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Parkinson's Patients "Roar" on Faster Route to A Cure
This is Parkinson’s Awareness Month. It’s a time to celebrate what has been learned and to push the process further along. There is no screening test to diagnose Parkinson’s disease (PD) early. Researchers are searching for biomarkers – telltale signs of the disease – that would allow earlier treatments and provide insight into possible cures. At the moment, medications, exercise, creative activities, and surgery can reduce the symptoms of PD, but there is no way of stopping the disease in its tracks.
Yet, this is a very promising time in PD research. A key reason is an emerging collaboration between PD patients, physicians and scientists in determining research directions. Patients are influencing the course of PD science as never before. Once considered weak victims of a devastating disease, they have become influential collaborators in the search for a cure.
When I was first diagnosed with PD over a decade ago, patient input was close to negligible. Definition of the disease was narrow. A diagnosis required a set of motor indicators shared, it was assumed, with all true PD patients. PD was a brain disease – short and simple. Now, through the collaboration of patients and experts, we know that PD looks different across patients at various points in time and some have little in the way of noticeable tremor. The disease may even reveal itself in gut or nasal bacteria before commonly known symptoms are evident.
Patient involvement in PD research is moving the route to a cure from pot-holed, one-lane back roads to multiple-lane avenues of shared information. Rather than passive objects of study, PD patients are actively involved in finding a cure. Their input has led to a realization that the best treatment for PD is individualized. In fact, Parkinson’s disease may not be one disease at all. Treating it may be more a matter of patient-doctor communication about which symptoms are in need of attention at any given point in time than finding a single medication to meet all challenges.
Not long ago, what became known as non-motor symptoms, among them changes in cognition, digestive problems, and sleep difficulties, were considered irrelevant to finding biomarkers or a cure. Yet patients live with these symptoms and they saw the link to PD. Now most non-motor symptoms are viewed as treatable aspects of PD and potential, crucial clues to a possible cure.
As Dr. Zolton Mari, MD, interim director of the Parkinson’s and Movement Disorders Center at Johns Hopkins University in Baltimore, explains, “Clinically there is heterogeneity. Patients may be tremor dominant; they may be more rigid. The prognosis varies across a significantly wide spectrum.” He adds, “In this whole complex mash of what works for whom, if we could make sense of that better, you know we don’t have to invent the magic, miracle pill to stop Parkinson’s if we could just use all the information and apply it to find what works for each individual patient.” How better to do that than to ask patients themselves to be involved?
Amy Comstock Rick, J.S., CEO of the Parkinson’s Action Network, shared with Neurology Now that patients and advocates need to be involved every step of the way. Her view: “No research is successful in isolation.” The Parkinson Disease Foundation, Parkinson’s Alliance and European Parkinson’s Disease Association, to name a few, invite patients to become advocates not only for spreading awareness of PD and involving patients in clinical trials, but in lending their voices to the choice of research directions.
Each April in New York City’s Central Park, thousands of PD patients, their families and friends join the Unity Walk. Such walks take place in Europe and around the world as well. These colorful, joyful experiences bring together the very people who hold the key to a disease that has long baffled those who commit their lives to studying it.
Research on a disease such as PD in isolation of patient input is a recipe for failure. Patient subjects are not the messy necessity of science. They are the reason for its existence. If science is to be useful, it’s imperative to understand the people being studied. They used to be the last group asked about the problem being investigated. They were victims. Today, you can hardly read about Parkinson’s without learning of the important role played by patients. They learn from each other, share their observations and increase the likelihood of better treatments and ultimately a cure.
Parkinson’s disease remains a tough challenge, but the battle is heating up and more soldiers are wearing t-shirts, carrying signs, marching in optimistic solidarity for a cure, raising funds, speaking up, sharing their research preferences and making a huge difference. It's a great model for PD research and for medical science as a whole.
Photo compliments of The Unity Walk
Sallie Krawcheck and Bob Kulhan will be talking money, jobs, and how the pandemic will disproportionally affect women's finances.
How can we promote the creation of new neurons - and why is it so important?
- Neurogenesis, the birth of neurons from stem cells, happens mostly before we are born - as we are formed in the womb, we are generating most of what we need after birth.
- After birth, neurogenesis is still possible in two parts of the brain: the olfactory bulb (which is responsible for our sense of smell) and the hippocampus (which is responsible for memory, spatial navigation, and emotional processing).
- Research from the 1960s proves creating new neurons as adults is possible, and modern-day research explains how (and why) we should promote new neuron growth.
Two parts of the brain can continue growing through neurogenesis<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMjkyMzk2NS9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYwOTAwODc1MH0.4GDLlZmkwuD0-pJ0s0UWcUoYXMy95a-AM61a_QAlAeA/img.jpg?width=980" id="2e77e" class="rm-shortcode" data-rm-shortcode-id="4e23499fdf3b2185533979083fd02db7" data-rm-shortcode-name="rebelmouse-image" alt="brain made of twigs and plants concept of neurogenesis" />
Neurogenesis is still possible well into adulthood in two very important parts of the human brain.
Image by EtiAmmos on Shutterstock<p>Although most people are aware that aging or bad habits such as heavy alcohol use can contribute to the deterioration of our brains, not many of us give thought to how we can generate new brain cells.</p><p>Neurogenesis, the birth of neurons from stem cells, happens mostly before we are born - as we are formed in the womb, we are generating most of what we need after birth. </p><p><strong>After birth, however, neurogenesis is still possible in two parts of the brain:</strong></p><ul><li>The olfactory bulb, which is a structure of the forebrain that's responsible for our sense of smell. </li><li>The hippocampus, which is a structure of the brain located within the temporal lobe (just above your ears) - this area is important for learning, memory, regulation, of emotions and spatial navigation. </li></ul><p>Of course, when this information first came to light <a href="https://www.ncbi.nlm.nih.gov/pubmed/13860748" target="_blank">back in the 1960s</a>, the next natural question was: How do we promote neurogenesis in those areas where it's still possible? </p><p>Researchers today believe there are activities you can do (some of them may be things you already do on a daily basis) that can promote neurogenesis in your brain. </p><p><strong>Why is it important to promote the growth of new neurons in adulthood?</strong></p><p>We produce an estimated 700 million neurons per day in the hippocampus - this means by the time we reach the age of 50, we will have exchanged the neurons we were born within that area of the brain with new (adult-generated) neurons. </p><p>If we don't promote this exchange with the growth of new neurons, we may block certain abilities these new neurons help us with (such as keeping our memory sharp, for example). </p>
4 ways to promote neurogenesis in your brain<img type="lazy-image" data-runner-src="https://assets.rebelmouse.io/eyJhbGciOiJIUzI1NiIsInR5cCI6IkpXVCJ9.eyJpbWFnZSI6Imh0dHBzOi8vYXNzZXRzLnJibC5tcy8yMjkyMzk2Ni9vcmlnaW4uanBnIiwiZXhwaXJlc19hdCI6MTYyNTE3NjczNH0.qyzh_AIUPKfaQIa1QEq4yTNCAAK9nYkH3HFV9vWXwww/img.jpg?width=1245&coordinates=0%2C0%2C0%2C104&height=700" id="64a68" class="rm-shortcode" data-rm-shortcode-id="ee1307fe2dd61ae425552da56db3c5ff" data-rm-shortcode-name="rebelmouse-image" alt="child playing trumpet concept of learning a new instrument neurogenesis" />
Learning a new instrument helps promote neurogenesis.
Photo by DenisProduction.com on Shutterstock<p><strong>Intermittent fasting</strong></p><p><a href="https://law.stanford.edu/2015/01/09/lawandbiosciences-2015-01-09-intermittent-fasting-try-this-at-home-for-brain-health/" target="_blank">A 2015 Stanford study</a> examined the link between <a href="https://www.healthline.com/nutrition/6-ways-to-do-intermittent-fasting#section1" target="_blank">intermittent fasting</a> and neurogenesis. Calorie restriction and fasting can not only increase synaptic plasticity and promote neuron growth but it can also decrease your risk of developing neurodegenerative diseases and boost cognitive function. </p><p><u>Two of the most common ways you can intermittently fast are: </u></p><ul><li>16 hours per day every day - this is a method where you are able to eat for an 8 hour period of the day and fast for 16 hours of the day. Many people begin their "fast" after dinner, pushing their morning meal far enough towards lunch that most of their "off" eating time happens while they are asleep anyways. </li></ul><ul><li>24 hours every week - this is a method where once a week you fast for an entire day. Some people prefer this method because the rest of the week can resume as normal - but for many, this is a difficult way to fast. </li></ul><p><strong>Traveling to new places</strong></p><p>While traveling is something many of us enjoy — scenic routes and new fun experiences — these things also promote neurogenesis while we're on vacation. <a href="https://www.chicagotribune.com/travel/ct-xpm-2014-01-28-sc-trav-0128-travel-mechanic-20140128-story.html" target="_blank">Paul Nussbaum</a>, a clinical neuropsychologist at the University of Pittsburgh, explains that the mental benefits of traveling are very clear.<br></p><p><em>"When you expose your brain to an environment that's novel and complex or new and difficult, the brain literally reacts. Those new and challenging situations cause the brain to sprout dendrites (dangling extensions) which grow the brain's capacity." </em></p><p><strong>Learning a new instrument</strong></p><p>The mental health benefits of music have long been studied, but did you know that learning a new instrument can promote new neuron growth? </p><p>According to <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996135/" target="_blank">this 2010 study</a>, learning to play a new musical instrument is an intense, multisensory motor experience that requires that acquisition and maintenance of skills over your entire lifetime - which of course, promotes the new formation of new neural networks. </p><p>When is the best time to begin learning a new instrument? Childhood, of course. </p><p><em>"Learning to play a new musical instrument in childhood can result in long-lasting changes in brain organization," </em>according to the study mentioned above. </p><p>While learning an instrument in adulthood will also promote neurogenesis, children who began training with a musical instrument before the age of 7 have shown that they have a significantly larger corpus callosum (the area of the brain the allows communication between the two hemispheres of the brain) than many adults. </p><p><strong>Reading novels</strong></p><p>A study from <a href="http://esciencecommons.blogspot.com/2013/12/a-novel-look-at-how-stories-may-change.html" target="_blank">Emory University</a> showed there was an increase in ongoing connectivity in the brains of participants after reading the same (fiction) novel. </p><p>In this study, enhanced brain activity was observed in the region that control physical sensations and movement. Reading a novel, according to lead researcher Gregory Berns, can transport you into the body of the protagonist. </p><p>This ability to shift into another mental state is a vital skill that promotes healthy neurogenesis in those areas of the brain. </p>
The coronavirus pandemic has brought out the perception of selfishness among many.
- Selfish behavior has been analyzed by philosophers and psychologists for centuries.
- New research shows people may be wired for altruistic behavior and get more benefits from it.
- Crisis times tend to increase self-centered acts.
Paul Krugman on the Virtues of Selfishness<div class="rm-shortcode" data-media_id="7ZtAkm6C" data-player_id="FvQKszTI" data-rm-shortcode-id="828936bf6953080e9018307354c0c02b"> <div id="botr_7ZtAkm6C_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/7ZtAkm6C-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/7ZtAkm6C-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/7ZtAkm6C-FvQKszTI.js"></script> </div> The Nobel Prize-winning economist on the virtues of selfishness.
Evolution Is Moving Us Away from Selfishness. But Where Is It Taking ...<div class="rm-shortcode" data-media_id="cyeqmYCb" data-player_id="FvQKszTI" data-rm-shortcode-id="6c5efecb56456e9acc25cf36935b1826"> <div id="botr_cyeqmYCb_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/cyeqmYCb-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/cyeqmYCb-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/cyeqmYCb-FvQKszTI.js"></script> </div>
Exploring Morality and Selfishness in Modern Times<div class="rm-shortcode" data-media_id="02eX1Cag" data-player_id="FvQKszTI" data-rm-shortcode-id="45cc6180db791f32683988fb52faff26"> <div id="botr_02eX1Cag_FvQKszTI_div" class="jwplayer-media" data-jwplayer-video-src="https://content.jwplatform.com/players/02eX1Cag-FvQKszTI.js"> <img src="https://cdn.jwplayer.com/thumbs/02eX1Cag-1920.jpg" class="jwplayer-media-preview" /> </div> <script src="https://content.jwplatform.com/players/02eX1Cag-FvQKszTI.js"></script> </div> Philosopher Peter Singer discusses the state of global ethics.
Parenting could be a distraction from what mattered most to him: his writing.
Ernest Hemingway was affectionately called “Papa," but what kind of dad was he?