Self-Motivation
David Goggins
Former Navy Seal
Career Development
Bryan Cranston
Actor
Critical Thinking
Liv Boeree
International Poker Champion
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Amaryllis Fox
Former CIA Clandestine Operative
Management
Chris Hadfield
Retired Canadian Astronaut & Author
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The Renaissance, Times a Thousand

Question: What keeps you up at night?

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Juan Enriquez: You know, the thing that keeps me most awake is the desire and curiosity to learn more.

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I sit there and I think, “I didn’t get through all of this, I didn’t learn more about that, I forgot to follow through on this link. There was this really interesting idea that I could have followed through on.” There is so much extraordinary opportunity if you’re curious, if you’re interested.

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It’s not fear that keeps me up. I mean, every generation has thought, this is the worst generation; the world’s going to hell in a hand basket. The reality is, people are living longer, and they’re living better. There are less interstate conflicts today than there have been traditionally throughout history. Yeah, the economy is a mess. Yes, government has done some stupid things. Yes, there has to be some more regulation. But our kids have this incredible buffet of they can work in genomics, they can work in pre-omics, or they can work in robotics, or they can work in this, or they can work in that. And within the next five years there will be entirely new industries that come out of nowhere that kids are working in that would have been inconceivable when they started college. Not when we started college.

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And so, it’s such an extraordinary time to be alive that you just don’t want to miss it. I mean, it’s a really neat historical period. There’s a creativity, a power, an energy, an ability to do things unlike any other period in history. It’s a little bit like sitting in the Renaissance, but multiplied a thousand-fold. And if you had a front row seat at the Renaissance, you would have seen Machiavelli come by plotting, and you would have seen murders in the streets, you would have seen violence, you have seen people burning books and it would have looked like the world was a horrible place, but that’s where all these incredible stuff we’re still living with comes out of.

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And now we have an opportunity to create that.

Recorded on November 9, 2009
Interviewed by Austin Allen

What keeps Excel Venture Management’s Juan Enriquez awake at night? Sheer excitement about our new golden age of discovery.

Hulu's original movie "Palm Springs" is the comedy we needed this summer

Andy Samberg and Cristin Milioti get stuck in an infinite wedding time loop.

Gear
  • Two wedding guests discover they're trapped in an infinite time loop, waking up in Palm Springs over and over and over.
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Our ‘little brain’ turns out to be pretty big

The multifaceted cerebellum is large — it's just tightly folded.

Image source: Sereno, et al
Mind & Brain
  • A powerful MRI combined with modeling software results in a totally new view of the human cerebellum.
  • The so-called 'little brain' is nearly 80% the size of the cerebral cortex when it's unfolded.
  • This part of the brain is associated with a lot of things, and a new virtual map is suitably chaotic and complex.

Just under our brain's cortex and close to our brain stem sits the cerebellum, also known as the "little brain." It's an organ many animals have, and we're still learning what it does in humans. It's long been thought to be involved in sensory input and motor control, but recent studies suggests it also plays a role in a lot of other things, including emotion, thought, and pain. After all, about half of the brain's neurons reside there. But it's so small. Except it's not, according to a new study from San Diego State University (SDSU) published in PNAS (Proceedings of the National Academy of Sciences).

A neural crêpe

A new imaging study led by psychology professor and cognitive neuroscientist Martin Sereno of the SDSU MRI Imaging Center reveals that the cerebellum is actually an intricately folded organ that has a surface area equal in size to 78 percent of the cerebral cortex. Sereno, a pioneer in MRI brain imaging, collaborated with other experts from the U.K., Canada, and the Netherlands.

So what does it look like? Unfolded, the cerebellum is reminiscent of a crêpe, according to Sereno, about four inches wide and three feet long.

The team didn't physically unfold a cerebellum in their research. Instead, they worked with brain scans from a 9.4 Tesla MRI machine, and virtually unfolded and mapped the organ. Custom software was developed for the project, based on the open-source FreeSurfer app developed by Sereno and others. Their model allowed the scientists to unpack the virtual cerebellum down to each individual fold, or "folia."

Study's cross-sections of a folded cerebellum

Image source: Sereno, et al.

A complicated map

Sereno tells SDSU NewsCenter that "Until now we only had crude models of what it looked like. We now have a complete map or surface representation of the cerebellum, much like cities, counties, and states."

That map is a bit surprising, too, in that regions associated with different functions are scattered across the organ in peculiar ways, unlike the cortex where it's all pretty orderly. "You get a little chunk of the lip, next to a chunk of the shoulder or face, like jumbled puzzle pieces," says Sereno. This may have to do with the fact that when the cerebellum is folded, its elements line up differently than they do when the organ is unfolded.

It seems the folded structure of the cerebellum is a configuration that facilitates access to information coming from places all over the body. Sereno says, "Now that we have the first high resolution base map of the human cerebellum, there are many possibilities for researchers to start filling in what is certain to be a complex quilt of inputs, from many different parts of the cerebral cortex in more detail than ever before."

This makes sense if the cerebellum is involved in highly complex, advanced cognitive functions, such as handling language or performing abstract reasoning as scientists suspect. "When you think of the cognition required to write a scientific paper or explain a concept," says Sereno, "you have to pull in information from many different sources. And that's just how the cerebellum is set up."

Bigger and bigger

The study also suggests that the large size of their virtual human cerebellum is likely to be related to the sheer number of tasks with which the organ is involved in the complex human brain. The macaque cerebellum that the team analyzed, for example, amounts to just 30 percent the size of the animal's cortex.

"The fact that [the cerebellum] has such a large surface area speaks to the evolution of distinctively human behaviors and cognition," says Sereno. "It has expanded so much that the folding patterns are very complex."

As the study says, "Rather than coordinating sensory signals to execute expert physical movements, parts of the cerebellum may have been extended in humans to help coordinate fictive 'conceptual movements,' such as rapidly mentally rearranging a movement plan — or, in the fullness of time, perhaps even a mathematical equation."

Sereno concludes, "The 'little brain' is quite the jack of all trades. Mapping the cerebellum will be an interesting new frontier for the next decade."

Economists show how welfare programs can turn a "profit"

What happens if we consider welfare programs as investments?

Spencer Platt/Getty Images
Politics & Current Affairs
  • A recently published study suggests that some welfare programs more than pay for themselves.
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Two MIT students just solved Richard Feynman’s famed physics puzzle

Richard Feynman once asked a silly question. Two MIT students just answered it.

Surprising Science

Here's a fun experiment to try. Go to your pantry and see if you have a box of spaghetti. If you do, take out a noodle. Grab both ends of it and bend it until it breaks in half. How many pieces did it break into? If you got two large pieces and at least one small piece you're not alone.

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Unhappy at work? How to find meaning and maintain your mental health

Finding a balance between job satisfaction, money, and lifestyle is not easy.

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  • "The evidence is that about 70 percent of people are not engaged in what they do all day long, and about 18 percent of people are repulsed," London Business School professor Dan Cable says, calling the current state of work unhappiness an epidemic. In this video, he and other big thinkers consider what it means to find meaning in your work, discuss the parts of the brain that fuel creativity, and share strategies for reassessing your relationship to your job.
  • Author James Citrin offers a career triangle model that sees work as a balance of three forces: job satisfaction, money, and lifestyle. While it is possible to have all three, Citrin says that they are not always possible at the same time, especially not early on in your career.
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