Scientists Use CRISPR Gene Editing to Create the World's First Mutant Social Insect
Researchers succeed in deleting key genes from ants, significantly modifying their behavior.
A staple of bad science fiction, mutant ants have been more of a figment of imagination rather than scientific reality. We’ve genetically altered mice and fruit flies, but growing mutant ants has eluded scientists due to the complex life cycle of the little critters. Now two teams announced that they managed to edit out certain genes from lab ants, altering their behavior.
The team from Rockefeller University published a paper outlining how they removed orco - a gene that plays a key part in an ant’s odor receptors. Deleting the gene by using the CRISPR-Cas9 technique resulted in the ants losing about 90% of their “olfaction”. This made them unable to socialize. The ants also changed in other ways, showing affected behavior. They laid very few eggs, wandered aimlessly, and showed poor parenting.
The other team, including scientists from NYU, Vanderbilt University, University of Pennsylvania, and Arizona State University, also used CRISPR to delete the orco protein in ants to affect their communication through pheromones, causing an "aberrant social behavior and defective neural development."
Researchers modified the ability of the ants to detect pheromones though porous hairs on their antennae. Credit: Rockefeller University.
This kind of interference with the social behavior of ants is considered a success because of the difficulty in altering the nature of insects with such a sophisticated social structure. NYU Professor Claude Desplan, who was involved in one of the studies called the modified ant they created “the first mutant in any social insect.”
“While ant behavior does not directly extend to humans, we believe that this work promises to advance our understanding of social communication, with the potential to shape the design of future research into disorders like schizophrenia, depression or autism that interfere with it,” said Desplan.
Why edit ant genes at all? Daniel Kronauer, author of the Rockefeller University study, says there are “interesting biologic questions” you can only study in ants.
“It was well known that ant language is produced through pheromones, but now we understand a lot more about how pheromones are perceived,” says Kronauer. “The way ants interact is fundamentally different from how solitary organisms interact, and with these findings we know a bit more about the genetic evolution that enabled ants to create structured societies.”
Check out this animation of how Kronauer and his colleagues tracked color-coded ants, while using an algorithm to analyze the resulting behavior.
Pfizer's partnerships strengthen their ability to deliver vaccines in developing countries.
- Community healthcare workers face many challenges in their work, including often traveling far distances to see their clients
- Pfizer is helping to drive the UN's sustainable development goals through partnerships.
- Pfizer partnered with AMP and the World Health Organization to develop a training program for healthcare workers.
The best-selling author tells us his methods.
- James Patterson has sold 300 million copies of his 130 books, making him one of the most successful authors alive today.
- He talks about how some writers can overdo it by adding too much research, or worse, straying from their outline for too long.
- James' latest book, The President is Missing, co-written with former President Bill Clinton, is out now.
Progressive America would be half as big, but twice as populated as its conservative twin.
- America's two political tribes have consolidated into 'red' and 'blue' nations, with seemingly irreconcilable differences.
- Perhaps the best way to stop the infighting is to go for a divorce and give the two nations a country each
- Based on the UN's partition plan for Israel/Palestine, this proposal provides territorial contiguity and sea access to both 'red' and 'blue' America
It's the first time the association hasn't hired a comedian in 16 years.
- The 2018 WHCA ended in controversy after comedian Michelle Wolf made jokes some considered to be offensive.
- The WHCA apologized for Wolf's jokes, though some journalists and many comedians backed the comedian and decried arguments in favor of limiting the types of speech permitted at the event.
- Ron Chernow, who penned a bestselling biography of Alexander Hamilton, will speak at next year's dinner.
SMARTER FASTER trademarks owned by The Big Think, Inc. All rights reserved.