Scientists reverse hair loss by making scalp "smell" sandalwood
It turns out the human scalp has an olfactory receptor that seems to play a crucial role in regulating hair follicle growth and death.
- Scientists treated scalp tissue with a chemical that mimics the odor of sandalwood.
- This chemical bound to an olfactory receptor in the scalp and stimulated hair growth.
- The treatment could soon be available to the public.
A synthetic chemical that mimics the odor of sandalwood could be the key to reversing hair loss, new research suggests. In a paper published in Nature on September 18, scientists describe how they were able to stimulate hair follicle growth and slow cell death by essentially getting scalp tissue to "smell" a sandalwood odorant called Sandalore. The unusual finding is explained by the existence of a particular olfactory receptor in the scalp, OR2AT4, to which Sandalore binds and promotes hair growth.
"This is actually a rather amazing finding," senior researcher and dermatologist Ralf Paus from the University of Manchester in the U.K. told The Independent. "This is the first time ever that it has been shown that the remodelling of a normal human mini-organ [a hair] can be regulated by a simple, cosmetically widely-used odorant."
A possible "olfactotherapy" treatment
Sandalore, which is used in perfumes and skin cleaners, is known to have unusually effective wound-healing properties because it interacts with certain kinds of olfactory receptors in the skin. With this in mind, the researchers hypothesized that the chemical could have similar effects on hair follicles.
To find out, the team treated samples of human scalp skin with Sandalore and found that it stimulated a hair-growth factor called IGF-1 when it bound to the olfactory receptor OR2AT4. As further evidence that OR2AT4 plays a key role in hair growth, the researchers showed that hair follicles died more quickly when they "silenced" the receptor.
While it's still unclear whether Sandalore could continuously stimulate hair growth over a long-term period, Paus said the chemical could soon be offered as an "olfactotherapy" treatment for hair loss, a condition that affects about 80 million men and women in the U.S."Sandalore is already offered as a cosmetic product in Italy by the company that has co-sponsored the current study," Paus told The Independent. "A very small, short and preliminary clinical pilot study performed by an independent CRO [contract research organization] in 20 female volunteers with topical Sandalore has already suggested a reduction of daily hair loss."
To create wiser adults, add empathy to the school curriculum.
- Stories are at the heart of learning, writes Cleary Vaughan-Lee, Executive Director for the Global Oneness Project. They have always challenged us to think beyond ourselves, expanding our experience and revealing deep truths.
- Vaughan-Lee explains 6 ways that storytelling can foster empathy and deliver powerful learning experiences.
- Global Oneness Project is a free library of stories—containing short documentaries, photo essays, and essays—that each contain a companion lesson plan and learning activities for students so they can expand their experience of the world.
An extinction events expert sounds a dire warning.
- The supervolcano in Yellowstone National Park could cause an "ultra-catastrophe," warns an extinction events writer.
- The full eruption of the volcano last happened 640,000 years ago.
- The blast could kill billions and make United States uninhabitable.
Just before I turned 60, I discovered that sharing my story by drawing could be an effective way to both alleviate my symptoms and combat that stigma.
I've lived much of my life with anxiety and depression, including the negative feelings – shame and self-doubt – that seduced me into believing the stigma around mental illness: that people knew I wasn't good enough; that they would avoid me because I was different or unstable; and that I had to find a way to make them like me.
A joint study by two England universities explores the link between sex and cognitive function with some surprising differences in male and female outcomes in old age.
- A joint study by the universities of Coventry and Oxford in England has linked sexual activity with higher cognitive abilities in older age.
- The results of this study suggest there are significant associations between sexual activity and number sequencing/word recall in men. In women, however, there was a significant association between sexual activity in word recall alone - number sequencing was not impacted.
- The differences in testosterone (the male sex hormone) and oxytocin (a predominantly female hormone) may factor into why the male cognitive level changes much more during sexual activity in older age.
Mathematicians studied 100 billion tweets to help computer algorithms better understand our colloquial digital communication.