Americans: Go Global

Question: How can Americans be more globally minded?

 

Alan Webber: It’s one of those kind of paint this full... how can you fill this canvass because it’s a requirement and yet as you know from your own experience, Americans while we talk global, we’re still very insulated and we’re still think that Democratic capitalism is a global concept that everybody subscribes to as oppose to, in some parts of the world, a huge oxymoron.

So, I would say if you’re going to aspire to be a leader in the future or today or in the future, in business, government, not for profit another one of my rules is you don’t know if you don’t go. You got to get out there and absorb it and see it and listen and participate in other parts of the world’s way of living and working and doing business, I’ve been very fortunate to get a fellowship to Japan, a fellowship to Germany, a chance to do some deep dives in other parts of the world, you just don’t experience culture shock, you experience business shock, you experience social shock, if you make friends with people in other parts of the world, your American eyes get relensed, they’ll tell you what their world is like.

I’ll give you an example, not long ago I spent some time in Sweden, I’m a huge fan of the Swedish way of life, I think they’re very generous people, I think they’re incredibly thoughtful, they have a standard of living that is terrific, and so as an American, I went in there with a lot of assumptions, biases, positive biases for the most part, but a kind of an American pair of glasses on. I started talking to my Swedish friends and they say, you have no idea what it’s like to be Swedish, there’s a code here that goes back if not years, centuries that prescribes behavior.

It’s written down, you can find it literally on the web, it says stuff like who do you think you are to be better than the rest of us, who do you think you are and be an entrepreneur and try new things? Who gave you the right to be different, better, smarter, wealthier? This isn’t how we behave, it is absolutely a sociological straightjacket that prescribes behavior, aspiration, a whole set of things that Americans, if we actually live there, would find very constraining. Where’s the freedom to be me? Where is the chance to take a risk and fail? Why can’t I dress weird or whatever right?

The Swedish culture as my friends introduced it to me was vastly different from what I was projecting onto to their canvas. So I think the job of a global citizen, never mind leader, is to get out into the world and taste it and listen, listen with open ears, don’t just project our own American biases or habits or assumptions onto other cultures whether it’s pro or con but do it, deep dive into it, listen to people who live there, get their experiences first hand and then use that to formulate a new code of conduct of how you want to be both at home and in the world, I think it opens up whole new vistas of personal conduct, business conduct, creativity, the opportunities to think in new ways or write in new ways, paint, dance, whatever your mode is, technologically to interact, they’re absolutely unlimited.

Once you get out of our straightjacket which is; well, basically, the whole world wants to be Americans, I’m sorry, it’s just doesn’t work that way anymore.

 

Recorded on: April 23, 2009

 

The business expert says you really need to get out into the world know your place in it.

To boost your self-esteem, write about chapters of your life

If you're lacking confidence and feel like you could benefit from an ego boost, try writing your life story.

Personal Growth

In truth, so much of what happens to us in life is random – we are pawns at the mercy of Lady Luck. To take ownership of our experiences and exert a feeling of control over our future, we tell stories about ourselves that weave meaning and continuity into our personal identity.

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Yale scientists restore brain function to 32 clinically dead pigs

Researchers hope the technology will further our understanding of the brain, but lawmakers may not be ready for the ethical challenges.

Still from John Stephenson's 1999 rendition of Animal Farm.
Surprising Science
  • Researchers at the Yale School of Medicine successfully restored some functions to pig brains that had been dead for hours.
  • They hope the technology will advance our understanding of the brain, potentially developing new treatments for debilitating diseases and disorders.
  • The research raises many ethical questions and puts to the test our current understanding of death.

The image of an undead brain coming back to live again is the stuff of science fiction. Not just any science fiction, specifically B-grade sci fi. What instantly springs to mind is the black-and-white horrors of films like Fiend Without a Face. Bad acting. Plastic monstrosities. Visible strings. And a spinal cord that, for some reason, is also a tentacle?

But like any good science fiction, it's only a matter of time before some manner of it seeps into our reality. This week's Nature published the findings of researchers who managed to restore function to pigs' brains that were clinically dead. At least, what we once thought of as dead.

What's dead may never die, it seems

The researchers did not hail from House Greyjoy — "What is dead may never die" — but came largely from the Yale School of Medicine. They connected 32 pig brains to a system called BrainEx. BrainEx is an artificial perfusion system — that is, a system that takes over the functions normally regulated by the organ. The pigs had been killed four hours earlier at a U.S. Department of Agriculture slaughterhouse; their brains completely removed from the skulls.

BrainEx pumped an experiment solution into the brain that essentially mimic blood flow. It brought oxygen and nutrients to the tissues, giving brain cells the resources to begin many normal functions. The cells began consuming and metabolizing sugars. The brains' immune systems kicked in. Neuron samples could carry an electrical signal. Some brain cells even responded to drugs.

The researchers have managed to keep some brains alive for up to 36 hours, and currently do not know if BrainEx can have sustained the brains longer. "It is conceivable we are just preventing the inevitable, and the brain won't be able to recover," said Nenad Sestan, Yale neuroscientist and the lead researcher.

As a control, other brains received either a fake solution or no solution at all. None revived brain activity and deteriorated as normal.

The researchers hope the technology can enhance our ability to study the brain and its cellular functions. One of the main avenues of such studies would be brain disorders and diseases. This could point the way to developing new of treatments for the likes of brain injuries, Alzheimer's, Huntington's, and neurodegenerative conditions.

"This is an extraordinary and very promising breakthrough for neuroscience. It immediately offers a much better model for studying the human brain, which is extraordinarily important, given the vast amount of human suffering from diseases of the mind [and] brain," Nita Farahany, the bioethicists at the Duke University School of Law who wrote the study's commentary, told National Geographic.

An ethical gray matter

Before anyone gets an Island of Dr. Moreau vibe, it's worth noting that the brains did not approach neural activity anywhere near consciousness.

The BrainEx solution contained chemicals that prevented neurons from firing. To be extra cautious, the researchers also monitored the brains for any such activity and were prepared to administer an anesthetic should they have seen signs of consciousness.

Even so, the research signals a massive debate to come regarding medical ethics and our definition of death.

Most countries define death, clinically speaking, as the irreversible loss of brain or circulatory function. This definition was already at odds with some folk- and value-centric understandings, but where do we go if it becomes possible to reverse clinical death with artificial perfusion?

"This is wild," Jonathan Moreno, a bioethicist at the University of Pennsylvania, told the New York Times. "If ever there was an issue that merited big public deliberation on the ethics of science and medicine, this is one."

One possible consequence involves organ donations. Some European countries require emergency responders to use a process that preserves organs when they cannot resuscitate a person. They continue to pump blood throughout the body, but use a "thoracic aortic occlusion balloon" to prevent that blood from reaching the brain.

The system is already controversial because it raises concerns about what caused the patient's death. But what happens when brain death becomes readily reversible? Stuart Younger, a bioethicist at Case Western Reserve University, told Nature that if BrainEx were to become widely available, it could shrink the pool of eligible donors.

"There's a potential conflict here between the interests of potential donors — who might not even be donors — and people who are waiting for organs," he said.

It will be a while before such experiments go anywhere near human subjects. A more immediate ethical question relates to how such experiments harm animal subjects.

Ethical review boards evaluate research protocols and can reject any that causes undue pain, suffering, or distress. Since dead animals feel no pain, suffer no trauma, they are typically approved as subjects. But how do such boards make a judgement regarding the suffering of a "cellularly active" brain? The distress of a partially alive brain?

The dilemma is unprecedented.

Setting new boundaries

Another science fiction story that comes to mind when discussing this story is, of course, Frankenstein. As Farahany told National Geographic: "It is definitely has [sic] a good science-fiction element to it, and it is restoring cellular function where we previously thought impossible. But to have Frankenstein, you need some degree of consciousness, some 'there' there. [The researchers] did not recover any form of consciousness in this study, and it is still unclear if we ever could. But we are one step closer to that possibility."

She's right. The researchers undertook their research for the betterment of humanity, and we may one day reap some unimaginable medical benefits from it. The ethical questions, however, remain as unsettling as the stories they remind us of.

Ashes of cat named Pikachu to be launched into space

A space memorial company plans to launch the ashes of "Pikachu," a well-loved Tabby, into space.

GoFundMe/Steve Munt
Culture & Religion
  • Steve Munt, Pikachu's owner, created a GoFundMe page to raise money for the mission.
  • If all goes according to plan, Pikachu will be the second cat to enter space, the first being a French feline named Felicette.
  • It might seem frivolous, but the cat-lovers commenting on Munt's GoFundMe page would likely disagree.
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