What is the most overrated book?

Question: What is the most overrated book?

Khakpour:    I can’t say books, but I can say genre.  I think a lot of the Iranian novels of the last 20 years or so – highly overrated.  I don’t think they . . . they have good writing in them.  And I don’t think it was a priority for those writers to push themselves in terms of writing.  Nor was it a priority of their publishers to put out great writing.  I think they were selling, again, the image of a woman in a veil crying maybe in a kitchen.  So I’m very frustrated with that.  And I hate to say that on some level, but I do take it personally that some of the writing is so bad.  I wonder if those people are writers even, you know?  It’s not enough to have a story to tell.  Everybody has a story to tell.  I really believe that.  And then there’s cycles in history where one person’s story becomes more relevant than someone else’s, say.  But what goes around comes around always, and so I just think that when you compare the sort of literary tradition in Iran, and then put that up against those types of books that have come out in the immigrant community, the exile community – it’s just shocking.  I mean Iran is a country where you had such a progressive poet like __________ – one of the, you know, greatest confessional poets probably in all of history – you know, writing this incredibly candid, startling verse in the ‘50s and ‘60s.  And then you also had a writer like _________ who, you know, could be talked of in the same breath as _________ and _________; and his sort of intensely scary, incredibly progressive, and innovative writing.  And then to compare it with the stuff that’s come out, it’s just sort of embarrassing.  You know it’s like looking at the great Indies versus Hollywood blockbusters.  So that motivated me to try to write a book where the actual sentences were, you know, rich and well done.  A lot of the female writers, I have been sent their books before.  And I . . .  Their shadow has sort of followed me a lot, you know.  And I’m sort of expected . . . been expected to embrace them and say, “We’re all a happy family of these female Iranian writers.”  But if anything I think they made it tough for me to get my book published because I wasn’t interested in those buzz words.  And I wasn’t interested in telling that same story that seems to over and over capture western audiences.  I wanted to tell a different type of story, and I wanna continue to write a different type of book.  I’d like it to be incidental that I’m Iranian eventually.  But for the time being I’m sort of interested in some of those Middle Eastern issues.  I happen to be, so I might linger there for a while longer.  But my hope is that I can eventually be freed of what’s expected of a person with my background.

Khakpour takes a whole genre to task.

An organism found in dirt may lead to an anxiety vaccine, say scientists

Can dirt help us fight off stress? Groundbreaking new research shows how.

University of Colorado Boulder
Surprising Science
  • New research identifies a bacterium that helps block anxiety.
  • Scientists say this can lead to drugs for first responders and soldiers, preventing PTSD and other mental issues.
  • The finding builds on the hygiene hypothesis, first proposed in 1989.

Are modern societies trying too hard to be clean, at the detriment to public health? Scientists discovered that a microorganism living in dirt can actually be good for us, potentially helping the body to fight off stress. Harnessing its powers can lead to a "stress vaccine".

Researchers at the University of Colorado Boulder found that the fatty 10(Z)-hexadecenoic acid from the soil-residing bacterium Mycobacterium vaccae aids immune cells in blocking pathways that increase inflammation and the ability to combat stress.

The study's senior author and Integrative Physiology Professor Christopher Lowry described this fat as "one of the main ingredients" in the "special sauce" that causes the beneficial effects of the bacterium.

The finding goes hand in hand with the "hygiene hypothesis," initially proposed in 1989 by the British scientist David Strachan. He maintained that our generally sterile modern world prevents children from being exposed to certain microorganisms, resulting in compromised immune systems and greater incidences of asthma and allergies.

Contemporary research fine-tuned the hypothesis, finding that not interacting with so-called "old friends" or helpful microbes in the soil and the environment, rather than the ones that cause illnesses, is what's detrimental. In particular, our mental health could be at stake.

"The idea is that as humans have moved away from farms and an agricultural or hunter-gatherer existence into cities, we have lost contact with organisms that served to regulate our immune system and suppress inappropriate inflammation," explained Lowry. "That has put us at higher risk for inflammatory disease and stress-related psychiatric disorders."

University of Colorado Boulder

Christopher Lowry

This is not the first study on the subject from Lowry, who published previous work showing the connection between being exposed to healthy bacteria and mental health. He found that being raised with animals and dust in a rural environment helps children develop more stress-proof immune systems. Such kids were also likely to be less at risk for mental illnesses than people living in the city without pets.

Lowry's other work also pointed out that the soil-based bacterium Mycobacterium vaccae acts like an antidepressant when injected into rodents. It alters their behavior and has lasting anti-inflammatory effects on the brain, according to the press release from the University of Colorado Boulder. Prolonged inflammation can lead to such stress-related disorders as PTSD.

The new study from Lowry and his team identified why that worked by pinpointing the specific fatty acid responsible. They showed that when the 10(Z)-hexadecenoic acid gets into cells, it works like a lock, attaching itself to the peroxisome proliferator-activated receptor (PPAR). This allows it to block a number of key pathways responsible for inflammation. Pre-treating the cells with the acid (or lipid) made them withstand inflammation better.

Lowry thinks this understanding can lead to creating a "stress vaccine" that can be given to people in high-stress jobs, like first responders or soldiers. The vaccine can prevent the psychological effects of stress.

What's more, this friendly bacterium is not the only potentially helpful organism we can find in soil.

"This is just one strain of one species of one type of bacterium that is found in the soil but there are millions of other strains in soils," said Lowry. "We are just beginning to see the tip of the iceberg in terms of identifying the mechanisms through which they have evolved to keep us healthy. It should inspire awe in all of us."

Check out the study published in the journal Psychopharmacology.

For most of history, humans got smarter. That's now reversing.

We were gaining three IQ points per decade for many, many years. Now, that's going backward. Could this explain some of our choices lately?

The Flynn effect appears to be in retrograde. (Credit: Shutterstock/Big Think)
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An ordained Lama in a Tibetan Buddhist lineage, Lama Rod grew up a queer, black male within the black Christian church in the American south. Navigating all of these intersecting, evolving identities has led him to a life's work based on compassion for self and others.

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