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Acupuncture Doesn't Work. But It Might Have Value.
Over 3,000 studies have shown acupuncture to be no better than a placebo. Yet it has led researchers to discover something that might aid in pain relief.
The efficacy of traditional Chinese medicine (TCM) has long been contested. With poachers decimating populations of wild tigers and rhinos to fuel superstitious myths regarding animalistic healing power, TCM has been a source of controversy for centuries.
One of the more benign aspects of Chinese medicine is acupuncture, a practice deemed superstitious in China in the 17th century until Mao Zedong reemployed it for political purposes in the fifties. Two decades later it infiltrated the American imagination. A myth was reborn.
Studies have found no meaningful difference between acupuncture and a wide range of sham treatments. Whether investigators penetrate the skin or not, use needles or toothpicks, target the particular locations on the body cited by acupuncturists or random ones, the same proportion of patients experience more or less the same degree of pain relief (the most common condition for which acupuncture is administered and the most well researched).
Why then is acupuncture starting to be covered by insurance plans? The placebo effect is a real phenomenon that exploits a peculiar aspect of human psychology: If we think we’re healing, our brain releases a cascade of beneficial chemicals, including dopamine and mu-opioid activity, that actually aid in the healing process. Optimism is strong medicine indeed.
As is relaxation. I experimented with acupuncture about a decade ago while living in New York. The hectic pace of the city dissipated when lying in a dark room listening to ambient music; an hour in such a state of meditation is certain to have beneficial effects.
Does this mean the acupuncture has no positive qualities? Actually, no, Interlandi counters. Even though studies have shown that needles stuck in meridian points or just randomly have pretty much the same effect, the pressure of the needle has led researchers to question the efficacy of something else: adenosine.
Most people recognize the term as part of ATP, adenosine triphosphate, which aids cells in metabolism and helps fuel exercise. As a neuromodulator it also helps us fall asleep. And, as Interlandi writes, it appears to help relieve pain, at least in studies with mice.
Injecting the mice with compounds similar to adenosine had the same effect as acupuncture needling. And injecting compounds that slowed the removal of adenosine from the body boosted the effects of acupuncture by making more adenosine available to the surrounding tissue for longer periods.
By exploiting the body’s natural opioid system, acupuncture needles might help boost healing by sending adenosine to the afflicted area. This is important, Interlandi concludes, because this could offer a new mechanism for pain relief to combat the opioid addiction crisis.
Read to get stuck? Not so fast, she concludes:
The researchers did not show that the release of adenosine was specific to acupuncture. Acupuncture needles might cause adenosine to flood the surrounding tissue, but so might a hard pinch, or applied pressure, or any number of other physical insults.
This doesn’t bode well for fans of TCM, but at least acupuncture has led to a potential new source of pain relief that can actually be verified.
Derek Beres is working on his new book, Whole Motion: Training Your Brain and Body For Optimal Health (Carrel/Skyhorse, Spring 2017). He is based in Los Angeles. Stay in touch @derekberes.
Emotional intelligence is a skill sought by many employers. Here's how to raise yours.
- Daniel Goleman's 1995 book Emotional Intelligence catapulted the term into widespread use in the business world.
- One study found that EQ (emotional intelligence) is the top predictor of performance and accounts for 58% of success across all job types.
- EQ has been found to increase annual pay by around $29,000 and be present in 90% of top performers.
Researchers hope the technology will further our understanding of the brain, but lawmakers may not be ready for the ethical challenges.
- Researchers at the Yale School of Medicine successfully restored some functions to pig brains that had been dead for hours.
- They hope the technology will advance our understanding of the brain, potentially developing new treatments for debilitating diseases and disorders.
- The research raises many ethical questions and puts to the test our current understanding of death.
What's dead may never die, it seems<p>The researchers did not hail from House Greyjoy — "What is dead may never die" — but came largely from the Yale School of Medicine. They connected 32 pig brains to a system called Brain<em>Ex</em>. Brain<em>Ex </em>is an artificial perfusion system — that is, a system that takes over the functions normally regulated by the organ. The pigs had been killed four hours earlier at a U.S. Department of Agriculture slaughterhouse; their brains completely removed from the skulls.</p><p>Brain<em>Ex</em> pumped an experiment solution into the brain that essentially mimic blood flow. It brought oxygen and nutrients to the tissues, giving brain cells the resources to begin many normal functions. The cells began consuming and metabolizing sugars. The brains' immune systems kicked in. Neuron samples could carry an electrical signal. Some brain cells even responded to drugs.</p><p>The researchers have managed to keep some brains alive for up to 36 hours, and currently do not know if Brain<em>Ex</em> can have sustained the brains longer. "It is conceivable we are just preventing the inevitable, and the brain won't be able to recover," said Nenad Sestan, Yale neuroscientist and the lead researcher.</p><p>As a control, other brains received either a fake solution or no solution at all. None revived brain activity and deteriorated as normal.</p><p>The researchers hope the technology can enhance our ability to study the brain and its cellular functions. One of the main avenues of such studies would be brain disorders and diseases. This could point the way to developing new of treatments for the likes of brain injuries, Alzheimer's, Huntington's, and neurodegenerative conditions.</p><p>"This is an extraordinary and very promising breakthrough for neuroscience. It immediately offers a much better model for studying the human brain, which is extraordinarily important, given the vast amount of human suffering from diseases of the mind [and] brain," Nita Farahany, the bioethicists at the Duke University School of Law who wrote the study's commentary, told <em><a href="https://www.nationalgeographic.com/science/2019/04/pig-brains-partially-revived-what-it-means-for-medicine-death-ethics/" target="_blank">National Geographic</a>.</em></p>
An ethical gray matter<p>Before anyone gets an <em>Island of Dr. Moreau</em> vibe, it's worth noting that the brains did not approach neural activity anywhere near consciousness.</p><p>The Brain<em>Ex</em> solution contained chemicals that prevented neurons from firing. To be extra cautious, the researchers also monitored the brains for any such activity and were prepared to administer an anesthetic should they have seen signs of consciousness. </p><p>Even so, the research signals a massive debate to come regarding medical ethics and our definition of death. </p><p>Most countries define death, clinically speaking, as the irreversible loss of brain or circulatory function. This definition was already at odds with some folk- and value-centric understandings, but where do we go if it becomes possible to reverse clinical death with artificial perfusion?</p><p>"This is wild," Jonathan Moreno, a bioethicist at the University of Pennsylvania, told <a href="https://www.nytimes.com/2019/04/17/science/brain-dead-pigs.html" target="_blank">the <em>New York Times</em></a>. "If ever there was an issue that merited big public deliberation on the ethics of science and medicine, this is one."</p><p>One possible consequence involves organ donations. Some European countries require emergency responders to use a process that preserves organs when they cannot resuscitate a person. They continue to pump blood throughout the body, but use a "thoracic aortic occlusion balloon" to prevent that blood from reaching the brain.</p><p>The system is already controversial because it raises concerns about what caused the patient's death. But what happens when brain death becomes readily reversible? Stuart Younger, a bioethicist at Case Western Reserve University, <a href="https://www.nature.com/articles/d41586-019-01216-4#ref-CR2" target="_blank">told <em>Nature</em></a> that if Brain<em>Ex</em> were to become widely available, it could shrink the pool of eligible donors.</p><p>"There's a potential conflict here between the interests of potential donors — who might not even be donors — and people who are waiting for organs," he said.</p><p>It will be a while before such experiments go anywhere near human subjects. A more immediate ethical question relates to how such experiments harm animal subjects.</p><p>Ethical review boards evaluate research protocols and can reject any that causes undue pain, suffering, or distress. Since dead animals feel no pain, suffer no trauma, they are typically approved as subjects. But how do such boards make a judgement regarding the suffering of a "cellularly active" brain? <a href="https://bigthink.com/philip-perry/after-death-youre-aware-that-youve-died-scientists-claim" target="_blank">The distress of a partially alive brain</a>? </p><p>The dilemma is unprecedented.</p>
Setting new boundaries<p>Another science fiction story that comes to mind when discussing this story is, of course, <em>Frankenstein</em>. As Farahany told <em>National Geographic</em>: "It is definitely has [sic] a good science-fiction element to it, and it is restoring cellular function where we previously thought impossible. But to have <em>Frankenstein</em>, you need some degree of consciousness, some 'there' there. [The researchers] did not recover any form of consciousness in this study, and it is still unclear if we ever could. But we are one step closer to that possibility."</p><p>She's right. The researchers undertook their research for the betterment of humanity, and we may one day reap some unimaginable medical benefits from it. The ethical questions, however, remain as unsettling as the stories they remind us of.</p>
Starting and running a business takes more than a good idea and the desire to not have a boss.
- Anyone can start a business and be an entrepreneur, but the reality is that most businesses will fail. Building something successful from the ground up takes hard work, passion, intelligence, and a network of people who are equally as smart and passionate as you are. It also requires the ability to accept and learn from your failures.
- In this video, entrepreneurs in various industries including 3D printing, fashion, hygiene, capital investments, aerospace, and biotechnology share what they've learned over the years about relationships, setting and attaining goals, growth, and what happens when things don't go according to plan.
- "People who start businesses for the exit, most of them will fail because there's just no true passion behind it," says Miki Agrawal, co-founder of THINX and TUSHY. A key point of Agrawal's advice is that if you can't see yourself in something for 10 years, you shouldn't do it.
Ever wonder how soft hair can dull a steel razor? So did scientists at MIT.
- Steel is fifty times harder than hair, yet shaving razors dull in a hurry.
- A new study finds much of this is caused by hair cracking razors at points of imperfection.
- The findings may lead to new ways of making razors that last longer.
An extremely magnified image of a razor blade cutting hair.
G. Roscioli<p>Lead author Gianluca Roscioli grew his facial hair out for three days before <a href="https://www.smithsonianmag.com/smart-news/why-razors-are-dull-within-weeks-according-science-180975534/" target="_blank">shaving</a>. He then brought his razors into the lab to examine them under an electron microscope. While the team expected to see even dulling on the blade edge, they instead noticed strange C-shaped chips missing. Intrigued, they attached a camera to the microscope so they could record the blade cutting the <a href="https://www.sciencemag.org/news/2020/08/your-hair-can-crack-steel-when-it-hits-right-spot" target="_blank">hair</a>. At the same time, they investigated the properties of the razors at the microscopic level.</p><p>This apparatus revealed that, when the razor blade hit the hairs at non-perpendicular angles, small cracks formed. These tended to develop in boundary areas between where the steel was harder and where it was softer due to differences in the properties at each location caused by the manufacturing <a href="https://www.newscientist.com/article/2251202-we-just-figured-out-why-shaving-soft-hair-blunts-steel-razor-blades/" target="_blank">process</a>. Over time, these cracks grew into chips. While these chips are too small to see with the naked eye, they were large enough to reduce the blade's effectiveness.</p><p>Roscioli told <a href="https://www.smithsonianmag.com/smart-news/why-razors-are-dull-within-weeks-according-science-180975534/" target="_blank" rel="noopener noreferrer dofollow">NPR</a>, "The size of the chips are about 1/10 of the diameter of a human hair."</p><p>The chips can be caused by hair of any thickness and appear to be unavoidable in blades with standard imperfections. </p><p>The finding surprised other scientists, who also quickly accepted the explanation. Professor Suveen Mathaudhu of UC Riverside explained to <a href="https://www.npr.org/2020/08/06/898577234/cutting-edge-research-shows-how-hair-dulls-razor-blades" target="_blank" rel="noopener noreferrer dofollow">NPR</a> that he had expected a larger role in the dulling process to be played by corrosion but that the findings made a great deal of sense. Other scientists expressed how impressed they were by the quality of the images and the difficulty of the study. </p>