Breast cancer vaccine could be available in 8 years, says Mayo Clinic
A new immunotherapy treatment is showing positive signs in early-stage clinical trials.
- Clinical trials of an immunotherapy treatment for breast cancer showed positive signs, and the researchers hope to move to larger trials in coming years.
- Immunotherapies train the body's immune system to find and kill cancer cells without harming healthy cells.
- Recent trials of immunotherapies for other cancers have also showed positive signs.
A vaccine that prevents the recurrence and development of breast and ovarian cancers could become available in less than a decade, according to researchers at the Mayo Clinic in Jacksonville, Florida.
The researchers developed an immunotherapy treatment that trains the immune system to recognize and kill breast cancer cells. Based on the results of early-stage clinical trials, the vaccine seems to have successfully removed cancer cells in one patient, and another is showing positive results.
"It's supposed to stimulate a patient's own immune response so that the immune cells, like t-cells, would go in and attack the cancer," Dr. Saranya Chumsri, an oncologist at the world-renowned medical center, told First Coast News.
Before the vaccine could be made available to a large amount of patients, it would need to pass the Food and Drug Administration's phase 3 trials, a process that probably won't start for another three years. But the researchers are confident their treatment will withstand the screening.
"It is reasonable to say that we could have a vaccine within eight years that may be available to patients through their pharmacy or their doctor," Mayo Clinic investigator, Keith L. Knutson, Ph.D., told Forbes.
Mayo Clinic immunologists have also developed two other cancer vaccines for Triple Negative Breast Cancer and HER2 Positive Breast Cancer.
"We know that they're safe," Knutson said. "We know that they stimulate the immune system [to fight cancer]. . . We know that they have had a positive impact on ovarian and breast cancer. We haven't seen any adverse events that are causing problems other than irritation in the area similar to a flu vaccination. Now we have to convince the FDA, through solid, rigorous clinical trials that we're seeing what we're seeing."
Since the 1990s, immunotherapies have increasingly become an area of interest among medical researchers who seek to defeat cancer without simultaneously destroying healthy cells in the body, as chemotherapy and radiation does. Immunotherapy is, in theory, is the ideal solution. But one major obstacle is that all cancers are different, so it's unclear when or whether immunotherapies will be able to treat the more than 100 types of cancer currently known to scientists.
Still, researchers are currently exploring a variety of immunotherapies, and the global immunotherapy drug market is expected to grow to a valuation of $101.6 billion by 2023.
"Other individuals are working on lung and prostate and other cancers," Knutson said. "Some are very similar to the approaches we are taking, but there are different cellular processes that have gone wrong in different cancers."
Chumsri and Kutson both said that early clinical trials of a variety of immunotherapies are showing positive signs.
"We have seen early signals that our vaccines have a very positive impact on disease," Knutson said. "We are building on that foundation."
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Whether or not women think beards are sexy has to do with "moral disgust"
- A new study found that women perceive men with facial hair to be more attractive as well as physically and socially dominant.
- Women tend to associate more masculine faces with physical strength, social assertiveness, and formidability.
- Women who display higher levels of "moral disgust," or feelings of repugnance toward taboo behaviors, are more likely to prefer hairy faces.
Beards and perceptions of masculinity<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMjU5OTg0MC9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY0NzkxMjM3N30.cH-GqNwP5GVqvstgJWAhBPn1B_lYpVEAI0I7iax7EQw/img.jpg?width=1245&coordinates=0%2C1900%2C0%2C849&height=700" id="caae6" class="rm-shortcode" data-rm-shortcode-id="cb0a355a4e8e1899789bc45f3f7aef56" data-rm-shortcode-name="rebelmouse-image" />
Photo Credit: Wikimedia<p>The study used 919 American (mostly white) women ages 18-70 who rated 30 pictures of men they were shown with various stages of facial hair growth. The photographs depicted men with faces that had been digitally altered to look more feminine or more masculine, with a beard and without a beard. The women rated the men according to perceived attractiveness for long-term and short-term relationships. The study found that the more facial hair the men had, the higher the men were rated on their attractiveness, particularly for their suitability for a long-term relationship.</p><p>Part of this might be attributed to facial masculinity — i.e. protruding brow ridge, wide cheekbones, thick jawline, and deeply set narrow eyes — which conveys information to a woman about a man's underlying health and formidability. Women tend to associate more masculine faces with physical strength and social assertiveness. It can also indicate a man with a superior immune response. The researchers suggested that their findings favoring bearded men could be due to the fact that facial hair enhances the masculine facial features on a man's face, like creating the illusion of a thicker jaw line. This could communicate direct benefits to women like resources and protection that would enhance survival among mothers and their infants. In other words, while a beard doesn't mean superior genetics in and of itself, it might be a primitive, ornamental way of saying, "Hey girl, I'm a testosterone-fueled lean, mean, pathogen fighting machine." <br></p><p>It could also be that a beard becomes its own destiny. The researchers in this study cite prior research that found that by growing a beard, men felt more masculine and had higher levels of serum testosterone, which was linked to a higher level of social dominance. They also tended to subscribe to more old-school beliefs about gender roles in their relationships with women as compared to men with clean-shaven faces.<span></span><br></p>
What does disgust have to do with beard preference?<p>Obviously, not all women dig beards. The researchers were particularly interested in what traits make a women prefer bearded men over clean-shaven faces. They looked into several factors including a woman's disgust levels on various concepts, her desire to become pregnant, and her exposure to facial hair in her personal life. </p><p>According to the study, women who were not into facial hair were turned-off by potential parasites or other critters they imagined could be in the hair or skin. Women ranking high on this "ectoparasite disgust" scale might have viewed beards as a sign of poor grooming habits. However, women who ranked higher in levels of "pathogen" did find the bearded men to be desirable, possibly because they perceived beards as a signal of good health and immune function. An intriguing discovery in the study was links to morality. Women who displayed higher levels of "moral disgust," or feelings of repugnance toward taboo behaviors, were more likely to prefer hairy faces. The authors opined that this could reflect a link between beardedness, politically conservative outlooks, and traditional views regarding performances of masculinity in heterosexual relationships.</p>
Additional findings<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMjU5OTg1My9vcmlnaW4uZ2lmIiwiZXhwaXJlc19hdCI6MTYyNDI1NjUyOX0.P9B8WbmJR0q4nfzYZKbuNSA-2SAigVWJgrQE-_Gxlds/img.gif?width=980" id="49143" class="rm-shortcode" data-rm-shortcode-id="2ed3b1d6f20fc170bf2974646e565e8d" data-rm-shortcode-name="rebelmouse-image" />Giphy<p>The correlations that existed between married and single women's rating on the attractiveness of beards were not particularly clear, although the researchers noted that single and married women who wanted children tended to find beards more attractive than the women who didn't want children. They also found that women with bearded husbands found beards to be more attractive, which might indicate that social exposure to beards influences how desirable they are perceived of as being. Or it could be that men with wives who like beards grow beards.</p><p>It's important to note that culture plays a huge role in how attractive women perceive certain male characteristics as being. This study looked at a small, culturally specific group of American women, so no big, universal claims should be made about masculinity, facial hair, and male desirability to women. However, research like this is important in highlighting how human grooming decisions are driven by much more than fashion trends. Sociobiological, economic, and ecological factors all play a part in the way we choose to present ourselves.</p>
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