Who are we?
Josh Lieb is the former Producer and Show Runner of The Tonight Show Starring Jimmy Fallon. His credits include stints as Executive Producer of NewsRadio and The Daily Show with Jon Stewart. He won 7 Prime Time Emmys as a producer and writer for The Daily Show. In 2009, he published a young adult novel, I Am A Genius of Unspeakable Evil and I Want to Be Your Class President, which was a New York Times Bestseller.
Lieb was raised in Columbia, South Carolina, and graduated from Harvard, where he was an editor of The Lampoon, the college humor magazine. After graduation, he found work writing for Twisted Puppet Theater, The Jon Stewart Show, and NewsRadio. He subsequently worked as a producer or consultant on shows including The Simpsons, Drawn Together, Sirens, Nikki, I Hate My Teenage Daughter, and Late Night with Jimmy Fallon.
Lieb's tenure at The Daily Show lasted from 2006 to 2010, during which he also served as Executive Producer of “The Rally to Restore Sanity And/Or Fear” and as co-editor and co-author of Earth: The Book.
In 2013, he wrote and directed a series of comedic shorts to raise money and awareness for the charity Water.Org. Stars featured in the shorts included Matt Damon, Jessica Biel, Sir Richard Branson, and Bono.
Penguin/ Random House released Lieb's second novel, Ratscalibur, in 2015.
In October 2016, NBCUniversal announced an exclusive writing deal with Lieb.
Question: What forces have shaped humanity most?
Josh Lieb: Oh come on! What forces have shaped humanity? I mean what kind of question is that? That’s so insanely broad. Where . . . I guess it’s evident we’re . . . you know . . . Hunger, boredom, sleepiness. Those are the forces that have shaped humanity. Boredom, that’s what gives me a job. You know I’m here to keep you from being bored. Yeah, you know it’s . . . We’re monkeys, and we wanna have sex, and that’s a big force. Also Catholic Church, a big force. Also books. You know, these are . . . I . . . I . . . I can’t say. Whatever. It’s all . . . the clash of cultures. Our base animal impulses are what have driven us forward. And then our aspirations. We are smart enough to think that we are better than just animals, and I think we are. I think we do have souls. And so . . . and so we do the base animal stuff, and then we make the cathedral because we have a higher self.
Lieb, on the battle between our animal impulses and our higher aspirations.
The controversial herbicide is everywhere, apparently.
- U.S. PIRG tested 20 beers and wines, including organics, and found Roundup's active ingredient in almost all of them.
- A jury on August 2018 awarded a non-Hodgkin's lymphoma victim $289 million in Roundup damages.
- Bayer/Monsanto says Roundup is totally safe. Others disagree.
Can dirt help us fight off stress? Groundbreaking new research shows how.
- New research identifies a bacterium that helps block anxiety.
- Scientists say this can lead to drugs for first responders and soldiers, preventing PTSD and other mental issues.
- The finding builds on the hygiene hypothesis, first proposed in 1989.
Are modern societies trying too hard to be clean, at the detriment to public health? Scientists discovered that a microorganism living in dirt can actually be good for us, potentially helping the body to fight off stress. Harnessing its powers can lead to a "stress vaccine".
Researchers at the University of Colorado Boulder found that the fatty 10(Z)-hexadecenoic acid from the soil-residing bacterium Mycobacterium vaccae aids immune cells in blocking pathways that increase inflammation and the ability to combat stress.
The study's senior author and Integrative Physiology Professor Christopher Lowry described this fat as "one of the main ingredients" in the "special sauce" that causes the beneficial effects of the bacterium.
The finding goes hand in hand with the "hygiene hypothesis," initially proposed in 1989 by the British scientist David Strachan. He maintained that our generally sterile modern world prevents children from being exposed to certain microorganisms, resulting in compromised immune systems and greater incidences of asthma and allergies.
Contemporary research fine-tuned the hypothesis, finding that not interacting with so-called "old friends" or helpful microbes in the soil and the environment, rather than the ones that cause illnesses, is what's detrimental. In particular, our mental health could be at stake.
"The idea is that as humans have moved away from farms and an agricultural or hunter-gatherer existence into cities, we have lost contact with organisms that served to regulate our immune system and suppress inappropriate inflammation," explained Lowry. "That has put us at higher risk for inflammatory disease and stress-related psychiatric disorders."
University of Colorado Boulder
This is not the first study on the subject from Lowry, who published previous work showing the connection between being exposed to healthy bacteria and mental health. He found that being raised with animals and dust in a rural environment helps children develop more stress-proof immune systems. Such kids were also likely to be less at risk for mental illnesses than people living in the city without pets.
Lowry's other work also pointed out that the soil-based bacterium Mycobacterium vaccae acts like an antidepressant when injected into rodents. It alters their behavior and has lasting anti-inflammatory effects on the brain, according to the press release from the University of Colorado Boulder. Prolonged inflammation can lead to such stress-related disorders as PTSD.
The new study from Lowry and his team identified why that worked by pinpointing the specific fatty acid responsible. They showed that when the 10(Z)-hexadecenoic acid gets into cells, it works like a lock, attaching itself to the peroxisome proliferator-activated receptor (PPAR). This allows it to block a number of key pathways responsible for inflammation. Pre-treating the cells with the acid (or lipid) made them withstand inflammation better.
Lowry thinks this understanding can lead to creating a "stress vaccine" that can be given to people in high-stress jobs, like first responders or soldiers. The vaccine can prevent the psychological effects of stress.
What's more, this friendly bacterium is not the only potentially helpful organism we can find in soil.
"This is just one strain of one species of one type of bacterium that is found in the soil but there are millions of other strains in soils," said Lowry. "We are just beginning to see the tip of the iceberg in terms of identifying the mechanisms through which they have evolved to keep us healthy. It should inspire awe in all of us."
Check out the study published in the journal Psychopharmacology.
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