How does the brain process curiosity?

Have you ever been curious about how curiosity works?

How does the brain process curiosity?
Pixabay

One of the most influential drivers of human behavior is curiosity. That urge to discover, learn, and explore has been the driver of some of the most significant achievements in history. While the benefits of curiosity for cats remains in debate, there is no question that it is a mainstay of human progress.


But, have you ever been curious about how curiosity works?

Curiosity has been a focus for psychologists since the dawn of the science. American philosopher and psychologist William James proposed that it was a major element of human motivation more than 100 years ago. More recently, however, several models of curiosity have been introduced offering to explain not only how it motivates us, but how individuals might differ from one another in how we are curious.

Dr. Todd Kashdan of George Mason University has spent years studying curiosity. Over his career, he has developed several models of curiosity, trying to determine how it works, inspires, and occasionally distracts us. His newest model breaks curiosity into five dimensions, which can be stronger or weaker in each individual.

Regrettably, the model cannot be applied to curious cats. 

This model defines curiosity as “the recognition, pursuit, and desire to explore novel, uncertain, complex, and ambiguous events.” Positing that this sensation can be experienced differently, the researchers behind the model worked with hundreds of American adults to help determine how they experienced curiosity and break it down into its core elements.

Later, they tried to quantify these elements into a single model. Ultimately, they settled on five dimensions of curiosity. Each of the five dimensions can be measured using a series of yes or no questions. Each “yes” answer indicates that dimension being more predominant for an individual.

The five dimensions, and the questions used to determine how strongly they influence a person are:

Joyous exploration: I view challenging situations as an opportunity to grow and learn. I am always looking for experiences that challenge how I think about myself and the world. I seek out situations where it is likely that I will have to think in depth about something. I enjoy learning about subjects that are unfamiliar to me. I find it fascinating to learn new information.

Deprivation sensitivity: I like to try to solve problems that puzzle me. Thinking about solutions to difficult conceptual problems can keep me awake at night. I can spend hours on a single problem because I just can’t rest without knowing the answer. I feel frustrated if I can’t figure out the solution to a problem, so I work even harder to solve it. I work relentlessly at problems that I feel must be solved.

Stress tolerance: The smallest doubt can stop me from seeking out new experiences. I cannot handle the stress that comes from entering uncertain situations. I find it hard to explore new places when I lack confidence in my abilities. I cannot function well if I am unsure whether a new experience is safe. It is difficult to concentrate when there is a possibility that I will be taken by surprise.

Social curiosity: I like to learn about the habits of others. I like finding out why people behave the way they do. When other people are having a conversation, I like to find out what it’s about. When around other people, I like listening to their conversations. When people quarrel, I like to know what’s going on.

Thrill-seeking: The anxiety of doing something new makes me feel excited and alive. Risk-taking is exciting to me. I would like to explore a strange city or section of town, even if it means getting lost. When I have free time, I want to do things that are a little scary. Creating an adventure as I go is much more appealing than a planned adventure.

What that adventure might consist of might be an important part of your answer. Planning a D&D adventure proably doesn't count. 

Furthermore, the model classifies individuals into four groups based on how predominant each facet of curiosity is for them.

1. The Fascinated – scored high on all dimensions of curiosity, particularly joyous exploration. They also showed various traits in their lives that reflected their high levels of curiosity, they claimed to read more and had a more extensive range of interests and hobbies than any other group.

2. Problem Solvers – scored high on deprivation sensitivity, and were midrange for other dimensions. In their personal lives, they had less diversity of interests than people in the Fascinated group and were heavily invested in a few areas of interest.

3. Empathizers – scored high on social curiosity, midrange on other dimensions and much lower on stress tolerance and thrill-seeking. They tend to frequent social media more than other groups and try to give the impression that their lives are under control. This group was 60% female, a much higher percentage than displayed in any other group.

4. Avoiders – scored low on all dimensions, particularly stress tolerance. They also had significant lifestyle differences from other groups, they were less educated, read less, had a high unemployment rate, and claimed to suffer from higher levels of stress than any other group.

An example of an "Avoider", who would rather not learn anything about you.  

So, what kind of curious person are you? Which elements of curiosity resonate most strongly with you and your learning style? This new system of understanding curiosity offers us the ability to understand how best to motivate a person to learn and grow. So, go ahead, try to answer the battery of questions listed above and figure out which kind of curious person you are. Then, learn something new

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Gain-of-function mutation research may help predict the next pandemic — or, critics argue, cause one.

Credit: Guillermo Legaria via Getty Images
Coronavirus

This article was originally published on our sister site, Freethink.

"I was intrigued," says Ron Fouchier, in his rich, Dutch-accented English, "in how little things could kill large animals and humans."

It's late evening in Rotterdam as darkness slowly drapes our Skype conversation.

This fascination led the silver-haired virologist to venture into controversial gain-of-function mutation research — work by scientists that adds abilities to pathogens, including experiments that focus on SARS and MERS, the coronavirus cousins of the COVID-19 agent.

If we are to avoid another influenza pandemic, we will need to understand the kinds of flu viruses that could cause it. Gain-of-function mutation research can help us with that, says Fouchier, by telling us what kind of mutations might allow a virus to jump across species or evolve into more virulent strains. It could help us prepare and, in doing so, save lives.

Many of his scientific peers, however, disagree; they say his experiments are not worth the risks they pose to society.

A virus and a firestorm

The Dutch virologist, based at Erasmus Medical Center in Rotterdam, caused a firestorm of controversy about a decade ago, when he and Yoshihiro Kawaoka at the University of Wisconsin-Madison announced that they had successfully mutated H5N1, a strain of bird flu, to pass through the air between ferrets, in two separate experiments. Ferrets are considered the best flu models because their respiratory systems react to the flu much like humans.

The mutations that gave the virus its ability to be airborne transmissible are gain-of-function (GOF) mutations. GOF research is when scientists purposefully cause mutations that give viruses new abilities in an attempt to better understand the pathogen. In Fouchier's experiments, they wanted to see if it could be made airborne transmissible so that they could catch potentially dangerous strains early and develop new treatments and vaccines ahead of time.

The problem is: their mutated H5N1 could also cause a pandemic if it ever left the lab. In Science magazine, Fouchier himself called it "probably one of the most dangerous viruses you can make."

Just three special traits

Recreated 1918 influenza virionsCredit: Cynthia Goldsmith / CDC / Dr. Terrence Tumpey / Public domain via Wikipedia

For H5N1, Fouchier identified five mutations that could cause three special traits needed to trigger an avian flu to become airborne in mammals. Those traits are (1) the ability to attach to cells of the throat and nose, (2) the ability to survive the colder temperatures found in those places, and (3) the ability to survive in adverse environments.

A minimum of three mutations may be all that's needed for a virus in the wild to make the leap through the air in mammals. If it does, it could spread. Fast.

Fouchier calculates the odds of this happening to be fairly low, for any given virus. Each mutation has the potential to cripple the virus on its own. They need to be perfectly aligned for the flu to jump. But these mutations can — and do — happen.

"In 2013, a new virus popped up in China," says Fouchier. "H7N9."

H7N9 is another kind of avian flu, like H5N1. The CDC considers it the most likely flu strain to cause a pandemic. In the human outbreaks that occurred between 2013 and 2015, it killed a staggering 39% of known cases; if H7N9 were to have all five of the gain-of-function mutations Fouchier had identified in his work with H5N1, it could make COVID-19 look like a kitten in comparison.

H7N9 had three of those mutations in 2013.

Gain-of-function mutation: creating our fears to (possibly) prevent them

Flu viruses are basically eight pieces of RNA wrapped up in a ball. To create the gain-of-function mutations, the research used a DNA template for each piece, called a plasmid. Making a single mutation in the plasmid is easy, Fouchier says, and it's commonly done in genetics labs.

If you insert all eight plasmids into a mammalian cell, they hijack the cell's machinery to create flu virus RNA.

"Now you can start to assemble a new virus particle in that cell," Fouchier says.

One infected cell is enough to grow many new virus particles — from one to a thousand to a million; viruses are replication machines. And because they mutate so readily during their replication, the new viruses have to be checked to make sure it only has the mutations the lab caused.

The virus then goes into the ferrets, passing through them to generate new viruses until, on the 10th generation, it infected ferrets through the air. By analyzing the virus's genes in each generation, they can figure out what exact five mutations lead to H5N1 bird flu being airborne between ferrets.

And, potentially, people.

"This work should never have been done"

The potential for the modified H5N1 strain to cause a human pandemic if it ever slipped out of containment has sparked sharp criticism and no shortage of controversy. Rutgers molecular biologist Richard Ebright summed up the far end of the opposition when he told Science that the research "should never have been done."

"When I first heard about the experiments that make highly pathogenic avian influenza transmissible," says Philip Dormitzer, vice president and chief scientific officer of viral vaccines at Pfizer, "I was interested in the science but concerned about the risks of both the viruses themselves and of the consequences of the reaction to the experiments."

In 2014, in response to researchers' fears and some lab incidents, the federal government imposed a moratorium on all GOF research, freezing the work.

Some scientists believe gain-of-function mutation experiments could be extremely valuable in understanding the potential risks we face from wild influenza strains, but only if they are done right. Dormitzer says that a careful and thoughtful examination of the issue could lead to processes that make gain-of-function mutation research with viruses safer.

But in the meantime, the moratorium stifled some research into influenzas — and coronaviruses.

The National Academy of Science whipped up some new guidelines, and in December of 2017, the call went out: GOF studies could apply to be funded again. A panel formed by Health and Human Services (HHS) would review applications and make the decision of which studies to fund.

As of right now, only Kawaoka and Fouchier's studies have been approved, getting the green light last winter. They are resuming where they left off.

Pandora's locks: how to contain gain-of-function flu

Here's the thing: the work is indeed potentially dangerous. But there are layers upon layers of safety measures at both Fouchier's and Kawaoka's labs.

"You really need to think about it like an onion," says Rebecca Moritz of the University of Wisconsin-Madison. Moritz is the select agent responsible for Kawaoka's lab. Her job is to ensure that all safety standards are met and that protocols are created and drilled; basically, she's there to prevent viruses from escaping. And this virus has some extra-special considerations.

The specific H5N1 strain Kawaoka's lab uses is on a list called the Federal Select Agent Program. Pathogens on this list need to meet special safety considerations. The GOF experiments have even more stringent guidelines because the research is deemed "dual-use research of concern."

There was debate over whether Fouchier and Kawaoka's work should even be published.

"Dual-use research of concern is legitimate research that could potentially be used for nefarious purposes," Moritz says. At one time, there was debate over whether Fouchier and Kawaoka's work should even be published.

While the insights they found would help scientists, they could also be used to create bioweapons. The papers had to pass through a review by the U.S. National Science Board for Biosecurity, but they were eventually published.

Intentional biowarfare and terrorism aside, the gain-of-function mutation flu must be contained even from accidents. At Wisconsin, that begins with the building itself. The labs are specially designed to be able to contain pathogens (BSL-3 agricultural, for you Inside Baseball types).

They are essentially an airtight cement bunker, negatively pressurized so that air will only flow into the lab in case of any breach — keeping the viruses pushed in. And all air in and out of the lap passes through multiple HEPA filters.

Inside the lab, researchers wear special protective equipment, including respirators. Anyone coming or going into the lab must go through an intricate dance involving stripping and putting on various articles of clothing and passing through showers and decontamination.

And the most dangerous parts of the experiment are performed inside primary containment. For example, a biocontainment cabinet, which acts like an extra high-security box, inside the already highly-secure lab (kind of like the radiation glove box Homer Simpson is working in during the opening credits).

"Many people behind the institution are working to make sure this research can be done safely and securely." — REBECCA MORITZ

The Federal Select Agent program can come and inspect you at any time with no warning, Moritz says. At the bare minimum, the whole thing gets shaken down every three years.

There are numerous potential dangers — a vial of virus gets dropped; a needle prick; a ferret bite — but Moritz is confident that the safety measures and guidelines will prevent any catastrophe.

"The institution and many people behind the institution are working to make sure this research can be done safely and securely," Moritz says.

No human harm has come of the work yet, but the potential for it is real.

"Nature will continue to do this"

They were dead on the beaches.

In the spring of 2014, another type of bird flu, H10N7, swept through the harbor seal population of northern Europe. Starting in Sweden, the virus moved south and west, across Denmark, Germany, and the Netherlands. It is estimated that 10% of the entire seal population was killed.

The virus's evolution could be tracked through time and space, Fouchier says, as it progressed down the coast. Natural selection pushed through gain-of-function mutations in the seals, similarly to how H5N1 evolved to better jump between ferrets in his lab — his lab which, at the time, was shuttered.

"We did our work in the lab," Fouchier says, with a high level of safety and security. "But the same thing was happening on the beach here in the Netherlands. And so you can tell me to stop doing this research, but nature will continue to do this day in, day out."

Critics argue that the knowledge gained from the experiments is either non-existent or not worth the risk; Fouchier argues that GOF experiments are the only way to learn crucial information on what makes a flu virus a pandemic candidate.

"If these three traits could be caused by hundreds of combinations of five mutations, then that increases the risk of these things happening in nature immensely," Fouchier says.

"With something as crucial as flu, we need to investigate everything that we can," Fouchier says, hoping to find "a new Achilles' heel of the flu that we can use to stop the impact of it."

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Sex & Relationships
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