Depression and suicidal ideation reduced after psychedelic usage

Another study confirms the positive effects of psychedelics on mental health.

mushrooms in a pill bottle
Photo: Daniel Patrick Martin / Shutterstock
  • Two studies found reduced rates in depression severity, suicidal ideation, and experiential avoidance four weeks after taking psychedelics.
  • With hundreds of millions of dollars in investment flowing into psychedelics companies, a renaissance in the field is occurring.
  • Researchers hope these findings will lead to better therapeutic modalities for mental health disorders.

From mysticism to mental health, the journey of psychedelics in American culture has been quite a trip. With hundreds of millions of dollars flowing into psychedelics startups—the "Rainbow Rush"—and a clinical study investigating the therapeutic effects of MDMA and LSD (besides many other single-substance trials), a renaissance is unfolding right before our eyes.

Researchers are picking up where their forebears left off. Hundreds of studies on LSD and psilocybin were conducted in the '50s and '60s. Psychiatrist Sidney Cohen wrote an extensive review in 1960 on the complications and side effects of LSD; he found minimal damaging effects in over 25,000 administrations. Likewise, psychiatrist Oscar Janiger used LSD therapeutically with 930 patients. He noted few adverse effects.

Writing about Janiger's experiments, medical anthropologist Marlene Dobkin de Rios notes, "The nature of the individual drug experience reflects the basic psychophysiological action of the substance as it interacts with the total life experience that the person brings to it."

The total life experience. Mental health today is expressed in terms of chemical imbalances, but that hypothesis has been on shaky ground for decades. Anxiety, depression, PTSD, suicidal ideation—conditions dependent on memories, environment, relationships, genetics, finances, a host of causes. Psychedelics help reframe your relationship to your situation, sometimes alleviating the existential weight of modernity.

How psychedelics can treat depression - Robin Carhart Harris

Dr Robin Carhart-Harris is the head of the Centre for Psychedelic Research at Imperial College London. He's published nearly a hundred studies on psychedelics. A recent research article, published in Frontiers in Psychiatry, found that the effects of psychedelics are associated with a decrease in the severity of depression and suicidal ideation.

The two studies in the article include 358 volunteers. Each participant filled out questionnaires about their levels of depression, suicidal ideation, and experiential avoidance—"openness to one's experiences and engagement in behaviors that are congruent with one's values." They then took part in either ceremonial psychedelic consumption (as in an ayahuasca ritual) or non-ceremonial usage. Carhart-Harris's team followed up two weeks and four weeks later.

The parameters of the first study were broad. The individuals had a variety of psychedelics to choose from: LSD, ayahuasca, DMT, salvia divinorum, mescaline, psilocybin mushrooms, or ibogaine. Interestingly, respondents that planned on using ketamine were excluded. While the sedative has recently been touted as a psychedelic, it's not classically considered in this regard.

The second study was slightly more structured, as the team accepted participants attending a psychedelic ceremony. This is especially important given the work by organizations like MAPS ( Multidisciplinary Association for Psychedelic Studies), which is training psychedelic therapists in the hopes of legalized MDMA by 2023.

"Such ceremonies usually involve the presence of one or more "facilitators"individuals who aim to provide a safe, conducive environment, emotional support, as well as certain contextual stimuli which are intended to enhance or structure the psychedelic experience."

person walking towards light in tunnel

Photo: fran_kies / Shutterstock

This research differs from previous studies in that psychedelic usage was not conducted in a clinical setting. As the environment is an important component of the psychedelic ritual, researchers are more likely to receive real-world results from anecdotal experiences. Letting go in a clinic poses challenges.

The results, the team writes, were overwhelmingly positive.

"Across two separate studies, we found significant decreases in depression severity and suicidal ideation 4-weeks after psychedelic use… We found that use of psychedelics was associated with decreases in experiential avoidance 2-weeks later and was sustained for at least 4-weeks."

Psychedelic researchers will continue to face is the difficulty of implementing a control group, although at least one study found that the placebo effect is relevant. A larger barrier will be financial support from pharmaceutical companies with vested interests in current drug protocols.

That said, this renaissance shows no signs of slowing. During a time when rates of anxiety, depression, and suicide are rising, a return to psychedelic rituals can help chip away at the frustration and confusion of this moment. These substances have been used for millennia to keep societies intact. Such ceremonies are sorely needed right now.


Stay in touch with Derek on Twitter, Facebook and Substack. His next book is "Hero's Dose: The Case For Psychedelics in Ritual and Therapy."

How New York's largest hospital system is predicting COVID-19 spikes

Northwell Health is using insights from website traffic to forecast COVID-19 hospitalizations two weeks in the future.

Credit: Getty Images
Sponsored by Northwell Health
  • The machine-learning algorithm works by analyzing the online behavior of visitors to the Northwell Health website and comparing that data to future COVID-19 hospitalizations.
  • The tool, which uses anonymized data, has so far predicted hospitalizations with an accuracy rate of 80 percent.
  • Machine-learning tools are helping health-care professionals worldwide better constrain and treat COVID-19.
Keep reading Show less

Designer uses AI to bring 54 Roman emperors to life

It's hard to stop looking back and forth between these faces and the busts they came from.

Meet Emperors Augustus, left, and Maximinus Thrax, right

Credit: Daniel Voshart
Technology & Innovation
  • A quarantine project gone wild produces the possibly realistic faces of ancient Roman rulers.
  • A designer worked with a machine learning app to produce the images.
  • It's impossible to know if they're accurate, but they sure look plausible.
Keep reading Show less

Dark matter axions possibly found near Magnificent 7 neutron stars

A new study proposes mysterious axions may be found in X-rays coming from a cluster of neutron stars.

A rendering of the XMM-Newton (X-ray multi-mirror mission) space telescope.

Credit: D. Ducros; ESA/XMM-Newton, CC BY-SA 3.0 IGO
Surprising Science
  • A study led by Berkeley Lab suggests axions may be present near neutron stars known as the Magnificent Seven.
  • The axions, theorized fundamental particles, could be found in the high-energy X-rays emitted from the stars.
  • Axions have yet to be observed directly and may be responsible for the elusive dark matter.
  • Keep reading Show less

    Put on a happy face? “Deep acting” associated with improved work life

    New research suggests you can't fake your emotional state to improve your work life — you have to feel it.

    Credit: Columbia Pictures
    Personal Growth
  • Deep acting is the work strategy of regulating your emotions to match a desired state.
  • New research suggests that deep acting reduces fatigue, improves trust, and advances goal progress over other regulation strategies.
  • Further research suggests learning to attune our emotions for deep acting is a beneficial work-life strategy.
  • Keep reading Show less
    Surprising Science

    World's oldest work of art found in a hidden Indonesian valley

    Archaeologists discover a cave painting of a wild pig that is now the world's oldest dated work of representational art.

    Scroll down to load more…