point that we could pinpoint, not just the immediate area, which is all that we’re good for now, and spotlight the entire galaxy. Or perhaps we’ll get good enough that we can really start looking at other galaxies. I think then we’ll start picking up evidence that there’s other life out there, but if you’re talking about places hundreds of thousands of light years away, there’s no conversation you’ll want to have waiting 100,000 years to get your response. And then it comes back to you and says, “Message garbled, please repeat.”
Question: Could the “Fermi paradox” simply stem from the difficulty of communication across vast distances?
Peter Ward: Well, it could be an aspect of communication, but it also could be just another indication that Medea is correct. The life gets going on a planet and then kills itself off through colossal blunders. A friend of mine said, I should call it the Medea Hypothesis, but evolution is more like Mr. Bean; Mr. Bean blundering into one situation after another. Let’s hey, let’s make oxygen, that’ll be cool; and then poisoning almost every bit of life around it. Or, hey let’s make photosynthesis; and then reducing carbon dioxide so much that we go into a snowball earth. Or, hey, let’s make forests; and then reducing CO2 even further and producing a gigantic, almost global ice age in the carboniferous. Let’s do this, says Mr. Bean.
Recorded on January 11, 2010
Interviewed by Austin Allen
Our inability to detect other life in the universe may stem from interstellar communication problems. Then again, it may be because Earth evolution is "like Mr. Bean."
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‘Designer baby’ book trilogy explores the moral dilemmas humans may soon create
How would the ability to genetically customize children change society? Sci-fi author Eugene Clark explores the future on our horizon in Volume I of the "Genetic Pressure" series.
18 January, 2021
Surprising Science
- A new sci-fi book series called "Genetic Pressure" explores the scientific and moral implications of a world with a burgeoning designer baby industry.
- It's currently illegal to implant genetically edited human embryos in most nations, but designer babies may someday become widespread.
- While gene-editing technology could help humans eliminate genetic diseases, some in the scientific community fear it may also usher in a new era of eugenics.
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<div class="amazon-assets-widget__title" style="display: block;">Genetic Pressure Volume I: Baby Steps</div>
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<p>Imagine it's 2045. You start hearing rumors from your well-heeled friends about a mysterious corporation based on an undisclosed island that's offering an unprecedented service: the ability to genetically design your baby.</p><p>The baby will have some of your genetics, and some genetics from a sperm or egg donor, selected by you. But the rest of your child's genetic profile will be engineered by science. These changes will make it impossible for your child to develop genetic diseases. They'll also allow you to customize your child for dozens of traits, including intelligence level, emotional disposition, sexual orientation, height, skin tone, hair color, and eye color, to name a few. </p><p>This raises unsettling philosophical questions for some customers. "When does my child stop being my child?" they ask the corporate representatives. These wary customers are reminded of how risky it is to reproduce the old-fashioned way. The Better Genetics Corporation's motto sums it up: "Only God plays dice—humans don't have to."</p><p>This is the world described in a new science-fiction series by Eugene Clark titled <a href="http://bigth.ink/38VhJn3" target="_blank" rel="noopener noreferrer">"Genetic Pressure"</a>, which explores the moral and scientific implications of a future in which designer babies are becoming a major industry. The first book begins with the story of Rachel, a renowned horse breeder who befriends a billionaire client, and soon gets the funding to visit the tropical island on which the Better Genetics Corporation is headquartered. </p><p>There, corporate executives walk her through the process of designing a baby—an experience that feels like an uncanny mix between visiting a doctor and designing a luxury car. The series is told from multiple perspectives, serving as a deep dive into a complex moral web that today's scientists may already be weaving.</p>
<blockquote>[T]he introduction of designer babies would create a labyrinth of philosophical dilemmas that society is only beginning to explore. </blockquote>
<p>Case in point: In 2018, Chinese scientist He Jiankui announced that he had helped create the world's first genetically engineered babies. Using the gene-editing tool CRISPR on embryos, He Jiankui modified a gene called <a href="https://ghr.nlm.nih.gov/gene/CCR5" target="_blank">CCR5</a>, which enables HIV to enter and infect immune system cells. His goal was to engineer children that were immune to the virus.</p><p>It's unclear whether he succeeded. But what's certain is that the experiment shocked the international scientific community, which generally agreed that it's unethical to conduct gene-editing procedures on humans, given that scientists don't yet fully understand the consequences.</p><p>"This experiment is monstrous," Julian Savulescu, a professor of practical ethics at the University of Oxford, told <a href="https://www.theguardian.com/science/2018/nov/26/worlds-first-gene-edited-babies-created-in-china-claims-scientist" target="_blank"><em>The Guardian</em></a>. "The embryos were healthy. No known diseases. Gene editing itself is experimental and is still associated with off-target mutations, capable of causing genetic problems early and later in life, including the development of cancer."</p><p>Importantly, He Jiankui wasn't treating a disease, but rather genetically engineering babies to prevent the future contraction of a virus. These kinds of changes are heritable, meaning the experiment could have major downstream effects on future generations. So, too, would a designer-baby industry, even if scientists can do it safely.</p><p>With major implications on inequality, discrimination, sexuality, and our conceptions of life, the introduction of designer babies would create a labyrinth of philosophical dilemmas that society is only beginning to explore. </p>
<a href="http://bigth.ink/38VhJn3" ><img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNTI2MTEzNi9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY0NDcxMzY4M30.5fwCPH_6sQ0RF19aAH4FQFue9HFJykzdEc0Xka1TY04/img.jpg?width=980" id="affdd" class="rm-shortcode" data-rm-shortcode-id="76374e8775bd9441a338cf513bb1fa55" data-rm-shortcode-name="rebelmouse-image" data-width="924" data-height="520" /></a>
Tribalism and discrimination
<p>One question the "Genetic Pressure" series explores: What would tribalism and discrimination look like in a world with designer babies? As designer babies grow up, they could be noticeably different from other people, potentially being smarter, more attractive and healthier. This could breed resentment between the groups—as it does in the series.</p><p>"[Designer babies] slowly find that 'everyone else,' and even their own parents, becomes less and less tolerable," author Eugene Clark told Big Think. "Meanwhile, everyone else slowly feels threatened by the designer babies."</p><p>For example, one character in the series who was born a designer baby faces discrimination and harassment from "normal people"—they call her "soulless" and say she was "made in a factory," a "consumer product." </p><p>Would such divisions emerge in the real world? The answer may depend on who's able to afford designer baby services. If it's only the ultra-wealthy, then it's easy to imagine how being a designer baby could be seen by society as a kind of hyper-privilege, which designer babies would have to reckon with. </p><p>Even if people from all socioeconomic backgrounds can someday afford designer babies, people born designer babies may struggle with tough existential questions: Can they ever take full credit for things they achieve, or were they born with an unfair advantage? To what extent should they spend their lives helping the less fortunate? </p>Sexuality dilemmas
<p>Sexuality presents another set of thorny questions. If a designer baby industry someday allows people to optimize humans for attractiveness, designer babies could grow up to find themselves surrounded by ultra-attractive people. That may not sound like a big problem.</p><p>But consider that, if designer babies someday become the standard way to have children, there'd necessarily be a years-long gap in which only some people are having designer babies. Meanwhile, the rest of society would be having children the old-fashioned way. So, in terms of attractiveness, society could see increasingly apparent disparities in physical appearances between the two groups. "Normal people" could begin to seem increasingly ugly.</p><p>But ultra-attractive people who were born designer babies could face problems, too. One could be the loss of body image. </p><p>When designer babies grow up in the "Genetic Pressure" series, men look like all the other men, and women look like all the other women. This homogeneity of physical appearance occurs because parents of designer babies start following trends, all choosing similar traits for their children: tall, athletic build, olive skin, etc. </p><p>Sure, facial traits remain relatively unique, but everyone's more or less equally attractive. And this causes strange changes to sexual preferences.</p><p>"In a society of sexual equals, they start looking for other differentiators," he said, noting that violet-colored eyes become a rare trait that genetically engineered humans find especially attractive in the series.</p><p>But what about sexual relationships between genetically engineered humans and "normal" people? In the "Genetic Pressure" series, many "normal" people want to have kids with (or at least have sex with) genetically engineered humans. But a minority of engineered humans oppose breeding with "normal" people, and this leads to an ideology that considers engineered humans to be racially supreme. </p>Regulating designer babies
<p>On a policy level, there are many open questions about how governments might legislate a world with designer babies. But it's not totally new territory, considering the West's dark history of eugenics experiments.</p><p>In the 20th century, the U.S. conducted multiple eugenics programs, including immigration restrictions based on genetic inferiority and forced sterilizations. In 1927, for example, the Supreme Court ruled that forcibly sterilizing the mentally handicapped didn't violate the Constitution. Supreme Court Justice Oliver Wendall Holmes wrote, "… three generations of imbeciles are enough." </p><p>After the Holocaust, eugenics programs became increasingly taboo and regulated in the U.S. (though some states continued forced sterilizations <a href="https://www.uvm.edu/~lkaelber/eugenics/" target="_blank">into the 1970s</a>). In recent years, some policymakers and scientists have expressed concerns about how gene-editing technologies could reanimate the eugenics nightmares of the 20th century. </p><p>Currently, the U.S. doesn't explicitly ban human germline genetic editing on the federal level, but a combination of laws effectively render it <a href="https://academic.oup.com/jlb/advance-article/doi/10.1093/jlb/lsaa006/5841599#204481018" target="_blank" rel="noopener noreferrer">illegal to implant a genetically modified embryo</a>. Part of the reason is that scientists still aren't sure of the unintended consequences of new gene-editing technologies. </p><p>But there are also concerns that these technologies could usher in a new era of eugenics. After all, the function of a designer baby industry, like the one in the "Genetic Pressure" series, wouldn't necessarily be limited to eliminating genetic diseases; it could also work to increase the occurrence of "desirable" traits. </p><p>If the industry did that, it'd effectively signal that the <em>opposites of those traits are undesirable. </em>As the International Bioethics Committee <a href="https://academic.oup.com/jlb/advance-article/doi/10.1093/jlb/lsaa006/5841599#204481018" target="_blank" rel="noopener noreferrer">wrote</a>, this would "jeopardize the inherent and therefore equal dignity of all human beings and renew eugenics, disguised as the fulfillment of the wish for a better, improved life."</p><p><em>"Genetic Pressure Volume I: Baby Steps"</em><em> by Eugene Clark is <a href="http://bigth.ink/38VhJn3" target="_blank">available now.</a></em></p>
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A psychiatric diagnosis can be more than an unkind ‘label’
A popular and longstanding wave of thought in psychology and psychotherapy is that diagnosis is not relevant for practitioners in those fields.
19 January, 2021
Chris J Ratcliffe/Getty Images for Sotheby's
Mind & Brain
When I was training as a clinical psychologist, I had a rotation in a low-cost psychotherapy clinic.
<p> Among the first people I met was a young man who believed that he might be responsible for harm coming to his family if he didn't engage in time-consuming rituals, including arranging his shoes very particularly for up to half an hour. The logic motivating this man's behaviour was notably rather magical and unrealistic, appealing to notions of spirit possession and evil, which were culturally alien to his family. My supervisor, a sensitive and empathic clinician, who believed that most issues could be addressed by attentive listening and interpretation, tended to have a single diagnostic concern. The central question for him was whether the person was experiencing anxiety or manifesting the early symptoms of a psychosis. The latter ought to receive a more thorough assessment and more support than our clinic could offer.</p><p>Because of the magical quality to this person's reasoning, my supervisor decided that this might be an early sign of psychosis. He instructed me to refer the man to a new research clinic near my training site, which specialised in treating and researching the 'at risk' state for psychosis.</p><p>Of course, sensible and cautious though this seemed to me, it entailed telling this young man that he could not be seen by us for talking therapy. Instead, he should go to a clinic that specialised in something serious and frightening-sounding. When I broke the news, he was devastated. He left our clinic, and I later learned that he never followed up with the referral.</p>
<p>What I failed to appreciate at the time – and what some remedial reading later painfully revealed to me – was that, rather than being an early manifestation of psychosis, this man's presentation was more likely a case of obsessive compulsive disorder (OCD), a common condition in which people develop obsessive thoughts and feel compelled to engage in actions to prevent feared harms. If I'd had the diagnostic knowledge and confidence to assert this to my supervisor during the initial consultation, the man I met would likely have received help, rather than being referred to an inappropriate clinic that led to him falling through the cracks.</p><p>Yet, a popular and longstanding wave of thought in psychology and psychotherapy is that diagnosis is not relevant for practitioners in those fields, and should be left to psychiatrists, if at all. This is not a fringe view, it has been perennially present in clinical psychology since at least the 1960s, when the iconoclastic psychiatrists Thomas Szasz and R D Laing presented a dual challenge to their profession.</p><p>Szasz, a Hungarian émigré to the United States, <a href="https://psycnet.apa.org/record/1961-01456-001" target="_blank">argued</a> that mental illness is a 'myth', rooted in a misuse of language. Neurological diseases are real, Szasz suggested, because they can be confirmed by a postmortem examination of the brain. In contrast, he argued that psychiatric 'illness' has no such neurological basis, and is just a medicalised way of talking about problems in life that could be solved by taking responsibility for yourself and your actions.</p><p>Meanwhile, Laing, a Scot who trained at the Tavistock Institute in London, <a href="https://www.penguinrandomhouse.com/books/274343/the-divided-self-by-r-d-laing/" rel="noopener noreferrer" target="_blank">argued</a> in <em>The Divided Self</em> (1960) that psychosis is a psychic response to an increasingly alienated 'false self' obscuring the true emotional core of an individual. He held that so-called 'symptoms' (hearing voices, believing unusual things) were actually attempts at recovery in the face of this alienation.</p>
<p>These ideas resonated and had significant influence over psychiatric thinking throughout the 1960s. They contributed to diagnostic approaches to mental health – the idea that there are illnesses called schizophrenia, bipolar disorder and depression – becoming decidedly <a href="https://aeon.co/essays/the-psychiatrist-who-didn-t-believe-in-mental-illness" target="_blank">unfashionable</a>. Indeed Szasz's and Laing's critiques became so popular that already by the early 1970s, the influential US clinical psychologist Paul Meehl grumbled in his 1973 paper 'Why I Do Not Attend Case Conferences' about an 'antinosological' (ie, antidiagnostic) bias taking hold in his profession.</p><p>Recently, the animus against psychiatric diagnosis has become more formal and scientifically argued. The British Psychological Society's Division of Clinical Psychology (DCP) – one of the official bodies representing the profession – published <a href="https://dxrevisionwatch.files.wordpress.com/2013/05/position-statement-on-diagnosis-master-doc.pdf" target="_blank">two</a> <a href="http://www.newvisionformentalhealth.com/2018/01/26/guidelines-on-language-in-relation-to-functional-psychiatric-diagnosis/" rel="noopener noreferrer" target="_blank">documents</a> in 2013 and 2015 articulating the difficulties with diagnosis, and promoting instead the value of individualised 'formulations'. While it is clear that the DCP's position on diagnosis is not universally held by practitioners in the UK, British psychologists are around half as likely to report regular use of a diagnostic classificatory system as their colleagues in some other countries (for <a href="https://onlinelibrary.wiley.com/doi/abs/10.1080/00207594.2013.804189" rel="noopener noreferrer" target="_blank">example</a>, fewer than 35 per cent of psychologists in the UK say that they use diagnosis regularly, compared with more than 70 per cent of psychologists in the US, Germany and South Africa). This likely reflects a UK professional culture steeped in suspicion of diagnostic thinking.</p><p>The suspicion is not unwarranted. One of the most interesting recent critiques of diagnosis has come from the Belgian psychoanalyst and clinical psychologist Stijn Vanheule. He <a href="https://www.ncbi.nlm.nih.gov/pubmed/22903905" rel="noopener noreferrer" target="_blank">invoked</a> the philosophy of language to argue that diagnosis necessarily draws our attention to the shared meanings conjured by diagnostic language, rather than to the individual meanings inherent to people's experiences. Thus, for example, when I say 'schizophrenia', I focus attention on a generalised, clinical definition that exists in a book, rather than on the individual, personal significance of hearing voices or believing unusual things. For psychotherapists, Vanheule argued, the former is irrelevant, the latter vital.</p>
<p>These arguments are valuable, and they are correct in important ways. Their conclusions are a significant part of what inspired me to get into clinical psychology in the first place. Reading Laing as a teenager, I thrilled to the challenge he presented: to understand people as they endure the most extreme and bewildering psychic states; to try to find coherence even where it seems to be absent. This impulse is essential. Patience and careful listening can reveal that people are capable of engaging in communication more often than we tend to give them credit for. But my clinical training has shown me that, despite the importance of understanding people in an individualised way, having a knowledge of diagnostic categories is also essential.</p><p>To return to the example above, my supervisor and I were ignorant of valuable diagnostic information; we were ignorant of the ways that clinicians can distinguish magical obsessions from the early hints of delusion. We were ignorant of the fact that even quite magical ideas are well within the range of the former without shading into the latter. We were ignorant of how easy it would have been to provide effective help without raising the prospect of a terrifying psychosis down the pipeline. Our ignorance cost someone dearly.</p><p>Diagnosis is often vital for ensuring good care. Apart from the importance of ruling out organic causes for apparently straightforward instances of depression and anxiety (which can be symptomatic of a surprising range of endocrine, infectious and neurological diseases), linking psychological distress into a broader framework also helps clinicians make sense of the people they are trying to help. Certain forms of substance misuse could represent attempts at self-medication for highly treatable disorders of mood or attention, for instance. Correct identification of trauma symptoms can avert diagnosis of a psychotic illness. Proper diagnosis of depression in later life can frequently account for changes in memory and attention that might otherwise be mistaken for dementia, as unfortunately often happens. Diagnosis of bipolar mood disorder can prevent people being inappropriately treated for personality disorders.</p><p>Psychology's antinosological tendency encourages a belief that diagnostic thinking is somehow inherently unkind; that in thinking about categories you are always only 'labelling' people, and that this is an inhumane thing to do.</p>
<p>Conversely, it also encourages a belief that all you really need in mental healthcare is sympathy, rapport and interpretative heroics. This appeals to some of the questionable impulses of professionals: to our desire to see ourselves as people uniquely able to understand others, and to our ordinary human laziness. Who would want to engage in learning about taxonomy if to do so is both unkind and unnecessary?</p><p>Understanding people is a multifaceted enterprise. We all manifest a splendid idiosyncrasy, living out lives that could never be copied or repeated, so it makes sense to consider one another in the light of this uniqueness. But we also bear resemblances to one another. Important though it is to be seen in all your individuality, it is also helpful to know when your problems have precedent.</p><p>Psychiatric diagnoses are imperfect, sketchy theories about how people's minds can give them trouble. We know that they are largely less precise and valid than is popularly understood, but this does not render them totally uninformative. We have learned snippets of useful information by considering psychological problems in terms of categories: the effectiveness, or not, of treatments for particular groups of people; the elevated risk of suicide among others. Many symptoms can seem to 'make sense' in the context of a person's life, but we know that humans are sense-making machines, so we need to be vigilant against 'making sense' where it is only illusory. The great intellectual challenge of clinical psychology is to integrate knowledge about reasons and people with knowledge about causes and mechanisms. We should avoid relying solely on diagnostic information, but we shouldn't discard it altogether.<img src="https://metrics.aeon.co/count/3533ace3-823d-4522-8d68-702c1e19f406.gif" alt="Aeon counter – do not remove"></p><p>Huw Green</p><p>This article was originally published at <a href="https://aeon.co/?utm_campaign=republished-article" target="_blank">Aeon</a> and has been republished under Creative Commons. Read the <a href="https://aeon.co/ideas/a-psychiatric-diagnosis-can-be-more-than-an-unkind-label" target="_blank">original article</a>.</p>
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Spinal cord injury breakthrough makes paralyzed mice walk again
Scientists regenerate damaged spinal cord nerve fibers with designer protein, helping paralyzed mice walk again.
19 January, 2021
Credit: Lehrstuhl für Zellphysiologie
Surprising Science
- Researchers from Germany use a designer protein to treat spinal cord damage in mice.
- The procedure employs gene therapy to regenerate damaged nerve fibers that carry signals to and from the brain.
- The scientists aim to eventually apply the technique to humans.
<p>When spinal cord injuries result in paralysis, science hasn't so far been able to provide a way to repair the damage and reverse the condition. Now a team of researchers from Germany used a designer protein to help paralyzed mice to walk again, raising hopes for a cure that can extend to humans.</p><p>The study was carried out by a team from the Department for Cell Physiology at Ruhr-Universität Bochum (RUB) in Germany, led by Professor Dietmar Fischer. The scientists restored the walking ability of mice who were paralyzed in both hind legs by manipulating the supply of the protein <em>hyper-interleukin-6</em> that causes nerve cells to regenerate.</p><p style="margin-left: 20px;">"This is a so-called designer cytokine, which means it doesn't occur like this in nature and has to be produced using genetic engineering," <a href="https://medicalxpress.com/news/2021-01-cytokine-paralyzed-mice.html" target="_blank" rel="noopener noreferrer">explained</a> Dietmar Fischer.</p>
<p>The protein works by taking on a key feature of spinal cord injuries that produce disability – damage to nerve fibers known as <em>axons</em> that transport signals back and forth between the brain, the muscles, and the skin. When these fibers stop working, the communication ceases as well. What's more, the fibers don't grow back if severed, leaving patients paralyzed and numb, with no current treatments available.<br></p><p>This is why advancements in this field are so vital, underscoring the achievement of the Bochum team. The researchers used viruses to make nerve cells in the motor-sensory cortex to produce hyper-interleukin-6 on their own. The viruses injected into the brains of the paralyzed mice were specially-tailored for gene therapy, carrying blueprints for protein production to nerve cells known as <em>motoneurons</em>. These motoneurons used axonal side branches to transport the proteins to cells involved in movement functions like walking, explained the <a href="https://news.rub.de/english/press-releases/2021-01-15-paraplegia-designer-cytokine-makes-paralyzed-mice-walk-again" target="_blank">press release</a> from the University. Normally these key cells are very hard to reach.</p><p>The technique succeeded and in a few weeks, the paralyzed mice began to walk.</p>
What is a spinal cord injury?
<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="88b8d4e44e46b7d5fe49d1f3bca56078"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/dKtBC2Sg_Bg?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><blockquote>"Thus, gene therapy treatment of only a few nerve cells stimulated the axonal regeneration of various nerve cells in the brain and several motor tracts in the spinal cord simultaneously," <a href="https://news.rub.de/english/press-releases/2021-01-15-paraplegia-designer-cytokine-makes-paralyzed-mice-walk-again" target="_blank">elaborated</a> Fischer. "Ultimately, this enabled the previously paralyzed animals that received this treatment to start walking after two to three weeks. This came as a great surprise to us at the beginning, as it had never been shown to be possible before after full paraplegia."<br></blockquote><p>Next the team plans to investigate further regenerative effects it can achieve with hyper-Interleukin-6, while striving to understand how these advancements in treatment can be applied to humans. </p><p>Check out the study published in <a href="https://www.nature.com/articles/s41467-020-20112-4" target="_blank">Nature Communications. </a></p>
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Archaeologists identify contents of ancient Mayan drug containers
Scientists use new methods to discover what's inside drug containers used by ancient Mayan people.
18 January, 2021
Credit: WSU
Surprising Science
- Archaeologists used new methods to identify contents of Mayan drug containers.
- They were able to discover a non-tobacco plant that was mixed in by the smoking Mayans.
- The approach promises to open up new frontiers in the knowledge of substances ancient people consumed.
<p>Ancient Mayans have been a continuing source of inspiration for their monuments, knowledge, and mysterious demise. Now a new study discovers some of the drugs they used. <a href="https://www.nature.com/articles/s41598-021-81158-y" target="_blank">For the first time</a>, scientists found remnants of a non-tobacco plant in Mayan drug containers. They believe their analysis methods can allow them exciting new ways of investigating the different types of psychoactive and non-psychoactive plants used by the Maya and other pre-Colombian societies.</p><p>The research was carried out by a team from Washington State University, led by anthropology postdoc <a href="https://wsu.academia.edu/MarioZimmermann" target="_blank">Mario Zimmermann</a>. They spotted residue of the Mexican marigold (Tagetes lucida) in 14 tiny ceramic vessels that were buried over a 1,000 years ago on Mexico's Yucatan peninsula. The containers also exhibited chemical traces of two types of tobacco: Nicotiana tabacum and N. rustica. Scientists think the marigold was mixed in with the tobacco to make the experience more pleasant.</p>
<blockquote>"While it has been established that tobacco was commonly used throughout the Americas before and after contact, evidence of other plants used for medicinal or religious purposes has remained largely unexplored," said Zimmermann. "The analysis methods developed in collaboration between the Department of Anthropology and the Institute of Biological Chemistry give us the ability to investigate drug use in the ancient world like never before."</blockquote><p>The scientists used a new method based on <a href="https://www.future-science.com/doi/full/10.2144/000113133" target="_blank">metabolomics</a> that is able to pinpoint thousands of plant compounds, or metabolites, in residue of archaeological artifacts like containers and pipes. This allows the researchers to figure out which specific plants were utilized. The way plant residue was identified before employed looking for specific biomarkers from nicotine, caffeine, and other such substances. That approach would not be able to spot what else was consumed outside of what biomarker was found. The new way gives much more information, showing the researchers a fuller picture of what the ancient people ingested. </p>
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNTQ5ODA2OS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYyMTU5NjU3MH0.yulUX2V5W_S-eR5JE89cKODfRv3numTn_cjeBqbcYAk/img.jpg?width=980" id="023b8" class="rm-shortcode" data-rm-shortcode-id="0a4f30654bf0f0c2b8463aaaae455714" data-rm-shortcode-name="rebelmouse-image" data-width="640" data-height="480" />
PARME staff archaeologists excavating a burial site at the Tamanache site, Mérida, Yucatan.
Credit: WSU
<p>The containers in the study were found by Zimmerman and a team of archaeologists in 2012.</p><p style="margin-left: 20px;">"When you find something really interesting like an intact container it gives you a sense of joy," <a href="https://phys.org/news/2021-01-scientists-contents-ancient-maya-drug.html" target="_blank">shared</a> Zimmermann. "Normally, you are lucky if you find a jade bead. There are literally tons of pottery sherds but complete vessels are scarce and offer a lot of interesting research potential."</p><p>The researchers are negotiating with various Mexican institutions to be able to study more ancient containers for plant residues. They also aim to look at organic materials possibly preserved in the dental plaque of ancient remains. </p><p>Check out the study published in <a href="https://www.nature.com/articles/s41598-021-81158-y" target="_blank">Scientific Reports. </a></p>
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Ten things you may not know about anxiety
Cold hands and feet? Maybe it's your anxiety.
19 January, 2021
Credit: Antonioguillem / Adobe Stock
Mind & Brain
- When we feel anxious, the brain's fight or flight instinct kicks in, and the blood flow is redirected from your extremities towards the torso and vital organs.
- According to the CDC, 7.1% of children between the ages of 3-17 (approximately 4.4 million) have an anxiety diagnosis.
- Anxiety disorders will impact 31% of Americans at some point in their lives.
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Here's what you may not know about anxiety...
<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="0ed8bd7fb8626babd10933f7ce630f96"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/w4jiLIzTAa0?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><p><strong>There's a fine line between stress and anxiety - and many people don't know what the difference is.</strong></p><p>Both stress and anxiety are <a href="https://www.apa.org/topics/stress-anxiety-difference" target="_blank">emotional responses</a>, but stress is typically caused by an external trigger and can be short-term (a looming deadline at work, for example). People under stress experience mental and physical symptoms such as irritability, anger, fatigue, muscle pain, digestive troubles, insomnia, and headache. </p><p>Anxiety, on the other hand, is defined as a persistent, excessive worry. Even in the absence of the thing that triggered it, anxiety lingers. It can lead to a nearly identical set of symptoms, which is why they are often confused. Feelings of anxiety then differ from an anxiety disorder - an anxiety disorder means your anxiety typically persists for months and negatively impacts your daily functioning. </p><p><strong>There are five major types of anxiety disorders:</strong></p><ol><li>Generalized anxiety (GAD) is characterized by chronic anxiety, exaggerated worry, and tension, even when there is little or nothing to provoke it. </li><li>Obsessive-Compulsive Disorder (OCD) is characterized by recurrent, unwanted thoughts (or obsessions) and/or repetitive behaviors (compulsions). </li><li>Panic disorder is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms such as chest pain, heart palpitations, shortness of breath, dizziness, and/or abdominal distress. </li><li>Post-Traumatic Stress Disorder (PTSD) is also an anxiety disorder, and it can develop after exposure to a terrifying event in which grave physical harm occurred or was threatened. Traumatic events that may trigger PTSD include things like personal assaults, natural and/or human-caused disasters, accidents, or military combat. </li><li>Social Anxiety Disorder (also known as 'social phobia') is characterized by overwhelming anxiety and excessive self-consciousness in everyday social situations. </li></ol><p><strong>Anxiety disorders can impact 31 percent of Americans at some point in their life. </strong></p><p>According to the <a href="https://www.apa.org/topics/stress-anxiety-difference" target="_blank" rel="noopener noreferrer">American Psychological Association</a>, 19 percent of Americans over the age of 18 have had an anxiety disorder in the past year and 31 percent of Americans will experience an anxiety disorder at some point in their lives. </p><p><strong>Anxiety may be genetic. </strong></p><p><a href="https://www.healthline.com/health/mental-health/is-anxiety-genetic#:~:text=Most%20researchers%20conclude%20that%20anxiety,and%20more%20research%20is%20needed." target="_blank" rel="noopener noreferrer">According to HealthLine</a>, anxiety may be genetic but can also be influenced by environmental factors. It's possible to have anxiety without it running in your family, however, there is speculated to be some genetic component that makes anxiety more prevalent in some individuals. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573560/" target="_blank" rel="noopener noreferrer">Research</a> has indicated some link between genetics and anxiety, though much more research is required in this area. </p><p><strong>Anxiety often begins in childhood. </strong></p><p><a href="https://www.cdc.gov/childrensmentalhealth/data.html#:~:text=For%20children%20aged%203%2D17,also%20have%20depression%20(32.3%25).&text=For%20children%20aged%203%2D17%20years%20with%20behavior%20problems%2C%20more,also%20have%20depression%20(20.3%25)." target="_blank" rel="noopener noreferrer">According to the CDC</a>, 7.1 percent of children between the ages of 3-17 (approximately 4.4 million) have an anxiety diagnosis. Six in ten children (59.3 percent) between the ages of 3-17 have received anxiety therapy or treatment. </p><p><strong>Having an anxiety disorder can increase your risk of other physical health complications. </strong></p><p>According to research from <a href="https://www.health.harvard.edu/topics/anxiety" target="_blank" rel="noopener noreferrer">Harvard Medical School</a>, anxiety has been indicated in several chronic physical illnesses, including heart disease, chronic respiratory disorders, gastrointestinal conditions such as IBS, and more. </p><p><strong>Cold hands and feet? Anxiety may be the reason. </strong></p><p>If you're someone who constantly struggles with having cold hands or feet, it could be a result of your anxiety. When we feel anxious, the brain's <a href="https://www.health.harvard.edu/staying-healthy/understanding-the-stress-response#:~:text=The%20autonomic%20nervous%20system%20has,can%20respond%20to%20perceived%20dangers." target="_blank" rel="noopener noreferrer">fight or flight instinct</a> kicks in, and the blood flow is redirected from your extremities towards the torso and vital organs. </p><p><strong>Anxiety can be related to anger issues and memory loss. </strong></p><p>A lesser-known side effect of anxiety is <a href="https://discoverymood.com/blog/anxiety-and-anger/#:~:text=Anxiety%20is%20often%20connected%20with,which%20can%20lead%20to%20anger." target="_blank" rel="noopener noreferrer">anger</a>. When you feel powerless over a situation, expressing anger is a natural way to feel as though you have some kind of control. With chronic sufferers of anxiety, depression is the most common issue to develop, but anger is close behind. As <a href="https://discoverymood.com/blog/anxiety-and-anger/#:~:text=Anxiety%20is%20often%20connected%20with,which%20can%20lead%20to%20anger." target="_blank" rel="noopener noreferrer">Discovery Mood</a> explains, "anxiety is often connected with overstimulation from a stressful environment or threat, combined with the perceived inability to deal with that threat. In contrast, anger is often tied to frustration. When anxiety is left unacknowledged or unexpressed, it can turn into frustration which then easily leads to anger." </p><p><strong>Anxiety can also cause memory problems. </strong></p><p>According to <a href="https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/in-depth/memory-loss/art-20046326#:~:text=Stress%2C%20anxiety%20or%20depression%20can,loss%20by%20interacting%20with%20medications." target="_blank" rel="noopener noreferrer">Mayo Clinic</a>, stress, anxiety, or depression can often cause forgetfulness, confusion, and difficulty concentrating. <a href="https://www.verywellmind.com/anxiety-and-memory-1393133" target="_blank" rel="noopener noreferrer">VeryWellMind</a> explains further, "memories can be affected when you are under periods of stress or experience some sort of disturbance in mood. Having a significant anxiety disorder like GAD can create some of these problems routinely, leaving you operating below your normal level of memory functioning." </p><p><strong>Anxiety can even impact your sense of smell. </strong></p><p>People who struggle with anxiety may be more likely to label natural smells as bad smells, according to research published in the <a href="https://www.jneurosci.org/content/33/39/15324" target="_blank" rel="noopener noreferrer">Journal of Neuroscience</a>. When processing smells, typically it's only the olfactory system that is activated. However, in people with high anxiety levels, the emotional system can become intertwined with the olfactory system, which can slightly alter our perception of smells.</p>
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