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19th-century medicine: Milk was used as a blood substitute for transfusions
Believe it or not, for a few decades, giving people "milk transfusions" was all the rage.
- Prior to the discovery of blood types in 1901, giving people blood transfusions was a risky procedure.
- In order to get around the need to transfuse others with blood, some doctors resorted to using a blood substitute: Milk.
- It went pretty much how you would expect it to.
For the bulk of human history, medical science has been a grim affair. Modern innovations in the scientific process and medical techniques mean that we can determine with a good deal of accuracy what's going to work and what won't, and we can test those theories in a relatively safe and scientifically sound way.
Not true for the past. Take blood transfusions, for instance. Prior to the discovery of blood types by Karl Landsteiner in 1901 and effective methods of avoiding coagulation when transfusing blood, human beings who had lost significant amounts of blood were pretty screwed, and not just because of the loss of blood, but also because of what we used to replace it with.
For a brief and bizarre time in the late 19th century, scientists were convinced that milk was the perfect substitute for lost blood.
The first successful transfusion of blood was performed in the 17th century by a physician named Richard Lower. He had developed a technique that enabled him to transfer blood without excess coagulation in the process, which he demonstrated when he bled a dog and then replaced its lost blood with that from a larger mastiff, who died in the process. Aside from being traumatized and abused, the receiving dog recovered with no apparent ill effects. Lower later transfused lamb blood into a mentally ill individual with the hope that the gentle lamb's temperament would ameliorate the man's insanity. The man survived; his mental illness persisted.
In 1667, Jean-Baptiste Denys transfused the blood of a sheep into a 15-year-old boy and a laborer, both of which survived. Denys and his contemporaries chose not to perform human-to-human transfusions since the process often killed the donor. Despite their initial successes, which likely only occurred due to the small quantities of blood involved, the later transfusions made by these physicians did not go so well. Denys, in particular, became responsible for the death of the Swedish Baron Gustaf Bonde and that of a mentally ill man named Antoine Mauroy.
Ultimately, these experiments were condemned by the Royal Society, the French government, and the Vatican by 1670. Research into blood transfusion stopped for 150 years. The practice had a brief revival in the early 19th century, but there had been no progress — many of the same problems were still around, like the difficulty of preventing blood from coagulating and the recipients' annoying habits of dying after their lives had just been saved by a blood transfusion. How best to get around blood's pesky characteristics? By the mid 19th century, physicians believed they had an answer: Don't use blood at all but use a blood substitute. Milk seemed like the perfect choice.
The first injection of milk into a human took place in Toronto in 1854 by Drs. James Bovell and Edwin Hodder. They believed that oily and fatty particles in milk would eventually be transformed into "white corpuscles," or white blood cells. Their first patient was a 40-year-old-man who they injected with 12 ounces of cows' milk. Amazingly, this patient seemed to respond to the treatment fairly well. They tried again with success. The next five times, however, their patients died.
Despite these poor outcomes, milk transfusion became a popular method of treating the sick, particularly in North America. Most of these patients were sick with tuberculosis, and, after receiving their blood transfusions, typically complained of chest pain, nystagmus (repetitive and involuntary movements of the eyes), and headaches. A few survived, and, according to the doctors carrying out these procedures, seemed to fare better after the treatment. Most, however, fell comatose and died soon after.
Most medical treatments today are first tested on animals and then on humans, but for milk transfusions, this process was reversed. One doctor, Dr. Joseph Howe, decided to perform an experiment to see whether it was the milk or some other factor causing these poor outcomes. He bled several dogs until they passed out and attempted to resuscitate them using milk. All of the dogs died.
From "Observations on the Transfusion of Blood," an illustration of James Blundell's Gravitator. Image source: The Lancet
However, Howe would go on to conduct another experiment in milk transfusion, believing that the milk itself wasn't responsible for the dogs' deaths, but rather the large quantity of milk he had administered. He also eventually hypothesized that the use of animal milk — he sourced it from goats — in humans was causing the adverse reactions. So, in 1880, Howe gathered three ounces of human milk with the goal of seeing whether using animal milk was somehow incompatible with human blood.
He transfused this into a woman with a lung disease, who stopped breathing very quickly after being injected with milk. Fortunately, Howe resuscitated the woman with artificial respiration and "injections of morphine and whiskey."
By this time, around 1884, the promise of milk as a perfect blood substitute had been thoroughly disproved. By the turn of the century, we had discovered blood types, and a safe and effective method of transfusing blood was established. Would these discoveries have occurred without the dodgy practice of injecting milk into the bloodstream? It's difficult to say. At the very least, we can say with confidence that life is much better — less hairy — for sick people in the 21st century than in the 19th.
Educators and administrators must build new supports for faculty and student success in a world where the classroom might become virtual in the blink of an eye.
- If you or someone you know is attending school remotely, you are more than likely learning through emergency remote instruction, which is not the same as online learning, write Rich DeMillo and Steve Harmon.
- Education institutions must properly define and understand the difference between a course that is designed from inception to be taught in an online format and a course that has been rapidly converted to be offered to remote students.
- In a future involving more online instruction than any of us ever imagined, it will be crucial to meticulously design factors like learner navigation, interactive recordings, feedback loops, exams and office hours in order to maximize learning potential within the virtual environment.
A leading British space scientist thinks there is life under the ice sheets of Europa.
- A British scientist named Professor Monica Grady recently came out in support of extraterrestrial life on Europa.
- Europa, the sixth largest moon in the solar system, may have favorable conditions for life under its miles of ice.
- The moon is one of Jupiter's 79.
Neil deGrasse Tyson wants to go ice fishing on Europa<div class="rm-shortcode" data-media_id="GLGsRX7e" data-player_id="FvQKszTI" data-rm-shortcode-id="f4790eb8f0515e036b24c4195299df28"> <div id="botr_GLGsRX7e_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/GLGsRX7e-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/GLGsRX7e-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/GLGsRX7e-FvQKszTI.js"></script> </div>
Water Vapor Above Europa’s Surface Deteced for First Time<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="9c4abc8473e1b89170cc8941beeb1f2d"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/WQ-E1lnSOzc?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span>
A study finds people are more influenced by what the other party says than their own. What gives?
- A new study has found evidence suggesting that conservative climate skepticism is driven by reactions to liberal support for science.
- This was determined both by comparing polling data to records of cues given by leaders, and through a survey.
- The findings could lead to new methods of influencing public opinion.
Mind the cues<div class="rm-shortcode" data-media_id="CabkeAzx" data-player_id="FvQKszTI" data-rm-shortcode-id="169377c88f392a86f6c42180b74820a5"> <div id="botr_CabkeAzx_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/CabkeAzx-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/CabkeAzx-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/CabkeAzx-FvQKszTI.js"></script> </div> <p>The gulf in accepting the science behind climate change also exists among party elites. It is well known to any American who is attentive to the news, as party leaders are often more than willing to discuss their take to journalists.</p><p>Using polling data going back to the 1980s, the researchers were able to create a chart showing the aggregate amount of climate skepticism among the general population. A similar diagram showing the Republicans' skepticism dating back to 2001 was sourced from a previous, similar study. It was shown to be highly correlated with the one produced for this study.</p><p>These charts were compared with media content from prominent newspapers that included implicit or explicit stances on climate change by significant political figures. These thousands of articles were classified by using key terms and which major political figures were quoted or referenced. The researchers compared the number of cues over time to measured skepticism and looked for "<a href="https://en.wikipedia.org/wiki/Granger_causality" target="_blank">Granger causality</a>," the tendency for one variable to predict the future value of another variable.</p><p>The model shows evidence of both in and out-group cue effects, though the repulsion to out-group cues was much more evident. A significant increase in Democratic cues in favor of climate science was followed by a rise in skepticism among Republican voters. Importantly, the cues lead, rather than follow opinion, and do so with consistency. Changes in view did not predict changes in the number or direction of cues. </p><p>The researchers also surveyed nearly 3000 adults to demonstrate the concept. This involved showing them a statement on the scientific consensus around climate change and a cue from either a Republican or a Democrat. This test confirmed the previous observation and provided further support for the notion that signals from leaders cause an increase in skepticism among some respondents.</p><p>Before my left-leaning and Democratic readers get too smug, this research references previous studies demonstrating a similar effect in the lead up to the Iraq War. However, in that case, the Democratic Party elites' mixed messages were countered by a Republican Party united behind the idea of invasion. The effect on the Democratic party rank and file was similar to that observed in this case. </p><p>Several other studies have examined effects similar to this for other issues. This study's importance is its focus on out-group cues and the effort placed into demonstrating a causal relationship between the statements of certain party elites and public opinion. Most previous studies focused purely on in-group cues or failed to differentiate between the two. </p>
Can thinking about the past really help us create a better present and future?
- There are two types of counterfactual thinking: upward and downward.
- Both upward and downward counterfactual thinking can be positive impacts on your current outlook - however, upward counterfactual thinking has been linked with depression.
- While counterfactual thinking is a very normal and natural process, experts suggest the best course is to focus on the present and future and allow counterfactual thinking to act as a motivator when possible.
“Upward” versus “downward” counterfactual thinking<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMzQ1NDYxOS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY0NDM2MDY2OX0.njWs1qrV1vDBxU1V75tUduUW4TjJvEHglDWsK8ZF2l4/img.jpg?width=1245&coordinates=0%2C556%2C0%2C209&height=700" id="a15fa" class="rm-shortcode" data-rm-shortcode-id="98314d4d2b256ed08f42d369fe4ae080" data-rm-shortcode-name="rebelmouse-image" alt="concept of man thinking about the past one line drawing counterfactual thinking" />
What are upward and downward counterfactual thinking?
Image by one line man on Shutterstock<p><strong>What is upward counterfactual thinking?</strong></p><p>Upward counterfactual thinking happens when we look at a scenario and ask ourselves "what if" in terms of how our life could have turned out better. </p><p>Examples of upward counterfactual thinking are: </p><ul><li><em>"I wish I had taken that other job instead of this one 10 years ago - my life would be so much better if I had." </em></li><li><em>"I wish I would have gotten the part in that high school play, maybe I could have gotten into a theatre school and became an actor…"</em> </li></ul><p>Both of these examples have the ideology that if you had made different choices, your life right now would be improved. </p><p><strong>What is downward counterfactual thinking?</strong></p><p>Downward counterfactual thinking is, naturally, the opposite of upward counterfactual thinking in that we think about how things could have been worse if other decisions had been made. </p><p>Examples of downward counterfactual thinking are: </p><ul><li><em>"I'm so thankful I studied secondary education in university instead of psychology like I had originally planned - I love teaching high school kids and I never would have gotten to do that…" </em></li><li><em>"I'm so happy I left David when I got the chance, I can't imagine still being in an unhappy marriage with someone who doesn't support me…"</em> </li></ul><p>In these examples, we see the idea that if you had made different choices your life would not be as good as it is right now. </p>
How counterfactual thinking can impact your life<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMzQ1NDYxNy9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYyNjI2MDQxOX0.DIVQ-Yk0d6yE3tc743MH1Fz2pOg1TGHLmhp8dPp9UdY/img.jpg?width=1245&coordinates=0%2C0%2C0%2C0&height=700" id="522d7" class="rm-shortcode" data-rm-shortcode-id="da7df6ad916b043e3610223900d0f8df" data-rm-shortcode-name="rebelmouse-image" alt="man thinking what if written on chalkboard" />
How do upward and downward counterfactual thinking impact your life?
Photo by Brasil Creativo on Shutterstock<p>While many people don't see the point in "what if" scenarios, various studies have found that downward counterfactual thinking can be more associated with psychological health compared with upward counterfactual thinking. Not only that, but research has also shown upward counterfactual thinking can be linked with current and future depression.</p> <p><strong>Downward counterfactual thinking tends to be more associated with psychological health </strong></p><p>According to a <a href="http://journal.sjdm.org/jdm06136.pdf" target="_blank">2000 study</a>, downward counterfactual thinking can be linked with better psychological health compared to upward counterfactual thinking. More importantly, in cases where downward counterfactual thinking did lead to negative feelings, those feelings acted as something of a motivator for people to take productive actions to better their current situation. </p> <p><strong>Upward counterfactual thinking tends to be more associated with depression </strong></p><p><a href="https://www.sciencedirect.com/science/article/abs/pii/S0272735816301714#:~:text=An%20upward%20counterfactual%20(as%20opposed,Markman%20and%20McMullen%2C%202003)." target="_blank">According to a 2017 study</a> that pooled a sample of over 13,000 respondents, thoughts about "better outcomes" and regret (upward counterfactual thinking) were associated with current and future depression. </p> <p><strong>Downward counterfactual thinking can actually improve your relationships and is more often engaged in by women than men.</strong></p><p>In a <a href="https://dspace.sunyconnect.suny.edu/bitstream/handle/1951/67589/Studer_Thesis.pdf?sequence=1&isAllowed=y" target="_blank">2016 research paper submitted</a> to the Department of Psychology at the State University of New York at New Paltz, downward counterfactual thinking in regards to romantic relationships was associated with relatively positive relationship outcomes. Interestingly, women were more likely than men to engage in downward counterfactual thinking about their romantic life. </p> <p><strong>Upward counterfactual thinking can have some benefits in certain scenarios. </strong></p><p>When we look back after a failed test and think "I wish I would have studied more" - this motivates us to study harder the next time a test comes up. In this way, upward counterfactual thinking (or the negative version of "what if") can actually benefit us. </p> <p><strong>This can be difficult, though, because much of the time upward counterfactual thinking is more associated with a pessimistic outlook that can be unmotivating. </strong></p> <p>Thinking in the past tense can be motivational (and even healthy) at times, but the best thing to do is look forward. </p><p>While counterfactual thinking as a whole can be used to motivate us to make better choices or appreciate where we are in life, <a href="https://www.psychologytoday.com/us/blog/darwins-subterranean-world/201809/the-psychology-what-if" target="_blank">this Psychology Today</a> article suggests that we should come up with ways to move on and focus on the present and the future instead of the past. Using counterfactual thinking as a motivational tool can be very helpful if we don't get stuck in the "what if" mindset that tends to pull us out of the present and back into the past, where things will always remain the same. </p>