The Helpless Y Chromosome
Dr. Marianne Legato is a Professor of Clinical Medicine at Columbia University, where she also directs and founded the Partnership for Gender-Specific Medicine.
Dr. Legato is the founder and editor of "The Journal of Gender-Specific Medicine and of Gender-Medicine" and a leading advocate for the inclusion of women in clinical trials. She is annually cited in New York Magazine's top doctors issues. She is also the author of Eve's Rib:The New Science of Gender-Specific Medicine and How It Can Save Your Life, The Female Heart, and Why Men Never Remember and Women Never Forget, and, most recently, "Why Men Die First: How to Lengthen Your Lifespan." She edited the medical textbook, "Principles of Gender Specific Medicine," the first compilation for professional audiences of the sex-specific aspects of normal human function and disease.
She lives in New York City.
Question: Is the Y chromosome prone to mutations?
Marianne Legato: The Y chromosome is definitely unique among all the chromosomes. Over most of its extent, it can’t exchange with its partner the X chromosome to repair its deficiencies or mutations in DNA. It’s learned to repair itself in an interesting and unique way. The issues with the Y chromosome are that they are exposed to environmental toxins because they are housed outside the body in the scrotal sack. Many millions are produced every day and, therefore, mutations are far more frequent in the Y chromosome than in the X or indeed in any of the other chromosomes. So the male drives evolutionary development because of this extraordinary proliferation of mutations that are characteristic of sperm and the Y chromosome.
The masculine chromosome is unique in its inability to repair itself, making it exceptionally prone to mutation and pollution.
NASA astronomer Michelle Thaller is coming back to Big Think to answer YOUR questions! Here's all you need to know to submit your science-related inquiries.
Big Think's amazing audience has responded so well to our videos from NASA astronomer and Assistant Director for Science Communication Michelle Thaller that we couldn't wait to bring her back for more!
And this time, she's ready to tackle any questions you're willing to throw at her, like, "How big is the Universe?", "Am I really made of stars?" or, "How long until Elon Musk starts a colony on Mars?"
All you have to do is submit your questions to the form below, and we'll use them for an upcoming Q+A session with Michelle. You know what to do, Big Thinkers!
Or how I learned to stop worrying and love my tsundoku.
- Many readers buy books with every intention of reading them only to let them linger on the shelf.
- Statistician Nassim Nicholas Taleb believes surrounding ourselves with unread books enriches our lives as they remind us of all we don't know.
- The Japanese call this practice tsundoku, and it may provide lasting benefits.
Calling all big thinkers!
SMARTER FASTER trademarks owned by The Big Think, Inc. All rights reserved.