The game is afoot to define the presidency of Gerald Ford. The dominant narrative from the mainstream media is that Ford was the "Great Healer," an extinct species of bi-partisan statesman who guided the country through the aftermath of the Watergate scandal and the pullout from Vietnam.
The lead to this front page story by Peter Baker of the Washington Post represents the dominant media narrative of "bi-partisan healer":
A nation deeply polarized by war and partisanship came together yesterday to mourn Gerald Rudolph Ford as a healer during a previous era of division, while Washington began preparing an elaborate farewell for the most modest of presidents....Ford's legacy as a bridge builder before, during and after his short presidency dominated the discussion in Washington and across the country yesterday, standing in contrast to a time when leaders in both parties often seem unable to join hands on the big issues of the day. During his final years, mostly privately but sometimes publicly, Ford often expressed regret at what he saw as a coarsening political environment that personalizes policy differences and undermines national unity.
Yet other stories remind us of the narrative that ultimately cost Ford the presidency in 1976: an out-of-touch stumbler and bumbler. This interpretation was reflected in Chevy Chase skits on Saturday Night Live, and then reinforced by selective media reporting of any spills that Ford might have taken in his many athletic outings or public appearances. Indeed, late night comedy's ability to define Ford might be the first example of the rise of infotainment as an important strategic communication arena.
Ford's SNL plague is also an example of what ultimately tortured future candidates like Al Gore. Media narratives lock in perceived personality flaws like Ford's "clumsiness," or Gore's "truth exaggeration," and every event or issue becomes re-interpreted through the specific narrative lens, regardless of truth or evidence. Despite being the most athletic president in history, Chevy Chase's SNL skits in combination with selective media reporting reinforced an impression that Ford was somehow physically challenged.
As another example, consider Ford's statement at the second 1976 Presidential debate that was later miscontrued by the Carter campaign and the news media as evidence of a bumbling president in a state of denial.
Contrary to the media interpretation that somehow Ford was disputing the notion that the Soviets controlled eastern Europe militarily, it is clear from the transcript that what Ford meant was that the "spirit of freedom" still existed among the citizens of the Eastern bloc countries, despite their Soviet occupation:
FORD:...there is no Soviet domination of Eastern Europe and there never will be under a Ford administration.
MAX FRANKEL: I'm sorry, I - could I just follow - did I understand you to say, sir, that the Russians are not using Eastern Europe as their own sphere of influence in occupying mo- most of the countries there and in - and making sure with their troops that it's a - that it's a Communist zone, whereas on our side of the line the Italians and the French are still flirting with the possibility of Communism?
FORD: I don't believe, - Mr. Frankel that - the Yugoslavians consider themselves dominated by the Soviet Union. I don't believe that the Rumanians consider themselves dominated by the Soviet Union. I don't believe that the Poles consider themselves dominated by the Soviet Union. Each of those countries is independent, autonomous: it has its own territorial integrity and the United States does not concede that those countries are under the domination of the Soviet Union. As a matter of fact, I visited Poland, Yugoslavia and Rumania to make certain that the people of those countries understood that the president of the United States and the people of the United are dedicated to their independence, their autonomy and their freedom.
Finally, a few media outlets on the left have focused heavily on Ford's role as enabler of Henry Kissinger, and specifically his tacit support for the General Suharto-led Indonesian invasion of East Timor. Consider this report and interview at the radio program Democracy Now.
Well documented in books, articles, and documentaries such as The Trials of Henry Kissinger, a search of major US newspapers archived in Lexis Nexis finds that not a single news article appearing this week has mentioned the event.
Somewhere Edward Herman and Noam Chomsky are probably smiling. The lack of coverage detailing Ford's mirky foreign policy decisions is consistent with the predictions of their Propaganda Model.
In recent years, our team at Iowa State University has found a way to make pigs an even closer stand-in for humans. We have successfully transferred components of the human immune system into pigs that lack a functional immune system. This breakthrough has the potential to accelerate medical research in many areas, including virus and vaccine research, as well as cancer and stem cell therapeutics.
Existing biomedical models
Severe Combined Immunodeficiency, or SCID, is a genetic condition that causes impaired development of the immune system. People can develop SCID, as dramatized in the 1976 movie “The Boy in the Plastic Bubble." Other animals can develop SCID, too, including mice.
Researchers in the 1980s recognized that SCID mice could be implanted with human immune cells for further study. Such mice are called “humanized" mice and have been optimized over the past 30 years to study many questions relevant to human health.
Mice are the most commonly used animal in biomedical research, but results from mice often do not translate well to human responses, thanks to differences in metabolism, size and divergent cell functions compared with people.
Nonhuman primates are also used for medical research and are certainly closer stand-ins for humans. But using them for this purpose raises numerous ethical considerations. With these concerns in mind, the National Institutes of Health retired most of its chimpanzees from biomedical research in 2013.
Alternative animal models are in demand.
Swine are a viable option for medical research because of their similarities to humans. And with their widespread commercial use, pigs are met with fewer ethical dilemmas than primates. Upwards of 100 million hogs are slaughtered each year for food in the U.S.
Humanizing pigs
In 2012, groups at Iowa State University and Kansas State University, including Jack Dekkers, an expert in animal breeding and genetics, and Raymond Rowland, a specialist in animal diseases, serendipitously discovered a naturally occurring genetic mutation in pigs that caused SCID. We wondered if we could develop these pigs to create a new biomedical model.
Our group has worked for nearly a decade developing and optimizing SCID pigs for applications in biomedical research. In 2018, we achieved a twofold milestone when working with animal physiologist Jason Ross and his lab. Together we developed a more immunocompromised pig than the original SCID pig – and successfully humanized it, by transferring cultured human immune stem cells into the livers of developing piglets.
During early fetal development, immune cells develop within the liver, providing an opportunity to introduce human cells. We inject human immune stem cells into fetal pig livers using ultrasound imaging as a guide. As the pig fetus develops, the injected human immune stem cells begin to differentiate – or change into other kinds of cells – and spread through the pig's body. Once SCID piglets are born, we can detect human immune cells in their blood, liver, spleen and thymus gland. This humanization is what makes them so valuable for testing new medical treatments.
We have found that human ovarian tumors survive and grow in SCID pigs, giving us an opportunity to study ovarian cancer in a new way. Similarly, because human skin survives on SCID pigs, scientists may be able to develop new treatments for skin burns. Other research possibilities are numerous.
The ultraclean SCID pig biocontainment facility in Ames, Iowa. Adeline Boettcher, CC BY-SA
Pigs in a bubble
Since our pigs lack essential components of their immune system, they are extremely susceptible to infection and require special housing to help reduce exposure to pathogens.
SCID pigs are raised in bubble biocontainment facilities. Positive pressure rooms, which maintain a higher air pressure than the surrounding environment to keep pathogens out, are coupled with highly filtered air and water. All personnel are required to wear full personal protective equipment. We typically have anywhere from two to 15 SCID pigs and breeding animals at a given time. (Our breeding animals do not have SCID, but they are genetic carriers of the mutation, so their offspring may have SCID.)
As with any animal research, ethical considerations are always front and center. All our protocols are approved by Iowa State University's Institutional Animal Care and Use Committee and are in accordance with The National Institutes of Health's Guide for the Care and Use of Laboratory Animals.
Every day, twice a day, our pigs are checked by expert caretakers who monitor their health status and provide engagement. We have veterinarians on call. If any pigs fall ill, and drug or antibiotic intervention does not improve their condition, the animals are humanely euthanized.
Our goal is to continue optimizing our humanized SCID pigs so they can be more readily available for stem cell therapy testing, as well as research in other areas, including cancer. We hope the development of the SCID pig model will pave the way for advancements in therapeutic testing, with the long-term goal of improving human patient outcomes.
Adeline Boettcher earned her research-based Ph.D. working on the SCID project in 2019.
Christopher Tuggle, Professor of Animal Science, Iowa State University and Adeline Boettcher, Technical Writer II, Iowa State University
This article is republished from The Conversation under a Creative Commons license. Read the original article.
Volcano erupting lava, volcanic sky active rock night Ecuador landscape
How can modern technology help warn us of impending volcanic eruptions?
One promising answer may lie in satellite imagery. In a recent study published in Nature Geoscience, researchers used infrared data collected by NASA satellites to study the conditions near volcanoes in the months and years before they erupted.
The results revealed a pattern: Prior to eruptions, an unusually large amount of heat had been escaping through soil near volcanoes. This diffusion of subterranean heat — which is a byproduct of "large-scale thermal unrest" — could potentially represent a warning sign of future eruptions.
For the study, the researchers conducted a statistical analysis of changes in surface temperature near volcanoes, using data collected over 16.5 years by NASA's Terra and Aqua satellites. The results showed that eruptions tended to occur around the time when surface temperatures near the volcanoes peaked.
Eruptions were preceded by "subtle but significant long-term (years), large-scale (tens of square kilometres) increases in their radiant heat flux (up to ~1 °C in median radiant temperature)," the researchers wrote. After eruptions, surface temperatures reliably decreased, though the cool-down period took longer for bigger eruptions.
"Volcanoes can experience thermal unrest for several years before eruption," the researchers wrote. "This thermal unrest is dominated by a large-scale phenomenon operating over extensive areas of volcanic edifices, can be an early indicator of volcanic reactivation, can increase prior to different types of eruption and can be tracked through a statistical analysis of little-processed (that is, radiance or radiant temperature) satellite-based remote sensing data with high temporal resolution."
Although using satellites to monitor thermal unrest wouldn't enable scientists to make hyper-specific eruption predictions (like predicting the exact day), it could significantly improve prediction efforts. Seismologists and volcanologists currently use a range of techniques to forecast eruptions, including monitoring for gas emissions, ground deformation, and changes to nearby water channels, to name a few.
Still, none of these techniques have proven completely reliable, both because of the science and the practical barriers (e.g. funding) standing in the way of large-scale monitoring. In 2014, for example, Japan's Mount Ontake suddenly erupted, killing 63 people. It was the nation's deadliest eruption in nearly a century.
In the study, the researchers found that surface temperatures near Mount Ontake had been increasing in the two years prior to the eruption. To date, no other monitoring method has detected "well-defined" warning signs for the 2014 disaster, the researchers noted.
The researchers hope satellite-based infrared monitoring techniques, combined with existing methods, can improve prediction efforts for volcanic eruptions. Volcanic eruptions have killed about 2,000 people since 2000.
"Our findings can open new horizons to better constrain magma–hydrothermal interaction processes, especially when integrated with other datasets, allowing us to explore the thermal budget of volcanoes and anticipate eruptions that are very difficult to forecast through other geophysical/geochemical methods."
