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What’s in James Watson’s Genome?
James Watson is an American molecular biologist best known for his discovery of the structure of DNA with Francis Crick in 1953. He was born in Chicago in 1928 and attended the University of Chicago for his undergraduate degree in zoology. While pursuing his Ph.D at Indiana University, Watson became interested in molecular biology, which led him to the University of Cambridge's Cavendish Laboratory for postdoctoral research. There he met Crick, the two recognized a common interest in discovering the structure of DNA. Watson, Crick, and another researcher Maurice Wilkins would later share the 1962 Nobel Prize in Physiology or Medicine for their work in this field.
In 1956, Watson became a junior member of Harvard University's Biological Laboratories, where he quickly advanced to the position of full professor. Then in 1968 he became director of Cold Spring Harbor Laboratory (CSHL) on Long Island, New York, where he shifted his research emphasis to the study of cancer. Between 1988 and 1992, Watson was also associated with the National Institutes of Health, spearheading the Human Genome Project. In 2007 he became the second person, after molecular biologist Craig Venter, to have his entire genome sequenced. Watson remained involved with CSHL, as president and later as chancellor, until 2007, when he retired following a controversy over comments he made claiming blacks are less intelligent than whites.
Watson has written many books, including the seminal textbook "The Molecular Biology of the Gene" (1965), his bestseller "The Double Helix" (1968) about his discovery of the DNA structure, and his memoir "Avoid Boring People" (2007).
Question: You were the second person, after Craig Venter, to have your genome sequenced; what did you learn?
James Watson: Not much. I learned that I had a polymorphism, which meant that I metabolized some important drugs more slowly and therefore they would pose greater risk to me if I took too much of them. So that was a very useful fact. And so, if I was you know, suddenly to go psychotic and they gave me an anti-psychotic, unless they were careful they could kill me with it. And you know, you’d just think it was an overdose, but no, it was my genes.
Then I sort of confirmed my hunch that I digested milk poorly, that... if I had a large consumption of ice cream. And I had noticed something was strange when I was working out the DNA structure, I was having constant stomach pains which other people were saying, “Well you’re just nervous about racing or with Linus Pauling.” But it was in fact, I’m still trying to be like an American and drinking a quart a day. And by that time I had lost the... was losing the ability to digest lactose.
Question: What did you choose not to learn about your genome?
James Watson: I chose not to find out whether I had a serious risk for Alzheimer’s. And at the time, you know, it was a little murky. It’s getting much clearer now. So Craig Venter, who put his entire sequence on, it came out that he’s at risk. But he could probably define the risk better by looking at the sequence today as opposed to a few years ago.
Question: How much does it cost to sequence a genome today?
James Watson: Well, I think it’s still, to be honest, about $20,000. There’s always a question about how you do the accounting and so on, but the cost of the reagents that you put into the machine and how often do you use the machine. So, but there’s a lot who believe it’s going to fall by another factor of 10, certainly within 10 years and maybe a soon as three or four. At which point then, the cost of you know, sequence scanning will be essentially trivial and the whole cost will then go toward interpreting it.
Recorded on September 28, 2010
Interviewed by Paul Hoffman
The molecular biologist’s genome is the second to ever be sequenced. The results gave him some potentially life-saving information.
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Gender and sexual minority populations are experiencing rising anxiety and depression rates during the pandemic.
- Anxiety and depression rates are spiking in the LGBTQ+ community, and especially in individuals who hadn't struggled with those issues in the past.
- Overall, depression increased by an average PHQ-9 score of 1.21 and anxiety increased by an average GAD-7 score of 3.11.
- The researchers recommended that health care providers check in with LGBTQ+ patients about stress and screen for mood and anxiety disorders—even among those with no prior history of anxiety or depression.
Study findings<p>For the study, <a href="https://link.springer.com/article/10.1007/s11606-020-05970-4" target="_blank">published in the Journal of General Internal Medicine</a><em>, </em>Flentje and her team evaluated survey responses from nearly 2,300 individuals who identified as being in the lesbian, gay, bisexual, transgender, and queer (LGBTQ+) community. Most of the participants were white, while nearly 19 percent identified as a racial or ethnic minority. Multiple genders were represented with cisgender women (27.2 percent) and men (24.6 percent) making up a majority of the participants. Sixty-three percent had been assigned female at birth. For the most part, participants identified their sexual orientations as queer (40.3 percent), gay (36.5 percent), and bisexual (30.3 percent).</p><p>The JGIM study participants were recruited from the 18,000-participant <a href="https://pridestudy.org/" target="_blank">PRIDE Study</a> (Population Research in Identity and Disparities for Equality), which is the first large-scale, long-term national study focusing on American adults who identify as LGBTQ+. It conducts annual questionnaires to understand factors related to health and disease in this population. </p><p>Participants filled out an annual questionnaire (starting in June 2019) and a COVID-19 impact survey this past spring. Flentje noted that on an individual level, some people may not have experienced a big change in anxiety or depression levels, but for others there was. Overall, depression increased by a <a href="https://patient.info/doctor/patient-health-questionnaire-phq-9" target="_blank">PHQ-9 score</a> of 1.21, putting it at 8.31 on average. Anxiety went up by a <a href="https://www.mdcalc.com/gad-7-general-anxiety-disorder-7" target="_blank">GAD-7</a> score of 3.11 to an average of 8.89. Interestingly, the average PHQ-9 scores for those who screened positive for depression at the first 2019 survey decreased by 1.08. Those who screened negative for depression saw their PHQ-9 scores increase by 2.17 on average. As for anxiety, researchers detected no GAD-7 change among the study participants who screened positive for anxiety in the first survey, but did see an overall increase of 3.93 among those who had initially been evaluated as negative for the disorder. </p>
Risks among gender and sexual minorities<span style="display:block;position:relative;padding-top:56.25%;" class="rm-shortcode" data-rm-shortcode-id="fc3fd1ae68b77bbbf58a6995638d6d65"><iframe type="lazy-iframe" data-runner-src="https://www.youtube.com/embed/EnUqDjCqg0A?rel=0" width="100%" height="auto" frameborder="0" scrolling="no" style="position:absolute;top:0;left:0;width:100%;height:100%;"></iframe></span><p>The LGBTQ+ community is a vulnerable population to mental health concerns because of their fear of stigmatization and previous discriminatory experiences.</p> <p>Previous research by the Human Rights Campaign has found "that LGBTQ Americans are more likely than the <a href="https://medicalxpress.com/tags/general+population/" target="_blank">general population</a> to live in poverty and lack access to adequate medical care, paid <a href="https://medicalxpress.com/tags/medical+leave/" target="_blank">medical leave</a>, and basic necessities during the pandemic," said researcher Tari Hanneman, director of the health and aging program at the campaign.</p> <p>"Therefore, it is not surprising to see this increase in anxiety and depression among this population," Hanneman said in the release. "This study highlights the need for <a href="https://medicalxpress.com/tags/health+care+professionals/" target="_blank">health care professionals</a> to support, affirm and provide <a href="https://medicalxpress.com/tags/critical+care/" target="_blank">critical care</a> for the LGBTQ community to manage and maintain their mental health, as well as their physical health, during this pandemic."</p>
What should health care providers do?<p>The authors of the study recommend that health care providers check in with LGBTQ+ patients about stress and screen for mood and anxiety disorders in members of that community—even among those with no prior history of anxiety or depression.</p><p>As cases of COVID-19 continue to mount, the sustained social distancing, potential isolation, economic precariousness, and personal illness, grief, and loss are bound to have increased and varied impacts on mental health. Effective treatments may include individual therapy and medications as well as more large-scale coronavirus support programs like peer-led groups and mindfulness practices. </p><p>"It will be important to find out what happens over time and to identify who is most at risk, so we can be sure to roll out public health interventions to support the mental health of our communities in the best and most effective ways," said Flentje.</p>
What we know about black holes is both fascinating and scary.
- When it comes to black holes, science simultaneously knows so much and so little, which is why they are so fascinating. Focusing on what we do know, this group of astronomers, educators, and physicists share some of the most incredible facts about the powerful and mysterious objects.
- A black hole is so massive that light (and anything else it swallows) can't escape, says Bill Nye. You can't see a black hole, theoretical physicists Michio Kaku and Christophe Galfard explain, because it is too dark. What you can see, however, is the distortion of light around it caused by its extreme gravity.
- Explaining one unsettling concept from astrophysics called spaghettification, astronomer Michelle Thaller says that "If you got close to a black hole there would be tides over your body that small that would rip you apart into basically a strand of spaghetti that would fall down the black hole."
The team caught a glimpse of a process that takes 18,000,000,000,000,000,000,000 years.
- In Italy, a team of scientists is using a highly sophisticated detector to hunt for dark matter.
- The team observed an ultra-rare particle interaction that reveals the half-life of a xenon-124 atom to be 18 sextillion years.
- The half-life of a process is how long it takes for half of the radioactive nuclei present in a sample to decay.
A new study looks at what would happen to human language on a long journey to other star systems.
- A new study proposes that language could change dramatically on long space voyages.
- Spacefaring people might lose the ability to understand the people of Earth.
- This scenario is of particular concern for potential "generation ships".