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Neanderthal DNA used to grow a 'mini-brain'
A team of scientists in Basel believes this will open up new lines of research.
- Switzerland-based researchers successfully used Neanderthal DNA to grow a brain organoid.
- The team, led by Grayson Camp, used induced pluripotent stem cells, which are used to research diabetes, leukemia, and neurological disorders.
- By tracing back our ancestral lineage, the team hopes to better understand genetic disease susceptibility.
You know someone has received their 23andMe report when they write one of two social media posts: they boast of having Neanderthal DNA or being an ancestor of Genghis Khan. Sure, it's a bit strange to take pride in a lineage filled with pillaging and murder, yet that's often how we view history from afar, downplaying shadowy events while championing warrior ancestry.
Let's move on to Neanderthals. The common understanding of evolutionary biology goes something like this: chimps to humans with a period of Neanderthal intermediaries along the way—the "starting to lose hair" phase. Of course, the picture is more complex.
The line from Australopithecus to Homo sapiens is not straight. There was Homo neanderthalensis (Man from Neander Vally), as well as Homo erectus (Upright Man), Homo soloensis (Man from the Solo Valley), Homo floresiensis (Dwarf man from Flores), Homo denisova (Man from Siberia), Homo rudolfensis (Man from Lake Rudolf), and Homo ergaster (Working Man).
What happened to all of these intriguing relatives? Most likely, Homo sapiens killed them. Our forebears procreated with whatever combinations worked, most famously Neanderthals, as recently as 40,000 years ago. Today an estimated 40 percent of Neanderthal genome lives on in 2 percent of modern, non-African humans (although the idea that Neanderthals and Africans didn't mingle is now being challenged). The Neanderthal genome is the topic of an exciting new study, published in the journal Cell Stem Reports.
Can Stem Cells Reverse Aging? With Dr. David Agus
In 2010, Swedish geneticist Svante Pääbo first mapped the Neanderthal genome. He successfully extracted and sequenced Neanderthal DNA, opening up an entirely new field of genetic research. Evolving on that work, a team lead by Grayson Camp at the Institute of Molecular and Clinical Opthalmology in Basel, Switzerland has grown Neanderthal DNA-containing brain tissue for the first time.
The team used induced pluripotent stem cells (iPSC), which are normally derived from human skin or blood cells. Stem cells are biological gold. By reprogramming these cells back to an embryonic-like state, researchers can develop a wide range of human cells for therapeutic purposes. This is exactly what Camp hopes this research on the Neanderthal genome will help accomplish.
Genetic codes reveal secrets around biological development and susceptibility to disease. Since stem cells can resemble brain, stomach, skin, kidney, and intestinal (among others) human tissues, their range of utility is endless. Researchers are hopeful that stem cells will help combat the ravages of diabetes, leukemia, and neurological disorders, among numerous other diseases.
As the team writes, Neanderthal DNA provides a wealth of genetic resources, including "skin and hair color, immune response, lipid metabolism, skull shape, bone morphology, blood coagulation, sleep patterns, and mood disorders."
Fabien Danjan of CNRS (French Research Institut Center) introduces embryonic stem cells in a mouse embryo to set a genetically modified line, on February 9, 2012.
Photo: Anne-Christine Poujoulat/AFP via Getty Images
Analyzing genome sequences from 173 mostly European participants, they were able to identity Neanderthal haplotypes (an inherited group of genes from a single parent). Alleles (gene variants) were identified for digestive function, immune response, and skin color. Camp believes this research is beneficial for studying human developmental processes.
After identifying Neanderthal genes, the team grew brain organoids, 3D blobs of brain tissue barely a few millimeters in size. Organoids are diverse resources in laboratory settings, especially in drug treatment research. Cancer treatment protocols are often tested on these blobs, for example.
While his team's work is exciting, Camp warns that this is no science fiction experiment.
"These are human cells, they're not Neanderthal cells but human cells that have Neanderthal DNA naturally inside them. This is totally different to Jurassic Park. It's more about studying the mechanism than try to recreate something."
While these culture systems are not yet optimal, the process has begun. Camp is interested in studying other Homo ancestors, such as Denisovan DNA. The further we dial back the clock, the better we understand our origins. If that path leads to treatments or cures for some of humanity's most prolific killers, the backpedaling will be worth it.
- Ancient Neanderthal DNA Shows What They Ate—And Who They ... ›
- Neanderthals could speak, like we do - Big Think ›
The father of all giant sea bugs was recently discovered off the coast of Java.
- A new species of isopod with a resemblance to a certain Sith lord was just discovered.
- It is the first known giant isopod from the Indian Ocean.
- The finding extends the list of giant isopods even further.
Humanity knows surprisingly little about the ocean depths. An often-repeated bit of evidence for this is the fact that humanity has done a better job mapping the surface of Mars than the bottom of the sea. The creatures we find lurking in the watery abyss often surprise even the most dedicated researchers with their unique features and bizarre behavior.
A recent expedition off the coast of Java discovered a new isopod species remarkable for its size and resemblance to Darth Vader.
The ocean depths are home to many creatures that some consider to be unnatural.
According to LiveScience, the Bathynomus genus is sometimes referred to as "Darth Vader of the Seas" because the crustaceans are shaped like the character's menacing helmet. Deemed Bathynomus raksasa ("raksasa" meaning "giant" in Indonesian), this cockroach-like creature can grow to over 30 cm (12 inches). It is one of several known species of giant ocean-going isopod. Like the other members of its order, it has compound eyes, seven body segments, two pairs of antennae, and four sets of jaws.
The incredible size of this species is likely a result of deep-sea gigantism. This is the tendency for creatures that inhabit deeper parts of the ocean to be much larger than closely related species that live in shallower waters. B. raksasa appears to make its home between 950 and 1,260 meters (3,117 and 4,134 ft) below sea level.
Perhaps fittingly for a creature so creepy looking, that is the lower sections of what is commonly called The Twilight Zone, named for the lack of light available at such depths.
It isn't the only giant isopod, far from it. Other species of ocean-going isopod can get up to 50 cm long (20 inches) and also look like they came out of a nightmare. These are the unusual ones, though. Most of the time, isopods stay at much more reasonable sizes.
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During an expedition, there are some animals which you find unexpectedly, while there are others that you hope to find. One of the animal that we hoped to find was a deep sea cockroach affectionately known as Darth Vader Isopod. The staff on our expedition team could not contain their excitement when they finally saw one, holding it triumphantly in the air! #SJADES2018
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What benefit does this find have for science? And is it as evil as it looks?
The discovery of a new species is always a cause for celebration in zoology. That this is the discovery of an animal that inhabits the deeps of the sea, one of the least explored areas humans can get to, is the icing on the cake.
Helen Wong of the National University of Singapore, who co-authored the species' description, explained the importance of the discovery:
"The identification of this new species is an indication of just how little we know about the oceans. There is certainly more for us to explore in terms of biodiversity in the deep sea of our region."
The animal's visual similarity to Darth Vader is a result of its compound eyes and the curious shape of its head. However, given the location of its discovery, the bottom of the remote seas, it may be associated with all manner of horrifically evil Elder Things and Great Old Ones.
It could lead to a massive uptake in those previously hesitant.
A financial shot in the arm could be just what is needed for Americans unsure about vaccination.
On May 12, 2021, the Republican governor of Ohio, Mike DeWine, announced five US$1 million lottery prizes for those who are vaccinated. Meanwhile, in West Virginia, younger citizens are being enticed to get the shot with $100 savings bonds, and a state university in North Carolina is offering students who get vaccinated a chance to win the cost of housing. Many companies are paying vaccinated employees more money through bonuses or extra paid time off.
The push to get as many people vaccinated as possible is laudable and may well work. But leading behavioral scientists are worried that paying people to vaccinate could backfire if it makes people more skeptical of the shots. And ethicists have argued that it would be wrong, citing concerns over fairness and equity.
As a behavioral scientist and ethicist, I draw on an extensive body of research to help answer these questions. It suggests that incentives might work to save lives and, if properly structured, need not trample individual rights or be a huge expense for the government.
In the United States, incentives and disincentives are already used in health care. The U.S. system of privatized health insurance exposes patients to substantial deductibles and copays, not only to cover costs but to cut down on what could be deemed as wasteful health care – the thinking being that putting a cost to an emergency room visit, for example, might deter those who aren't really in need of that level of care.
In practice, this means patients are encouraged to decline both emergency and more routine care, since both are exposed to costs.
Paying for health behaviors
In the case of COVID-19, the vaccines are already free to consumers, which has undoubtedly encouraged people to be immunized. Studies have shown that reducing out-of-pocket costs can improve adherence to life-sustaining drugs, whether to prevent heart attacks or to manage diabetes.
A payment to take a drug goes one step further than simply reducing costs. And if properly designed, such incentives can change health behaviors.
And for vaccination in particular, payments have been successful for human papillomavirus (HPV) in England; hepatitis B in the United States and the United Kingdom; and tetanus toxoid in Nigeria. The effects can be substantial: For example, for one group in the HPV study, the vaccination rate more than doubled with an incentive.
For COVID-19, there are no field studies to date, but several survey experiments, including one my group conducted with 1,000 Americans, find that incentives are likely to work. In our case, the incentive of a tax break was enough to encourage those hesitant about vaccinations to say they would take the shot.
Even if incentives will save lives by increasing vaccinations, there are still other ethical considerations. A key concern is protecting the autonomous choices of people to decide what they put into their own bodies. This may be especially important for the COVID-19 vaccines, which – although authorized as likely safe and effective – are not yet fully approved by the Food and Drug Administration.
But already people are often paid to participate in clinical trials for drugs that have not yet been approved by the FDA. Ethicists have worried that such payments may be “coercive" if the money is so attractive as to override a person's free choices or make them worse off overall.
One can quibble about whether the term “coercion" applies to offers of payment. But even if offers were coercive, payments may still be reasonable to save lives in a pandemic if they succeed in greater levels of immunization.
During the smallpox epidemic nearly 100 years ago, the U.S. Supreme Court upheld the power of states to mandate vaccines. Compared with mandating vaccination, the incentives to encourage vaccines seem innocuous.
Exploitation and paternalism
Yet some still worry. Bioethicists Emily Largent and Franklin Miller wrote in a recent paper that a payment might “unfairly" exploit “those U.S. residents who have lost jobs … or slipped into poverty during the pandemic," which could leave them feeling as if they have “no choice but to be vaccinated for cash." Others have noted that vaccine hesitancy is higher in nonwhite communities, where incomes tend to be lower, as is trust in the medical establishment.
Ethicists and policymakers should indeed focus on the poorest members of our community and seek to minimize racial disparities in both health outcomes and wealth. But there is no evidence that offering money is actually detrimental to such populations. Receiving money is a good thing. To suggest that we have to protect adults by denying them offers of money may come across as paternalism.
Some ethicists also argue that the money is better spent elsewhere to increase participation. States could spend the money making sure vaccines are convenient to everyone, for example, by bringing them to community events and churches. Money could also support various efforts to fight misinformation and communicate the importance of getting the shot.
The cost of incentives
Financial incentives could be expensive as a policy solution. As in Ohio, lottery drawings are one way to cap the overall cost of incentives while giving millions of people an additional reason to get their shot.
The tax code could also allow for a no-cost incentive for vaccination. Tax deductions and credits are often designed to encourage behaviors, such as savings or home ownership. Some states now have big budget surpluses and are considering tax relief measures. If a state announced now that such payments would be conditional on being vaccinated, then each person declining the shot would save the government money.
Ultimately, a well-designed vaccination incentive can help save lives and need not keep the ethicists up at night.
Geologists discover a rhythm to major geologic events.
- It appears that Earth has a geologic "pulse," with clusters of major events occurring every 27.5 million years.
- Working with the most accurate dating methods available, the authors of the study constructed a new history of the last 260 million years.
- Exactly why these cycles occur remains unknown, but there are some interesting theories.
Our hearts beat at a resting rate of 60 to 100 beats per minute. Lots of other things pulse, too. The colors we see and the pitches we hear, for example, are due to the different wave frequencies ("pulses") of light and sound waves.
Now, a study in the journal Geoscience Frontiers finds that Earth itself has a pulse, with one "beat" every 27.5 million years. That's the rate at which major geological events have been occurring as far back as geologists can tell.
A planetary calendar has 10 dates in red
Credit: Jagoush / Adobe Stock
According to lead author and geologist Michael Rampino of New York University's Department of Biology, "Many geologists believe that geological events are random over time. But our study provides statistical evidence for a common cycle, suggesting that these geologic events are correlated and not random."
The new study is not the first time that there's been a suggestion of a planetary geologic cycle, but it's only with recent refinements in radioisotopic dating techniques that there's evidence supporting the theory. The authors of the study collected the latest, best dating for 89 known geologic events over the last 260 million years:
- 29 sea level fluctuations
- 12 marine extinctions
- 9 land-based extinctions
- 10 periods of low ocean oxygenation
- 13 gigantic flood basalt volcanic eruptions
- 8 changes in the rate of seafloor spread
- 8 times there were global pulsations in interplate magmatism
The dates provided the scientists a new timetable of Earth's geologic history.
Tick, tick, boom
Credit: New York University
Putting all the events together, the scientists performed a series of statistical analyses that revealed that events tend to cluster around 10 different dates, with peak activity occurring every 27.5 million years. Between the ten busy periods, the number of events dropped sharply, approaching zero.
Perhaps the most fascinating question that remains unanswered for now is exactly why this is happening. The authors of the study suggest two possibilities:
"The correlations and cyclicity seen in the geologic episodes may be entirely a function of global internal Earth dynamics affecting global tectonics and climate, but similar cycles in the Earth's orbit in the Solar System and in the Galaxy might be pacing these events. Whatever the origins of these cyclical episodes, their occurrences support the case for a largely periodic, coordinated, and intermittently catastrophic geologic record, which is quite different from the views held by most geologists."
Assuming the researchers' calculations are at least roughly correct — the authors note that different statistical formulas may result in further refinement of their conclusions — there's no need to worry that we're about to be thumped by another planetary heartbeat. The last occurred some seven million years ago, meaning the next won't happen for about another 20 million years.