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Sugar does rot your brain after all: Scientists connect to Alzheimer's
Is Alzheimer's triggered by too much sugar? We have long known that consuming too much sugar is related to obesity and diabetes. A new UK study has found a molecular "tipping point," where a crucial enzyme related to insulin regulation is damaged by excess glucose. This may have a major impact on our understanding of the cognitive disease along with our diet.
Time to lower your sugar intake.
Scientists from the University of Bath have just found the first connection between excess blood sugar glucose and Alzheimer's disease. Researchers in this unprecedented study found what they describe as a molecular "tipping point," where a crucial enzyme related to inflammation response and insulin regulation is damaged by excess glucose. While the scientists involved do not make the direct assertion, the takeaway is Alzheimer's disease may be triggered by consuming too much sugar.
This potentially groundbreaking study, published in the journal Scientific Reports, could have major implications for our understanding of Alzheimer's and its relationship with our diet. Alzheimer's disease is a degenerative neurological condition that impacts 5.5 million Americans and an estimated 46 million people worldwide.
While we have long known sugar's link to obesity and diabetes, our understanding of its relationship with Alzheimer's has been less studied. This latest research offers greater credence for Alzheimer's to be referred to as Type 3 Diabetes. Earlier studies have showcased a those with diabetes have a greater prevalence of Alzheimer's.
How Did Researchers Establish This Link?
The scientists relied on donated brain tissue from both those with and without Alzheimer's. The brain tissue was provided by Brains for Dementia Research, a large brain bank network with a mission of advancing research into dementia.
The brains of those who were in the early stages of Alzheimer's had the crucial enzyme MIF (macrophage migration inhibitory factor) that was damaged. The enzyme, which is related to inflammation response and insulin regulation, was injured through a process called glycation. The researchers believe that the tipping point for Alzheimer's to progress may be when MIF is damaged through glycation. As Alzheimer's advances, so does the glycation of the MIF enzymes.
“Normally MIF would be part of the immune response to the build-up of abnormal proteins in the brain, and we think that because sugar damage reduces some MIF functions and completely inhibits others that this could be a tipping point that allows Alzheimer's to develop."-Professor Jean van den Elsen (University of Bath), commenting about the study in its press release.
We Consume a Lot of Added Sugars in Our Diet
The average American drinks about 38 gallons of soda each year. A 20-ounce bottle of soda contains around 14 1/2 teaspoons of added sugar. As nutritionists have been arguing for years, we are consuming too much sugar. The heighten blood sugar level (hyperglycemia) from our consumption of soda and other sugary items has already been clearly established as increasing the likelihood of obesity and diabetes.
This latest research has uncovered the specific molecular link between glucose and Alzheimer's. So forget the extra pounds from drinking too much soda and eating too many donuts: sugar may be truly rotting your brain.
Ever since we've had the technology, we've looked to the stars in search of alien life. It's assumed that we're looking because we want to find other life in the universe, but what if we're looking to make sure there isn't any?
Here's an equation, and a rather distressing one at that: N = R* × fP × ne × f1 × fi × fc × L. It's the Drake equation, and it describes the number of alien civilizations in our galaxy with whom we might be able to communicate. Its terms correspond to values such as the fraction of stars with planets, the fraction of planets on which life could emerge, the fraction of planets that can support intelligent life, and so on. Using conservative estimates, the minimum result of this equation is 20. There ought to be 20 intelligent alien civilizations in the Milky Way that we can contact and who can contact us. But there aren't any.
Building a personal connection with students can counteract some negative side effects of remote learning.
- Not being able to engage with students in-person due to the pandemic has presented several new challenges for educators, both technical and social. Digital tools have changed the way we all think about learning, but George Couros argues that more needs to be done to make up for what has been lost during "emergency remote teaching."
- One interesting way he has seen to bridge that gap and strengthen teacher-student and student-student relationships is through an event called Identity Day. Giving students the opportunity to share something they are passionate about makes them feel more connected and gets them involved in their education.
- "My hope is that we take these skills and these abilities we're developing through this process and we actually become so much better for our kids when we get back to our face-to-face setting," Couros says. He adds that while no one can predict the future, we can all do our part to adapt to it.
Frequent shopping for single items adds to our carbon footprint.
- A new study shows e-commerce sites like Amazon leave larger greenhouse gas footprints than retail stores.
- Ordering online from retail stores has an even smaller footprint than going to the store yourself.
- Greening efforts by major e-commerce sites won't curb wasteful consumer habits. Consolidating online orders can make a difference.
A pile of recycled cardboard sits on the ground at Recology's Recycle Central on January 4, 2018 in San Francisco, California.
Photo by Justin Sullivan/Getty Images<p>A large part of the reason is speed. In a competitive market, pure players use the equation, <em>speed + convenience</em>, to drive adoption. This is especially relevant to the "last mile" GHG footprint: the distance between the distribution center and the consumer.</p><p>Interestingly, the smallest GHG footprint occurs when you order directly from a physical store—even smaller than going there yourself. Pure players, such as Amazon, are the greatest offenders. Variables like geographic location matter; the team looked at shopping in the UK, the US, China, and the Netherlands. </p><p>Sadegh Shahmohammadi, a PhD student at the Netherlands' Radboud University and corresponding author of the paper, <a href="https://www.cnn.com/2020/02/26/tech/greenhouse-gas-emissions-retail/index.html" target="_blank">says</a> the above "pattern holds true in countries where people mostly drive. It really depends on the country and consumer behavior there."</p><p>The researchers write that this year-and-a-half long study pushes back on previous research that claims online shopping to be better in terms of GHG footprints.</p><p style="margin-left: 20px;">"They have, however, compared the GHG emissions per shopping event and did not consider the link between the retail channels and the basket size, which leads to a different conclusion than that of the current study."</p><p>Online retail is where convenience trumps environment: people tend to order one item at a time when shopping on pure player sites, whereas they stock up on multiple items when visiting a store. Consumers will sometimes order a number of separate items over the course of a week rather than making one trip to purchase everything they need. </p><p>While greening efforts by online retailers are important, until a shift in consumer attitude changes, the current carbon footprint will be a hard obstacle to overcome. Amazon is trying to have it both ways—carbon-free and convenience addicted—and the math isn't adding up. If you need to order things, do it online, but try to consolidate your purchases as much as possible.</p><p>--</p><p><em>Stay in touch with Derek on <a href="http://www.twitter.com/derekberes" target="_blank">Twitter</a>, <a href="https://www.facebook.com/DerekBeresdotcom" target="_blank">Facebook</a> and <a href="https://derekberes.substack.com/" target="_blank">Substack</a>. His next book is</em> "<em>Hero's Dose: The Case For Psychedelics in Ritual and Therapy."</em></p>
Chronic irregular sleep in children was associated with psychotic experiences in adolescence, according to a recent study out of the University of Birmingham's School of Psychology.