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You've got 10 minutes with Einstein. What do you talk about? Black holes? Time travel?
Why not gambling? The Art of War? Contemporary parenting?
Each week, host Jason Gots surprises some of the world's brightest minds with ideas they're not at all prepared to discuss. Join us and special guests Neil Gaiman, Alan Alda, Salman Rushdie, Margaret Atwood, Richard Dawkins, Maria Popova, Mary-Louise Parker, Neil deGrasse Tyson and many more...
19 October, 2019
Gail Collins (NY Times columnist) – The brief social media life of Glam-ma
Though what constitutes "getting old" for women in America has been a moving target throughout US history, it has rarely been a picnic. But our history's also full of women who have raised hell and pushed back in a hundred different ways against the cultural and literal corsets America keeps trying to stuff them into.
Think Again Podcasts
In 1972, the year I was born, there was apparently a famous TV ad for Geritol. My guest today describes it thus:
"…a husband spoke to the camera while his wife draped herself over his shoulder, smiling like something between a model and the brainwashed resident of a creepy commune…"My wife's incredible. She took care of the baby all day, cooked a great dinner and even went to a school meeting—and look at her!"
Her potion of eternal youth, of course, is Geritol. It's got all the vitamins and iron she needs. This perfect woman grins silently at the camera as her husband concludes: "My wife: I think I'll keep her."
Though what constitutes "getting old" for women in America has been a moving target throughout US history, it has rarely been a picnic. But our history's also full of women who have raised hell and pushed back in a hundred different ways against the cultural and literal corsets America keeps trying to stuff them into.
My guest today is New York Times columnist and celebrated author Gail Collins. Her new book is No Stopping Us Now: the Adventures of Older Women in American History. It's a bumpy, often exhilarating ride through the lives of older women in America from colonial times up to the present day. And Gail's good company as our wise, wisecracking stagecoach driver. We're headed West, and there's hope on the horizon.
Conversation starters in this episode:
Liz Plank on masculinity from Think Again, episode #214
‘Designer baby’ book trilogy explores the moral dilemmas humans may soon create
How would the ability to genetically customize children change society? Sci-fi author Eugene Clark explores the future on our horizon in Volume I of the "Genetic Pressure" series.
18 January, 2021
Surprising Science
- A new sci-fi book series called "Genetic Pressure" explores the scientific and moral implications of a world with a burgeoning designer baby industry.
- It's currently illegal to implant genetically edited human embryos in most nations, but designer babies may someday become widespread.
- While gene-editing technology could help humans eliminate genetic diseases, some in the scientific community fear it may also usher in a new era of eugenics.
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<div class="amazon-assets-widget__title" style="display: block;">Genetic Pressure Volume I: Baby Steps</div>
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<p>Imagine it's 2045. You start hearing rumors from your well-heeled friends about a mysterious corporation based on an undisclosed island that's offering an unprecedented service: the ability to genetically design your baby.</p><p>The baby will have some of your genetics, and some genetics from a sperm or egg donor, selected by you. But the rest of your child's genetic profile will be engineered by science. These changes will make it impossible for your child to develop genetic diseases. They'll also allow you to customize your child for dozens of traits, including intelligence level, emotional disposition, sexual orientation, height, skin tone, hair color, and eye color, to name a few. </p><p>This raises unsettling philosophical questions for some customers. "When does my child stop being my child?" they ask the corporate representatives. These wary customers are reminded of how risky it is to reproduce the old-fashioned way. The Better Genetics Corporation's motto sums it up: "Only God plays dice—humans don't have to."</p><p>This is the world described in a new science-fiction series by Eugene Clark titled <a href="http://bigth.ink/38VhJn3" target="_blank" rel="noopener noreferrer">"Genetic Pressure"</a>, which explores the moral and scientific implications of a future in which designer babies are becoming a major industry. The first book begins with the story of Rachel, a renowned horse breeder who befriends a billionaire client, and soon gets the funding to visit the tropical island on which the Better Genetics Corporation is headquartered. </p><p>There, corporate executives walk her through the process of designing a baby—an experience that feels like an uncanny mix between visiting a doctor and designing a luxury car. The series is told from multiple perspectives, serving as a deep dive into a complex moral web that today's scientists may already be weaving.</p>
<blockquote>[T]he introduction of designer babies would create a labyrinth of philosophical dilemmas that society is only beginning to explore. </blockquote>
<p>Case in point: In 2018, Chinese scientist He Jiankui announced that he had helped create the world's first genetically engineered babies. Using the gene-editing tool CRISPR on embryos, He Jiankui modified a gene called <a href="https://ghr.nlm.nih.gov/gene/CCR5" target="_blank">CCR5</a>, which enables HIV to enter and infect immune system cells. His goal was to engineer children that were immune to the virus.</p><p>It's unclear whether he succeeded. But what's certain is that the experiment shocked the international scientific community, which generally agreed that it's unethical to conduct gene-editing procedures on humans, given that scientists don't yet fully understand the consequences.</p><p>"This experiment is monstrous," Julian Savulescu, a professor of practical ethics at the University of Oxford, told <a href="https://www.theguardian.com/science/2018/nov/26/worlds-first-gene-edited-babies-created-in-china-claims-scientist" target="_blank"><em>The Guardian</em></a>. "The embryos were healthy. No known diseases. Gene editing itself is experimental and is still associated with off-target mutations, capable of causing genetic problems early and later in life, including the development of cancer."</p><p>Importantly, He Jiankui wasn't treating a disease, but rather genetically engineering babies to prevent the future contraction of a virus. These kinds of changes are heritable, meaning the experiment could have major downstream effects on future generations. So, too, would a designer-baby industry, even if scientists can do it safely.</p><p>With major implications on inequality, discrimination, sexuality, and our conceptions of life, the introduction of designer babies would create a labyrinth of philosophical dilemmas that society is only beginning to explore. </p>
<a href="http://bigth.ink/38VhJn3" ><img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yNTI2MTEzNi9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTY0NDcxMzY4M30.5fwCPH_6sQ0RF19aAH4FQFue9HFJykzdEc0Xka1TY04/img.jpg?width=980" id="affdd" class="rm-shortcode" data-rm-shortcode-id="76374e8775bd9441a338cf513bb1fa55" data-rm-shortcode-name="rebelmouse-image" data-width="924" data-height="520" /></a>
Tribalism and discrimination
<p>One question the "Genetic Pressure" series explores: What would tribalism and discrimination look like in a world with designer babies? As designer babies grow up, they could be noticeably different from other people, potentially being smarter, more attractive and healthier. This could breed resentment between the groups—as it does in the series.</p><p>"[Designer babies] slowly find that 'everyone else,' and even their own parents, becomes less and less tolerable," author Eugene Clark told Big Think. "Meanwhile, everyone else slowly feels threatened by the designer babies."</p><p>For example, one character in the series who was born a designer baby faces discrimination and harassment from "normal people"—they call her "soulless" and say she was "made in a factory," a "consumer product." </p><p>Would such divisions emerge in the real world? The answer may depend on who's able to afford designer baby services. If it's only the ultra-wealthy, then it's easy to imagine how being a designer baby could be seen by society as a kind of hyper-privilege, which designer babies would have to reckon with. </p><p>Even if people from all socioeconomic backgrounds can someday afford designer babies, people born designer babies may struggle with tough existential questions: Can they ever take full credit for things they achieve, or were they born with an unfair advantage? To what extent should they spend their lives helping the less fortunate? </p>Sexuality dilemmas
<p>Sexuality presents another set of thorny questions. If a designer baby industry someday allows people to optimize humans for attractiveness, designer babies could grow up to find themselves surrounded by ultra-attractive people. That may not sound like a big problem.</p><p>But consider that, if designer babies someday become the standard way to have children, there'd necessarily be a years-long gap in which only some people are having designer babies. Meanwhile, the rest of society would be having children the old-fashioned way. So, in terms of attractiveness, society could see increasingly apparent disparities in physical appearances between the two groups. "Normal people" could begin to seem increasingly ugly.</p><p>But ultra-attractive people who were born designer babies could face problems, too. One could be the loss of body image. </p><p>When designer babies grow up in the "Genetic Pressure" series, men look like all the other men, and women look like all the other women. This homogeneity of physical appearance occurs because parents of designer babies start following trends, all choosing similar traits for their children: tall, athletic build, olive skin, etc. </p><p>Sure, facial traits remain relatively unique, but everyone's more or less equally attractive. And this causes strange changes to sexual preferences.</p><p>"In a society of sexual equals, they start looking for other differentiators," he said, noting that violet-colored eyes become a rare trait that genetically engineered humans find especially attractive in the series.</p><p>But what about sexual relationships between genetically engineered humans and "normal" people? In the "Genetic Pressure" series, many "normal" people want to have kids with (or at least have sex with) genetically engineered humans. But a minority of engineered humans oppose breeding with "normal" people, and this leads to an ideology that considers engineered humans to be racially supreme. </p>Regulating designer babies
<p>On a policy level, there are many open questions about how governments might legislate a world with designer babies. But it's not totally new territory, considering the West's dark history of eugenics experiments.</p><p>In the 20th century, the U.S. conducted multiple eugenics programs, including immigration restrictions based on genetic inferiority and forced sterilizations. In 1927, for example, the Supreme Court ruled that forcibly sterilizing the mentally handicapped didn't violate the Constitution. Supreme Court Justice Oliver Wendall Holmes wrote, "… three generations of imbeciles are enough." </p><p>After the Holocaust, eugenics programs became increasingly taboo and regulated in the U.S. (though some states continued forced sterilizations <a href="https://www.uvm.edu/~lkaelber/eugenics/" target="_blank">into the 1970s</a>). In recent years, some policymakers and scientists have expressed concerns about how gene-editing technologies could reanimate the eugenics nightmares of the 20th century. </p><p>Currently, the U.S. doesn't explicitly ban human germline genetic editing on the federal level, but a combination of laws effectively render it <a href="https://academic.oup.com/jlb/advance-article/doi/10.1093/jlb/lsaa006/5841599#204481018" target="_blank" rel="noopener noreferrer">illegal to implant a genetically modified embryo</a>. Part of the reason is that scientists still aren't sure of the unintended consequences of new gene-editing technologies. </p><p>But there are also concerns that these technologies could usher in a new era of eugenics. After all, the function of a designer baby industry, like the one in the "Genetic Pressure" series, wouldn't necessarily be limited to eliminating genetic diseases; it could also work to increase the occurrence of "desirable" traits. </p><p>If the industry did that, it'd effectively signal that the <em>opposites of those traits are undesirable. </em>As the International Bioethics Committee <a href="https://academic.oup.com/jlb/advance-article/doi/10.1093/jlb/lsaa006/5841599#204481018" target="_blank" rel="noopener noreferrer">wrote</a>, this would "jeopardize the inherent and therefore equal dignity of all human beings and renew eugenics, disguised as the fulfillment of the wish for a better, improved life."</p><p><em>"Genetic Pressure Volume I: Baby Steps"</em><em> by Eugene Clark is <a href="http://bigth.ink/38VhJn3" target="_blank">available now.</a></em></p>
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01 February, 2020
Sharon Salzberg - On Balance
In this episode master teacher Sharon Salzberg considers whether it's ok to teach mindfulness to the armed forces, how practitioners of meditation and mindfulness should balance openness with discipline, and so much more.
Think Again Podcasts
<p>Since 1974, <a href="https://www.sharonsalzberg.com/" target="_blank">Sharon Salzberg</a> has been sharing ancient meditation and mindfulness practices in a voice the contemporary West can understand. Her warm, funny, down-to-earth books, dharma talks, and guided meditations have helped struggling meditators worldwide establish a strong practice and reduce the suffering in their lives. In this episode Sharon sits down with Jason to consider whether it's ok to teach mindfulness to the armed forces, how western practitioners should deal with the almost militant tone of some eastern teachers when it comes to discipline and "right effort", and so much more. Sharon's latest book is <a href="https://www.sharonsalzberg.com/real-happiness-book/" target="_blank">Real Happiness: a 28 day program for realizing the power of meditation</a>, now thoroughly updated and revised for its 10th anniversary.</p>
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25 January, 2020
Roz Chast and Patricia Marx (cartoons, words, ukuleles) – the Beatles stole everything from us
The New Yorker-based comedy team on never exercising or going outside, and so much more.
Think Again Podcasts
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<p>Thelma and Louise, Ponch and John, Pancho and Lefty, Quixote and Sancho Panza, Marx and Engels, Marx and Chast…history and literature are full of magical buddy stories. Every now and then, for reasons no one can explain, Two people come together and produce something greater, or at least very different, from the sum of their parts.</p><p>I'm here today with one such team: the writer-cartoonist duo of <a href="https://www.newyorker.com/contributors/patricia-marx" target="_blank">Patricia Marx</a> and <a href="https://www.newyorker.com/contributors/roz-chast" target="_blank">Roz Chast</a>. They're both longtime contributors to the New Yorker and fearsome humorists in their own rights. But together they form a third fearsome thing, a thing which has created books such as Why Don't You Write My Eulogy Now So I Can Correct it: A Mother's Suggestions, And their latest: <a href="https://celadonbooks.com/books/you-can-only-yell-at-me-for-one-thing-at-a-time/" target="_blank">You Can Only Yell At Me For One Thing At A Time: Rules for Couples</a>. They're also the enigmatic figures behind yet a fourth thing, the legendary ukulele band Ukelear Meltdown.</p><p>– <a href="http://jasongots.com/" target="_blank">Jason Gots</a></p>
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20 January, 2020
mindfulness and meditation teacher Joseph Goldstein – doubt comes masquerading as wisdom
In this first episode of 2020, beloved dharma teacher Joseph Goldstein is back for a conversation about struggle, doubt, and growth on the spiritual path.
Think Again Podcasts
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<p>Freedom. Everyone wants it, but knowing where to look for it is another matter. And to make matters worse, the world is full of things that feel like freedom but might just get us more tangled up in everything we're trying to escape. How much freedom can money buy? How much money? How free are you on a tropical vacation? Would uploading your consciousness into the cloud and downloading it into a robot avatar on Alpha Centauri make you more free? How about falling in love again? How about three margaritas with friends? Or six? How about falling in love again? A better government? Less government? No government at all? </p><p>I'm here today with <a href="https://www.dharma.org/teacher/joseph-goldstein/" target="_blank">Joseph Goldstein</a>, a beloved teacher of Buddhist ideas and practice in the West and a personal inspiration to me, to talk about freedom of the mind and spirit—and the kinds of effort and insight that can lead there. Joseph is the co-founder of <a href="https://www.dharma.org/" target="_blank">Insight Meditation Society</a> in Barre, Massachusetts and the author, most recently, of <a href="https://www.soundstrue.com/store/mindfulness-3372.html" target="_blank">Mindfulness: a Practical Guide to Awakening</a>.</p>
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