New research sheds light on a possible cause of autism: processed foods
The more we learn about the microbiome, the more the pieces are fitting together.
- A new study from the University of Central Florida makes the case for the emerging connection of autism and the human microbiome.
- High levels of Propionic Acid (PPA), used in processed foods to extend shelf life, reduces neuronal development in fetal brains.
- While more research is needed, this is another step in fully understanding the consequences of poor nutrition.
A new study from the University of Central Florida, published in Scientific Reports on June 19, makes the case for the emerging connection of autism and the human microbiome. High levels of Propionic Acid (PPA), which is used in processed foods to extend shelf life and inhibit the growth of mold, appears to reduce neuronal development in fetal brains.
Turning to diet to better understand autism is not new. This new study implicates the mother's diet in the onset of autism in the developing fetus. Such a finding, if proven true, could have important consequences for prenatal care moving forward.
As the team comprised of Latifa S. Abdelli, Aseela Samsam, and Saleh A. Naser writes, autism spectrum disorder (ASD) is marked by neuro-inflammation and gastrointestinal symptoms. The spectrum includes varying levels of impaired social communication, as well as repetitive behaviors that impede a child's learning progress and ability to relate to others.
The number of children diagnosed with ASD has been ticking up by the year, though as Silberman writes, the spectrum is not new. Still, something is changing in societies causing this surge. In 2000, the CDC observed one out of every 150 children exhibiting such behaviors; by 2018, that number climbed to one of out every 59.
Could Autism Be Caused by Gut Microbes? | Dr. Emeran Mayer
The research team notes that thousands of genes are associated with ASD. While there is no singular likely culprit — they believe it is an interplay between genetic and environmental forces — they focused on maternal immune system abnormalities. Naser, who specializes in gastroenterology research, homed in on PPA as he had previously observed high levels of this carboxylic acid in stool samples of children with autism.
Excessive PPA reduces the number of neurons in the brain while simultaneously overproducing glial cells, resulting in inflammation, a marker of autism. Increased amounts of PPA damage neuronal pathways that allow the brain to communicate with the body. This toxic cocktail matches the symptoms of autism: repetitive behaviors, mobility issues, trouble communicating with others.
PPA naturally occurs in the human microbiome. Increased amounts of the acid, consumed by mothers by way of processed foods, appears to have a negative effect on their children. Increased PPA crosses into the fetus, potentially stunting neuronal development, which could aid in triggering the cascading effects that lead to the spectrum.
The acid was first discovered in 1844 by Austrian chemist, Johann Gottlieb, who noticed it in degraded sugar products. Isolated, it gives off the scent of unpleasant body odor. Manufactured, however, it is used to stop molding in animal feed, as well as human food products, including grains, baked goods, and cheese. It is approved for usage in the EU, USA, Australia, and New Zealand.
Autistic child attends the World Autism Awareness Day 2019 celebrations on April 2, 2019 in Kuala Lumpur, Malaysia. Photo credit: Mohd Samsul Mohd Said / Getty Images
Previous research has linked too much PPA with everything from nose and throat irritation to birth defects and cancer (in rats). While it is generally considered low in toxicity if swallowed, this study from UCF suggests that its effects on the maternal microbiome is far greater than previously imagined. It is, according to the researchers, only a first step, but an important one:
"This research is only the first step towards better understanding of Autism Spectrum Disorder. But we have confidence we are on the right track to finally uncovering autism etiology."
There is no benefit without cost. The low health cost of vaccines, for example — some injuries compared to untold millions of lives saved — seems a worthwhile tradeoff.
The high cost of processed foods does not seem to be worth the tradeoff, however. Convenience food is a market creation, not an evolution in good nutrition. Bread should not last for weeks on a shelf. Animals should not be fattened with low-nutrition foodstuffs, especially if the chemistry involved in producing it is ultimately harming our species.
These are the real costs of our agricultural system, which is having a direct, negative impact on our microbiomes. The research might not provide the answers that we're predisposed to believing, but science is not about popularity of responses. PPA might not be the cause of autism, and this research requires follow-up studies, but still, it's pointing to one potentially important marker.
Researchers documented the most common negative side effects of smoking weed, and who might be most susceptible.
- A team of researchers identified a total of 26 possible adverse reactions to cannabis use.
- Coughing fits, anxiety, and paranoia are among the top three most common adverse reactions to smoking weed.
- It was the people who smoke on a less frequent basis who were more likely to have had the bad experiences.
The most common adverse effects of pot<p>As it turns out, coughing fits are among the top three most common adverse reactions to cannabis use, along with anxiety and paranoia, according to a new study published in the <em>Journal</em><a href="https://jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-019-0013-x" target="_blank"><em> of Cannabis Research</em></a>. </p><p>Now that weed is legal in the state, a team of researchers at Washington State University sought to document potential negative reactions to cannabis in order to paint a detailed picture of the effects of smoking weed for newbies. The authors surveyed more than 1,500 college students on the specific type and frequency of adverse reactions they had experienced while using pot. Additionally, the students in the study were surveyed about their demographics, personality traits, reasons for using cannabis and their use patterns. </p><p>Despite marijuana's <a href="https://bigthink.com/sex-relationships/marijuana-sex" target="_self">numerous benefits</a>, the team identified a total of <a href="https://jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-019-0013-x/tables/2" target="_blank">26 possible adverse reactions to</a> the drug. More than half of the study participants reported having coughing fits along with anxiety and/or paranoia while using cannabis. The most frequently occuring of these were the coughing fits, along with chest/lung discomfort and body humming. A subset of the study group reported these reactions occurring around 30–40% of the time they were using pot. On the flip side, the three <em>least</em>-commonly reported reactions to cannabis use were fainting, visual hallucinations and cold sweats. </p><p>"There's been surprisingly little research on the prevalence or frequency of various adverse reactions to cannabis and almost no research trying to predict who is more likely to experience these types of adverse reactions," <a href="https://news.wsu.edu/2020/03/30/new-research-sheds-light-potentially-negative-effects-cannabis/" target="_blank">said Carrie Cuttler</a>, assistant professor of psychology and an author on the paper, according to WSU News. "With the legalization of cannabis in Washington and 10 other states, we thought it would be important to document some of this information so that more novice users would have a better sense of what types of adverse reactions they may experience if they use cannabis."</p><p>The most distressing of the 26 negative reactions were panic attacks, fainting, and vomiting. Yet, the survey data suggested that cannabis users generally do not find even acute adverse reactions to cannabis to be severely distressing.</p>
What causes a bad reaction?<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMjkwOTEwOC9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYyNTQ5MDQ2Mn0.S2Pkbh3VAgB4Gk5tkavamMv0_4t76dg65yGWpCHG17U/img.jpg?width=1245&coordinates=0%2C1872%2C0%2C1252&height=700" id="dee45" class="rm-shortcode" data-rm-shortcode-id="df6e30ecae156ba0012f4773a374800c" data-rm-shortcode-name="rebelmouse-image" />
Tea and coffee have known health benefits, but now we know they can work together.
Credit: NIKOLAY OSMACHKO from Pexels
- A new study finds drinking large amounts of coffee and tea lowers the risk of death in some adults by nearly two thirds.
- This is the first study to suggest the known benefits of these drinks are additive.
- The findings are great, but only directly apply to certain people.
Maybe you should enjoy this article with a cup of coffee or tea.<p> The <a href="https://drc.bmj.com/content/8/1/e001252?T=AU" target="_blank" rel="noopener noreferrer">study</a> involved 4,923 type 2 diabetics living in Japan. The average participant was 66 years old. All of the participants were taken from the rolls of the Fukuoka Diabetes Registry, a study geared at learning about the effects of new treatments and lifestyle changes on the health of diabetics. <br> <br> The participants filled out questionnaires concerning their health, diet, habits, and other factors. Among the questions were two focused on determining how much green tea or coffee, if any, the participants consumed over the course of a week. The health of the participants was recorded for five years. During this time, 309 of the test subjects died from a variety of causes. <br> <br> Subjects who drank more than one cup of tea or coffee per day demonstrated lower odds of dying than those who had none. Those who consumed the most tea and coffee, more than four and two cups a day, respectively, enjoyed the most significant reductions in their risk of death. This level of consumption was associated with a 40 percent lower risk of <a href="https://www.sciencedaily.com/releases/2020/10/201020190129.htm" target="_blank" rel="noopener noreferrer">death</a>. </p><p>Most interestingly, the effects of drinking tea and coffee appear to combine to reduce risk even further. Those who reported drinking two or three cups of tea a day and two or more cups of coffee were 51 percent less likely to die during the study, while those who drank a whopping four or more cups of tea and two or more cups of coffee had a 63 percent lower risk of <a href="https://www.medicalnewstoday.com/articles/diabetes-coffee-and-green-tea-might-reduce-death-risk" target="_blank" rel="noopener noreferrer">death</a>. </p>
So, should I start swimming in a vat of coffee and green tea?<iframe width="730" height="430" src="https://www.youtube.com/embed/LY0E-JQxeoY" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen></iframe><p> Not quite. </p><p> The primary takeaway from this study is that Japanese adults with type 2 diabetes who drink a lot of green tea and/or coffee die less often than similar people who do not. If this effect is caused by something in the drink, lifestyle choices people who drink that much tea all make, or something else remains unknown. The finding must be considered an association at this point. <br> <br> The eye-popping reductions in mortality rates are compared to the risk of death of others in the study. The people who died reported drinking less tea and coffee than those who lived. Unless you have several demographic and conditional similarities to the subjects of this study, you probably won't suddenly be at a two-thirds lower risk of death than your peers because you drink green tea. </p><p> Like all studies that depend on self-reporting, it is also possible that people misstated how much they consumed any one item. The study also did not look into other factors like socioeconomic status or education level, also known to impact death rates and potentially linked to coffee and tea consumption. </p><p> However, it is yet another study in the pile that suggests that <a href="https://www.healthline.com/nutrition/top-13-evidence-based-health-benefits-of-coffee" target="_blank" rel="noopener noreferrer">coffee</a> and <a href="https://www.healthline.com/nutrition/top-10-evidence-based-health-benefits-of-green-tea" target="_blank" rel="noopener noreferrer">green tea</a> are good for you. That much is increasingly <a href="https://www.health.harvard.edu/press_releases/health-benefits-linked-to-drinking-tea" target="_blank" rel="noopener noreferrer">agreed</a><a href="https://www.rush.edu/health-wellness/discover-health/health-benefits-coffee" target="_blank" rel="noopener noreferrer"> upon</a>. This study also suggests the benefits are additive, which is a new development.</p><p><br> So, while it isn't time to start the IV drip of green tea, a cup or two probably won't <a href="https://www.webmd.com/diabetes/news/20201022/coffee-green-tea-might-extend-life-for-folks-with-type-2-diabetes" target="_blank" rel="noopener noreferrer">hurt</a>. </p>
But most city dwellers weren't seeing the science — they were seeing something out of Blade Runner.
On Sept. 9, many West Coast residents looked out their windows and witnessed a post-apocalyptic landscape: silhouetted cars, buildings and people bathed in an overpowering orange light that looked like a jacked-up sunset.