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New therapy turns cancer cells into fat to stop it from spreading
Researchers at the University of Basel in Switzerland have hijacked cancer's cellular plasticity to turn the disease against itself.
- In 2018, an estimated 627,000 women died from breast cancer worldwide.
- Researchers recently discovered a drug combination that turned cancer cells into fat cells, preventing its proliferation.
- The drug therapy could be used to halt metastasis, the leading cause of death from cancer.
It may be a family member, a friend, a coworker, or even yourself, but chances are breast cancer will invade your life at some point. According to the Center for Disease Control and Prevention, 242,476 new cases of female breast cancer were reported in 2015 alone. The disease took the lives of 41,523 women that same year. This makes breast cancer the most commonly diagnosed cancer, and the second leading cause of cancer deaths among American women.
Worldwide, cancers represent the second leading cause of death, surpassed only by heart disease. Yet despite these disheartening numbers, we are making progress in developing effective treatments against this deadly affliction.
Scientists may have given us another tool to further this progress. They've developed a new drug therapy that prevents malignant cancer growth. How? By turning cancer cells into fat.
The good kind of fat
Low magnification micrograph of a metastatic tumor [left side] in the ovary. This tumor metastasized from a tumor in the woman's breast. Photo credit: Wikimedia Commons
Metastasis is the leading cause of death from cancer, occurring when cancer cells separate from the original tumor to proliferate elsewhere. These new cancer cells travel through the bloodstream or lymphatic system. Since these bodily systems are thoroughly connected, cancer can spread to a variety of locations. Breast cancer, for example, "tends to spread to the bones, liver, lungs, chest wall, and brain."
Cancer cell plasticity — an ability that allows cancer cells to shift physiological characteristics dramatically — fosters metastasis and is responsible for cancer's resistance to treatments. To combat its resistance, researchers at the University of Basel in Switzerland decided to turn cancer's cellular plasticity against itself. They used Rosiglitazone, an anti-diabetic drug, along with MEK inhibitors in mice implanted with breast cancer cells. Their aim was to alter the cancer cells.
The drug combination hijacked the breast cancer cells during epithelial-mesenchymal transition (EMT), a process by which the cells undergo biochemical changes. EMT plays a role in many bodily functions, such as tissue repair. In unaltered cancer cells, EMT allows them to migrate away from the original tumor while maintaining their oncogenic properties.
But in cancer cells assaulted by the new drug therapy, EMT changes them into adipocytes, or fat cells. Like normal fat cells, these former breast cancer cells were both functional and post-mitotic, meaning they could no longer divide and proliferate.
While the therapy did not alter the original tumor, it did prevent new cancer cells from dividing and spreading elsewhere in the body. This repressed metastasis in the researcher's preclinical trials.
The researchers published their findings on January 14 in the journal Cancer Cell.
"In future, this innovative therapeutic approach could be used in combination with conventional chemotherapy to suppress both primary tumor growth and the formation of deadly metastases," senior study author Gerhard Christofori told Medical News Today.
Since the research used FDA-approved drugs to study the treatment's effects, the study notes, "a clinical translation may be possible."
Will we win the battle against cancer?
Members of Lebanon's Ladies of Harley hold placards as take part in an event organised by Pink Steps Lebanon to raise awareness about breast cancer on October 28, 2018. Photo credit: MAHMOUD ZAYYAT / AFP / Getty Images
This article opened with some fearful figures about cancer and its effect on people worldwide. But there's reason to hope.
While the total number of new cancer cases and deaths continues to increase, the rates of cancer diagnoses and deaths decline each year — as absolute figures don't account for rises in life expectancy, population growth, or aging populations. We've made great strides in understanding the disease and its various genetic and environmental origins. And events like Breast Cancer Awareness Month continue to educate the populace about the preventative measures available to them.
Thanks to scientists like those at the University of Basel in Switzerland, we may have more reasons to be hopeful very soon.
Scientists used CT scanning and 3D-printing technology to re-create the voice of Nesyamun, an ancient Egyptian priest.
- Scientists printed a 3D replica of the vocal tract of Nesyamun, an Egyptian priest whose mummified corpse has been on display in the UK for two centuries.
- With the help of an electronic device, the reproduced voice is able to "speak" a vowel noise.
- The team behind the "Voices of the Past" project suggest reproducing ancient voices could make museum experiences more dynamic.
Howard et al.<p style="margin-left: 20px;">"While this approach has wide implications for heritage management/museum display, its relevance conforms exactly to the ancient Egyptians' fundamental belief that 'to speak the name of the dead is to make them live again'," they wrote in a <a href="https://www.nature.com/articles/s41598-019-56316-y#Fig3" target="_blank">paper</a> published in Nature Scientific Reports. "Given Nesyamun's stated desire to have his voice heard in the afterlife in order to live forever, the fulfilment of his beliefs through the synthesis of his vocal function allows us to make direct contact with ancient Egypt by listening to a sound from a vocal tract that has not been heard for over 3000 years, preserved through mummification and now restored through this new technique."</p>
Connecting modern people with history<p>It's not the first time scientists have "re-created" an ancient human's voice. In 2016, for example, Italian researchers used software to <a href="https://www.smithsonianmag.com/smart-news/hear-recreated-voice-otzi-iceman-180960570/" target="_blank">reconstruct the voice of Ötzi,</a> an iceman who was discovered in 1991 and is thought to have died more than 5,000 years ago. But the "Voices of the Past" project is different, the researchers note, because Nesyamun's mummified corpse is especially well preserved.</p><p style="margin-left: 20px;">"It was particularly suited, given its age and preservation [of its soft tissues], which is unusual," Howard told <em><a href="https://www.livescience.com/amp/ancient-egypt-mummy-voice-reconstructed.html" target="_blank">Live Science</a>.</em></p><p>As to whether Nesyamun's reconstructed voice will ever be able to speak complete sentences, Howard told <em><a href="https://abcnews.go.com/Weird/wireStory/ancient-voice-scientists-recreate-sound-egyptian-mummy-68482015" target="_blank">The Associated Press</a>, </em>that it's "something that is being worked on, so it will be possible one day."</p><p>John Schofield, an archaeologist at the University of York, said that reproducing voices from history can make museum experiences "more multidimensional."</p><p style="margin-left: 20px;">"There is nothing more personal than someone's voice," he told <em>The Associated Press.</em> "So we think that hearing a voice from so long ago will be an unforgettable experience, making heritage places like Karnak, Nesyamun's temple, come alive."</p>
Inequality in wealth, gender, and race grew to unprecedented levels across the world, according to OxFam report.
- A new report by global poverty nonprofit OxFam finds inequality has increased in every country in the world.
- The alarming trend is made worse by the coronavirus pandemic, which strained most systems and governments.
- The gap in wealth, race and gender treatment will increase until governments step in with changes.
People wait in line to receive food at a food bank on April 28, 2020 in Brooklyn.
Photo by Spencer Platt/Getty Images
Credit: Oxfam International
A supernova exploded near Earth about 2.5 million years ago, possibly causing an extinction event.
- Researchers from the University of Munich find evidence of a supernova near Earth.
- A star exploded close to our planet about 2.5 million years ago.
- The scientists deduced this by finding unusual concentrations of isotopes, created by a supernova.
This Manganese crust started to form about 20 million years ago. Growing layer by layer, it resulted in minerals precipitated out of seawater. The presence of elevated concentrations of 60 Fe and 56 Mn in layers from 2.5 million years ago hints at a nearby supernova explosion around that time.
Credit: Dominik Koll/ TUM