Targeted Cancer Drugs Advance

While only a subset of patients responds to targeted cancer drugs, scientists are starting to figure out how to make those drugs work more effectively in a larger number of patients.

Institute Professor at the Koch Institute for Integrative Cancer Research at MIT, Philip Sharp says: "'To personalize cancer care, we must interpret changes in cellular networks or mutations to predict the correct drug combination to use.' In two studies focusing on a promising class of drugs for lung cancer called EGFR tyrosine kinase inhibitors, researchers have pinpointed new drug targets that could enhance the drugs' activity. They hope the findings will enable a new approach to personalized cancer care, suggesting specific combinations of drugs that will be most effective for an individual's cancer."

​There are two kinds of failure – but only one is honorable

Malcolm Gladwell teaches "Get over yourself and get to work" for Big Think Edge.

Big Think Edge
  • Learn to recognize failure and know the big difference between panicking and choking.
  • At Big Think Edge, Malcolm Gladwell teaches how to check your inner critic and get clear on what failure is.
  • Subscribe to Big Think Edge before we launch on March 30 to get 20% off monthly and annual memberships.
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Is this why time speeds up as we age?

We take fewer mental pictures per second.

(MPH Photos/giphy/yShutterstock/Big Think)
Mind & Brain
  • Recent memories run in our brains like sped-up old movies.
  • In childhood, we capture images in our memory much more quickly.
  • The complexities of grownup neural pathways are no match for the direct routes of young brains.
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Trauma in childhood leads to empathy in adulthood

It's not just a case of "what doesn't kill you makes you stronger."

Mind & Brain

  • A new study suggests children who endure trauma grow up to be adults with more empathy than others.
  • The effect is not universal, however. Only one kind of empathy was greatly effected.
  • The study may lead to further investigations into how people cope with trauma and lead to new ways to help victims bounce back.
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Why are so many objects in space shaped like discs?

It's one of the most consistent patterns in the unviverse. What causes it?

Videos
  • Spinning discs are everywhere – just look at our solar system, the rings of Saturn, and all the spiral galaxies in the universe.
  • Spinning discs are the result of two things: The force of gravity and a phenomenon in physics called the conservation of angular momentum.
  • Gravity brings matter together; the closer the matter gets, the more it accelerates – much like an ice skater who spins faster and faster the closer their arms get to their body. Then, this spinning cloud collapses due to up and down and diagonal collisions that cancel each other out until the only motion they have in common is the spin – and voila: A flat disc.