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Why we need to restrict calories right now
A new study shows the benefits of calorie restriction. Never has such advice been more needed.

- A new study based at Salk Institute has discovered the cellular mechanisms behind calorie restriction.
- Rats on a higher-calorie diet experienced more inflammation and immune problems than rats that ate less.
- This research is especially relevant right now, as immunodeficient patients are at high risk of complications from COVID-19.
Finding kale and quinoa has never been easier than it is right now. Oreos and Spam, not so much.
We know about the toilet paper and hand sanitizer shortages. There are other problems. I've visited at least five grocers in the last week in my Los Angeles neighborhood, and the processed foods shelves are empty.
That problem is not only occurring here. Food giants like General Mills and Campbell Soup are experiencing sales gains between 10-20 percent. Popcorn, pretzels, and potato chips are even higher, between 30-48 sales increases over this time last year.
This is not the direction we should be moving in during a pandemic—or ever, but especially right now.
First, we must differentiate between processed foods and packaged goods. The latter is understandable: beans, pasta, rice, sauces—these too have been filling carts. The issue is "comfort foods," processed and packaged foodstuffs high in sugars and emulsifiers, which are selling at an even higher rate. At a time when we need our immune systems to be as healthy as possible, diet has never mattered more.
Emotional eating during such an unprecedented time is understandable, expectable even. We gravitate toward sugar- and carb-heavy foods when stressed. But for the sake of not only your health, but our overtaxed health care system, we all need to think more deeply about what we're putting into our bodies.
Salk scientists show how caloric restriction prevents negative effects of aging in cells
I've covered health for Big Think since 2012 and have read hundreds of studies concerning diet and fitness. Time and again, two methods appear to work best: closing your feeding window and calorie restriction. The former is usually packaged with the title "intermittent fasting," but really it's just about not eating from the moment you wake up until right before bed. Restricting your feeding window to 10 hours a day or less seems to bestow the greatest benefits; even 12 hours is beneficial. The majority of Americans eat over the course of 14 hours per day.
Calorie restriction is usually associated with the Singularity set as an anti-aging protocol, but don't be dissuaded by that crowd. Plenty of research has backed up the health benefits of reducing your caloric load. A new study from a team of collaborators from the US and China discusses why that is.
Published in the journal Cell, a team at Salk Institute's Gene Expression Laboratory in La Jolla (along with former Salk alumni now based in China) tested 56 rats over the course of nine months, age 18 months to 27 months. For comparison sake, that is the equivalent of tracking human diets from age 50 to 70.
The parameters are pretty simple: one group was given one caloric load, while the other was fed 30 percent fewer calories. The team then analyzed 168,703 cells from 40 different cell types, including cells from bone marrow, skin, brain, and muscle tissue.
Cells from rats on the calorie-restricted diet resembled young rats by the end of the study. A total of 57 percent of the aging changes in the non-restricted rats were not prevalent in the dieting group. Co-corresponding author Guang-Hui Liu (at the Chinese Academy of Sciences) breaks it down:
"This approach not only told us the effect of calorie restriction on these cell types, but also provided the most complete and detailed study of what happens at a single-cell level during aging."
Photo: Getty Images
The cells most affected by higher calorie intake include those linked to lipid metabolism as well as immunity and inflammation response. In fact, inflammation kept increasing in rat bingers. Chronic inflammation is one of the biggest consequences of the "Western diet," which negatively impacts a range of cancers and metabolic and cardiovascular diseases.
Even more urgent at this moment are the cytokine storms caused by COVID-19. While the virus is hitting elderly and immune-suppressed populations hardest, victims of every age group are experiencing this deadly inflammatory response. Whether or not diet is specifically related to COVID-19 is unknown, but we do know that two consequences of obesity are immune problems and inflammation. If you prime your body by eating foods that promote inflammation, you're going to have trouble fighting off disease.
Juan Carlos Izpisua Belmonte, also a co-corresponding author on this paper, is hopeful that this research will open up new avenues of treatment.
"We already knew that calorie restriction increases life span, but now we've shown all the changes that occur at a single-cell level to cause that. This gives us targets that we may eventually be able to act on with drugs to treat aging in humans."
Never in history has it been so apparent that we're all in this together. Social media keeps us dialed in for constant updates. If a greater emphasis on our health care system (as well as individual health) is an outcome of this pandemic, we can at least chalk that up as one small victory.
Right now, of course, we need to focus on the most vulnerable populations. While we live through this, however, don't put yourself at risk of being in that population. Eat smarter, and eat less.
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Stay in touch with Derek on Twitter and Facebook. His next book is "Hero's Dose: The Case For Psychedelics in Ritual and Therapy."
- The Benefits of Calorie Restriction - Big Think ›
- Here's Why Calorie Restriction Makes Us Live Longer - Big Think ›
- Emotional eating: why do I eat when I'm bored? - Big Think ›
There are 5 eras in the universe's lifecycle. Right now, we're in the second era.
Astronomers find these five chapters to be a handy way of conceiving the universe's incredibly long lifespan.
Image based on logarithmic maps of the Universe put together by Princeton University researchers, and images produced by NASA based on observations made by their telescopes and roving spacecraft
- We're in the middle, or thereabouts, of the universe's Stelliferous era.
- If you think there's a lot going on out there now, the first era's drama makes things these days look pretty calm.
- Scientists attempt to understand the past and present by bringing together the last couple of centuries' major schools of thought.
The 5 eras of the universe
<p>There are many ways to consider and discuss the past, present, and future of the universe, but one in particular has caught the fancy of many astronomers. First published in 1999 in their book <a href="https://amzn.to/2wFQLiL" target="_blank"><em>The Five Ages of the Universe: Inside the Physics of Eternity</em></a>, <a href="https://en.wikipedia.org/wiki/Fred_Adams" target="_blank">Fred Adams</a> and <a href="https://en.wikipedia.org/wiki/Gregory_P._Laughlin" target="_blank">Gregory Laughlin</a> divided the universe's life story into five eras:</p><ul><li>Primordial era</li><li>Stellferous era</li><li>Degenerate era</li><li>Black Hole Era</li><li>Dark era</li></ul><p>The book was last updated according to current scientific understandings in 2013.</p><p>It's worth noting that not everyone is a subscriber to the book's structure. Popular astrophysics writer <a href="https://www.forbes.com/sites/ethansiegel/#30921c93683e" target="_blank">Ethan C. Siegel</a>, for example, published an article on <a href="https://www.forbes.com/sites/startswithabang/2019/07/26/we-have-already-entered-the-sixth-and-final-era-of-our-universe/#7072d52d4e5d" target="_blank"><em>Medium</em></a> last June called "We Have Already Entered The Sixth And Final Era Of Our Universe." Nonetheless, many astronomers find the quintet a useful way of discuss such an extraordinarily vast amount of time.</p>The Primordial era
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMjkwMTEyMi9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYyNjEzMjY1OX0.PRpvAoa99qwsDNprDme9tBWDim6mS7Mjx6IwF60fSN8/img.jpg?width=980" id="db4eb" class="rm-shortcode" data-rm-shortcode-id="0e568b0cc12ed624bb8d7e5ff45882bd" data-rm-shortcode-name="rebelmouse-image" data-width="1440" data-height="1049" />Image source: Sagittarius Production/Shutterstock
<p> This is where the universe begins, though what came before it and where it came from are certainly still up for discussion. It begins at the Big Bang about 13.8 billion years ago. </p><p> For the first little, and we mean <em>very</em> little, bit of time, spacetime and the laws of physics are thought not yet to have existed. That weird, unknowable interval is the <a href="https://www.universeadventure.org/eras/era1-plankepoch.htm" target="_blank">Planck Epoch</a> that lasted for 10<sup>-44</sup> seconds, or 10 million of a trillion of a trillion of a trillionth of a second. Much of what we currently believe about the Planck Epoch eras is theoretical, based largely on a hybrid of general-relativity and quantum theories called quantum gravity. And it's all subject to revision. </p><p> That having been said, within a second after the Big Bang finished Big Banging, inflation began, a sudden ballooning of the universe into 100 trillion trillion times its original size. </p><p> Within minutes, the plasma began cooling, and subatomic particles began to form and stick together. In the 20 minutes after the Big Bang, atoms started forming in the super-hot, fusion-fired universe. Cooling proceeded apace, leaving us with a universe containing mostly 75% hydrogen and 25% helium, similar to that we see in the Sun today. Electrons gobbled up photons, leaving the universe opaque. </p><p> About 380,000 years after the Big Bang, the universe had cooled enough that the first stable atoms capable of surviving began forming. With electrons thus occupied in atoms, photons were released as the background glow that astronomers detect today as cosmic background radiation. </p><p> Inflation is believed to have happened due to the remarkable overall consistency astronomers measure in cosmic background radiation. Astronomer <a href="https://www.youtube.com/watch?v=IGCVTSQw7WU" target="_blank">Phil Plait</a> suggests that inflation was like pulling on a bedsheet, suddenly pulling the universe's energy smooth. The smaller irregularities that survived eventually enlarged, pooling in denser areas of energy that served as seeds for star formation—their gravity pulled in dark matter and matter that eventually coalesced into the first stars. </p>The Stelliferous era
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMjkwMTEzNy9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYxMjA0OTcwMn0.GVCCFbBSsPdA1kciHivFfWlegOfKfXUfEtFKEF3otQg/img.jpg?width=980" id="bc650" class="rm-shortcode" data-rm-shortcode-id="c8f86bf160ecdea6b330f818447393cd" data-rm-shortcode-name="rebelmouse-image" data-width="481" data-height="720" />Image source: Casey Horner/unsplash
<p>The era we know, the age of stars, in which most matter existing in the universe takes the form of stars and galaxies during this active period. </p><p>A star is formed when a gas pocket becomes denser and denser until it, and matter nearby, collapse in on itself, producing enough heat to trigger nuclear fusion in its core, the source of most of the universe's energy now. The first stars were immense, eventually exploding as supernovas, forming many more, smaller stars. These coalesced, thanks to gravity, into galaxies.</p><p>One axiom of the Stelliferous era is that the bigger the star, the more quickly it burns through its energy, and then dies, typically in just a couple of million years. Smaller stars that consume energy more slowly stay active longer. In any event, stars — and galaxies — are coming and going all the time in this era, burning out and colliding.</p><p>Scientists predict that our Milky Way galaxy, for example, will crash into and combine with the neighboring Andromeda galaxy in about 4 billion years to form a new one astronomers are calling the Milkomeda galaxy.</p><p>Our solar system may actually survive that merger, amazingly, but don't get too complacent. About a billion years later, the Sun will start running out of hydrogen and begin enlarging into its red giant phase, eventually subsuming Earth and its companions, before shrining down to a white dwarf star.</p>The Degenerate era
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMjkwMTE1MS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYxNTk3NDQyN30.gy4__ALBQrdbdm-byW5gQoaGNvFTuxP5KLYxEMBImNc/img.jpg?width=980" id="77f72" class="rm-shortcode" data-rm-shortcode-id="08bb56ea9fde2cee02d63ed472d79ca3" data-rm-shortcode-name="rebelmouse-image" data-width="1440" data-height="810" />Image source: Diego Barucco/Shutterstock/Big Think
<p>Next up is the Degenerate era, which will begin about 1 quintillion years after the Big Bang, and last until 1 duodecillion after it. This is the period during which the remains of stars we see today will dominate the universe. Were we to look up — we'll assuredly be outta here long before then — we'd see a much darker sky with just a handful of dim pinpoints of light remaining: <a href="https://earthsky.org/space/evaporating-giant-exoplanet-white-dwarf-star" target="_blank">white dwarfs</a>, <a href="https://earthsky.org/space/new-observations-where-stars-end-and-brown-dwarfs-begin" target="_blank">brown dwarfs</a>, and <a href="https://earthsky.org/astronomy-essentials/definition-what-is-a-neutron-star" target="_blank">neutron stars</a>. These"degenerate stars" are much cooler and less light-emitting than what we see up there now. Occasionally, star corpses will pair off into orbital death spirals that result in a brief flash of energy as they collide, and their combined mass may become low-wattage stars that will last for a little while in cosmic-timescale terms. But mostly the skies will be be bereft of light in the visible spectrum.</p><p>During this era, small brown dwarfs will wind up holding most of the available hydrogen, and black holes will grow and grow and grow, fed on stellar remains. With so little hydrogen around for the formation of new stars, the universe will grow duller and duller, colder and colder.</p><p>And then the protons, having been around since the beginning of the universe will start dying off, dissolving matter, leaving behind a universe of subatomic particles, unclaimed radiation…and black holes.</p>The Black Hole era
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMjkwMTE2MS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYzMjE0OTQ2MX0.ifwOQJgU0uItiSRg9z8IxFD9jmfXlfrw6Jc1y-22FuQ/img.jpg?width=980" id="103ea" class="rm-shortcode" data-rm-shortcode-id="f0e6a71dacf95ee780dd7a1eadde288d" data-rm-shortcode-name="rebelmouse-image" data-width="1400" data-height="787" />Image source: Vadim Sadovski/Shutterstock/Big Think
<p> For a considerable length of time, black holes will dominate the universe, pulling in what mass and energy still remain. </p><p> Eventually, though, black holes evaporate, albeit super-slowly, leaking small bits of their contents as they do. Plait estimates that a small black hole 50 times the mass of the sun would take about 10<sup>68</sup> years to dissipate. A massive one? A 1 followed by 92 zeros. </p><p> When a black hole finally drips to its last drop, a small pop of light occurs letting out some of the only remaining energy in the universe. At that point, at 10<sup>92</sup>, the universe will be pretty much history, containing only low-energy, very weak subatomic particles and photons. </p>The Dark Era
<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMjkwMTE5NC9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY0Mzg5OTEyMH0.AwiPRGJlGIcQjjSoRLi6V3g5klRYtxQJIpHFgZdZkuo/img.jpg?width=980" id="60c77" class="rm-shortcode" data-rm-shortcode-id="7a857fb7f0d85cf4a248dbb3350a6e1c" data-rm-shortcode-name="rebelmouse-image" data-width="1440" data-height="810" />Image source: Big Think
<p>We can sum this up pretty easily. Lights out. Forever.</p>Dark energy: The apocalyptic wild card of the universe
Dr. Katie Mack explains what dark energy is and two ways it could one day destroy the universe.
- The universe is expanding faster and faster. Whether this acceleration will end in a Big Rip or will reverse and contract into a Big Crunch is not yet understood, and neither is the invisible force causing that expansion: dark energy.
- Physicist Dr. Katie Mack explains the difference between dark matter, dark energy, and phantom dark energy, and shares what scientists think the mysterious force is, its effect on space, and how, billions of years from now, it could cause peak cosmic destruction.
- The Big Rip seems more probable than a Big Crunch at this point in time, but scientists still have much to learn before they can determine the ultimate fate of the universe. "If we figure out what [dark energy is] doing, if we figure out what it's made of, how it's going to change in the future, then we will have a much better idea for how the universe will end," says Mack.
Astrophysicists find unique "hot Jupiter" planet without clouds
A unique exoplanet without clouds or haze was found by astrophysicists from Harvard and Smithsonian.
Illustration of WASP-62b, the Jupiter-like planet without clouds or haze in its atmosphere.
- Astronomers from Harvard and Smithsonian find a very rare "hot Jupiter" exoplanet without clouds or haze.
- Such planets were formed differently from others and offer unique research opportunities.
- Only one other such exoplanet was found previously.
Munazza Alam – a graduate student at the Center for Astrophysics | Harvard & Smithsonian.
Credit: Jackie Faherty
Jupiter's Colorful Cloud Bands Studied by Spacecraft
<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="8a72dfe5b407b584cf867852c36211dc"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/GzUzCesfVuw?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span>Five collectibles with better returns than the stock market
People often make a killing in stocks, but there are other ways to potentially turn major profits.
